LOCUS       NM_001036626            3548 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus zinc finger protein 36, C3H type-like 2
            (Zfp36l2), mRNA.
ACCESSION   NM_001036626 XM_238444
VERSION     NM_001036626.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3548)
  AUTHORS   Prenzler F, Fragasso A, Schmitt A and Munz B.
  TITLE     Functional analysis of ZFP36 proteins in keratinocytes
  JOURNAL   Eur J Cell Biol 95 (8), 277-284 (2016)
   PUBMED   27182009
REFERENCE   2  (bases 1 to 3548)
  AUTHORS   Galloway A, Saveliev A, Lukasiak S, Hodson DJ, Bolland D, Balmanno
            K, Ahlfors H, Monzon-Casanova E, Mannurita SC, Bell LS, Andrews S,
            Diaz-Munoz MD, Cook SJ, Corcoran A and Turner M.
  TITLE     RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence
  JOURNAL   Science 352 (6284), 453-459 (2016)
   PUBMED   27102483
REFERENCE   3  (bases 1 to 3548)
  AUTHORS   Adachi S, Homoto M, Tanaka R, Hioki Y, Murakami H, Suga H,
            Matsumoto M, Nakayama KI, Hatta T, Iemura S and Natsume T.
  TITLE     ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK
            pathway
  JOURNAL   Nucleic Acids Res 42 (15), 10037-10049 (2014)
   PUBMED   25106868
REFERENCE   4  (bases 1 to 3548)
  AUTHORS   Tan FE and Elowitz MB.
  TITLE     Brf1 posttranscriptionally regulates pluripotency and
            differentiation responses downstream of Erk MAP kinase
  JOURNAL   Proc Natl Acad Sci U S A 111 (17), E1740-E1748 (2014)
   PUBMED   24733888
REFERENCE   5  (bases 1 to 3548)
  AUTHORS   Zhang L, Prak L, Rayon-Estrada V, Thiru P, Flygare J, Lim B and
            Lodish HF.
  TITLE     ZFP36L2 is required for self-renewal of early burst-forming unit
            erythroid progenitors
  JOURNAL   Nature 499 (7456), 92-96 (2013)
   PUBMED   23748442
REFERENCE   6  (bases 1 to 3548)
  AUTHORS   Hacker C, Valchanova R, Adams S and Munz B.
  TITLE     ZFP36L1 is regulated by growth factors and cytokines in
            keratinocytes and influences their VEGF production
  JOURNAL   Growth Factors 28 (3), 178-190 (2010)
   PUBMED   20166898
REFERENCE   7  (bases 1 to 3548)
  AUTHORS   Stumpo DJ, Broxmeyer HE, Ward T, Cooper S, Hangoc G, Chung YJ,
            Shelley WC, Richfield EK, Ray MK, Yoder MC, Aplan PD and Blackshear
            PJ.
  TITLE     Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger
            RNA-binding protein, results in defective hematopoiesis
  JOURNAL   Blood 114 (12), 2401-2410 (2009)
   PUBMED   19633199
REFERENCE   8  (bases 1 to 3548)
  AUTHORS   Blackshear PJ, Phillips RS, Ghosh S, Ramos SB, Richfield EK and Lai
            WS.
  TITLE     Zfp36l3, a rodent X chromosome gene encoding a placenta-specific
            member of the Tristetraprolin family of CCCH tandem zinc finger
            proteins
  JOURNAL   Biol Reprod 73 (2), 297-307 (2005)
   PUBMED   15814898
  REMARK    Erratum:[Biol Reprod. 2005 Nov;73(5):1072. Ramos, Silvia V B
            [corrected to Ramos, Silvia B V]]
REFERENCE   9  (bases 1 to 3548)
  AUTHORS   Ciais D, Cherradi N, Bailly S, Grenier E, Berra E, Pouyssegur J,
            Lamarre J and Feige JJ.
  TITLE     Destabilization of vascular endothelial growth factor mRNA by the
            zinc-finger protein TIS11b
  JOURNAL   Oncogene 23 (53), 8673-8680 (2004)
   PUBMED   15467755
REFERENCE   10 (bases 1 to 3548)
  AUTHORS   Phillips RS, Ramos SB and Blackshear PJ.
  TITLE     Members of the tristetraprolin family of tandem CCCH zinc finger
            proteins exhibit CRM1-dependent nucleocytoplasmic shuttling
  JOURNAL   J Biol Chem 277 (13), 11606-11613 (2002)
   PUBMED   11796723
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000163.1.
            
            [WARNING] On Mar 31, 2024 this sequence was replaced by
            NM_001036626.3.
            
            On Feb 11, 2021 this sequence version replaced NM_001036626.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CV112816.1, CB547818.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-284               JACYVU010000163.1  10490032-10490315
            285-3548            JACYVU010000163.1  10490810-10494073
FEATURES             Location/Qualifiers
     source          1..3548
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q12"
     gene            1..3548
                     /gene="Zfp36l2"
                     /note="zinc finger protein 36, C3H type-like 2"
                     /db_xref="GeneID:298765"
                     /db_xref="RGD:1308913"
     exon            1..284
                     /gene="Zfp36l2"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..1682
                     /gene="Zfp36l2"
                     /note="butyrate response factor 2; zinc finger protein 36,
                     C3H1 type-like 2; zinc finger protein 36, C3H1 type-like
                     2-like"
                     /codon_start=1
                     /product="mRNA decay activator protein ZFP36L2"
                     /protein_id="NP_001031703.2"
                     /db_xref="GeneID:298765"
                     /db_xref="RGD:1308913"
                     /translation="MSTTLLSAFYDIDFLCKTEKSLANLNLNNMLDKKAVGTPVAAAP
                     SSSFTPGFLRRHSASNLHALAHPSPGSCSPKFPGAPNGSSCGPAGAGGPSSYGQLKEP
                     SGGSGTALVNKESKFRDRSFSENGERSQHLLHLQQQQKGGSGSQINSTRYKTELCRPF
                     EESGTCKYGEKCQFAHGFHELRSLTRHPKYKTELCRTFHTIGFCPYGPRCHFIHNADE
                     RRPAPSGGASGDLRAFGARDALHLGFAREPRPKLHHSLSFSGFPSGHHQPPGGLESPL
                     LLDSPTSRTPPPPSCSSASSCSSSASSCSSTSAASTPSGAPTCCASAAAAAAAALLYG
                     PGGAEDLLTPGAPCATCSTTSCANNAFTFGPELSSLITPLAIQTHNFAAAAAAYYRSQ
                     QQGLAGLAPAPAQPPAAPAPPSPPFGFQLPRRLSESPVFDAPPSPPDSLSDRDSYLSG
                     SLSSGSLSGSESPSLDPGRRLPIFSRLSISDD"
     exon            285..3548
                     /gene="Zfp36l2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccgcgagct gccgacggct cgcgcggggg gcaggccggg gcgccgagct gcgctctcgc
       61 ttctcctctg ccccccactc cgcgcgccgc ggcctccttc ctcggccccg caagcaaact
      121 ttccgtccct ccctgcccct cgtccgttat tcgtcttggt ttgagctgcg ccgcaccgag
      181 ggctcctccc aacctccccg cttgcagttc cgaccattac aggacccaga aaaatgtcga
      241 ccactcttct gtcagctttc tacgatatcg acttcttgtg caagacggag aaatccctgg
      301 caaacctcaa tctgaacaac atgctggaca agaaggcggt ggggacgccc gtggctgctg
      361 cccccagctc gagcttcact ccggggttcc tgagacgcca ctccgccagc aacctacacg
      421 cgctcgccca ccccagtcct ggcagctgct cgcctaagtt cccaggcgcc cctaacggca
      481 gcagctgtgg cccggcaggc gcgggcggcc cgtcctccta cggccagctc aaggagcctt
      541 cagggggcag cggcacggcg ctggtcaaca aggaaagcaa attccgggat cgctctttca
      601 gcgagaacgg tgagcgcagc cagcacctcc tgcacctgca gcagcagcag aaggggggca
      661 gcggctccca aatcaactcc acgcgctaca agaccgagct gtgccggccc ttcgaggaga
      721 gcggcacgtg caagtacggc gagaagtgcc agttcgcgca cggcttccat gagctgcgca
      781 gcctcactcg gcaccccaag tacaagacgg agctgtgccg caccttccac accatcggct
      841 tctgccccta cggcccgcgc tgccatttca tccacaacgc agacgagcgg cggcccgcac
      901 catcgggggg cgcctccggg gacctgcgag cgtttggcgc gcgcgacgcg ctgcacctgg
      961 gctttgcccg ggagccgcgg ccaaagctgc accacagcct cagtttctcc ggcttcccgt
     1021 cgggccacca ccagccgccc gggggactgg agtcgccgct gctgctcgac agccccacgt
     1081 cgcgcacgcc gccgccgccc tcctgttcct ccgcctcgtc ctgttcctca tcagcctctt
     1141 cctgctcctc cacctcagcg gcctccacac cctcgggcgc cccgacgtgc tgtgcctcag
     1201 cggcggcggc ggcggcggcc gcgctgctct acggccccgg aggcgcggag gacctgctga
     1261 ctcccggagc gccgtgcgcc acttgctcga ccacctcgtg cgccaacaac gccttcacct
     1321 tcggcccgga gctgagcagc ctcatcacgc cacttgccat ccagacccac aacttcgccg
     1381 ccgcggccgc cgcctactac cgcagccagc agcagggcct ggcgggcctc gcgccggccc
     1441 ctgcgcagcc ccccgcggcc cccgcgccgc cctcgccgcc cttcggcttc cagctgccgc
     1501 gccgtctgtc cgagtcgccg gtgttcgacg cgccccccag ccccccggac tcgctgtcgg
     1561 accgcgacag ttacctgagt ggctcgctga gctcgggcag cctcagcggc tccgagtccc
     1621 ccagcctgga ccccggccgc cgcctgccca tcttcagccg cctctccatc tccgacgact
     1681 gaggcaaggg ggcgcccgcg aggggttggg agaggcgtta caggggcacc ggttgggggg
     1741 tgacactgcc gcaggccgac tttaaggccc ctccgagcac ttggactcga actctgccgg
     1801 gaggggccct gccccttccc tttcggtttt ctcgtttcgt tctttttttt tattttatta
     1861 ttaatattat tattattatt attgcaaagt ttcgttcttg ttgaaataaa agccaacgaa
     1921 cttttcgaat ggatgaacaa aatatccaca acagggcggt tgtgatgcag aaagaacaaa
     1981 ggataccaaa cacttgcttt aggtcccaga agagtttgaa actctagttt taaaagaaaa
     2041 aaataaaaat cagcccatca ccagcagcta ccaaccatca ttccatctct tcactggaaa
     2101 gccttagcta cagatgtgag aactctgacc ttggaagggg ttccaagacc agtgtgagcc
     2161 cgccggctgc cacctcccta aagtataagc ttctagaatt caaactaatg ccaagaacat
     2221 gccttggtag gagtagctct ctgcctcctt cctggtggtt gtttaccttg tttatgtttt
     2281 ttaacaaagt tctatgtgtc tgggggtggg ggagcccttg cattccaaag tttggtaaca
     2341 gtctccttgc cagcactcag tgggtgttta gcttagaacc atttcctctg ccctctggaa
     2401 gccttgggca gagctcagtt catagttggg aaataagtgc ttcattttta gctgttttga
     2461 gttgatccgc accactgcac cacaactcaa tatgaaaaac tatttaactt atttattatt
     2521 cttgtgaaaa gtatacattt gaggatgttg ttcatactgt atttatcgag tatgatgaaa
     2581 gcaatagata tatattcttt tattatgtta aattataatt gccattatta atcggcaaaa
     2641 cgtggagtgt gttcttttca cagtaatata tgccttttgt aacttcactt gggttatttt
     2701 attgtaaatg agtaagaaaa atcttaattt aagagattgt atgtaatatt tatttcatta
     2761 atttctttcc ttgtttacgt aaatttcgga agattgcatg gtttctttac agaaatctat
     2821 cttgatgctg tggaagtagt ttgaggaaca ttttgagttt ttttagaatg cataatggtt
     2881 gtagcccatc cgactttaaa gaggaaaaga atgcccagag actctgcagt cagactcacg
     2941 tggcatgcta taaaccagca aggaaaggac agtttcctag ttccaccagc tctactgtga
     3001 cattgagtat aaagacatgt agcaataatg gggggggggg gggtctcagt gccttcacag
     3061 ggcccgaact tgccttaaat cttcctcagc caaataagta ttccattagt gcttgagaat
     3121 ttgaatgtgg gatgggttcg cctgcacaag aggaaaagaa ttttaccact ttttttttta
     3181 accatagcta tgatgtgaag aggccaggtc ttcacgctga attgttggtg gtacacgaat
     3241 ataccttgct taatgacagt ccagaacttg tactattatt tttcattgta aagaggcagg
     3301 aaagtctccc ggctttgccg gatgacaaat gaatgatcag ccgcttagtt tgtgccgtag
     3361 gtacagttgg agcaccacga gtgcactctg gactactttg acagaagtag gtttttgaat
     3421 gtaacgagat aagtcaactt gagttgtaat atattttggg gaatcagttc actacaaatt
     3481 gtgactgtaa acattgtact gtaaatgttt tgtagttttc ccccaataaa attttttgga
     3541 aaaaaaaa
//
