LOCUS       NM_001039021            3384 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus zinc finger DHHC-type palmitoyltransferase 8
            (Zdhhc8), mRNA.
ACCESSION   NM_001039021 XM_221272
VERSION     NM_001039021.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3384)
  AUTHORS   Ivatt,R.M., Sanchez-Martinez,A., Godena,V.K., Brown,S., Ziviani,E.
            and Whitworth,A.J.
  TITLE     Genome-wide RNAi screen identifies the Parkinson disease GWAS risk
            locus SREBF1 as a regulator of mitophagy
  JOURNAL   Proc Natl Acad Sci U S A 111 (23), 8494-8499 (2014)
   PUBMED   24912190
REFERENCE   2  (bases 1 to 3384)
  AUTHORS   Ohno,Y., Kashio,A., Ogata,R., Ishitomi,A., Yamazaki,Y. and
            Kihara,A.
  TITLE     Analysis of substrate specificity of human DHHC protein
            acyltransferases using a yeast expression system
  JOURNAL   Mol Biol Cell 23 (23), 4543-4551 (2012)
   PUBMED   23034182
REFERENCE   3  (bases 1 to 3384)
  AUTHORS   Thomas,G.M., Hayashi,T., Chiu,S.L., Chen,C.M. and Huganir,R.L.
  TITLE     Palmitoylation by DHHC5/8 targets GRIP1 to dendritic endosomes to
            regulate AMPA-R trafficking
  JOURNAL   Neuron 73 (3), 482-496 (2012)
   PUBMED   22325201
REFERENCE   4  (bases 1 to 3384)
  AUTHORS   Maynard,T.M., Meechan,D.W., Dudevoir,M.L., Gopalakrishna,D.,
            Peters,A.Z., Heindel,C.C., Sugimoto,T.J., Wu,Y., Lieberman,J.A. and
            Lamantia,A.S.
  TITLE     Mitochondrial localization and function of a subset of 22q11
            deletion syndrome candidate genes
  JOURNAL   Mol Cell Neurosci 39 (3), 439-451 (2008)
   PUBMED   18775783
REFERENCE   5  (bases 1 to 3384)
  AUTHORS   Ohno,Y., Kihara,A., Sano,T. and Igarashi,Y.
  TITLE     Intracellular localization and tissue-specific distribution of
            human and yeast DHHC cysteine-rich domain-containing proteins
  JOURNAL   Biochim Biophys Acta 1761 (4), 474-483 (2006)
   PUBMED   16647879
REFERENCE   6  (bases 1 to 3384)
  AUTHORS   Mukai,J., Liu,H., Burt,R.A., Swor,D.E., Lai,W.S., Karayiorgou,M.
            and Gogos,J.A.
  TITLE     Evidence that the gene encoding ZDHHC8 contributes to the risk of
            schizophrenia
  JOURNAL   Nat Genet 36 (7), 725-731 (2004)
   PUBMED   15184899
REFERENCE   7  (bases 1 to 3384)
  AUTHORS   Becker,K.G., Barnes,K.C., Bright,T.J. and Wang,S.A.
  TITLE     The genetic association database
  JOURNAL   Nat Genet 36 (5), 431-432 (2004)
   PUBMED   15118671
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Feb 10, 2021 this sequence version replaced NM_001039021.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY871204.1, SRR21887622.2120622.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-230               JAXUCZ010000011.1  96259449-96259678
            231-352             JAXUCZ010000011.1  96265663-96265784
            353-510             JAXUCZ010000011.1  96265950-96266107
            511-683             JAXUCZ010000011.1  96266198-96266370
            684-786             JAXUCZ010000011.1  96266559-96266661
            787-878             JAXUCZ010000011.1  96266989-96267080
            879-1014            JAXUCZ010000011.1  96267246-96267381
            1015-1135           JAXUCZ010000011.1  96267669-96267789
            1136-1245           JAXUCZ010000011.1  96267867-96267976
            1246-2243           JAXUCZ010000011.1  96269070-96270067
            2244-3384           JAXUCZ010000011.1  96270918-96272058
FEATURES             Location/Qualifiers
     source          1..3384
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..3384
                     /gene="Zdhhc8"
                     /note="zinc finger DHHC-type palmitoyltransferase 8"
                     /db_xref="GeneID:303796"
                     /db_xref="RGD:1308875"
     exon            1..230
                     /gene="Zdhhc8"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..2415
                     /gene="Zdhhc8"
                     /EC_number="2.3.1.225"
                     /note="zinc finger, DHHC domain containing 8; probable
                     palmitoyltransferase ZDHHC8; zinc finger, DHHC-type
                     containing 8-like"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC8"
                     /protein_id="NP_001034110.1"
                     /db_xref="GeneID:303796"
                     /db_xref="RGD:1308875"
                     /translation="MPRSPGTRLKPAKYIPVATAAALLVGSSTLFFVFTCPWLTRAVS
                     PAIPVYNGILFLFVLANFSMATFMDPGVFPRADEDEDKEDDFRAPLYKNVDVRGIQVR
                     MKWCATCHFYRPPRCSHCSVCDNCVEDFDHHCPWVNNCIGRRNYRYFFLFLLSLSAHM
                     VGVVAFGLLYVLNHSEGLGAAHTTITMAVMCVAGLFFIPVIGLTGFHVVLVTRGRTTN
                     EQVTGKFRGGVNPFTRGCYGNVEHVLCSPLAPRYVVEAPRMPLSVSLKPPFLRPELLE
                     RAVPLKVKLSDNGLKAGRSKSKGSLDQLDEKPLDLGPPLPPKMEAGTFGRDLKTPRPG
                     SAESALSVQRTSPPTPAMYKFRPAFSTAPKTPFCGPSEQVPGPDSLTLADDSTHSLDF
                     VSEPSLDLPDHGPGGLHPTYPPSPPLSATDAFSGALRSLSLKAASRRGGDHMTLQPLR
                     SEGGPPTPHRGLFAPHALPNRNGSLSYDSLLNPGSPSGHACPTHPSVGMAGYHSPYLH
                     PGPSDPPRPPPRSFSPVLGPRPREPSPVRYDNLSRTIMASIQERKDREERERLLRSQT
                     DSLFGDSGVYDTPSSYSLQQASVLTEGPRGSVLRYGSRDDLVAGPGFGGARNPALQTS
                     LSSLSSSMSRAPRTSSSSLQADQANNNAPGPRPGSGSHRSPARQGLPSPPGTPRSPSY
                     SGSKAVAFIHTDLPDRQPSLAMQRDHPQLKTPPSKLNGQSPGMARLGPAASPMGPNAS
                     PARHTLVKKVSGVGGTTYEISV"
     exon            231..352
                     /gene="Zdhhc8"
                     /inference="alignment:Splign:2.1.0"
     exon            353..510
                     /gene="Zdhhc8"
                     /inference="alignment:Splign:2.1.0"
     exon            511..683
                     /gene="Zdhhc8"
                     /inference="alignment:Splign:2.1.0"
     exon            684..786
                     /gene="Zdhhc8"
                     /inference="alignment:Splign:2.1.0"
     exon            787..878
                     /gene="Zdhhc8"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1014
                     /gene="Zdhhc8"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1135
                     /gene="Zdhhc8"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1245
                     /gene="Zdhhc8"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..2243
                     /gene="Zdhhc8"
                     /inference="alignment:Splign:2.1.0"
     exon            2244..3384
                     /gene="Zdhhc8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggatttcct ccactgccgc tgccgcggat cctgcgccgc gtccagcccg cgcgcccgac
       61 cccggcccga cccggccggc cccgcccgcc cggcccgggg agggatgcgg cggcgcggcg
      121 cccaggatgc cccgcagccc cgggacgcgc ctcaaacccg ccaagtacat cccggtggcc
      181 acggccgcgg cgctgttggt tggctccagc accctcttct tcgtattcac gtgcccgtgg
      241 ttgacaagag ctgtctctcc agctattcct gtctacaatg gcatcctctt cctctttgtc
      301 ctggccaact tcagtatggc taccttcatg gaccccggag tcttcccccg agcggacgag
      361 gacgaggaca aggaggatga cttccgggcc ccactgtaca agaacgtgga tgtgcggggc
      421 atccaggtcc gcatgaagtg gtgtgcaaca tgccacttct accgtccgcc gcgctgctca
      481 cactgcagcg tctgcgacaa ctgtgtggag gactttgacc accactgccc ctgggtgaac
      541 aactgcatcg gacgccgtaa ctaccgttac ttcttcctgt tcctgctgtc actcagcgca
      601 cacatggtgg gggtggtggc cttcggcctg ctctacgtgc tcaaccactc ggaggggctg
      661 ggggcggccc acaccaccat caccatggct gtcatgtgtg tggctggcct tttcttcatt
      721 cctgtcatcg gcctcactgg cttccacgtg gtactggtca cccggggacg caccaccaat
      781 gagcaggtga ctgggaagtt ccgcgggggt gtgaatccct tcacccgagg ctgctatggg
      841 aacgtggagc acgtgttatg cagtcccctg gcgccccggt atgtggtgga agctcccagg
      901 atgccactct cagtgagcct aaagccaccc ttcctgaggc ctgagctcct ggaacgagct
      961 gtgcccctca aggtcaaact cagcgacaat gggctgaaag ctggccgcag caagtctaag
     1021 ggcagtctag accagctgga tgagaaacct ctggacctgg gacctccact gccccccaag
     1081 atggaggctg gcacctttgg aagagatctg aagaccccaa gacctggcag tgctgagagt
     1141 gccctgtcag tacagaggac cagcccccca acacctgcca tgtataagtt ccggccagcc
     1201 ttctccactg ctcccaagac acccttttgt ggacctagtg agcaggtccc aggccctgac
     1261 tccctcactc tggccgatga cagcacccac agtctagact ttgtatcaga gcccagcctg
     1321 gatctcccag accatgggcc tggtggtctg catcctacct accctccctc cccacccctc
     1381 agtgccactg atgccttctc aggtgcctta cgctccctga gtctcaaggc tgccagtcgg
     1441 cggggtgggg accacatgac cttacagcca ctgcgctctg aaggtgggcc ccctacaccc
     1501 caccgtggtc tctttgctcc tcacgcactg cccaaccgaa atggcagcct gtcatacgac
     1561 agcctactta accctggctc acccagtggc cacgcatgcc ccacacaccc ctctgttggt
     1621 atggccggct accattcacc ctacctgcac cctgggccat cagatcctcc acggccccca
     1681 ccccgcagct tcagccctgt gctgggtccc cggcctaggg agccctctcc tgtgcgctat
     1741 gacaacctgt ctcggaccat catggcctct atccaggagc gcaaggacag agaagagcgt
     1801 gaacggctgc tgcggtccca gactgactca ctctttggcg actctggtgt ctatgacaca
     1861 cccagctcct acagcctgca acaggccagt gtgttaacag aaggtccccg cggctctgtg
     1921 ctgcgctatg gctccaggga tgacctcgtg gccgggcctg gctttggtgg tgcccgaaat
     1981 cctgccctgc agacatcatt gtcctcactg tccagctcca tgagtcgggc acctcggaca
     2041 tcctcctctt ccctgcaggc tgaccaggcc aacaacaatg ccccaggacc ccggcctggc
     2101 agtggttcac acaggtcacc tgcccgtcag ggcctgcctt ccccaccagg caccccccga
     2161 tcgccctcct actcgggctc caaggctgtc gccttcatcc acacggacct tccggaccgg
     2221 cagccctcac tggctatgca gagggatcac cctcagctga agaccccccc aagtaagctt
     2281 aacggtcagt ccccgggcat ggcccggctg gggcctgctg ccagccccat ggggcccaac
     2341 gccagccctg cccggcacac gctggttaag aaggtgtccg gcgtgggtgg gactacgtac
     2401 gaaatctcgg tgtgagaact gaccactact catctgctgt gattccacgg ggaccaggac
     2461 ccccacagca gctccccaac cctatcaagt tctctgcccc agggaggagg ctacccaagc
     2521 ctgctgtgga cacgtcaaca ggaaagaaag ccttgcctcc acaagcttgt gctccggcct
     2581 cagcctgttc atctacttat ctagtactca cagggcagac ggatccaagg ctgtgagctg
     2641 tgatggggac ctggactgcc tgtcatcagc caagctcagc cctgcaccct cttgccctca
     2701 tcccctaagg ccagtcccca acagtcccgt gggcctgccc actcctgtct ggatgggttg
     2761 ctcagccctg ttctccagct gctcctaatt catggccttt cactgacaaa gctggtcgct
     2821 tgttgcttgg caaggcctat gctttgcagg gggcgtaacc ctggcctgct ctgggttggg
     2881 atggatggat gaacagatgg acagataatc cagctgtagc aggtcccagc tccctctgtt
     2941 cctgtcttgc ctggctggtg ggttcatgtc cctatgtctg tatgctgtgc taccgtccca
     3001 tgtctgatgt tagtgcttgg ctgccactgc tctttcatca aagccttaac ttctgcttta
     3061 tgctcttgtg ggaggtgatg gggggtgggg taggccagag cagaaagggg gccagatgct
     3121 gccccaggga ccagcggggc ctagagcccc ccccccctca ggccttccct gccaagctgg
     3181 agagtcctca ccccaaagca taccgagttc ccagcactgg cttggccagc gcagctggaa
     3241 agcacatcag ggaggggtca gttcttcccc tggcgtcagg gacctgagta agcacatggc
     3301 agcgtctgct tgcattgtgt ctgttttatg tttttatatt tacatctata tatctataat
     3361 tttattaaaa aaaaggaaaa atca
//
