LOCUS       XP_038954238            3730 aa            linear   ROD 11-JUN-2023
DEFINITION  zinc finger homeobox protein 3 isoform X1 [Rattus norvegicus].
ACCESSION   XP_038954238
VERSION     XP_038954238.1
DBLINK      BioProject: PRJNA677964
DBSOURCE    REFSEQ: accession XM_039098310.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051354.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Jan 25, 2024 this sequence was replaced by
            NP_001414410.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..3730
                     /organism="Rattus norvegicus"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     Protein         1..3730
                     /product="zinc finger homeobox protein 3 isoform X1"
                     /calculated_mol_wt=407194
     Region          672..692
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          727..744
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1374..1394
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1412..1432
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     Site            order(1419..1421,1423..1424,1428,1431,1445,1448..1452,
                     1454..1455)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275371"
     Region          1440..1461
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     Region          1556..1580
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1607..1625
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          2156..2212
                     /region_name="HOX"
                     /note="Homeodomain; smart00389"
                     /db_xref="CDD:197696"
     Site            order(2157..2161,2163,2180,2186,2199,2201..2202,
                     2205..2206,2208..2210,2212..2213)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     Site            order(2159,2162,2202,2205..2206,2209)
                     /site_type="other"
                     /note="specific DNA base contacts [nucleotide binding]"
                     /db_xref="CDD:238039"
     Region          2254..2310
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          2604..2750
                     /region_name="COG5576"
                     /note="Homeodomain-containing transcription factor
                     [Transcription]"
                     /db_xref="CDD:227863"
     Region          2654..2710
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          2958..3014
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     CDS             1..3730
                     /gene="Zfhx3"
                     /coded_by="XM_039098310.1:10228..21420"
                     /db_xref="GeneID:307829"
                     /db_xref="RGD:1560268"
ORIGIN      
        1 megcdspvvs gkdngcgipq hrqwtelnst hlpdkpssme qptgeshgpl dslrapfner
       61 ladsstsagp paepaskevs cnecsasfss lqtymehhcp gthpppalre esasdtseeg
      121 eeesdvenla geivyqpdgs ayiveslsql aqsgaacgss sgsggvpslf lnslpgvggk
      181 qgdpscaapv ypqiintfhi assfgkwfeg sdqafpntsa laglspvlhs frvfdvrhks
      241 nkdylnsdgs aksscvskdv pnnvdlskfd gfvlygkrkp ilmcflckls fgyvrsfvth
      301 avhdhrmtls eeerkllsnk ntsaiiqgig kdkeplvsfl epknknfqhp lvstanligp
      361 ghsfygkfsg icmdgeealp agaaagpeqp qaglltpstl lnlggltssv lktpitsvpl
      421 gplassptks segkdsgaae gdkrevgdqd cfsekvepae eeeaeeeeee eeeaeeeeee
      481 eeeeeeedeg ckglfpnele eeledrppee sgatagggsk kdlalsnqsi snsplmpnvl
      541 qtlsrgtast tsnsasnfvv fdganrrsrl sfnsegvran vaegrrldfa desankdsat
      601 apepnesteg ddggfaphhq hagslcelgv gecpsgsgve cpkcdtvlgs srslgghmtm
      661 mhsrnscktl kcpkcnwhyk yqqtleahmk ekhpepggsc vycksgqphp rlargesytc
      721 gykpfrcevc nystttkgnl sihmqsdkhl nnmqnlqngg geqvfshsag aaaaaaaaaa
      781 aaanigsscg apsptkpktk ptwrcevcdy etnvarnlri hmtsekhmhn mmllqqnmtq
      841 iqhnrhlglg slpspaeael yqyylaqnmn lpnlkmdnta sdaqfmmsgf qldptgpmaa
      901 mtpalvggei pldmrlgggq lvseelmnlg esfiqtndps lklfqcavcn kfttdnldml
      961 glhmnversl sedewkavmg dsyqcklcry ntqlkanfql hcktdkhvqk yqlvahikeg
     1021 gkanewrlkc vaignpvhlk cnacdyytns leklrlhtvn srheaslkly khlqqhesgv
     1081 egescyyhcv lcnystkakl nliqhvrsmk hqrseslrkl qrlqkglpee dedlgqifti
     1141 rrcpstdpee aiedaegpse asadpeelak dqgssggeeg qskrtasssq aekeltdspa
     1201 askrssfpgs setplsskrp kaseeikpeq myqcpyckys nadvnrlrvh amtqhsvqpm
     1261 lrcplcqdml nnkihlqlhl thlhsvapdc veklimtvta pemvmpssmf lpaaapdrdg
     1321 npnleeagkq petsedlgkn tlpsaimehs gdlkpssadp scmredsgfl cwkkgcnqvf
     1381 ktsatlqthf nevhakrpql pvsdrhvyky rcnqcslafk tieklqlhsq yhviraatmc
     1441 clcqrsfrtf qalkkhlets hlelseadiq qlyggllang dllamgdptl aedhtiivee
     1501 dkeeesdled kqsptgsdsg svqedsgsep kralpfrkgp nftmekfldp srpykctvck
     1561 esftqknill vhynsvshlh klkralqesa tgqpeptssp dnkpfkcntc nvaysqsstl
     1621 eihmrsvlhq tkaraaklea asgssngtgn sagvslssst pspvgssgan ntftaanpss
     1681 atmapsvnal sqvppesvvl pplgnpisan isspsepket nrkkladmia srqqqqqqqq
     1741 qqqqqqaqtl aqaqaqvqah lqqelqqqaa liqsqlfnpt llphfpmtte tllqlqqqhh
     1801 llfpfyipsa efqlnpevsl pvtsgaltlt gsgpglledl kaqiqipqqs hpqilqqqqq
     1861 qqqqqsqlsl sqshsallqp sqhpekknkv vikekdkesq reregpegae gnpgpkeslp
     1921 dalkakekke lapgggsegs mlppriasda rgnatkalle nfgfelviqy nenkqkaqkk
     1981 ngkaeqgses leklecdscg klfsnililk shqehvhqny fpfkqlerfa kqyrehydkl
     2041 yplrpqtpep pppppppppp plpaappqpa stpaipasap pitsptiapa qpsvpltqls
     2101 mpmelpifsp lmmqtmplqt lpaqlppqlg pveplpadla qlyqhqlnpt llqqqnkrpr
     2161 tritddqlrv lrqyfdinns pseeqikema dksglpqkvi khwfrntlfk erqrnkdspy
     2221 nfsnppitsl eelkidsrpp spepqkqeyw gskrssrtrf tdyqlrvlqd ffdanaypkd
     2281 defeqlsnll nlptrvivvw fqnarqkark nyenqgegkd gerreltndr yirtsnlnyq
     2341 ckkcslvfqr ifdlikhqkk lcykdedeeg qddsqnedsm dameiltpts sscstpmpsq
     2401 aystpapssa stapsaflql taetdelatf nskaeasdek pkqadppsvq pnqtqekqgq
     2461 pkpevqqqeq aeqktnvpqp klpqlaapsl pqpppqappp qcplpqssps psqlshlplk
     2521 plhtstpqql anlppqlipy qcdqcklafp sfehwqehqq lhflsaqnqf ihpqfldrsl
     2581 dmpfmlfdps npllasqlls gaipqipass atspstptst mntlkrklee kasgaspgen
     2641 dssgtggeep qrdkrlrtti tpeqleilyq kylldsnptr kmldhiahev glkkrvvqvw
     2701 fqntrarerk gqfravgpaq ahrrcpfcra lfkaktalea hirsrhwhea kragynltls
     2761 amlldcdggl qmkgdifdgt sfshlppsgs dgqgvplspv sktmelsprt llspssikve
     2821 gledfespsm ssvnlnfdqt kldnddcssv ntaitdtttg degnadndsa tgianetkss
     2881 apnegltkaa mmamseyedr lssglvspap sfyskeydne gtvdysetss ladpcspspg
     2941 asgsagksgd sgdrpgqkrf rtqmtnlqlk vlkscfndyr tptmlecevl gndiglpkrv
     3001 vqvwfqnara kekksklsma khfginqtsy egpktectlc gikysarlsv rdhifsqqhi
     3061 skvkdtigsq ldkekeyfdp atvrqlmaqq eldrikkane vlglaaqqqg mfdnaplqal
     3121 nlpttypalq gippvllpgl nspslpgftp sntaltspkp nlmglpsttv pspglptsgl
     3181 pnkpssasls sptpaqatma mapqqppqpq qpqpqvqppp ppaaqqiptp qlplpqqrkd
     3241 kdgekgkeke kahkgkgepp pvpkkekgea ptaatatisa plpameytvd paqlqalqaa
     3301 ltsdptallt sqflpyfvpg fspyyapqip galqsgylqp mygmeglfpy spalsqalmg
     3361 lspgsllqqy qqyqqslqea iqqqqqqqqq qqqqqqrqlq qqqqqqqkvq qqqqqqqqqq
     3421 qqqqpkasqt pvpqgpaspd kdpakespkp eeqknvprev spllpkppee peaesksasa
     3481 dslcdpfivp kvqyklvcrk cqagfgdeea arshlkslcf fgqsvvnlqe mvlhvptgsg
     3541 gggggggsgg ggggsyhcla cesalcgeea lsqhlesalh khrtitraar nakehpsllp
     3601 hsacfpdpst astsqsaahs ndsppppsaa psssasphas rkswppvgsr asaakppsfp
     3661 plsssstvts sscstsgvqp smptddysee sdtdlsqksd gpaspvegpk dpscpkdsgl
     3721 tsvgtdtfrl
//
