LOCUS       NM_001393718            4901 bp    mRNA    linear   ROD 08-APR-2024
DEFINITION  Rattus norvegicus zinc finger protein 423 (Zfp423), mRNA.
ACCESSION   NM_001393718
VERSION     NM_001393718.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4901)
  AUTHORS   Shao,M., Ishibashi,J., Kusminski,C.M., Wang,Q.A., Hepler,C.,
            Vishvanath,L., MacPherson,K.A., Spurgin,S.B., Sun,K., Holland,W.L.,
            Seale,P. and Gupta,R.K.
  TITLE     Zfp423 Maintains White Adipocyte Identity through Suppression of
            the Beige Cell Thermogenic Gene Program
  JOURNAL   Cell Metab 23 (6), 1167-1184 (2016)
   PUBMED   27238639
REFERENCE   2  (bases 1 to 4901)
  AUTHORS   Zubiria,M.G., Vidal-Bravo,J., Spinedi,E. and Giovambattista,A.
  TITLE     Relationship between impaired adipogenesis of retroperitoneal
            adipose tissue and hypertrophic obesity: role of endogenous
            glucocorticoid excess
  JOURNAL   J Cell Mol Med 18 (8), 1549-1561 (2014)
   PUBMED   24913911
REFERENCE   3  (bases 1 to 4901)
  AUTHORS   Masserdotti,G., Badaloni,A., Green,Y.S., Croci,L., Barili,V.,
            Bergamini,G., Vetter,M.L. and Consalez,G.G.
  TITLE     ZFP423 coordinates Notch and bone morphogenetic protein signaling,
            selectively up-regulating Hes5 gene expression
  JOURNAL   J Biol Chem 285 (40), 30814-30824 (2010)
   PUBMED   20547764
REFERENCE   4  (bases 1 to 4901)
  AUTHORS   Hata,A., Seoane,J., Lagna,G., Montalvo,E., Hemmati-Brivanlou,A. and
            Massague,J.
  TITLE     OAZ uses distinct DNA- and protein-binding zinc fingers in separate
            BMP-Smad and Olf signaling pathways
  JOURNAL   Cell 100 (2), 229-240 (2000)
   PUBMED   10660046
REFERENCE   5  (bases 1 to 4901)
  AUTHORS   Tsai,R.Y. and Reed,R.R.
  TITLE     Identification of DNA recognition sequences and protein interaction
            domains of the multiple-Zn-finger protein Roaz
  JOURNAL   Mol Cell Biol 18 (11), 6447-6456 (1998)
   PUBMED   9774661
REFERENCE   6  (bases 1 to 4901)
  AUTHORS   Tsai,R.Y. and Reed,R.R.
  TITLE     Cloning and functional characterization of Roaz, a zinc finger
            protein that interacts with O/E-1 to regulate gene expression:
            implications for olfactory neuronal development
  JOURNAL   J Neurosci 17 (11), 4159-4169 (1997)
   PUBMED   9151733
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.75496.1,
                                           SRR26360194.726141.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-401               JAXUCZ010000019.1  35284640-35285040
            402-461             JAXUCZ010000019.1  35337338-35337397
            462-662             JAXUCZ010000019.1  35381486-35381686
            663-3877            JAXUCZ010000019.1  35458015-35461229
            3878-3962           JAXUCZ010000019.1  35467728-35467812
            3963-4094           JAXUCZ010000019.1  35555134-35555265
            4095-4210           JAXUCZ010000019.1  35556637-35556752
            4211-4901           JAXUCZ010000019.1  35580083-35580773
FEATURES             Location/Qualifiers
     source          1..4901
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p11"
     gene            1..4901
                     /gene="Zfp423"
                     /gene_synonym="Roaz; Znf423"
                     /note="zinc finger protein 423"
                     /db_xref="GeneID:94188"
                     /db_xref="RGD:621664"
     exon            1..401
                     /gene="Zfp423"
                     /gene_synonym="Roaz; Znf423"
                     /inference="alignment:Splign:2.1.0"
     CDS             362..4240
                     /gene="Zfp423"
                     /gene_synonym="Roaz; Znf423"
                     /note="olf1/EBF-associated zinc finger protein; smad- and
                     Olf-interacting zinc finger protein; Olf-1/EBF associated
                     Zn finger protein Roaz"
                     /codon_start=1
                     /product="zinc finger protein 423"
                     /protein_id="NP_001380647.1"
                     /db_xref="GeneID:94188"
                     /db_xref="RGD:621664"
                     /translation="MSRRKQAKPRSVKVEEGEASDFSLAWDSSVAAAGGLEGESECDR
                     KTSRALEDRNSVTSQEERNEDDEDVEDESIYTCDHCQQDFESLADLTDHRAHRCPGDG
                     DDDPQLSWVASSPSSKDVASPTQMIGDGCDLGLGEEEGGTGLPYPCQFCDKSFIRLSY
                     LKRHEQIHSDKLPFKCTFCSRLFKHKRSRDRHIKLHTGDKKYHCHECEAAFSRSDHLK
                     IHLKTHSSSKPFKCSVCKRGFSSTSSLQSHMQAHKKNKEHLAKSEKEAKKDDFMCDYC
                     EDTFSQTEELEKHVLTLHPQLSEKADLQCIHCPEVFVDESTLLAHIHQAHANQKHKCP
                     MCPEQFSSVEGVYCHLDSHRQPDSSNHSVSPDPVLGSVASMSSATPDSSASVERGSTP
                     DSTLKPLRGQKKMRDDGQSWSKVVYSCPYCSKRDFTSLAVLEIHLKTIHADKPQQSHT
                     CQICLDSMPTLYNLNEHVRKLHKSHAYPVMQFGNISAFHCNYCPEMFADINSLQEHIR
                     VSHCGPNANPPDGNNAFFCNQCSMGFLTESSLTEHIQQAHCSVGSTKLESPVIQPTQS
                     FMEVYSCPYCTNSPIFGSILKLTKHIKENHKNIPLAHSKKSKAEQSPVSSDVEVSSPK
                     RQRLSGSANSISNGEYPCNQCDLKFSNFESFQTHLKLHLELLLRKQACPQCKEDFDSQ
                     ESLLQHLTVHYMTTSTHYVCESCDKQFSSVDDLQKHLLDMHTFVLYHCTLCQEVFDSK
                     VSIQVHLAVKHSNEKKMYRCTACNWDFRKEADLQVHVKHSHLGNPAKAHKCIFCGETF
                     STEVELQCHITTHSKKYNCRFCSKAFHAVLLLEKHLREKHCVFDPAAENGTANGVPPT
                     STKKAEPADLQGMLLKNPEAPNSHEASEDDVDASEPMYGCDICGAAYTMEVLLQNHRL
                     RDHNIRPGEDDGSRKKAEFIKGSHKCNVCSRTFFSENGLREHLQTHRGPAKHYMCPIC
                     GERFPSLLTLTEHKVTHSKSLDTGTCRICKMPLQSEEEFIEHCQMHPDLRNSLTGFRC
                     VVCMQTVTSTLELKIHGTFHMQKLAGSSAASSPNGQGLQKLYKCALCLKEFRSKQDLV
                     RLDVNGLPYGLCAGCMARSANGQVGGLAPPEPADRPCAGLRCPECNVKFESAEDLESH
                     MQVDHRDLTPETSGPRKGAQTSPVPRKKTYQCIKCQMTFENEREIQIHVANHMIEEGI
                     NHECKLCNQMFDSPAKLLCHLIEHSFEGMGGTFKCPVCFTVFVQANKLQQHIFAVHGQ
                     EDKIYDCSQCPQKFFFQTELQNHTMSQHAQ"
     exon            402..461
                     /gene="Zfp423"
                     /gene_synonym="Roaz; Znf423"
                     /inference="alignment:Splign:2.1.0"
     exon            462..662
                     /gene="Zfp423"
                     /gene_synonym="Roaz; Znf423"
                     /inference="alignment:Splign:2.1.0"
     exon            663..3877
                     /gene="Zfp423"
                     /gene_synonym="Roaz; Znf423"
                     /inference="alignment:Splign:2.1.0"
     exon            3878..3962
                     /gene="Zfp423"
                     /gene_synonym="Roaz; Znf423"
                     /inference="alignment:Splign:2.1.0"
     exon            3963..4094
                     /gene="Zfp423"
                     /gene_synonym="Roaz; Znf423"
                     /inference="alignment:Splign:2.1.0"
     exon            4095..4210
                     /gene="Zfp423"
                     /gene_synonym="Roaz; Znf423"
                     /inference="alignment:Splign:2.1.0"
     exon            4211..4901
                     /gene="Zfp423"
                     /gene_synonym="Roaz; Znf423"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttttttttt tttttttttt ttgcataact cggctcggcc gagtggcctc cggactcccc
       61 gcgccgctgg gaccgccgct gggacccgga gcccccggct gccgcattgc aacaggcagg
      121 gccccggcgc gccccccggg cctcccccca tcccctagcg gcctgggctg gctagggctg
      181 ccccccgcag ggaggctgcc cgggacctgc ggtccgttcc ttacggccgc cgacccggcg
      241 gcaaaaaaca aagtttccga gaggcaggcg gaggagaagg gggagaaggg ctgcccggag
      301 cggcgggggg cggtacgggg agccggccgc ggacggcgac ggagcgcccg gagccccgga
      361 catgtccagg cggaagcagg cgaagccgcg atcggtgaaa gttgaagagg gggaggcctc
      421 ggacttctcg ctggcctggg attcctctgt ggcagcagcg ggaggcctag aaggagagtc
      481 agagtgtgat cggaaaacca gccgtgcgct ggaagacagg aacagcgtga caagtcaaga
      541 ggagagaaac gaggacgatg aagatgtgga agatgagtca atttacacct gcgatcactg
      601 tcagcaggac ttcgagtctc tggcagacct gacggaccac cgggcccacc gctgtcctgg
      661 agatggtgat gacgacccac agctctcctg ggtggcttca tctccctcca gcaaggatgt
      721 tgcgtcaccc acgcagatga tcggcgatgg ttgtgacctt ggcctcggcg aggaggaagg
      781 cggcaccggc ctgccgtacc cttgccagtt ctgcgacaag tccttcatcc gcctgagcta
      841 cttgaagagg catgaacaga tccacagcga caagctgccg ttcaagtgca ccttctgcag
      901 ccgcctcttc aaacacaaga ggagccggga ccggcacatc aagctgcaca caggcgacaa
      961 gaagtaccac tgccacgagt gcgaggcggc tttctcccgc agcgaccacc tcaagatcca
     1021 cctgaagacc cacagctcca gcaagccgtt caagtgcagc gtgtgcaaac gcgggttctc
     1081 ctccaccagc tccctgcaga gccacatgca ggcccacaag aagaataagg aacacctggc
     1141 taagtcagag aaggaagcca agaaggacga cttcatgtgt gactactgcg aggacacctt
     1201 tagccagaca gaagagctgg agaagcatgt gcttaccctc cacccgcagc tctcagagaa
     1261 ggcggacctc cagtgtatcc actgccccga ggtctttgtc gacgagagca cgctgctggc
     1321 ccacatccac caagctcacg ccaaccagaa acacaagtgc cccatgtgcc ctgagcagtt
     1381 ctcctccgtg gagggtgtgt actgccacct ggacagccac cggcagcctg attccagcaa
     1441 tcacagtgtc agccccgacc ccgtgctggg cagtgtggct tccatgagca gtgctacacc
     1501 tgactcgagc gcctctgtgg agcgcgggtc cacgccagac tccaccttga agccgctgag
     1561 ggggcagaag aagatgcggg atgacgggca gagctggtcc aaggttgtct acagctgccc
     1621 ctactgttct aagcgggact ttaccagcct ggctgtgcta gagattcatc tgaagaccat
     1681 tcacgcggac aaacctcagc agagtcacac gtgtcagatt tgcctggact ccatgcccac
     1741 gctctacaac ctcaacgagc atgtgcgcaa gctgcacaag agccacgctt accccgtcat
     1801 gcaattcggc aacatctccg ccttccactg caactactgc cccgagatgt tcgcggacat
     1861 caacagcctg caggagcaca tccgagtctc gcactgtggc cccaatgcca acccccccga
     1921 cgggaacaat gctttcttct gtaaccagtg ttctatgggc tttctcactg aatcctccct
     1981 cacagagcac atccaacagg cacactgcag tgtggggagc accaagctgg agtctcccgt
     2041 tatccagccc acacagtcct tcatggaggt ctactcctgc ccttactgta ccaactcccc
     2101 tatctttggc tccatcctga agctcactaa gcacatcaaa gagaaccaca agaacatccc
     2161 gttggcacac agcaagaagt ccaaggcgga gcagagtccg gtctcctctg acgtcgaggt
     2221 gtcttccccg aaacgacagc gcctctcggg gagtgccaac tccatctcta acggcgagta
     2281 cccctgcaat cagtgcgacc tcaagttctc caacttcgag agcttccaga cccacttgaa
     2341 gctgcacctg gagctgctgc tccggaagca ggcctgcccc cagtgcaaag aggacttcga
     2401 ctctcaggag tccctcctgc agcatctgac cgtgcactac atgaccacgt ccacccacta
     2461 cgtctgcgag agctgtgaca agcagttctc ctcagtggac gacctgcaga agcacctgct
     2521 ggacatgcac acctttgtgc tataccactg caccctgtgt caggaggtct tcgactctaa
     2581 ggtgtccatc caggtgcacc tggccgtgaa gcacagcaac gagaagaaga tgtaccgttg
     2641 caccgcctgc aactgggact tccgcaagga ggctgacctg caggtgcacg tcaagcacag
     2701 tcacctcggc aacccggcca aggcccacaa gtgcatcttc tgtggtgaga ccttcagcac
     2761 cgaggtggag ctccagtgcc acatcaccac gcacagcaag aagtacaatt gcaggttctg
     2821 cagcaaagcc ttccacgccg tcctcctgct ggagaagcac cttcgggaga agcattgtgt
     2881 gtttgaccca gctgcagaga atggcacggc caacggggtg ccccccacct ccaccaagaa
     2941 ggcagagccc gccgacctgc agggcatgct gctcaagaac cctgaggcac cgaacagcca
     3001 cgaggccagt gaggacgatg tggatgcatc agagcccatg tacggctgtg acatctgtgg
     3061 tgcagcctac accatggagg tgctgctgca gaaccaccga ctccgggatc ataacatccg
     3121 gcccggagag gacgatggct cacgcaagaa ggcagagttc ataaagggca gccacaagtg
     3181 taacgtgtgc tctcggactt tcttctcgga gaacgggctc cgggaacacc tgcagacgca
     3241 ccggggccct gccaagcact acatgtgtcc catctgtggc gagcgcttcc cctcgctgct
     3301 gacgctcact gagcacaagg tgacccacag caagagtctg gacacaggca cctgtcgcat
     3361 ctgcaaaatg cccctgcaga gtgaggagga gtttatcgag cactgccaga tgcaccccga
     3421 cttgcggaac tccctcactg gtttccgctg tgtggtctgt atgcagactg tcacctcaac
     3481 cctggagctc aagatccatg gcacctttca catgcagaag ctggctggca gctcagctgc
     3541 ttcctccccc aatggccagg ggctgcagaa gctctacaag tgcgccctgt gcctcaaaga
     3601 gttccgtagc aagcaggacc tggtcaggct tgacgtcaat gggctgccct atggcctatg
     3661 tgccggctgc atggcccgta gtgccaatgg acaggtgggt ggcctggccc cacccgaacc
     3721 tgccgaccgg ccctgcgctg gcctccgctg ccctgaatgt aacgtgaagt ttgagagtgc
     3781 tgaggacctg gagagccaca tgcaggtgga ccaccgtgat cttaccccag agaccagtgg
     3841 gccccggaaa ggtgcccaga cgtcaccagt gccccggaag aagacgtacc agtgcatcaa
     3901 gtgccagatg accttcgaga acgagagaga gatccagatc cacgtcgcca accacatgat
     3961 cgaggaaggc atcaaccatg agtgtaagct gtgcaaccag atgttcgact ccccagccaa
     4021 gctcctttgt cacctcatcg aacacagctt cgagggcatg ggtggtactt tcaagtgccc
     4081 cgtgtgcttc acagtcttcg tccaggccaa caagctgcaa cagcacatct tcgccgtgca
     4141 cgggcaggag gacaaaatct acgactgctc gcagtgccca cagaagtttt tcttccagac
     4201 agagttgcag aaccacacga tgagccagca cgcacagtga gggacctcgc gacaggacac
     4261 ctctccgcag aaggcttgcc ggagacgccg tggggagggc catttgaaca ttacatccaa
     4321 tcaaagtgtc atttgcaacc cagatgtaaa actctaatga tttggccatg aggcgctgct
     4381 attataagca gctggaaatg aatattaatg gcagagatta aaagtattcc atgctcagtg
     4441 ttttttattg tcctgctaca gctagtgtgc ttttagagtt ttcgccgcag actacatttc
     4501 tagtgttaga gaaacctgct tttttgaggc tattgtcctt tgttccttca tgtattatat
     4561 tgatagtttt ttttaaagga ttagtgtgat tttttttgct tcttttctat ttctttcttt
     4621 cttgtttttc tttctccccc ttcagttaac tactttttaa ttgaaattct aggtaattgt
     4681 gcatcgtgat gtgattgctt ggctattgtc tgaatatttc cttttaattt tttaattaaa
     4741 gactaatgct ttgattggat ttgccagttc accggacagt gattaaaact ctgtaatgaa
     4801 tataatcggt ttccgtgcaa ctggatggtc tgcttttaaa tgtgacttga tctgactgca
     4861 gtaactagtt cagctcaata aagggaatcc atgcgttcag c
//
