LOCUS       NM_001107403            4862 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus zinc finger protein 521 (Zfp521), transcript
            variant 1, mRNA.
ACCESSION   NM_001107403 XM_001073019 XM_226153
VERSION     NM_001107403.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4862)
  AUTHORS   Xie,X.T., Zhan,X.L. and Hu,Z.H.
  TITLE     [Zinc finger protein 521 suppresses osteogenic differentiation of
            rat mesenchymal stem cells by inhibiting the Wnt/beta-catenin
            signaling pathway]
  JOURNAL   Mol Biol (Mosk) 51 (3), 464-472 (2017)
   PUBMED   28707663
  REMARK    GeneRIF: Therefore, we conclude that Zfp521 regulates osteogenic
            differentiation of rat MSCs through the suppression of the
            Wnt/beta-catenin signaling pathway.
REFERENCE   2  (bases 1 to 4862)
  AUTHORS   Lou,S., Pan,X., Huang,T., Duan,B., Yang,F.C., Yang,J., Xiong,M.,
            Liu,Y. and Ma,Q.
  TITLE     Incoherent feed-forward regulatory loops control segregation of
            C-mechanoreceptors, nociceptors, and pruriceptors
  JOURNAL   J Neurosci 35 (13), 5317-5329 (2015)
   PUBMED   25834056
REFERENCE   3  (bases 1 to 4862)
  AUTHORS   Warming,S., Liu,P., Suzuki,T., Akagi,K., Lindtner,S.,
            Pavlakis,G.N., Jenkins,N.A. and Copeland,N.G.
  TITLE     Evi3, a common retroviral integration site in murine B-cell
            lymphoma, encodes an EBFAZ-related Kruppel-like zinc finger protein
  JOURNAL   Blood 101 (5), 1934-1940 (2003)
   PUBMED   12393497
REFERENCE   4  (bases 1 to 4862)
  AUTHORS   Tchernev,V.T., Mansfield,T.A., Giot,L., Kumar,A.M., Nandabalan,K.,
            Li,Y., Mishra,V.S., Detter,J.C., Rothberg,J.M., Wallace,M.R.,
            Southwick,F.S. and Kingsmore,S.F.
  TITLE     The Chediak-Higashi protein interacts with SNARE complex and signal
            transduction proteins
  JOURNAL   Mol Med 8 (1), 56-64 (2002)
   PUBMED   11984006
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Mar 19, 2021 this sequence version replaced NM_001107403.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.50767.1,
                                           SRR26360194.1950101.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               JAXUCZ010000018.1  5342899-5343043     c
            146-186             JAXUCZ010000018.1  5341775-5341815     c
            187-366             JAXUCZ010000018.1  5312351-5312530     c
            367-3722            JAXUCZ010000018.1  5216393-5219748     c
            3723-3807           JAXUCZ010000018.1  5188332-5188416     c
            3808-3939           JAXUCZ010000018.1  5090685-5090816     c
            3940-4055           JAXUCZ010000018.1  5088072-5088187     c
            4056-4862           JAXUCZ010000018.1  5061918-5062724     c
FEATURES             Location/Qualifiers
     source          1..4862
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p13"
     gene            1..4862
                     /gene="Zfp521"
                     /gene_synonym="Znf521"
                     /note="zinc finger protein 521"
                     /db_xref="GeneID:307579"
                     /db_xref="RGD:1307345"
     exon            1..145
                     /gene="Zfp521"
                     /gene_synonym="Znf521"
                     /inference="alignment:Splign:2.1.0"
     exon            146..186
                     /gene="Zfp521"
                     /gene_synonym="Znf521"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..4085
                     /gene="Zfp521"
                     /gene_synonym="Znf521"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 521 isoform 1"
                     /protein_id="NP_001100873.2"
                     /db_xref="GeneID:307579"
                     /db_xref="RGD:1307345"
                     /translation="MSRRKQAKPRSLKDPNCKLEDKIEDGEAVDCKKRPDDGEELEED
                     AVHSCDSCLQVFESLSDITEHKIHQCQLTDGVDVEDDPTCSWPASSPSSKDQTSPSHG
                     EGCDFGEEEGGPGLPYPCQFCDKSFSRLSYLKHHEQSHSDKLPFKCTYCSRLFKHKRS
                     RDRHIKLHTGDKKYHCSECDAAFSRSDHLKIHLKTHTSNKPYKCAVCRRGFLSSSSLH
                     GHMQVHERSKDGSQSGSRMEDWKMKDTQKCSQCEEGFDFPEDLQKHIAECHPECSPNE
                     DRAALQCVYCHELFVEETSLMNHIEQVHGGEKKNSCSICSESFLTVEELYSHMDSHQQ
                     PESCNHSNSPSLVTVGYTSVSSTTPDSNLSVDSSTMVEAAPPIPKSRGRKRAAQQTSD
                     MTGPSSKQAKVTYSCIYCNKQLFSSLAVLQIHLKTMHLDKPEQAHICQYCLEVLPSLY
                     NLNEHLKQVHEAQDPGLIVSAMPAIIYQCNFCSEVVNDLNTLQEHIRCSHGFANPAAK
                     DSNAFFCPHCYMGFLTDSSLEEHIRQVHCDLSGSRFGSPVLGTPKEPVVEVYSCSYCT
                     NSPIFNSVLKLNKHIKENHKNIPLALNYIHNGKKSRALSPLSPVAIEQTSLKMMQTVG
                     GGPARAAGEYICNQCGAKYTSLDSFQTHLKTHLDTVLPKLTCPQCNKEFPNQESLLKH
                     VTIHFMITSTYYICESCDKQFTSVDDLQKHLLDMHTFVFFRCTLCQEVFDSKVSIQLH
                     LAVKHSNEKKVYRCTSCNWDFRNETDLQLHVKHNHLENQGKVHKCIFCGESFGTEVEL
                     QCHITTHSKKYNCRFCSKAFHAVLLLEKHLREKHCVFETKTPNCGTNGASEQVQKEEA
                     ELQTLLTNSQESHNSHDGSEEDVDSSEPMYGCDICGAAYTMETLLQNHQLRDHNIRPG
                     ESAIVKKKAELIKGNYKCNVCSRTFFSENGLREHMQTHLGPVKHYMCPICGERFPSLL
                     TLTEHKVTHSKSLDTGNCRICKMPLQSEEEFLEHCQMHPDLRNSLTGFRCVVCMQTVT
                     STLELKIHGTFHMQKTGNGSSVQTTGRGQHVQKLYKCASCLKEFRSKQDLVKLDINGL
                     PYGLCAGCVNLSKSSSPGLGLPPVASRPGLGQNESLSAMEGKGKAGGLKTTRCSSCNV
                     KFESESELQNHIQTVHRELVPDANSTQLKTPQVSPMPRISPSQSDEKKTYQCIKCQMV
                     FYNEWDIQVHVANHMIDEGLNHECKLCSQTFDSPAKLQCHLIEHSFEGMGGTFKCPVC
                     FTVFVQANKLQQHIFSAHGQEDKIYDCTQCPQKFFFQTELQNHTMTQHSS"
     exon            187..366
                     /gene="Zfp521"
                     /gene_synonym="Znf521"
                     /inference="alignment:Splign:2.1.0"
     exon            367..3722
                     /gene="Zfp521"
                     /gene_synonym="Znf521"
                     /inference="alignment:Splign:2.1.0"
     exon            3723..3807
                     /gene="Zfp521"
                     /gene_synonym="Znf521"
                     /inference="alignment:Splign:2.1.0"
     exon            3808..3939
                     /gene="Zfp521"
                     /gene_synonym="Znf521"
                     /inference="alignment:Splign:2.1.0"
     exon            3940..4055
                     /gene="Zfp521"
                     /gene_synonym="Znf521"
                     /inference="alignment:Splign:2.1.0"
     exon            4056..4862
                     /gene="Zfp521"
                     /gene_synonym="Znf521"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatttcctca gtgattacgt acagagcgag tccctgcggg ttaggggccc cctctggagc
       61 catcctgatg gctttggggg ccttgcttcc attttccatt attatgtgga ctaccggagc
      121 gacagcgcag tccaagacct tgcaggatgt ctcgccgcaa gcaagcgaaa ccgagatccc
      181 tcaaagaccc caactgtaaa cttgaagaca agattgaaga tggggaggca gtagactgca
      241 agaagaggcc agacgacggg gaggagttgg aggaggatgc tgtgcacagc tgtgacagct
      301 gcctccaggt gttcgagtca ctgagcgata tcacagagca caagatccat cagtgccagc
      361 tgacagatgg agttgatgtt gaggacgacc ccacctgctc ttggccagct tcctcacctt
      421 ccagtaagga ccagacttcc cctagccatg gtgaaggctg tgatttcgga gaggaagaag
      481 gtggccctgg actgccttac ccgtgccagt tctgtgacaa gtcctttagc cgcctcagct
      541 acctaaagca ccatgagcag agccacagtg acaagctgcc cttcaagtgt acctactgca
      601 gccggctgtt caaacacaag cggagccgtg acaggcacat caagctccac acgggggaca
      661 agaagtacca ctgtagcgag tgcgacgcag cgttctcccg gagcgaccac ctcaagatcc
      721 acttaaagac tcatacctcc aacaagccat acaaatgcgc cgtctgccgc agaggcttcc
      781 tgtcttctag ctccttgcac ggacatatgc aggttcatga gcggagcaag gacggctccc
      841 agtctggctc caggatggag gactggaaga tgaaggacac tcagaagtgc agccagtgtg
      901 aggaaggctt tgacttccca gaagacctcc agaagcacat cgcagagtgc caccccgagt
      961 gctccccaaa tgaggacagg gcagccctcc agtgtgtgta ctgccacgag ctgtttgtgg
     1021 aggagacctc cctcatgaac cacatagagc aggtgcacgg gggtgagaaa aagaactcat
     1081 gtagcatatg ctcagagagc ttcctcactg tcgaggagct gtatagccac atggacagcc
     1141 accagcaacc agagtcctgc aatcacagca acagcccttc cctggtcacc gtgggataca
     1201 cctctgtgtc cagcaccact ccagattcca acctctcagt ggacagctca accatggtgg
     1261 aggccgcacc accaattcca aagagccgcg ggaggaagcg agctgcccag cagacctccg
     1321 atatgactgg cccctccagt aaacaggcaa aagtcaccta cagctgcatt tactgcaaca
     1381 agcagttatt ctcgagtctc gcggtcctgc agattcactt gaaaactatg catttagata
     1441 agccggagca ggctcatatc tgtcagtatt gcttggaggt cttgccctca ctctataacc
     1501 taaatgaaca tcttaaacaa gtgcacgaag ctcaggaccc gggcctgatt gtttcggcca
     1561 tgcctgccat catttaccag tgcaacttct gttccgaagt tgtcaatgac ctcaacaccc
     1621 ttcaggagca catccgatgt tctcacgggt ttgccaatcc cgcagccaag gacagcaatg
     1681 ctttcttttg tccccattgt tacatggggt ttctcacaga ctcttccctt gaagagcata
     1741 taaggcaggt ccactgtgac ctcagcggct cccggtttgg gtctcctgtg cttgggactc
     1801 cgaaagaacc ggtagttgaa gtctactcct gttcctattg tacaaactcg ccaatattca
     1861 acagtgttct taaactgaat aagcatatta aagagaatca taaaaacatt cccttggccc
     1921 tgaattatat tcacaatggg aagaaatccc gggccctgag ccccttgtct cctgtggcta
     1981 tagaacagac atcgcttaag atgatgcaga cagtgggagg tggccctgcc cgtgctgctg
     2041 gagaatatat ctgtaaccag tgtggtgcta agtacacgtc cctagacagc tttcagactc
     2101 acctcaaaac ccatctggac accgtgctgc cgaaactgac ctgccctcag tgtaacaaag
     2161 agttccccaa tcaggagtcc ctgctgaagc acgtgaccat ccacttcatg atcacctcaa
     2221 cctactacat ctgcgagagc tgcgacaagc agttcacctc cgtggacgac ctccagaagc
     2281 acctgctgga catgcacacc ttcgtgttct tccgctgcac gctgtgccag gaggtgttcg
     2341 actcgaaggt gtccatccag ctgcacctgg ccgtgaagca cagtaacgag aagaaagtgt
     2401 accgctgcac gtcctgcaac tgggacttcc gcaacgagac cgacctgcag ctgcacgtga
     2461 agcacaacca cctggagaac cagggcaagg tgcacaagtg catcttctgt ggcgagtctt
     2521 tcggcaccga ggtggagctg cagtgccaca tcaccacgca cagcaagaag tacaactgca
     2581 ggttctgcag caaggccttc cacgcagtcc tcctgctgga gaagcacctg cgggagaagc
     2641 actgcgtgtt tgaaaccaag acccccaact gcggcaccaa cggagcctcg gagcaggtgc
     2701 agaaggagga ggccgagctg cagaccttgc tcaccaacag ccaggagtcc cataacagcc
     2761 acgacgggag cgaggaggac gtggacagct ccgaacccat gtatggctgc gacatctgcg
     2821 gggcggccta caccatggag actctgctgc agaaccacca gctccgggat cacaacatcc
     2881 gaccgggaga gagtgccatc gtgaagaaga aggcggagct cattaaaggg aattacaagt
     2941 gcaacgtgtg ctcgagaacc ttcttctctg agaacgggct ccgtgagcac atgcagactc
     3001 acttaggccc tgtcaaacac tacatgtgcc ccatctgtgg agagcgcttc ccttcccttt
     3061 tgactctgac cgaacacaaa gtcacgcaca gcaagagctt ggatactgga aactgtcgca
     3121 tttgcaagat gcccctgcag agcgaagagg agttcttaga gcattgtcag atgcaccctg
     3181 acctgaggaa ttccctcacc gggtttcgct gcgtggtgtg catgcagact gtgacctcca
     3241 ccttggaact caaaatccac gggaccttcc acatgcagaa gacggggaac gggtcctccg
     3301 tgcagaccac cgggcgtggc cagcacgttc agaaactgta taagtgcgca tcttgcctca
     3361 aagagttccg ttccaagcaa gatctggtga aacttgatat caacggcctg ccatatggtc
     3421 tctgtgccgg ctgtgtgaat ctcagtaaga gcagtagccc gggcctcggt ctccctcctg
     3481 ttgcgagcag accaggcttg ggccagaatg agagtctgag cgccatggaa ggaaaaggca
     3541 aggcaggggg tctgaagacg actcgctgtt caagctgcaa tgtcaagttt gagtctgaaa
     3601 gcgaactgca gaaccacatc cagacggtgc accgggagct cgtgccagac gccaacagca
     3661 cacagttgaa aacgccccaa gtgtcaccca tgcccagaat cagtccctcc cagtcagatg
     3721 agaagaagac ctaccagtgt atcaagtgtc agatggtttt ctacaacgag tgggacatcc
     3781 aggttcatgt ggcaaatcac atgattgatg aagggctgaa ccatgaatgc aaactctgca
     3841 gccagacctt tgactcccct gccaaacttc agtgtcacct gatagagcac agcttcgaag
     3901 ggatgggagg caccttcaag tgccccgtct gtttcacagt gtttgtccaa gctaacaagt
     3961 tgcagcagca catattctcc gcccatggac aagaagacaa aatctatgac tgcacacaat
     4021 gccctcagaa gtttttcttc caaacagagc tacagaatca tacgatgact cagcatagca
     4081 gttagttcac atacgcacga cctctctcga ggagaaggac tttgtggcac aaaaagggaa
     4141 catgttttac tctttgcacg aaactcccat tgttaatgta tattcttcag aagcattgta
     4201 ttgtatcata caacttgtat tatgaaaact gttggatgtt catgtgttgg aacttttgag
     4261 caccagatag accccttgta tataaagtgt tgcacatgta ctatgtcgcc aatgctacaa
     4321 tggtcttaaa aagacaagtg gacttgggcc ctgtccaggc aagattttca aagcgataaa
     4381 aatggcttaa gagaaaatgt ttccaaggaa gacagaactt aaatgaactg ttatcacatg
     4441 actatggttg gacttccttt tatgtacact taagcctaga acttctcttt ttggtatatc
     4501 aatggttaaa acccaagact attttttatt gctggagatt ctcgtgaacc atgaagagac
     4561 actctcacag aacagaaccc tacatctgga tacggcccat atatatattt gtaagccttg
     4621 cagtgtgaca ggtagcctcg ccatatatgc aatagttgtt atgtagactg tcaacgattt
     4681 tttttcctgg ctacatttga agctttgagt gttcgaggtt ctccttaatg atttcacaca
     4741 gccaaatcct tgaatcggtt gaactaacct gtatgttact gttctcaatg tttactctgc
     4801 ggtctgaacc tggagattac tggaattgtt ttccaagagg aaataaattc agtttaccat
     4861 ca
//
