LOCUS       NM_133290               1811 bp    mRNA    linear   ROD 12-DEC-2024
DEFINITION  Rattus norvegicus zinc finger protein 36 (Zfp36), mRNA.
ACCESSION   NM_133290
VERSION     NM_133290.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1811)
  AUTHORS   Cao,Y., Huang,W., Wu,F., Shang,J., Ping,F., Wang,W., Li,Y., Zhao,X.
            and Zhang,X.
  TITLE     ZFP36 protects lungs from intestinal I/R-induced injury and
            fibrosis through the CREBBP/p53/p21/Bax pathway
  JOURNAL   Cell Death Dis 12 (7), 685 (2021)
   PUBMED   34238924
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1811)
  AUTHORS   Canzoneri,R., Naipauer,J., Stedile,M., Rodriguez Pena,A.,
            Lacunza,E., Gandini,N.A., Curino,A.C., Facchinetti,M.M., Coso,O.A.,
            Kordon,E. and Abba,M.C.
  TITLE     Identification of an AP1-ZFP36 Regulatory Network Associated with
            Breast Cancer Prognosis
  JOURNAL   J Mammary Gland Biol Neoplasia 25 (2), 163-172 (2020)
   PUBMED   32248342
REFERENCE   3  (bases 1 to 1811)
  AUTHORS   Nowotarski,S.L., Origanti,S., Sass-Kuhn,S. and Shantz,L.M.
  TITLE     Destabilization of the ornithine decarboxylase mRNA transcript by
            the RNA-binding protein tristetraprolin
  JOURNAL   Amino Acids 48 (10), 2303-2311 (2016)
   PUBMED   27193233
REFERENCE   4  (bases 1 to 1811)
  AUTHORS   Prenzler,F., Fragasso,A., Schmitt,A. and Munz,B.
  TITLE     Functional analysis of ZFP36 proteins in keratinocytes
  JOURNAL   Eur J Cell Biol 95 (8), 277-284 (2016)
   PUBMED   27182009
REFERENCE   5  (bases 1 to 1811)
  AUTHORS   Shi,J.X., Li,J.S., Hu,R., Shi,Y., Su,X., Li,Q. and Zhang,F.
  TITLE     CNOT7/hCAF1 is involved in ICAM-1 and IL-8 regulation by
            tristetraprolin
  JOURNAL   Cell Signal 26 (11), 2390-2396 (2014)
   PUBMED   25038453
REFERENCE   6  (bases 1 to 1811)
  AUTHORS   Lai,W.S., Carballo,E., Strum,J.R., Kennington,E.A., Phillips,R.S.
            and Blackshear,P.J.
  TITLE     Evidence that tristetraprolin binds to AU-rich elements and
            promotes the deadenylation and destabilization of tumor necrosis
            factor alpha mRNA
  JOURNAL   Mol Cell Biol 19 (6), 4311-4323 (1999)
   PUBMED   10330172
REFERENCE   7  (bases 1 to 1811)
  AUTHORS   Carballo,E., Lai,W.S. and Blackshear,P.J.
  TITLE     Feedback inhibition of macrophage tumor necrosis factor-alpha
            production by tristetraprolin
  JOURNAL   Science 281 (5379), 1001-1005 (1998)
   PUBMED   9703499
REFERENCE   8  (bases 1 to 1811)
  AUTHORS   Taylor,G.A., Carballo,E., Lee,D.M., Lai,W.S., Thompson,M.J.,
            Patel,D.D., Schenkman,D.I., Gilkeson,G.S., Broxmeyer,H.E.,
            Haynes,B.F. and Blackshear,P.J.
  TITLE     A pathogenetic role for TNF alpha in the syndrome of cachexia,
            arthritis, and autoimmunity resulting from tristetraprolin (TTP)
            deficiency
  JOURNAL   Immunity 4 (5), 445-454 (1996)
   PUBMED   8630730
REFERENCE   9  (bases 1 to 1811)
  AUTHORS   Taylor,G.A., Thompson,M.J., Lai,W.S. and Blackshear,P.J.
  TITLE     Phosphorylation of tristetraprolin, a potential zinc finger
            transcription factor, by mitogen stimulation in intact cells and by
            mitogen-activated protein kinase in vitro
  JOURNAL   J Biol Chem 270 (22), 13341-13347 (1995)
   PUBMED   7768935
REFERENCE   10 (bases 1 to 1811)
  AUTHORS   Kaneda,N., Oshima,M., Chung,S.Y. and Guroff,G.
  TITLE     Sequence of a rat TIS11 cDNA, an immediate early gene induced by
            growth factors and phorbol esters
  JOURNAL   Gene 118 (2), 289-291 (1992)
   PUBMED   1511903
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC060308.1 and BP474238.1.
            
            On May 26, 2007 this sequence version replaced NM_133290.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060308.1, DN947963.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132305, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1564              BC060308.1         5-1568
            1565-1811           BP474238.1         1-247               c
FEATURES             Location/Qualifiers
     source          1..1811
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1811
                     /gene="Zfp36"
                     /gene_synonym="Tis11"
                     /note="zinc finger protein 36"
                     /db_xref="GeneID:79426"
                     /db_xref="RGD:620722"
     exon            1..82
                     /gene="Zfp36"
                     /gene_synonym="Tis11"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1021
                     /gene="Zfp36"
                     /gene_synonym="Tis11"
                     /note="tristetraprolin; tristetraproline; TTP; zfp-36;
                     TPA-induced sequence 11"
                     /codon_start=1
                     /product="mRNA decay activator protein ZFP36"
                     /protein_id="NP_579824.2"
                     /db_xref="GeneID:79426"
                     /db_xref="RGD:620722"
                     /translation="MAIRATMDLSAIYESLMSMSHDLSPDHGGTESSGGLWNINSSDS
                     IPSGVTSRLTGRSTSLVEGRSCSWVPPPPGFAPLAPRPGPELSPSPTSPTATPTTSSR
                     YKTELCRTYSESGRCRYGAKCQFAHGPGELRQANRHPKYKTELCHKFYLQGRCPYGSR
                     CHFIHNPTEDLALPGQPHVLRQSISFSGLPSGRRTSPPPPGFSGPSLSSCSFSPSSSP
                     PPPGDLPLSPSAFSAAPGTPVSRRDPTPACCPSCRRSTTPSTIWGPLGGLARSPSAHS
                     LGSDPDDYASSGSSLGGSDSPVFEAGVFGPPQPPAPPRRLPIFNRISVSE"
     exon            83..1811
                     /gene="Zfp36"
                     /gene_synonym="Tis11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagcctgac ttctgcgaac cgactgtcgg tctcttctcc atggccattc gcgccaccat
       61 ggatctctct gccatctacg agagccttat gtcgatgagc catgacctgt cacccgacca
      121 cggaggaact gagtcctccg gaggactttg gaacataaac tcatcggact ccatcccatc
      181 tggggtcacc tctcgcctga ctggccgctc cactagcctg gtggagggcc gaagctgcag
      241 ctgggtaccc ccaccccctg gtttcgcacc cttggctccc cgcccgggcc ctgagctgtc
      301 accctcacct acttcgccta ctgcaactcc caccacctcc tctcgataca agactgagct
      361 ctgtcggacc tactcagaga gcgggcgttg tcgctatggg gccaagtgcc agtttgccca
      421 cggcccgggt gaactgcgcc aagccaatcg ccaccccaag tacaaaacgg aactctgcca
      481 caagttctac ctccagggcc gctgccccta cggctctcga tgccacttca tccacaaccc
      541 taccgaggac ctggctctcc ctggccagcc ccatgtgctc cgacaaagca tcagcttctc
      601 aggcttgcct tcaggccgca gaacctcacc accacctcca ggcttctctg gcccttccct
      661 gtcctcttgc tccttttcgc cttccagctc cccaccaccg cctggggacc ttccactttc
      721 cccttctgcc ttctctgctg cccctgggac ccctgtgtct cgaagagacc ctaccccagc
      781 ctgttgtccc tcctgccgaa ggtctactac ccctagcacc atctgggggc ccttgggtgg
      841 tctggctcgg agcccatctg cacactctct gggatccgac cctgatgatt acgccagcag
      901 cggcagcagc ctgggtgggt cagactcgcc tgtctttgag gccggggtgt ttgggcctcc
      961 tcagccccct gcacccccaa ggcgtcttcc catcttcaat cgcatctctg tctctgagtg
     1021 acaagtgcct gcccagtgtg gatcagctag atctcaaaga agagggaggg aactgctcgt
     1081 tgctgtgggg acctgggggg actcctctaa gtccctcctc ctggacattc caagttgcat
     1141 taacccattc ccctggtgct gggctagggc aggtccctag tttgcaaatt cagtgtttgg
     1201 gtggatccgt tcctagggta cctgagatgt agcatgtttg aggggtacag ttgacagttg
     1261 atcttccagg tctcaagtct tatgttgttt ctgagatagg ggattattac ggtaccccag
     1321 gctggctttg aactcaatat aatcctgcct tagccttttc caagttctgg ggttacaggt
     1381 atgcaccagc ccctcggaaa ctctggtctc ctggaatctt aagtgctgtg aagagccggc
     1441 tcccacaata ctatcctaat ttttactaga ccccgaagtt cagtgtccgg tggttgtagc
     1501 ctctcctgag aatcctggtg ctcaaatttc cctcccaaag caaatagcca aagccattgc
     1561 caaatccctt ttcccccacg cccctgcccc aaccaatgga ccctttattt atgacgactt
     1621 tatttattgt aataagattt tatagtattt atatatattg ggtcgtctac tccgtttttc
     1681 tttttgtaat gttaaaactg atactgtatt aagtatatac tataatatat taagtaatat
     1741 attgttaccg tacaagtcta tttttgtggg tttttttgga atttttaaat aaaatcttga
     1801 gtgtgaactg t
//
