LOCUS       NM_001033705            3936 bp    mRNA    linear   ROD 25-MAR-2024
DEFINITION  Rattus norvegicus zinc finger protein 451 (Zfp451), mRNA.
ACCESSION   NM_001033705 XM_237039
VERSION     NM_001033705.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3936)
  AUTHORS   Cappadocia,L., Pichler,A. and Lima,C.D.
  TITLE     Structural basis for catalytic activation by the human ZNF451 SUMO
            E3 ligase
  JOURNAL   Nat Struct Mol Biol 22 (12), 968-975 (2015)
   PUBMED   26524494
REFERENCE   2  (bases 1 to 3936)
  AUTHORS   Feng,Y., Wu,H., Xu,Y., Zhang,Z., Liu,T., Lin,X. and Feng,X.H.
  TITLE     Zinc finger protein 451 is a novel Smad corepressor in transforming
            growth factor-beta signaling
  JOURNAL   J Biol Chem 289 (4), 2072-2083 (2014)
   PUBMED   24324267
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001033705.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC101930.1, SRR26643299.38679.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               JAXUCZ010000009.1  43536414-43536606   c
            194-277             JAXUCZ010000009.1  43535815-43535898   c
            278-358             JAXUCZ010000009.1  43526529-43526609   c
            359-484             JAXUCZ010000009.1  43508675-43508800   c
            485-596             JAXUCZ010000009.1  43506246-43506357   c
            597-747             JAXUCZ010000009.1  43505451-43505601   c
            748-874             JAXUCZ010000009.1  43504690-43504816   c
            875-1028            JAXUCZ010000009.1  43502461-43502614   c
            1029-1176           JAXUCZ010000009.1  43501770-43501917   c
            1177-2759           JAXUCZ010000009.1  43499043-43500625   c
            2760-2900           JAXUCZ010000009.1  43495694-43495834   c
            2901-3031           JAXUCZ010000009.1  43493377-43493507   c
            3032-3218           JAXUCZ010000009.1  43492331-43492517   c
            3219-3284           JAXUCZ010000009.1  43488374-43488439   c
            3285-3936           JAXUCZ010000009.1  43481401-43482052   c
FEATURES             Location/Qualifiers
     source          1..3936
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q21"
     gene            1..3936
                     /gene="Zfp451"
                     /note="zinc finger protein 451"
                     /db_xref="GeneID:316312"
                     /db_xref="RGD:1305865"
     exon            1..193
                     /gene="Zfp451"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..3331
                     /gene="Zfp451"
                     /codon_start=1
                     /product="E3 SUMO-protein ligase ZNF451"
                     /protein_id="NP_001028877.2"
                     /db_xref="GeneID:316312"
                     /db_xref="RGD:1305865"
                     /translation="MGDPGPEIIESVPPAGPEPSESTADENEDDIQFVSEGPLRPVLE
                     YIDLVSSDDEEPSTSHSDENFKHKDYIDHQKDKVALTLARLARHVEVEKQQKEEKNRA
                     FREKIDFQHAHGLQELEFIQGHSETEAARQCVDQWLKMSGLRTSAINSGSKKSFQSGG
                     RMRRSDKSILCPIMHCNKEFDNGHLLLGHLKRFDHSPCDPTITLHGPLANVFACAVCY
                     EHFVTQQQYKDHLLSKAAAADGHSNDLPPQIIQCFACPHCFLLFSTKDECLKHMSAKN
                     HFHQSLKLGDDKGTARPVSFPSFAKKLLVSLCKDVPFLVKCVACHQTLRSHMELSAHF
                     RVRCRNAGPVAIAEKSITQVAKEFLVRGYCSDCNQVFMDEASTQSHKNPGHKMSFANS
                     VEESVLLYCHISEGSRPPCDLHLFNQPKISSLKRILSSKESSAEDCVIPTKKVNLGVD
                     SQGGTARVQRQRSTVTAWFCECSRRFPSEDAVEKHVFSANTMCYKCVVCGKVCEDSGV
                     MRLHMSRFHGGAHLNNFLFWCRMCKKELIRKDAIMAHVTEFHSGHRYFYEMDEVEAAV
                     PSSSTENHLNADKPPSPIAVVDHSPASSPPRGRWQCRICEDMFDSHECVQQHCASLTS
                     HRFHRYSCAHCRKTFHKVETLCRHCQDEHSGEVRMMYCCGLCDLIFNKEEAFLSHYTE
                     QHSGDYVFVPEKTKTSIKTEDDFKIIETSNLLSCGCHESYICKVNRRDDYDRCLQIML
                     EKGKLWFRCGSCSATAQNLADINTHVCQAHRKVRGDEEQQYVIKCGVCTKAFHNTESA
                     QQHFHRKHAAFQKPVTAHVRADHGSTGQLAASVSHAEKNPRHTSYQKCSDVERSAEHD
                     VCCQNIEEEVELPDVDYLRTMTHIVFVDFDNWSNFFGHLPGHLNQGTFIWGFQGGNTN
                     WKPPLGCKVYNYLNRIGCFFLHPRCSKRKDAADFAICMHAGRLDEQLPKQIPFTILSG
                     DQGFLELENQFKKTQRPAHILNPHHLEGDMMCALLNSISDTTKECDSDDSMGVKGSPV
                     EELRATEDVELEEAIRRSLEEM"
     exon            194..277
                     /gene="Zfp451"
                     /inference="alignment:Splign:2.1.0"
     exon            278..358
                     /gene="Zfp451"
                     /inference="alignment:Splign:2.1.0"
     exon            359..484
                     /gene="Zfp451"
                     /inference="alignment:Splign:2.1.0"
     exon            485..596
                     /gene="Zfp451"
                     /inference="alignment:Splign:2.1.0"
     exon            597..747
                     /gene="Zfp451"
                     /inference="alignment:Splign:2.1.0"
     exon            748..874
                     /gene="Zfp451"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1028
                     /gene="Zfp451"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1176
                     /gene="Zfp451"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..2759
                     /gene="Zfp451"
                     /inference="alignment:Splign:2.1.0"
     exon            2760..2900
                     /gene="Zfp451"
                     /inference="alignment:Splign:2.1.0"
     exon            2901..3031
                     /gene="Zfp451"
                     /inference="alignment:Splign:2.1.0"
     exon            3032..3218
                     /gene="Zfp451"
                     /inference="alignment:Splign:2.1.0"
     exon            3219..3284
                     /gene="Zfp451"
                     /inference="alignment:Splign:2.1.0"
     exon            3285..3936
                     /gene="Zfp451"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcgcttgg ggtccggcag ctctacgtcc ccgcggcccg aggcgtcagc tgcgtgggcg
       61 ctcacgcagg gcgggtcgcg cggtgccggg cgagagggaa gtcgtggcgg cggcgtcggc
      121 gtcgggaaca gcagcggcgg cgggagcgtg gtgctgacag gccgtgggag aaatgggaga
      181 cccagggccg gagataatag aatctgtccc accagctggg cccgagccat cagagtcaac
      241 ggcggatgaa aacgaagatg acattcagtt tgttagtgaa ggaccgttaa gacccgttct
      301 tgaatatatt gatctggtca gcagtgatga tgaagagcct agtacctctc acagtgatga
      361 gaattttaaa cacaaagact atatagacca tcagaaggat aaagttgctt taacattggc
      421 tcgcctggcc cgccatgttg aagtggaaaa acaacaaaaa gaagagaaga acagggcatt
      481 cagggaaaaa attgattttc agcacgcgca tggtttacaa gaattggaat ttattcaagg
      541 acattcagaa acagaagcag ccagacagtg tgtggaccag tggctaaaaa tgtcaggact
      601 cagaacaagt gcaattaatt ctggatcaaa aaaatcattc caaagtggag gcaggatgcg
      661 gaggtctgac aagtcaattt tgtgtccgat aatgcactgt aacaaggaat ttgacaatgg
      721 gcaccttctg ttaggacatt tgaaaaggtt tgatcactcc ccatgtgatc ccacaattac
      781 cttacatgga cctctcgcca atgtgtttgc atgtgcagtg tgctacgagc attttgttac
      841 tcagcagcaa tataaggacc atcttctctc caaggcagct gcggctgatg gacacagcaa
      901 tgaccttcct cctcagatta ttcagtgttt tgcttgtcca cattgctttc ttctgtttag
      961 caccaaggac gagtgcttga aacatatgtc tgcaaagaat catttccatc agagcttgaa
     1021 actgggtgac gataagggaa cagcccgccc agtatcattt ccatcttttg caaagaagct
     1081 tttggtgtct ctgtgcaaag atgttccgtt tctggttaag tgtgtggcct gccaccagac
     1141 tctgcgttcc cacatggagc tcagtgccca tttcagggtt cgttgtcgaa atgctggacc
     1201 tgtagctata gctgagaaaa gcattactca ggttgcaaaa gaattcctag taagaggtta
     1261 ttgttcagat tgcaaccagg tctttatgga tgaagccagc acccaaagtc acaagaatcc
     1321 aggacacaaa atgagctttg ctaactccgt ggaagaatct gtcctactct attgccacat
     1381 cagtgaaggg agtaggcctc cttgtgactt acatttattc aatcaaccaa aaatttcatc
     1441 cctgaaacga attctgtcta gtaaagagtc cagtgcagag gattgtgtca ttccgacaaa
     1501 gaaggtgaac ttaggagttg acagccaggg cggtacagct cgtgtgcaga ggcagaggtc
     1561 aacagtcaca gcctggtttt gtgaatgcag tcggcggttt ccaagtgaag atgctgtaga
     1621 aaagcatgtt ttctcagcaa acacaatgtg ttacaagtgt gtggtgtgtg gaaaggtttg
     1681 tgaagattcg ggggtcatgc gtttacacat gagccggttt catggagggg cgcatttaaa
     1741 taactttcta ttctggtgtc ggatgtgcaa gaaggagtta ataaggaaag atgccatcat
     1801 ggcgcacgtt actgagttcc acagtgggca caggtatttc tatgagatgg atgaggtaga
     1861 ggcggctgtg ccgtcgtctt cgactgagaa ccatttgaat gctgacaaac ccccttcacc
     1921 cattgctgtc gtggatcact ccccggcaag cagtcctccc aggggcaggt ggcaatgccg
     1981 catctgtgaa gacatgtttg attcccatga gtgtgtacag cagcactgtg cgtccttgac
     2041 gagccaccgg ttccacaggt acagctgtgc ccactgcaga aagactttcc ataaggtgga
     2101 gaccctgtgc agacactgcc aggacgagca tagtggtgag gtgaggatga tgtactgctg
     2161 tgggctgtgt gacctcattt tcaacaagga agaagccttt ctgagccact atacagagca
     2221 gcacagtgga gattatgtgt ttgtgccaga aaaaactaaa acttcaatta agactgaaga
     2281 tgattttaaa ataatagaga ccagtaattt attaagctgt ggctgtcatg agagttacat
     2341 ctgtaaagtc aacagaaggg acgattatga tagatgtctt caaatcatgc tggaaaaagg
     2401 aaaactgtgg tttcgctgcg ggtcgtgttc agccacagca cagaatctgg ctgacattaa
     2461 cactcacgtc tgtcaagcgc acaggaaagt aagaggcgat gaggagcagc agtatgtgat
     2521 caagtgtggc gtctgcacca aagccttcca caacacggag agtgcccagc agcacttcca
     2581 caggaagcac gccgccttcc agaaacccgt tactgcccac gtcagagccg accacggaag
     2641 cacgggccag cttgctgcta gtgtctcaca cgctgagaaa aacccgagac atacgagcta
     2701 tcagaaatgt tcagatgtgg aaagaagtgc tgagcatgac gtatgctgcc agaacataga
     2761 ggaggaagtg gagcttccag acgtggatta ccttcgaacc atgactcata tagtctttgt
     2821 agattttgat aactggtcga acttttttgg tcatctacct gggcatctta atcaaggaac
     2881 atttatttgg ggctttcaag gaggaaacac caattggaag cccccgctcg gctgtaaggt
     2941 ctataattac ttgaacagga tcggatgctt ctttcttcat cctcgctgca gtaagagaaa
     3001 agacgctgct gattttgcca tatgtatgca cgctggccgt ctagatgagc agctgcctaa
     3061 gcaaattcct ttcaccatcc tctcaggaga ccaaggcttt ctggagctag agaatcaatt
     3121 taagaagacc cagaggccgg ctcatatact gaaccctcac cacttagagg gagacatgat
     3181 gtgtgccttg ttaaatagca tatctgatac taccaaagag tgtgacagcg atgacagcat
     3241 gggggtgaaa ggctctccag tagaggagct cagggccacg gaggatgtgg aattagaaga
     3301 agctattaga agaagtcttg aggaaatgta attaaagata ttaccacaca acatcaagtg
     3361 gccttgaaga gactcaggaa aatgaattct tgactttgtt ttctaaaaga gaccagaaat
     3421 ctactaggat aaatgtatca aagcgtgttt tattcttttc tatgttcaga atctcgtatt
     3481 tgctttgtat ttgtgctgtt gtaagaaatg gaagggcaga gtgcacacag tggagacatg
     3541 aagtgtgttc tgacggtggg tcacgctcct ccagccggct tggaatccat gtgtttaggt
     3601 cacagtcatt ttctagaagg aaggtctgtg taaacttctg cctttcctta gcgttgcaac
     3661 ttttcctgtg ctttacaaat ggctctgttt tattttttta ggaatgaaaa tgaatataaa
     3721 taaaaggtgc cataactcag ttttccagac attgtgtgtt gtgtgacctg gatgtataat
     3781 gtaccttgga gagcactgca tatggtttta gaagacagta tggaaactga taacagaaca
     3841 gattcaagtc agcaaggttc tgtgtgctgt catgcagctg tatgctcact ctggtgagag
     3901 ccactcattg ctacaataaa aacatcttta aagcaa
//
