LOCUS       NM_001007630            1571 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus zinc finger AN1-type containing 6 (Zfand6), mRNA.
ACCESSION   NM_001007630 XM_214987
VERSION     NM_001007630.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1571)
  AUTHORS   Zhan,J., Qin,W., Zhang,Y., Jiang,J., Ma,H., Li,Q. and Luo,Y.
  TITLE     Upregulation of neuronal zinc finger protein A20 expression is
            required for electroacupuncture to attenuate the cerebral
            inflammatory injury mediated by the nuclear factor-kB signaling
            pathway in cerebral ischemia/reperfusion rats
  JOURNAL   J Neuroinflammation 13 (1), 258 (2016)
   PUBMED   27716383
  REMARK    GeneRIF: This study demonstrated that the Ischemia/reperfusion
            cortical neurons in MCAO rats are the main cell types that express
            A20, and there is a correlation between A20 expression and the
            suppression of neuroinflammation and the resulting neuroprotective
            effects.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1571)
  AUTHORS   Dai,F.Z., Yang,J., Chen,X.B. and Xu,M.Q.
  TITLE     Zinc finger protein A20 inhibits maturation of dendritic cells
            resident in rat liver allograft
  JOURNAL   J Surg Res 183 (2), 885-893 (2013)
   PUBMED   23481562
  REMARK    GeneRIF: Zinc finger protein A20 inhibits maturation of dendritic
            cells resident in rat liver allograft.
REFERENCE   3  (bases 1 to 1571)
  AUTHORS   Peluffo,H., Gonzalez,P., Acarin,L., Aris,A., Beyaert,R.,
            Villaverde,A. and Gonzalez,B.
  TITLE     Overexpression of the nuclear factor kappaB inhibitor A20 is
            neurotoxic after an excitotoxic injury to the immature rat brain
  JOURNAL   Neurol Res 35 (3), 308-319 (2013)
   PUBMED   23336395
  REMARK    GeneRIF: A20 is expressed in astrocytes after brain damage, and its
            overexpression is neurotoxic for cortical neurons in basal mixed
            neuron-glia culture conditions and exacerbates postnatal brain
            excitotoxic damage.
REFERENCE   4  (bases 1 to 1571)
  AUTHORS   Miyata,N., Okumoto,K., Mukai,S., Noguchi,M. and Fujiki,Y.
  TITLE     AWP1/ZFAND6 functions in Pex5 export by interacting with
            cys-monoubiquitinated Pex5 and Pex6 AAA ATPase
  JOURNAL   Traffic 13 (1), 168-183 (2012)
   PUBMED   21980954
REFERENCE   5  (bases 1 to 1571)
  AUTHORS   Chang,E.J., Ha,J., Kang,S.S., Lee,Z.H. and Kim,H.H.
  TITLE     AWP1 binds to tumor necrosis factor receptor-associated factor 2
            (TRAF2) and is involved in TRAF2-mediated nuclear factor-kappaB
            signaling
  JOURNAL   Int J Biochem Cell Biol 43 (11), 1612-1620 (2011)
   PUBMED   21810480
REFERENCE   6  (bases 1 to 1571)
  AUTHORS   Lutz,J., Luong le,A., Strobl,M., Deng,M., Huang,H., Anton,M.,
            Zakkar,M., Enesa,K., Chaudhury,H., Haskard,D.O., Baumann,M.,
            Boyle,J., Harten,S., Maxwell,P.H., Pusey,C., Heemann,U. and
            Evans,P.C.
  TITLE     The A20 gene protects kidneys from ischaemia/reperfusion injury by
            suppressing pro-inflammatory activation
  JOURNAL   J Mol Med (Berl) 86 (12), 1329-1339 (2008)
   PUBMED   18813897
  REMARK    GeneRIF: It was observed that A20 was induced in rat kidneys
            exposed to ischaemia/reperfusion.
REFERENCE   7  (bases 1 to 1571)
  AUTHORS   Duan,W., Sun,B., Li,T.W., Tan,B.J., Lee,M.K. and Teo,T.S.
  TITLE     Cloning and characterization of AWP1, a novel protein that
            associates with serine/threonine kinase PRK1 in vivo
  JOURNAL   Gene 256 (1-2), 113-121 (2000)
   PUBMED   11054541
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC076394.1.
            
            On Nov 29, 2004 this sequence version replaced XM_214987.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK473343.1, CK481082.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1571
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..1571
                     /gene="Zfand6"
                     /gene_synonym="Za20d3; zgc:101121"
                     /note="zinc finger AN1-type containing 6"
                     /db_xref="GeneID:293067"
                     /db_xref="RGD:1359317"
     exon            1..92
                     /gene="Zfand6"
                     /gene_synonym="Za20d3; zgc:101121"
                     /inference="alignment:Splign:2.1.0"
     exon            93..263
                     /gene="Zfand6"
                     /gene_synonym="Za20d3; zgc:101121"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..781
                     /gene="Zfand6"
                     /gene_synonym="Za20d3; zgc:101121"
                     /note="zinc finger A20 domain-containing protein 3; zinc
                     finger, A20 domain containing 3; protein associated with
                     PRK1; zinc finger, AN1-type domain 6"
                     /codon_start=1
                     /product="AN1-type zinc finger protein 6"
                     /protein_id="NP_001007631.1"
                     /db_xref="GeneID:293067"
                     /db_xref="RGD:1359317"
                     /translation="MAQETNHSQAPMLCSTGCGFYGNPRTNGMCSVCYKEHLQRQNSS
                     NGRISPPAASVSSLSESLPVQCADGSVPDAQSALDSTSSSMQPGPVSNQSLLSESVAP
                     SQVDSTSVDKAVSETEDLQGPRAEGLVPLECDPPSSVSDTTQQPSEEQSKSLEKPKQK
                     KNRCFMCRKKVGLTGFECRCGNVYCGVHRYSDVHNCSYNYKADAAEKIRKENPVVVGE
                     KIQKI"
     exon            264..372
                     /gene="Zfand6"
                     /gene_synonym="Za20d3; zgc:101121"
                     /inference="alignment:Splign:2.1.0"
     exon            373..473
                     /gene="Zfand6"
                     /gene_synonym="Za20d3; zgc:101121"
                     /inference="alignment:Splign:2.1.0"
     exon            474..518
                     /gene="Zfand6"
                     /gene_synonym="Za20d3; zgc:101121"
                     /inference="alignment:Splign:2.1.0"
     exon            519..632
                     /gene="Zfand6"
                     /gene_synonym="Za20d3; zgc:101121"
                     /inference="alignment:Splign:2.1.0"
     exon            633..1553
                     /gene="Zfand6"
                     /gene_synonym="Za20d3; zgc:101121"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgagtgggg gttcggcggc ctcacctgtc ctcactcagc ggcggcgaga ggcggcggcg
       61 gcagcgcgtc cggcggagag ggccgccgcc aggtgtgcaa cagaagaaca tggcgcaaga
      121 aactaatcac agccaagcac ctatgctttg ctccactggc tgcggatttt atggaaaccc
      181 tcgtacaaat ggcatgtgct cagtatgcta taaagaacat cttcaaagac agaacagtag
      241 caatggtaga ataagcccac ctgcagcttc tgtcagcagt ctgtctgaat ccttaccagt
      301 acagtgcgca gatggcagtg tcccagacgc tcagtcggcg ctagattcta cgtcttcatc
      361 tatgcagcca ggccctgtat caaatcagtc acttttatca gaatctgtag caccttccca
      421 agtggacagt acatcagtgg acaaagcagt atccgagaca gaagacctgc aaggacccag
      481 agcagagggc cttgttcctc ttgaatgtga tcctccatct tcagtatcag atacgacaca
      541 gcagccatct gaagagcaaa gcaagtctct tgaaaaacca aaacaaaaaa agaatcgctg
      601 tttcatgtgc aggaagaaag tgggacttac tgggtttgaa tgccggtgtg gaaatgttta
      661 ctgtggtgtg caccgttact cagatgttca caattgctct tacaattaca aagctgatgc
      721 tgctgagaaa atcagaaaag aaaatccagt agttgttggt gaaaagatcc agaagatttg
      781 aactcctgct ggaatacaaa atcctttgac tatctgcaaa ctaaacattg acttgaggtt
      841 ttttttccta gtccttggga atgtagagca ccgtatcttg catagaccgt tgaatcatgc
      901 atgtcatcag aagaatagat ttttgttttt gttttgaaaa tgactctgaa catttatttc
      961 cattgcagtt tctgtggctg aaaagaagta ttatactttt aagatcattt taattttagt
     1021 tgagtgcaga gggcttttat aacaaatgtg gagaaattct ggagggctgt gatttttttc
     1081 cagtattaaa catgcatgcg ttgatcttgc agtttatttc tcattgtgta tgtatatata
     1141 gcttttctct gcagcacgat tcccttttga taaggccctt ctgggtacaa ctagttatca
     1201 gtaactgaat gtatcttaat cattacggct gcttctgttt gtttggtttt tcattaacaa
     1261 aggttataca tatgttagca tatagtttct ttacatccac tatttatgtt tgaatcattt
     1321 gtcacagcag aatatgtgct gacgagattc taaatttgtg gctttcggtt cctttttttt
     1381 ttaaacaagg gaaagaaaag ctgagtgcat ttcactgctg actgcaagtt tctttgcgat
     1441 tactgttcat tggtctgtgt gtgcacagta tgaagaatga tctggtcatt gtgcggtatt
     1501 tatgtttatt caccagtctt tgattaaata aaaaggaaaa ccagaaaaaa aaaaaaaaaa
     1561 aaaaaaaaaa a
//
