LOCUS       NM_001033701            9081 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus zinc finger E-box binding homeobox 2 (Zeb2),
            mRNA.
ACCESSION   NM_001033701 XM_242005
VERSION     NM_001033701.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9081)
  AUTHORS   Souza,C.S., Deluque,A.L., Oliveira,B.M., Maciel,A.L.D.,
            Giovanini,C., Boer,P.A., de Paula,F.J.A., Costa,R.S.,
            Franscecato,H.D.C., de Almeida,L.F. and Coimbra,T.M.
  TITLE     Vitamin D deficiency contributes to the diabetic kidney disease
            progression via increase ZEB1/ZEB2 expressions
  JOURNAL   Nutr Diabetes 13 (1), 9 (2023)
   PUBMED   37391399
  REMARK    GeneRIF: Vitamin D deficiency contributes to the diabetic kidney
            disease progression via increase ZEB1/ZEB2 expressions.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9081)
  AUTHORS   Zhao,G.F. and Huang,L.B.
  TITLE     Zinc finger E-box binding homebox 2 alleviated experimental
            osteoarthritis in rats
  JOURNAL   Connect Tissue Res 64 (4), 323-336 (2023)
   PUBMED   36880168
  REMARK    GeneRIF: Zinc finger E-box binding homebox 2 alleviated
            experimental osteoarthritis in rats.
REFERENCE   3  (bases 1 to 9081)
  AUTHORS   Zhao,Z., Hu,X., Wang,J., Wang,J., Hou,Y. and Chen,S.
  TITLE     Zinc finger E-Box binding homeobox 2 (ZEB2)-induced astrogliosis
            protected neuron from pyroptosis in cerebral ischemia and
            reperfusion injury
  JOURNAL   Bioengineered 12 (2), 12917-12930 (2021)
   PUBMED   34852714
  REMARK    GeneRIF: Zinc finger E-Box binding homeobox 2 (ZEB2)-induced
            astrogliosis protected neuron from pyroptosis in cerebral ischemia
            and reperfusion injury.
REFERENCE   4  (bases 1 to 9081)
  AUTHORS   Guo,Q., Xie,M., Guo,M., Yan,F., Li,L. and Liu,R.
  TITLE     ZEB2, interacting with MDM2, contributes to the dysfuntion of brain
            microvascular endothelial cells and brain injury after
            intracerebral hemorrhage
  JOURNAL   Cell Cycle 20 (17), 1692-1707 (2021)
   PUBMED   34334113
  REMARK    GeneRIF: ZEB2, interacting with MDM2, contributes to the dysfuntion
            of brain microvascular endothelial cells and brain injury after
            intracerebral hemorrhage.
REFERENCE   5  (bases 1 to 9081)
  AUTHORS   Tu,J., Ma,L., Zhang,M. and Zhang,J.
  TITLE     Long Non-Coding RNA SOX2 Overlapping Transcript Aggravates H9c2
            Cell Injury via the miR-215-5p/ZEB2 Axis and Promotes Ischemic
            Heart Failure in a Rat Model
  JOURNAL   Tohoku J Exp Med 254 (3), 221-231 (2021)
   PUBMED   34321385
REFERENCE   6  (bases 1 to 9081)
  AUTHORS   Molyneaux,B.J., Arlotta,P., Hirata,T., Hibi,M. and Macklis,J.D.
  TITLE     Fezl is required for the birth and specification of corticospinal
            motor neurons
  JOURNAL   Neuron 47 (6), 817-831 (2005)
   PUBMED   16157277
REFERENCE   7  (bases 1 to 9081)
  AUTHORS   Collart,C., Remacle,J.E., Barabino,S., van Grunsven,L.A.,
            Nelles,L., Schellens,A., Van de Putte,T., Pype,S., Huylebroeck,D.
            and Verschueren,K.
  TITLE     Smicl is a novel Smad interacting protein and cleavage and
            polyadenylation specificity factor associated protein
  JOURNAL   Genes Cells 10 (9), 897-906 (2005)
   PUBMED   16115198
REFERENCE   8  (bases 1 to 9081)
  AUTHORS   Lin,S.Y. and Elledge,S.J.
  TITLE     Multiple tumor suppressor pathways negatively regulate telomerase
  JOURNAL   Cell 113 (7), 881-889 (2003)
   PUBMED   12837246
REFERENCE   9  (bases 1 to 9081)
  AUTHORS   Van de Putte,T., Maruhashi,M., Francis,A., Nelles,L., Kondoh,H.,
            Huylebroeck,D. and Higashi,Y.
  TITLE     Mice lacking ZFHX1B, the gene that codes for Smad-interacting
            protein-1, reveal a role for multiple neural crest cell defects in
            the etiology of Hirschsprung disease-mental retardation syndrome
  JOURNAL   Am J Hum Genet 72 (2), 465-470 (2003)
   PUBMED   12522767
REFERENCE   10 (bases 1 to 9081)
  AUTHORS   Wakamatsu,N., Yamada,Y., Yamada,K., Ono,T., Nomura,N.,
            Taniguchi,H., Kitoh,H., Mutoh,N., Yamanaka,T., Mushiake,K.,
            Kato,K., Sonta,S. and Nagaya,M.
  TITLE     Mutations in SIP1, encoding Smad interacting protein-1, cause a
            form of Hirschsprung disease
  JOURNAL   Nat Genet 27 (4), 369-370 (2001)
   PUBMED   11279515
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Oct 29, 2022 this sequence version replaced NM_001033701.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.4115.1,
                                           SRR26643290.11492.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760400,
                                           SAMN12840105 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               JAXUCZ010000003.1  49754144-49754323   c
            181-322             JAXUCZ010000003.1  49751392-49751533   c
            323-580             JAXUCZ010000003.1  49664620-49664877   c
            581-652             JAXUCZ010000003.1  49659524-49659595   c
            653-841             JAXUCZ010000003.1  49643284-49643472   c
            842-1056            JAXUCZ010000003.1  49642372-49642586   c
            1057-1165           JAXUCZ010000003.1  49639615-49639723   c
            1166-3135           JAXUCZ010000003.1  49636763-49638732   c
            3136-3316           JAXUCZ010000003.1  49635095-49635275   c
            3317-9081           JAXUCZ010000003.1  49624028-49629792   c
FEATURES             Location/Qualifiers
     source          1..9081
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q12"
     gene            1..9081
                     /gene="Zeb2"
                     /gene_synonym="Zfhx1b"
                     /note="zinc finger E-box binding homeobox 2"
                     /db_xref="GeneID:311071"
                     /db_xref="RGD:1307272"
     exon            1..180
                     /gene="Zeb2"
                     /gene_synonym="Zfhx1b"
                     /inference="alignment:Splign:2.1.0"
     exon            181..322
                     /gene="Zeb2"
                     /gene_synonym="Zfhx1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..3897
                     /gene="Zeb2"
                     /gene_synonym="Zfhx1b"
                     /function="transcription factor"
                     /note="zinc finger homeobox 1b"
                     /codon_start=1
                     /product="zinc finger E-box-binding homeobox 2"
                     /protein_id="NP_001028873.2"
                     /db_xref="GeneID:311071"
                     /db_xref="RGD:1307272"
                     /translation="MKQPIMADGPRCKRRKQANPRRKNVVNYDNVVDAGSETDEEDKL
                     HIAEDDGIANPLDQETSPASMPNHESSPHMSQGLLPREEEEDEIRESVVEHSWHSGEI
                     LQASVDGPEEMKEDYDALGPEATIQTTINNGTVKNANCTSDFEEYFAKRKLEERDGHA
                     VSIEEYLQRSDTAIIYPEAPEELSRLGTPEANGQEENDLPPGTPDAFAQLLTCPYCDR
                     GYKRLTSLKEHIKYRHEKNEENFSCPLCSYTFAYRTQLERHMVTHKPGTDQHQMLTQG
                     AGNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKC
                     IGLISVNGRMRNNIKTGSSPNSVSSSPTNSAITQLRNKLENGKPLSMSEQTGLLKIKT
                     EPLDFNDYKVLMATHGFSGTSPFMNGGLGATSPLGVHPSAQSPMQHLGVGLEAPLLGF
                     PTMNSNLSEVQKVLQIVDNTVSRQKMDCKTEDISKLKGYHMKDPCSQPEEQGVTSPSI
                     PAVGLPVVSHNGATKSIIDYTLEKVNEAKACLQSLTTDSRRQISNIKKEKLRTLIDLV
                     TDDKMIENHSIPTPFSCQFCKESFPGPIPLHQHERYLCKMNEEIKAVLQPHENIVPNK
                     AGVFVDNKALLLSSVLSEKGLTSPINPYKDHMSVLKAYYAMNMEPNSDELLKISIAVG
                     LPQEFVKEWFEQRKVYQYSSSRSPSLERNSKPLAPNSNPTTKDSLLPRSPVKPMDSIT
                     SPSIAELHNSVTSCDPPLRLTKSSHFTNIKAVDKLDHSRSNTPSPLNLSSTSSKNSHS
                     SSYTPNSFSSEELQAEPLDLSLPKQMREPKSIIATKNKTKATSISLDHNSVSSSSENS
                     DEPLNLTFIKKEFSNSNNLDNKSTNPVFGMNPFSAKPLYTALPPQSAFPPATFMPPVQ
                     TSIPGLRPYPGLDQMSFLPHMAYTYPTGAATFADMQQRRKYQRKQGFQGELLDGAQDY
                     MSGLDDLTDSDSCLSRKKIKKTESGMYACDLCDKTFQKSSSLLRHKYEHTGKRPHQCQ
                     ICKKAFKHKHHLIEHSRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEER
                     EAAEREAREKGHLEPTELLMNRAYLQSITPQGYSDSEERESMPRDGESEKEHEKEGEE
                     GYGKLRRRDGDEEEEEEEEESENKSMDTDPETIRDEEETGDHSMDDSSEDGKMETKSD
                     HEEDNMEDGME"
     exon            323..580
                     /gene="Zeb2"
                     /gene_synonym="Zfhx1b"
                     /inference="alignment:Splign:2.1.0"
     exon            581..652
                     /gene="Zeb2"
                     /gene_synonym="Zfhx1b"
                     /inference="alignment:Splign:2.1.0"
     exon            653..841
                     /gene="Zeb2"
                     /gene_synonym="Zfhx1b"
                     /inference="alignment:Splign:2.1.0"
     exon            842..1056
                     /gene="Zeb2"
                     /gene_synonym="Zfhx1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1165
                     /gene="Zeb2"
                     /gene_synonym="Zfhx1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..3135
                     /gene="Zeb2"
                     /gene_synonym="Zfhx1b"
                     /inference="alignment:Splign:2.1.0"
     exon            3136..3316
                     /gene="Zeb2"
                     /gene_synonym="Zfhx1b"
                     /inference="alignment:Splign:2.1.0"
     exon            3317..9081
                     /gene="Zeb2"
                     /gene_synonym="Zfhx1b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttctaacc tgctcggcag gaataacggt cctgcctccc gacactcttg gcgaggtttt
       61 gttcagtttg ctccgggagc tgtttcttcg cctccacctt tttctccccc acacttcgcg
      121 gcttcttcat gctttttctt ctcaccattt ctggccaaaa ctacaaacaa gacttcgcag
      181 atcgagcctg cgtgctgccg aagcagggcg ccgagtccat gcgaactgcc atctgatccg
      241 ctcttatcaa tgaagcagcc gatcatggcg gatggccccc ggtgcaagag gcgcaaacaa
      301 gccaatccca ggaggaaaaa cgtggtgaac tatgacaacg tagtggacgc aggttccgaa
      361 acagacgagg aggacaagct gcacattgct gaggatgacg gcattgcaaa ccctctggac
      421 caggagacga gtccagctag catgcccaac cacgagtcct ccccacacat gagccaaggc
      481 ctgctaccaa gagaggaaga agaagacgag ataagggaga gcgttgtgga acacagctgg
      541 cacagcggtg agattctgca agcctctgta gacggtccag aagaaatgaa ggaggattat
      601 gatgctctgg ggccagaagc cacgatccag accacaatta acaatggtac agttaagaat
      661 gcaaattgca catcagactt tgaggaatac tttgccaaaa gaaaactgga ggaaagagat
      721 ggccacgcag tcagcattga agagtacctt cagcgaagcg acacggccat tatttaccca
      781 gaagcccctg aggagctgtc tcgccttggc acgccagagg ccaatgggca agaagaaaat
      841 gacctgccac ctggaactcc agatgctttt gcccaactgc tgacctgccc ctactgcgac
      901 cgcggctaca agcgcttgac atcgctgaag gagcacatca agtaccgcca cgagaagaat
      961 gaagagaact tttcctgccc tctttgtagc tacacgttcg cctaccgcac ccagctcgaa
     1021 aggcatatgg tgacgcacaa gccagggaca gatcagcacc aaatgctaac ccaaggagca
     1081 ggtaaccgca agttcaagtg cacagagtgt ggcaaggcct tcaagtacaa gcaccacctg
     1141 aaagaacacc tgagaattca cagtggtgaa aaaccttacg aatgccccaa ctgcaagaaa
     1201 cgcttctctc attctggttc ctacagttca catatcagca gcaagaaatg tattggttta
     1261 atctcagtaa atggccgaat gagaaacaat atcaagacgg gttcttcccc taattctgtt
     1321 tcttcttctc ctactaactc agccattact caactaagga acaagttgga aaatggaaaa
     1381 ccacttagca tgtctgagca gacgggctta cttaagatta aaacagaacc actagacttc
     1441 aatgactata aagttcttat ggcaacacat gggtttagtg gcactagtcc ctttatgaac
     1501 ggtgggcttg gagccaccag ccctttaggt gtgcacccat ctgctcagag tccaatgcag
     1561 cacttaggtg tagggttaga agccccttta cttggatttc ccactatgaa tagtaatctg
     1621 agtgaggtac aaaaggttct acagattgtg gataatacgg tttctaggca aaagatggac
     1681 tgcaaaactg aagacatttc aaagttgaaa ggttaccaca tgaaggatcc atgttctcag
     1741 ccagaagaac aaggggttac ttctcctagt attccagccg tcggtcttcc agtagtgagt
     1801 cataatggtg ccactaaaag tatcattgac tataccttag agaaagtcaa cgaagccaaa
     1861 gcttgcctcc agagcttgac tactgactca aggagacaga tcagtaatat aaagaaagag
     1921 aagctacgta ctttgataga tttggtcacc gatgataaaa tgattgagaa ccacagcata
     1981 cccactccgt tttcatgcca gttctgtaaa gaaagcttcc caggtcctat ccccctgcat
     2041 cagcatgaac gctacctgtg taaaatgaat gaagagatca aggcggtcct gcaacctcac
     2101 gaaaacatag tccccaacaa agctggggtg ttcgttgaca ataaagccct cctcttgtca
     2161 tctgtacttt ctgagaaagg actgacaagc ccgatcaacc cgtacaagga ccacatgtct
     2221 gtactcaaag catactatgc tatgaatatg gaacccaact ctgatgaact gctgaaaatc
     2281 tccattgctg tgggccttcc tcaggagttt gtgaaggaat ggtttgagca gagaaaagtc
     2341 taccagtact ccagttccag gtcaccatca ctggagagga actccaagcc cttagctccc
     2401 aacagcaacc ccaccacaaa agactctttg ttacccaggt ctcctgtaaa acctatggac
     2461 tcaatcacgt caccatctat agcagaactc cacaacagtg tcacgagttg tgatcctcct
     2521 ctcaggctaa caaaatcttc ccacttcacc aatattaaag cagttgataa actggaccac
     2581 tcaaggagta acactccttc tcctttgaat ctttcttcca cgtcttctaa aaactcccac
     2641 agtagctcgt acactccaaa tagcttctct tccgaggagc tgcaggctga gccgttggac
     2701 ctgtcattac caaaacaaat gagagagccc aaaagtatta tagccacaaa gaacaagacg
     2761 aaagctacta gcataagttt agaccacaac agtgtttctt catcctctga aaactcagat
     2821 gaacctctga atttgacttt tatcaagaaa gagttttcaa attctaataa cctggacaat
     2881 aaaagcacta accctgtgtt cggcatgaac ccatttagtg ccaagccttt atacacagct
     2941 cttccaccac agagcgcatt tccccctgcc actttcatgc caccagtcca gaccagcatc
     3001 cccgggctac gaccataccc agggctggat cagatgagct tcctaccaca tatggcctat
     3061 acctacccaa cgggagcagc tacctttgct gatatgcagc aaaggaggaa ataccagcgg
     3121 aaacaaggat ttcagggaga attgcttgat ggagcacaag actacatgtc gggcctagat
     3181 gacttgacag actccgattc ctgtctgtct cgaaagaaga taaagaagac agaaagtggc
     3241 atgtatgcat gtgacttatg tgacaagaca ttccagaaaa gcagttccct tctgcgacat
     3301 aaatacgaac acacaggaaa gagaccacac cagtgtcaga tttgtaagaa agcgttcaaa
     3361 cacaaacacc accttatcga gcactcgagg ctgcactcgg gcgagaagcc ctatcagtgt
     3421 gacaaatgtg gcaagcgctt ttcacactcg ggctcctact cgcagcacat gaatcacagg
     3481 tactcctact gcaagcggga ggcggaggag cgggaagcgg ccgagcgcga ggcacgagag
     3541 aaagggcact tggaacccac cgagctgctg atgaaccggg cttacttgca gagcatcacc
     3601 cctcaggggt actctgactc ggaggagagg gagagcatgc cgagggatgg cgagagcgag
     3661 aaggagcacg agaaggaggg cgaggagggc tatgggaagc tgcggagaag ggacggcgac
     3721 gaggaggaag aggaggaaga ggaagaaagt gaaaataaaa gtatggatac ggatcccgag
     3781 acgatacggg atgaggagga gactggggat cactcaatgg atgacagttc agaggatggg
     3841 aaaatggaaa ccaaatcaga ccacgaggaa gacaatatgg aagacggcat ggaataaact
     3901 actgcatttt aagcttccta tttttttcca gtagtattgt tacctgcttg aaaacactgc
     3961 tgtgttaagc tgttcatgca cgtgcctgac gcttccagga agctgtagag agggacagaa
     4021 ggggcagttc agccaagaca gatttagatg gagttggata ttgtttaaaa aaaaaaaact
     4081 gcattatgca aaaattttgt acagtgttaa ggcctaaaaa ctgtgtggtt cagagactaa
     4141 ttcctgtgtt taatagcatt tatactttaa gcacaactag aaaattctaa gaattgcact
     4201 ctacgtatgt atcactacaa acttaaaaaa aattatgtct aatttatatt aatacatttt
     4261 taaaaggtgc ccgcactacc atacatcagt attttattat tattattatt attgttattc
     4321 ctgtttaatt taatgtgccc gcactacagt gcatcagtat tacgattcct ctccactttc
     4381 ctttcgctat tcatgaattt cccattgttt tacagcctaa gtaaccacac acttttaggc
     4441 ctcaattttt ttttttttct gtgaaggaac ttgaagtgat gcatgtgtga atttaagata
     4501 ccgaagtctt aaagtgacct ggatgtgaag gaaaaaagta agaagagaag taaagaaagc
     4561 ctttgtaagg tggttttaaa agccttatgc aaacctttta atctgtgtct ctgcaagtgc
     4621 cacccttgta cagtgttcag agggtaacga gggttacctt tgcaccagct tcagtgttaa
     4681 gctcactctg ttctttgaag cacccgtgtc agtattagac gaataggcag cagttcctta
     4741 gtttacatat gtttgtgcaa ttattttctg tacttttttt ttgttcatta atttttgtca
     4801 gtattacacc aaactttttt tgcaacaaaa aaaatttttt tttgcattca tttaatttta
     4861 ggtcaaataa cattttattt atgtggctca ttttatattt cctaatttta tttatttcat
     4921 actgtagtgt acagtattat agttcttcaa tatatagata tattttagta aaaaaggaac
     4981 atgacgttga tcatttgggc aaattttacg taaagagaag agcatttatt gtgttttgga
     5041 acattaattg tgagatggga tttttcaatt tcattatttt attttttgtt tttgtttttt
     5101 ccaattactg gaaattccaa atttgggaac ttttgataca atcttgtgaa aacactgtat
     5161 tttcgactga aaattccact ttcttcatct tgttttttag ctaacctcaa gagggactgt
     5221 taaatacaat gtatgatacc atgacaaaaa tctttcctga attgtctttg taaaagtatt
     5281 attgaatttt caatttgtaa tttcttttga aaatgaccat gctcgaataa aaatgtagcc
     5341 aaactaagaa tgtagttaat gagttctgta cttttagaga gttttccttc aatgaccatt
     5401 aacatgtaac ttgcttatgc ttataataat gctaattatg tttttcaata taattttagt
     5461 ttagcaataa ttttgactgg taccaataac tgttttttaa aattccatac ttatgtacag
     5521 caattttaca gcttttctca actgatcctg attccagatt gtgtattttt tatgtgaggt
     5581 tatattattc aaatttagtc tatttacttt acagacattt ctacttttgc attacaagta
     5641 tttagagatt atgtgtttaa aaactcactt ttctgtccaa ggggtctctg tgatttattc
     5701 cgaaaagtct aatttcaaaa agaccactat tattccatgt tatttataat gtgtaacttt
     5761 ttttctaaga gctgggataa tttatctcac tttttgaaat gcagactgta gtttatcctt
     5821 tatctaagat tataaagtgg ggggggtggg ggtggggggt atgcaaagct aaaggcacat
     5881 gctaacaaaa ataaccttca ttttccaaga cagtctttca gtttttacga gatgacccta
     5941 atattcagta tatgaatgta ttcataggtt tttacacaat gattttttta tcagaagcca
     6001 gactctgatt cctaaatcta ataacaaagt cagaataata gaaaagcaga ttaccttatg
     6061 aaatttacag ctcttgagta tacgtaacta taatatagta gctgtccaca tattttttct
     6121 actttagaat caaaaaagaa aagcatgatt ttgctattga atttgctaaa aaaccttaaa
     6181 tgtgacacct caagttggca agaaaagcat atttttatta tttagccatt ttcctaaatt
     6241 tcataagcat tgttccttga aatgacactc aattaatata tatatatgtg tatatatata
     6301 atatacacac gtacacaggc acacatgcac gcatgcctgc acacaacaca tacacatccc
     6361 acgagagaga gaaggtgtaa tgaacacaca gaggcaactg agcagatcct tctagaaaaa
     6421 catgtttcca gctctatctt ccaacctggt gaggagtggc acgaggagaa atggcgtaag
     6481 acattctgct cgtcatccgc accctagagt tttcatgttt gggaagttta gggcattctt
     6541 tccctatttc tccttctttg ggtggcacaa ataaatacac tacacagaga ggatttttcc
     6601 ccccgatttt aaaggctcta ggcaatatct ttattaattc aacctgaaaa tatcaagcca
     6661 ttaaatcttg tctgggtaga ataaatccct gtggcctcct ttaaagcaat gtaggtctct
     6721 gctgcccatg gggcatagct gtgtccctat ccgcaagaga caggaccaac aaagaacaca
     6781 cgtgcaaggc actgtttctc ccccagaaga agaaggcatg aggagtgagg gagcataggc
     6841 cctccctccc tcctgaaatc cctcctccca tcattgtttt tataaattac ttttcacagg
     6901 aaggctcaga atacctgagt ctgaaaggat caggttaaca cttgtaaatt cgtgacaatc
     6961 actacaatgt cctatatctt aaggtttgtt tttggttttt tttaatgcaa atatccacta
     7021 atagtattgc acattagagc tgcataatct tccaactcta gggaagaatg aaacattggg
     7081 cttatcctaa gattcctttc caaggtcata aacaagaaag ccctccaagt catgacacat
     7141 aatctccttt tcttatcaaa cactcttccc atgttctagg cttaagtatt accctttacc
     7201 cctgaggata ggggctggga aaaggtgatg aaatcctgga actgaacgtc cctgccccgt
     7261 tttctcaaga gccttttgta ttctagcaga tctgggaggt tctttctttc tttctttctt
     7321 tcttccttcc ttccttcctt tctttctttc tttctctctc tctttttttt ttttttgcac
     7381 atgacactgt aagcttagtt ctgagaaact ggggaagaga gaccagtatt tctcagccag
     7441 aactaacagc gttcatctcc cttagcacga actgaacttg cagtggagtg ggagggcttg
     7501 acagaaggag gagagaaggg actatatttg aataggtatt aataaattta ttagatactt
     7561 ttcacaatca gataacttta aaatattatt tttatcttct aaggacataa gccttaacaa
     7621 catcaacatt tgaagatatt ccccaataat aagtttatat atatatatac atatatatat
     7681 ttgaaataaa aaaaattgtt agccatgttt tttgctccag gatgtgtggc cattccaggc
     7741 tgtgagccct gggtatgcac acaaataagc ctgtgtgctc tgaagacccc cgcacattgt
     7801 aataaacaca gctgcattta tttgagtatg tgctcccatg tacgtgtaaa aacactcaaa
     7861 caaacacact cggcagattt atgtcatgtg caaacggggc aattattcaa ataaatatgc
     7921 tcaatacaat tatttgagtc tcgcatcgca tgctcaccac tcacagcact aacactaaaa
     7981 gagggggaaa caccaaagaa tttacgtggg ggaaaatata tgtgaaaaca atgttattgt
     8041 agatgttcta aggtagctaa ggctgtggct cccttcttaa ctgaaacgca atgattttgt
     8101 actcagtggc atttgtttct aacgatgact agaacttcac tcgcttgatc attacatcag
     8161 aatgacgaca gaatttggat tcatgtaata gcaaactttc tgaagcagat agggatgaca
     8221 catctctata tttcaaaagc ggaacagtcc tttctgcctc ccttacatca gtggaatgct
     8281 gatgcattat tacggctcac atacgacgta gctataaatt taaaatgtta cacacacata
     8341 gaaaaaaaaa acattcctac attttaaacc attaaaaagt cacagatgac tcgtgtgatc
     8401 attttatata ttaataaata ctacaatata tacgcgaaca catcacaaat cacattggtg
     8461 aacctagagg ctgcagtgcc tctcttcagt atactgacat aacctgatat actaaaatgg
     8521 gaaggggctt ttagtcactg aatatgcatc gtgaaacaaa gacgaagaaa atacatgacg
     8581 tgttcccatc atgaaaaaga ttcatactga aggcttagct ttggttttta ttcaattaaa
     8641 ttgtcaaact gtgcacagtg aacttttttt ttttttttag aacttgagac atttgtgatg
     8701 ttggctgttt aaatctttgt taccttcgct gtgaattgaa attgtacata tttagtaaat
     8761 catgcaaaca aaaccaactt tttagacaat atttttattg gagagttttc ttttcctgta
     8821 tccatgtttt aaaaaaaaaa gacctccttt cccaaaataa aagatgtcaa tactaaattt
     8881 aaagaagtat aaaggaataa ttgcttcctt tagagcaaat acttaaataa atatggagag
     8941 aattggcaac atgttcgttt ggggctaata ggctgtgttc aattttttgg ggggggggtt
     9001 aaagtttcag aaggcctctg tttcacattt gaagataata tattaatctc tgaattaaac
     9061 aaatgctctt aagcaacagg a
//
