LOCUS       NP_998730                406 aa            linear   ROD 27-APR-2025
DEFINITION  zinc finger protein 57 [Rattus norvegicus].
ACCESSION   NP_998730 XP_342080
VERSION     NP_998730.2
DBSOURCE    REFSEQ: accession NM_213565.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 406)
  AUTHORS   Takahashi,N., Coluccio,A., Thorball,C.W., Planet,E., Shi,H.,
            Offner,S., Turelli,P., Imbeault,M., Ferguson-Smith,A.C. and
            Trono,D.
  TITLE     ZNF445 is a primary regulator of genomic imprinting
  JOURNAL   Genes Dev 33 (1-2), 49-54 (2019)
   PUBMED   30602440
REFERENCE   2  (residues 1 to 406)
  AUTHORS   Buck-Koehntop,B.A. and Defossez,P.A.
  TITLE     On how mammalian transcription factors recognize methylated DNA
  JOURNAL   Epigenetics 8 (2), 131-137 (2013)
   PUBMED   23324617
  REMARK    Review article
REFERENCE   3  (residues 1 to 406)
  AUTHORS   Gehrig,S.M., van der Poel,C., Sayer,T.A., Schertzer,J.D.,
            Henstridge,D.C., Church,J.E., Lamon,S., Russell,A.P., Davies,K.E.,
            Febbraio,M.A. and Lynch,G.S.
  TITLE     Hsp72 preserves muscle function and slows progression of severe
            muscular dystrophy
  JOURNAL   Nature 484 (7394), 394-398 (2012)
   PUBMED   22495301
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 406)
  AUTHORS   Li,X., Ito,M., Zhou,F., Youngson,N., Zuo,X., Leder,P. and
            Ferguson-Smith,A.C.
  TITLE     A maternal-zygotic effect gene, Zfp57, maintains both maternal and
            paternal imprints
  JOURNAL   Dev Cell 15 (4), 547-557 (2008)
   PUBMED   18854139
REFERENCE   5  (residues 1 to 406)
  AUTHORS   Mackay,D.J., Callaway,J.L., Marks,S.M., White,H.E., Acerini,C.L.,
            Boonen,S.E., Dayanikli,P., Firth,H.V., Goodship,J.A., Haemers,A.P.,
            Hahnemann,J.M., Kordonouri,O., Masoud,A.F., Oestergaard,E.,
            Storr,J., Ellard,S., Hattersley,A.T., Robinson,D.O. and Temple,I.K.
  TITLE     Hypomethylation of multiple imprinted loci in individuals with
            transient neonatal diabetes is associated with mutations in ZFP57
  JOURNAL   Nat Genet 40 (8), 949-951 (2008)
   PUBMED   18622393
REFERENCE   6  (residues 1 to 406)
  AUTHORS   Alonso,M.B., Zoidl,G., Taveggia,C., Bosse,F., Zoidl,C., Rahman,M.,
            Parmantier,E., Dean,C.H., Harris,B.S., Wrabetz,L., Muller,H.W.,
            Jessen,K.R. and Mirsky,R.
  TITLE     Identification and characterization of ZFP-57, a novel zinc finger
            transcription factor in the mammalian peripheral nervous system
  JOURNAL   J Biol Chem 279 (24), 25653-25664 (2004)
   PUBMED   15070898
REFERENCE   7  (residues 1 to 406)
  AUTHORS   Okazaki,S., Tanase,S., Choudhury,B.K., Setoyama,K., Miura,R.,
            Ogawa,M. and Setoyama,C.
  TITLE     A novel nuclear protein with zinc fingers down-regulated during
            early mammalian cell differentiation
  JOURNAL   J Biol Chem 269 (9), 6900-6907 (1994)
   PUBMED   8120052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA511208.1 and BC127468.1.
            
            On Dec 7, 2007 this sequence version replaced NP_998730.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CA511208.1, DY312591.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..406
                     /organism="Rattus norvegicus"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     Protein         1..406
                     /product="zinc finger protein 57"
                     /note="zfp-57"
                     /calculated_mol_wt=46457
     Region          17..70
                     /region_name="KRAB"
                     /note="krueppel associated box; smart00349"
                     /db_xref="CDD:214630"
     Region          57..77
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A0JPK3.1)"
     Region          92..134
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(97,99,101,103..104,107..108,114,147,149,153..154,
                     157..158,161,175,177,179,181..182,185..186,189)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          142..162
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          169..190
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          170..190
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            178
                     /site_type="other"
                     /note="Crucial for 5-methylcytosine recognition.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (A0JPK3.1)"
     Region          194..226
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A0JPK3.1)"
     Region          272..292
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(277,279,281,283..284,287..288,291,309..310,313..314,
                     317,325,327,329,331..332,335..336)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          320..337
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          372..406
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A0JPK3.1)"
     CDS             1..406
                     /gene="Zfp57"
                     /coded_by="NM_213565.4:265..1485"
                     /db_xref="GeneID:361783"
                     /db_xref="RGD:1302981"
ORIGIN      
        1 maakkqsksa kalrttvrye dvavsftqee weyltstqkt lyqkvmsetf knltfveskk
       61 kpqepnpnlk dkdddksstc tgvfkggpff fcltcgkcfk kntflfnhqf pvrsrrlavt
      121 kpqsrkalgh kpqhrgdrpf fcnlcgktyr dasglsrhrr ahvgyrprsc pecgkcfrdq
      181 sevnrhlkvh qnkkpvagsh vkvhqnkpva snqkqkgrvp pttrespapa lrhlkviqgp
      241 varakarssr asslevrsts vtvarprekv ycpycritft mrtcllnhlk ihfrrqpnqh
      301 fcckeshssn tlrmqkiync pvcdssfrgk esllnhlcsr rpirlskcwe ilghllgylr
      361 eplgnifkvr esrkrrrkri ssdssetegp sgsdevmevd tdsdls
//
