LOCUS       NM_001317059            1102 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus zinc finger protein 580 (Zfp580), mRNA.
ACCESSION   NM_001317059
VERSION     NM_001317059.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1102)
  AUTHORS   Yin,C., Ji,Y., Ma,N., Chen,K., Zhang,W., Bai,D., Jia,X., Xia,S. and
            Yin,H.
  TITLE     RNA-seq Analysis Reveals Potential Molecular Mechanisms of
            ZNF580/ZFP580 Promoting Neuronal Survival and Inhibiting Apoptosis
            after Hypoxic-ischemic Brain damage
  JOURNAL   Neuroscience 483, 52-65 (2022)
   PUBMED   34929337
  REMARK    GeneRIF: RNA-seq Analysis Reveals Potential Molecular Mechanisms of
            ZNF580/ZFP580 Promoting Neuronal Survival and Inhibiting Apoptosis
            after Hypoxic-ischemic Brain damage.
REFERENCE   2  (bases 1 to 1102)
  AUTHORS   Wei,S., Zhang,J., Han,B., Liu,J., Xiang,X., Zhang,M., Xia,S.,
            Zhang,W. and Zhang,X.
  TITLE     Novel Zinc Finger Transcription Factor ZFP580 Facilitates All-Trans
            Retinoic Acid -Induced Vascular Smooth Muscle Cells Differentiation
            by Raralpha-Mediated PI3K/Akt and ERK Signaling
  JOURNAL   Cell Physiol Biochem 50 (6), 2390-2405 (2018)
   PUBMED   30423583
  REMARK    GeneRIF: Overexpression of ZFP580 promoted vascular smooth muscle
            cells differentiation by enhancing expression of SM22alpha and
            SMalpha-actin and reducing expression of SMemb. In contrast,
            silencing ZFP580 dramatically reduced the expression of
            differentiation markers and increased expression of
            dedifferentiation markers.
REFERENCE   3  (bases 1 to 1102)
  AUTHORS   Wei,S., Huang,J., Li,Y., Zhao,J., Luo,Y., Meng,X., Sun,H., Zhou,X.,
            Zhang,M. and Zhang,W.
  TITLE     Novel zinc finger transcription factor ZFP580 promotes
            differentiation of bone marrow-derived endothelial progenitor cells
            into endothelial cells via eNOS/NO pathway
  JOURNAL   J Mol Cell Cardiol 87, 17-26 (2015)
   PUBMED   26268592
  REMARK    GeneRIF: ZFP580 promotes not only the differentiation of EPCs into
            ECs by increasing the expression of eNOS and the availability of
            nitric oxide, but also the vessel formation in vitro and in vivo
REFERENCE   4  (bases 1 to 1102)
  AUTHORS   Meng,X.Y., Yu,H.L., Zhang,W.C., Wang,T.H., Mai,X., Liu,H.T. and
            Xu,R.C.
  TITLE     ZFP580, a novel zinc-finger transcription factor, is involved in
            cardioprotection of intermittent high-altitude hypoxia against
            myocardial ischemia-reperfusion injury
  JOURNAL   PLoS One 9 (4), e94635 (2014)
   PUBMED   24722354
  REMARK    GeneRIF: Our findings demonstrate that the cardioprotective effect
            of intermitten high altitude hypoxia against ischemia-reperfusion
            injury is mediated via ZFP580, a downstream target of ERK1/2
            signaling with anti-apoptotic roles in myocardial cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1102)
  AUTHORS   DangLi,R., HeKong,W., JiQin,L., MingHua,Z. and WenCheng,Z.
  TITLE     ROS-induced ZNF580 expression: a key role for H2O2/NF-kappaB
            signaling pathway in vascular endothelial inflammation
  JOURNAL   Mol Cell Biochem 359 (1-2), 183-191 (2012)
   PUBMED   21830064
REFERENCE   6  (bases 1 to 1102)
  AUTHORS   Luo,Y., Hu,W., Xu,R., Hou,B., Zhang,L. and Zhang,W.
  TITLE     ZNF580, a novel C2H2 zinc-finger transcription factor, interacts
            with the TGF-beta signal molecule Smad2
  JOURNAL   Cell Biol Int 35 (11), 1153-1157 (2011)
   PUBMED   21599657
REFERENCE   7  (bases 1 to 1102)
  AUTHORS   Sun,H.Y., Wei,S.P., Xu,R.C., Xu,P.X. and Zhang,W.C.
  TITLE     Sphingosine-1-phosphate induces human endothelial VEGF and MMP-2
            production via transcription factor ZNF580: novel insights into
            angiogenesis
  JOURNAL   Biochem Biophys Res Commun 395 (3), 361-366 (2010)
   PUBMED   20382120
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB807411.1 and JAXUCZ010000001.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.867.1, SRR26643291.666.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840105, SAMN12840111
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-406               CB807411.1         1-406
            407-1102            JAXUCZ010000001.1  77815959-77816654   c
FEATURES             Location/Qualifiers
     source          1..1102
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..1102
                     /gene="Zfp580"
                     /gene_synonym="Znf580"
                     /note="zinc finger protein 580"
                     /db_xref="GeneID:308336"
                     /db_xref="RGD:1306892"
     exon            1..162
                     /gene="Zfp580"
                     /gene_synonym="Znf580"
                     /inference="alignment:Splign:2.1.0"
     exon            163..1102
                     /gene="Zfp580"
                     /gene_synonym="Znf580"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..693
                     /gene="Zfp580"
                     /gene_synonym="Znf580"
                     /codon_start=1
                     /product="zinc finger protein 580"
                     /protein_id="NP_001303988.1"
                     /db_xref="GeneID:308336"
                     /db_xref="RGD:1306892"
                     /translation="MLLLPPRPPHPRSSSPEVMDPPPPKTPPFPKAEGPSSTSSSVAG
                     PRPPRLGRHLLIDANGVPYTYTVQLEEEPRGPPQREATPGEPGPRKGYSCPECARVFA
                     SPLRLQSHRVSHSDLKPFTCGACGKAFKRSSHLSRHRATHRARAGPPHTCPLCPRRFQ
                     DAAELAQHVRLH"
ORIGIN      
        1 gtcgcccctc gcgcccctgc gccccccgac ccgcgtcccc ggcgccgccg gcccggagct
       61 gcccggaagc tcgctcctac cgcggcgctc gtcagggcaa gcccgggtcc gtccgggacc
      121 tcggccccgt tctcccccgg acccgagagg ctgctgcacc ggctgccgct ccagatgctg
      181 ctgctgccgc cgcggccacc ccaccctcgg tcctcctctc cggaggtcat ggacccaccg
      241 ccccccaaga ctcccccttt tcccaaggcg gaaggcccct cctccacttc ttcctcggtg
      301 gcggggccgc ggccaccgcg gctgggccgc catctgctca tcgacgccaa cggggtcccc
      361 tacacgtaca cggtgcagct ggaggaggaa cctaggggcc cgccgcagcg cgaggcgacc
      421 ccgggagagc caggtcctcg caagggctac agctgcccag agtgcgctcg tgtctttgcc
      481 agccctctgc ggctgcagag ccaccgtgtg tcgcactcgg acctcaagcc ctttacttgt
      541 ggtgcttgtg gcaaagcttt caagcgctcc agccacctgt cgcggcaccg cgccacccac
      601 cgtgcgcgcg ctggtccacc tcacacctgc ccactctgtc cacgccgctt ccaggacgcc
      661 gcggagctgg cgcaacacgt gcgcctgcac taagttcagc cctgctctct ctgggccacc
      721 acgttcgtcc cacacagtgt cattcctaca catatcccag ttctgctgag gttactgcct
      781 taccctaggc ctcagtttcc ccaccaaccc ccaaagagaa acatcatttc gtcttttctt
      841 ctgtctagct gtgtgatgta gaccaaagtt gttgcccctc tgggcctggg tgtcaattgg
      901 aactgggctt cagtccagcc gtgctgtgta agcctttgca aatgctacga cctctcctga
      961 gtcttggtcg tctactcttc ccaagtagta aggtcctcgt ggaagaaatg acaaaagcac
     1021 cagcacggtc tggatcacct ctgtacttcc ctctaatgcc catgatccct cgttctttgc
     1081 ccaataaaca ttccgcactt ca
//
