LOCUS       NM_001308265            5191 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus zinc finger E-box binding homeobox 1 (Zeb1),
            mRNA.
ACCESSION   NM_001308265
VERSION     NM_001308265.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5191)
  AUTHORS   Souza,C.S., Deluque,A.L., Oliveira,B.M., Maciel,A.L.D.,
            Giovanini,C., Boer,P.A., de Paula,F.J.A., Costa,R.S.,
            Franscecato,H.D.C., de Almeida,L.F. and Coimbra,T.M.
  TITLE     Vitamin D deficiency contributes to the diabetic kidney disease
            progression via increase ZEB1/ZEB2 expressions
  JOURNAL   Nutr Diabetes 13 (1), 9 (2023)
   PUBMED   37391399
  REMARK    GeneRIF: Vitamin D deficiency contributes to the diabetic kidney
            disease progression via increase ZEB1/ZEB2 expressions.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5191)
  AUTHORS   Zhu,X., Yan,F., Liu,L. and Huang,Q.
  TITLE     ZEB1 regulates bone metabolism in osteoporotic rats through
            inducing POLDIP2 transcription
  JOURNAL   J Orthop Surg Res 17 (1), 423 (2022)
   PUBMED   36123704
  REMARK    GeneRIF: ZEB1 regulates bone metabolism in osteoporotic rats
            through inducing POLDIP2 transcription.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5191)
  AUTHORS   Chen,Y.Y., Jiang,K.S., Bai,X.H., Liu,M., Lin,S.Y., Xu,T., Wei,J.Y.,
            Li,D., Xiong,Y.C., Xin,W.J. and Li,Z.Y.
  TITLE     ZEB1 Induces Ddr1 Promoter Hypermethylation and Contributes to the
            Chronic Pain in Spinal Cord in Rats Following Oxaliplatin Treatment
  JOURNAL   Neurochem Res 46 (8), 2181-2191 (2021)
   PUBMED   34032956
  REMARK    GeneRIF: ZEB1 Induces Ddr1 Promoter Hypermethylation and
            Contributes to the Chronic Pain in Spinal Cord in Rats Following
            Oxaliplatin Treatment.
REFERENCE   4  (bases 1 to 5191)
  AUTHORS   Sun,D., Liu,X., Zhu,L. and Zhang,B.
  TITLE     Zinc-finger E-box-binding homeobox 1 alleviates acute kidney injury
            by activating autophagy and the AMPK/mTOR pathway
  JOURNAL   Mol Med Rep 23 (6) (2021)
   PUBMED   33846788
  REMARK    GeneRIF: Zincfinger Eboxbinding homeobox 1 alleviates acute kidney
            injury by activating autophagy and the AMPK/mTOR pathway.
REFERENCE   5  (bases 1 to 5191)
  AUTHORS   Xian,S., Chen,A., Wu,X., Lu,C., Wu,Y., Huang,F. and Zeng,Z.
  TITLE     Activation of activin/Smad2 and 3 signaling pathway and
            the&nbsp;potential involvement of endothelial-mesenchymal
            transition in the valvular damage due to rheumatic heart disease
  JOURNAL   Mol Med Rep 23 (1) (2021)
   PUBMED   33179113
REFERENCE   6  (bases 1 to 5191)
  AUTHORS   Gong,S.G. and Eulenberg,R.L.
  TITLE     Palatal development in Twirler mice
  JOURNAL   Cleft Palate Craniofac J 38 (6), 622-628 (2001)
   PUBMED   11681996
REFERENCE   7  (bases 1 to 5191)
  AUTHORS   Cabanillas,A.M., Smith,G.E. and Darling,D.S.
  TITLE     T3-activation of the rat growth hormone gene is inhibited by a zinc
            finger/homeodomain protein
  JOURNAL   Mol Cell Endocrinol 181 (1-2), 131-137 (2001)
   PUBMED   11476947
REFERENCE   8  (bases 1 to 5191)
  AUTHORS   Takagi,T., Moribe,H., Kondoh,H. and Higashi,Y.
  TITLE     DeltaEF1, a zinc finger and homeodomain transcription factor, is
            required for skeleton patterning in multiple lineages
  JOURNAL   Development 125 (1), 21-31 (1998)
   PUBMED   9389660
REFERENCE   9  (bases 1 to 5191)
  AUTHORS   Higashi,Y., Moribe,H., Takagi,T., Sekido,R., Kawakami,K.,
            Kikutani,H. and Kondoh,H.
  TITLE     Impairment of T cell development in deltaEF1 mutant mice
  JOURNAL   J Exp Med 185 (8), 1467-1479 (1997)
   PUBMED   9126927
REFERENCE   10 (bases 1 to 5191)
  AUTHORS   Cabanillas,A.M. and Darling,D.S.
  TITLE     Alternative splicing gives rise to two isoforms of Zfhep, a zinc
            finger/homeodomain protein that binds T3-response elements
  JOURNAL   DNA Cell Biol 15 (8), 643-651 (1996)
   PUBMED   8769566
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000293.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001308265.3.
            
            On Nov 27, 2020 this sequence version replaced NM_001308265.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U51583.1, SRR8487231.90894.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676807 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                JACYVU010000293.1  9115979-9116059     c
            82-282              JACYVU010000293.1  9007873-9008073     c
            283-444             JACYVU010000293.1  8966752-8966913     c
            445-647             JACYVU010000293.1  8963821-8964023     c
            648-753             JACYVU010000293.1  8961850-8961955     c
            754-2558            JACYVU010000293.1  8956125-8957929     c
            2559-2736           JACYVU010000293.1  8953887-8954064     c
            2737-5191           JACYVU010000293.1  8949793-8952247     c
FEATURES             Location/Qualifiers
     source          1..5191
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.1"
     gene            1..5191
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="zinc finger E-box binding homeobox 1"
                     /db_xref="GeneID:25705"
                     /db_xref="RGD:3831"
     exon            1..81
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..3353
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /note="zfhep; zinc finger homeodomain enhancer-binding
                     protein; TCF-8; transcription factor 8 (represses
                     interleukin 2 expression)"
                     /codon_start=1
                     /product="zinc finger E-box-binding homeobox 1"
                     /protein_id="NP_001295194.1"
                     /db_xref="GeneID:25705"
                     /db_xref="RGD:3831"
                     /translation="MADGPRCKRRKQANPRRNNVTNYNTVVEANSDSDDEDKLHIVEE
                     ESVTDAADCEGGVPDDELPTDQTVLPGGSDRAGSAKNCWQDDVKDDECDSDAENEQNH
                     DPNVEEFLQQQDTAVIYPEAPEEDQRQGTPEASGHDDNGTPDAFSQLLTCPYCDRGYK
                     RFTSLKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGREQRHVTQSGGNR
                     KFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCISLM
                     PVNGRPRSGLKTSQCSSPSLSTSPGSPTRPQIRQKIENKPLQEPLSVNQIKTEPVDYE
                     FKPIVVASGINCSTPLQNGVFSGGGQLQATSSPQGVVQAVVLPTVGLVSPISINLSDI
                     QNVLKVAVDGNIIRQVLENNQASLASKEQEAVSASSIQQGGHSVISAISLPLVDQDGT
                     TKIIINYSLEQPGQLQVVPQNLKKENPAPPKSCKSEKSPEDLTVKSEKDKSFDGAADE
                     STCLLCEDCPGDLNALPELKHYDPEHPAQPPPPAPATEKPESSASSAGNGDLSPSQPP
                     LKNLLSLLKAYYALNAQPSTEELTKIADSVNLPLDVVKKWFEKMQAGQIPGQSLEPPS
                     PGPGSGNIPAKTEEQPQPVDGNEPQEDSTRGQSPLKMTSSPVLPVGSAINGSRSCTSS
                     PSPLNLSSARNPQGYSCVSEGTQEEPQVEPLDLSLPKQQGELLERSTVSSVYQNSVYS
                     VQEEPLNLSCAKKEPQKDSCVTDSEPVVNVVPPSANPINIAIPTVTAQLPTIVAIADQ
                     NSVPCLRALAANKQTILIPQVAYTYSATVSPAMQEPPVKVIQPNGNQDERQDTSSEGV
                     SVEDQNDSDCTPPKKKTRKAENGMYACDLCDKIFQKSSSLLRHKYEHTGKRPHECGIC
                     RKAFKHKHHLIEHMRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKRGAEDRDA
                     MEQEDTGPEALPEVLPTELVGARASPSQADSDERESLTREEDEDSEKEEEEEDKEMEE
                     LQEDKECENPQEEEEEEEEEEEEEEEEEEEEAEEAEHEAAAAKTGGAVEEEAAQQAGS
                     FQQKASGSESKRLSEEKTNEA"
     exon            82..282
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /inference="alignment:Splign:2.1.0"
     exon            283..444
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /inference="alignment:Splign:2.1.0"
     exon            445..647
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /inference="alignment:Splign:2.1.0"
     exon            648..753
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /inference="alignment:Splign:2.1.0"
     exon            754..2558
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2559..2736
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2737..5191
                     /gene="Zeb1"
                     /gene_synonym="deltaEF1; Tcf8; Zfhx1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atttagacac aagcgagagg atcatggcgg atggccccag gtgtaagcgc agaaagcagg
       61 cgaacccgcg gcgcaataac gttacaaatt ataatactgt ggtagaagca aattcagatt
      121 cggatgatga agacaaactc catattgtgg aagaagaaag tgtcacagat gcagctgact
      181 gtgaaggtgg tgtgccagat gatgagctgc caacagacca gacagtgtta ccaggaggca
      241 gtgacagggc gggcagtgcc aagaactgct ggcaagacga cgtaaaagat gacgaatgcg
      301 actcagatgc agaaaacgag caaaaccatg atcccaacgt ggaagagttc ctgcagcaac
      361 aggacaccgc ggtcatctac cctgaggcac ccgaggagga ccagcggcag ggcacgccag
      421 aagccagcgg tcatgatgac aatggaacac cagatgcatt ttcccagttg ctcacctgcc
      481 cgtattgtga tagaggctac aagcgcttta cctctttgaa agaacacatt aagtaccgcc
      541 atgagaagaa tgaagacaac ttcagctgct ccctgtgcag ttacaccttt gcatacagaa
      601 cccagcttga acgtcatatg acatcacata agtcaggaag agagcaaaga catgtgacac
      661 agtctggagg taaccgtaag ttcaagtgca ccgagtgtgg gaaagcgttc aagtacaaac
      721 accatctgaa ggagcactta cggatccaca gtggagagaa gccatatgaa tgcccaaact
      781 gcaagaaacg tttttcccat tctggctctt atagctcaca cataagcagt aagaagtgta
      841 ttagcttgat gcctgtgaat ggtaggccca gatcaggact caagacatct cagtgttcct
      901 cgccatctct ttcaacatca ccaggcagtc ccacacgccc acagatacgg cagaagatag
      961 agaataaacc ccttcaagaa ccgctttctg taaaccaaat caaaactgaa cctgtggatt
     1021 atgagttcaa acccatagtg gttgcttcag gaatcaactg ttcaacccct ttacaaaatg
     1081 gggtttttag cggtggtggc caattgcagg caaccagttc tcctcagggt gtggtgcaag
     1141 ctgttgttct gccaacagtt ggtttggtat ctcccataag tatcaactta agtgacattc
     1201 agaatgtact taaagtggct gtagatggta acataatacg acaggttttg gagaataatc
     1261 aagccagtct tgcatccaaa gagcaagaag ccgtgagtgc ttcatccatc cagcagggcg
     1321 gccattctgt catttctgcc atcagtcttc ctttagttga tcaggatggc acaaccaaaa
     1381 tcatcatcaa ctacagtctt gagcagcccg gccaacttca ggttgttccc cagaatctaa
     1441 agaaagaaaa cccagcccct ccaaagagct gcaaaagtga gaagtcacca gaagatctta
     1501 ctgtcaagtc agagaaggac aaaagctttg atggggctgc ggatgagagc acttgccttt
     1561 tgtgtgagga ctgcccagga gacctcaatg cacttccaga actaaagcac tatgacccag
     1621 agcaccctgc tcaacctcca ccccctgccc cagccaccga gaagccagag tcctctgctt
     1681 catcagccgg caatggagat ttgtctccca gtcagccacc tttaaagaac cttctgtcgc
     1741 tcttaaaagc ctactatgct ctgaatgcac agccaagcac agaagagctc accaagattg
     1801 ccgattctgt gaacctgccg ctggatgtag ttaaaaagtg gtttgaaaag atgcaagctg
     1861 gacagattcc cgggcagtct cttgaaccac cttctccagg accggggtca ggaaacatcc
     1921 ctgcaaaaac tgaggagcag cctcaacctg tggatggaaa tgagccccag gaagacagca
     1981 cacgtggaca gagtcctctc aagatgacaa gctctccagt tttaccagta ggatcagcca
     2041 ttaacggttc cagaagttgc acatcatccc catcccctct aaacctttcc tcagccagga
     2101 acccgcaggg ttactcttgt gtgtcagagg gtacccagga ggagccccaa gtagaacctc
     2161 ttgatctctc actaccaaag caacagggag agttactgga aaggtcgaca gtcagtagcg
     2221 tttaccagaa cagtgtttat tctgtccagg aagaaccctt gaacttgtct tgtgcaaaaa
     2281 aggagccaca aaaggacagt tgtgttacag actcagaacc agttgtaaat gtagtcccac
     2341 caagtgccaa ccccataaac attgctattc ctacagtcac tgcccagtta cccacaatcg
     2401 tggccatcgc tgaccagaac agtgttccgt gcttacgggc actcgctgcc aacaagcaga
     2461 ctattctgat tccccaagtg gcatatacat actccgctac agtcagccca gccatgcagg
     2521 agccaccagt gaaggtgatc cagccaaatg gaaaccagga tgaaagacaa gacactagct
     2581 cagaaggagt ctccgtggag gaccagaatg actctgactg cacgccaccc aaaaagaaaa
     2641 ctcggaaggc agagaatggg atgtacgcat gtgacctgtg tgacaagata tttcagaaga
     2701 gcagctccct gctgagacac aaatatgagc atacaggtaa gaggccccac gagtgcggaa
     2761 tctgtagaaa ggcatttaaa cacaagcatc atttgattga gcacatgcga ctgcactctg
     2821 gggaaaagcc ctaccaatgt gacaagtgtg gcaagcgctt ctcacactcg gggtcttact
     2881 ctcaacacat gaatcaccgc tactcctact gcaagagagg agctgaagac agagatgcca
     2941 tggagcagga agacactggg ccggaagccc tgccggaagt cctgcccact gagcttgttg
     3001 gtgcccgggc atctccctca caggctgact cggacgagag agaaagtttg acaagggaag
     3061 aggatgaaga cagtgaaaag gaggaggagg aggaggataa agagatggaa gaattgcagg
     3121 aagacaagga atgtgagaac ccacaggagg aggaggagga ggaagaggag gaagaagaag
     3181 aggaggagga ggaagaggaa gaggaggcag aggaagctga gcatgaggcg gcagcagcca
     3241 agactggggg tgcagtggag gaggaagcgg ctcagcaggc aggcagcttc cagcagaagg
     3301 ccagcgggag cgagagcaag cgactgtctg aagagaagac aaatgaagcc taggagctct
     3361 tccaaaagga agtcctgctt ggtaatgaaa tttgctctat attacccacg cttttcatgg
     3421 aaacatggct cctgtgctat ggttcctgct cactactgtg taatgtcaga actgaaaaac
     3481 aaaatactaa aaaaaaaaaa aaaaaaaaaa aaaaaaaatc cgggtgtgcc tgaacctcaa
     3541 acctagtaat ttttcatgca gttttcaaag ttaggaacaa gtttgtaaca tgaagcagat
     3601 tagaaaacaa aggtttctca gcaggttaca ggaagctcga tgggcatctg gcttggctgg
     3661 cagtattatc actcttacgt tgttcattct aagctgtaca atgggagaaa ttttataatt
     3721 ttttattggt aaacatatgc taaatccact tcagtatttt attatgtttt ttttaaatgt
     3781 gagaacttct gcactacaga attcccttca ccgagcagta gaaagcagtt cagaccgtgc
     3841 tggctacctg ctgccacccc accagtcagg aggtaggacc tctgacctta gatgccatgc
     3901 tgccatctaa cgtgcatcgc tagccttaag gaagcagaga gaggagcggg agtttcttac
     3961 tcgtgtgatc ttaaatggag ttcaaaggtt gtccttgagt tctgactgca gggacggcca
     4021 gtgttgatgt ggcgaggacg gcagaggcgg cagaatcagt gttcgtgatt gtgtttgcgt
     4081 acgtgacagc aactatgaag gatctatagg aagcgctgtg tccctttggc cttaagcaag
     4141 acctatgtgc tgtaagtgcc attgtcagtg tttcaaggct gtaacagcct tcactcagtg
     4201 tgtggcctac aataactagc atttgttgat ttgtttgttg tgtcaaaatt cccaaataaa
     4261 actcaaacca ctgactctgt cagagaagct gaagcactgg gacatttcac acttctgttc
     4321 ctcagtattc atgttacgtt gattgactca gaaatctcta cagaaataaa agggaaattc
     4381 tccaactact tagtccatgt acttgcgtgt cagacatgga taagccattg gttcttggct
     4441 cacagccatt tccaaatgtt agttattacg gacccaggtg atgaacagca gctgattttt
     4501 acctaccagt attattttat ttcttttagt ttgtagatct gtgcaacatt tttgtactgt
     4561 acgtcttcaa gcctggcagt attaataccc ttcttactga cacgtacttt tagttttaga
     4621 aaacttttat atttatgtgt cttattttta tatttcttta tttattacac agtgtagtgt
     4681 ataatactgt agtttgtatt aatacaataa tatattttag tatgaaattt tggaaagttg
     4741 ataagattta aagtagagat gcaattggtt ctcgtgcatt gagatttgat ttaacagtgt
     4801 tctgttaaca tttatactcg cctcggactg tagaacagag tttaaatggg aatgtattag
     4861 ttttacaact acaatcaagt cattctccct ttacccagtt tttaatatga aactcttaca
     4921 ctttgaaact cactgtgtgt gactcatagc atgctgctct tctgttaaga gttagcccag
     4981 ccataactca ttcccttagc aagccaaatt agaattgcct tctgtaaaca gtgttgggaa
     5041 caatgtttaa catggtgtgc caatttgttc ctgtatccat gtatgtaagc taccaatccg
     5101 actcttcctt ttaagttcct tgttacacca tggtcatttt ctagtttttt accagactcc
     5161 cagctcacaa taaacgcatc aacaagcctg a
//
