LOCUS       NM_133394               2659 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus zinc finger DHHC-type palmitoyltransferase 7
            (Zdhhc7), mRNA.
ACCESSION   NM_133394
VERSION     NM_133394.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2659)
  AUTHORS   Aramsangtienchai,P., Spiegelman,N.A., Cao,J. and Lin,H.
  TITLE     S-Palmitoylation of Junctional Adhesion Molecule C Regulates Its
            Tight Junction Localization and Cell Migration
  JOURNAL   J Biol Chem 292 (13), 5325-5334 (2017)
   PUBMED   28196865
REFERENCE   2  (bases 1 to 2659)
  AUTHORS   Du,K., Murakami,S., Sun,Y., Kilpatrick,C.L. and Luscher,B.
  TITLE     DHHC7 Palmitoylates Glucose Transporter 4 (Glut4) and Regulates
            Glut4 Membrane Translocation
  JOURNAL   J Biol Chem 292 (7), 2979-2991 (2017)
   PUBMED   28057756
REFERENCE   3  (bases 1 to 2659)
  AUTHORS   Chen,B., Zheng,B., DeRan,M., Jarugumilli,G.K., Fu,J., Brooks,Y.S.
            and Wu,X.
  TITLE     ZDHHC7-mediated S-palmitoylation of Scribble regulates cell
            polarity
  JOURNAL   Nat Chem Biol 12 (9), 686-693 (2016)
   PUBMED   27380321
REFERENCE   4  (bases 1 to 2659)
  AUTHORS   Rossin,A., Durivault,J., Chakhtoura-Feghali,T., Lounnas,N.,
            Gagnoux-Palacios,L. and Hueber,A.O.
  TITLE     Fas palmitoylation by the palmitoyl acyltransferase DHHC7 regulates
            Fas stability
  JOURNAL   Cell Death Differ 22 (4), 643-653 (2015)
   PUBMED   25301068
REFERENCE   5  (bases 1 to 2659)
  AUTHORS   Lemonidis,K., Gorleku,O.A., Sanchez-Perez,M.C., Grefen,C. and
            Chamberlain,L.H.
  TITLE     The Golgi S-acylation machinery comprises zDHHC enzymes with major
            differences in substrate affinity and S-acylation activity
  JOURNAL   Mol Biol Cell 25 (24), 3870-3883 (2014)
   PUBMED   25253725
REFERENCE   6  (bases 1 to 2659)
  AUTHORS   Tsutsumi,R., Fukata,Y., Noritake,J., Iwanaga,T., Perez,F. and
            Fukata,M.
  TITLE     Identification of G protein alpha subunit-palmitoylating enzyme
  JOURNAL   Mol Cell Biol 29 (2), 435-447 (2009)
   PUBMED   19001095
REFERENCE   7  (bases 1 to 2659)
  AUTHORS   Greaves,J., Salaun,C., Fukata,Y., Fukata,M. and Chamberlain,L.H.
  TITLE     Palmitoylation and membrane interactions of the neuroprotective
            chaperone cysteine-string protein
  JOURNAL   J Biol Chem 283 (36), 25014-25026 (2008)
   PUBMED   18596047
REFERENCE   8  (bases 1 to 2659)
  AUTHORS   Ohno,Y., Kihara,A., Sano,T. and Igarashi,Y.
  TITLE     Intracellular localization and tissue-specific distribution of
            human and yeast DHHC cysteine-rich domain-containing proteins
  JOURNAL   Biochim Biophys Acta 1761 (4), 474-483 (2006)
   PUBMED   16647879
REFERENCE   9  (bases 1 to 2659)
  AUTHORS   Fukata,M., Fukata,Y., Adesnik,H., Nicoll,R.A. and Bredt,D.S.
  TITLE     Identification of PSD-95 palmitoylating enzymes
  JOURNAL   Neuron 44 (6), 987-996 (2004)
   PUBMED   15603741
REFERENCE   10 (bases 1 to 2659)
  AUTHORS   Chaudhary,J. and Skinner,M.K.
  TITLE     Identification of a novel gene product, Sertoli cell gene with a
            zinc finger domain, that is important for FSH activation of
            testicular Sertoli cells
  JOURNAL   Endocrinology 143 (2), 426-435 (2002)
   PUBMED   11796495
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Nov 26, 2020 this sequence version replaced NM_133394.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY040615.1, AY886525.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760494,
                                           SAMN12840108 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               JAXUCZ010000019.1  65065084-65065286   c
            204-288             JAXUCZ010000019.1  65056675-65056759   c
            289-619             JAXUCZ010000019.1  65054231-65054561   c
            620-744             JAXUCZ010000019.1  65052667-65052791   c
            745-841             JAXUCZ010000019.1  65051960-65052056   c
            842-923             JAXUCZ010000019.1  65051476-65051557   c
            924-1054            JAXUCZ010000019.1  65050226-65050356   c
            1055-2659           JAXUCZ010000019.1  65048140-65049744   c
FEATURES             Location/Qualifiers
     source          1..2659
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..2659
                     /gene="Zdhhc7"
                     /gene_synonym="DHHC7; Serz-1; Serz1"
                     /note="zinc finger DHHC-type palmitoyltransferase 7"
                     /db_xref="GeneID:170906"
                     /db_xref="RGD:620205"
     exon            1..203
                     /gene="Zdhhc7"
                     /gene_synonym="DHHC7; Serz-1; Serz1"
                     /inference="alignment:Splign:2.1.0"
     exon            204..288
                     /gene="Zdhhc7"
                     /gene_synonym="DHHC7; Serz-1; Serz1"
                     /inference="alignment:Splign:2.1.0"
     exon            289..619
                     /gene="Zdhhc7"
                     /gene_synonym="DHHC7; Serz-1; Serz1"
                     /inference="alignment:Splign:2.1.0"
     CDS             305..1231
                     /gene="Zdhhc7"
                     /gene_synonym="DHHC7; Serz-1; Serz1"
                     /EC_number="2.3.1.225"
                     /note="membrane-associated DHHC7 zinc finger protein;
                     DHHC-7; zinc finger DHHC domain-containing protein 7;
                     sertoli cell gene with a zinc finger domain protein;
                     putative zinc finger protein SERZ-1; zinc finger, DHHC
                     domain containing 7; zinc finger, DHHC-type containing 7;
                     acyltransferase ZDHHC7"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC7"
                     /protein_id="NP_596885.1"
                     /db_xref="GeneID:170906"
                     /db_xref="RGD:620205"
                     /translation="MQPSGHRLRDIEHHPLLTDNDNYDSASSSSSEADMADRVWFIRD
                     GCGMVCAVMTWLLVVYADFVVTFVMLLPSKDFWYSVVNGVLFNCLAVLALSSHLRTML
                     TDPGAVPKGNATKEYMESLQLKPGEVIYKCPKCCCIKPERAHHCSICKRCIRKMDHHC
                     PWVNNCVGEKNQRFFVLFTMYIALSSIHALILCGLQFISCVRGQWTECSDFSPPITVI
                     LLVFLCLEGLLFFTFTAVMFGTQIHSICNDETEIERLKSEKPTWERRLRWEGMKSVFG
                     GPPSLLWMNPFVGFRFRRLQMRTRKGGPEFSV"
     exon            620..744
                     /gene="Zdhhc7"
                     /gene_synonym="DHHC7; Serz-1; Serz1"
                     /inference="alignment:Splign:2.1.0"
     exon            745..841
                     /gene="Zdhhc7"
                     /gene_synonym="DHHC7; Serz-1; Serz1"
                     /inference="alignment:Splign:2.1.0"
     exon            842..923
                     /gene="Zdhhc7"
                     /gene_synonym="DHHC7; Serz-1; Serz1"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1054
                     /gene="Zdhhc7"
                     /gene_synonym="DHHC7; Serz-1; Serz1"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..2659
                     /gene="Zdhhc7"
                     /gene_synonym="DHHC7; Serz-1; Serz1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagctccgc gtcgggctcc cgcttctgct ggtcggctgc ctcccgcaca cctgccgggc
       61 cggaccgagc cgaacggaac cgagcggatc cgggtccacc cggcccggcc atgagcgctg
      121 ccgcatgatg cgtcgccgcc cgcgccgctg cagccgccgg ccgcgaggag cctcagcact
      181 gggcgacccc gcccgggcct cgggccacat cacacaggac agcatgcggc ttacggtcct
      241 gaaaaaaagg cacaagtgct cccatgatgc ttagaagcaa cttgtaaggc tgtgccaggg
      301 aatcatgcag ccgtcaggac acaggctccg ggacattgag caccatcctc tcctgactga
      361 caatgacaat tatgactctg cgtcctcctc gtcctccgag gctgacatgg cagacagggt
      421 gtggttcatc cgagatggct gtggcatggt ctgtgctgtc atgacatggc ttctggtcgt
      481 ctatgcagac tttgtggtga ccttcgtcat gctgctgcct tccaaagact tctggtactc
      541 cgtggtgaac ggggtcctct tcaactgctt ggcggtgctc gcgctgtcct cccacctaag
      601 aaccatgctc actgacccgg gggctgtccc caaaggcaac gccacgaagg agtacatgga
      661 gagcttgcag ctgaagccgg gcgaggtgat ctacaagtgc cccaagtgtt gctgcatcaa
      721 gccggagcgt gcccaccact gcagtatctg caagaggtgc attcgaaaga tggaccacca
      781 ctgcccgtgg gtgaacaact gtgtgggaga gaagaaccag cgcttcttcg tgctcttcac
      841 catgtacata gctctgtctt caatccatgc tctgattctc tgcgggcttc agttcatctc
      901 ttgcgtccga gggcagtgga cagagtgcag tgacttctct cctcccataa ctgtaatcct
      961 gttggtcttc ctgtgccttg agggcctcct gttcttcact ttcaccgcag tcatgttcgg
     1021 cacccagatc cactcaatat gcaatgacga aactgagatc gagaggctga agagtgagaa
     1081 gcctacgtgg gagcgaaggc tgcggtggga agggatgaag tctgtcttcg ggggccctcc
     1141 ctccctcctc tggatgaacc cctttgtggg cttccgattc aggcggctgc agatgaggac
     1201 caggaaggga ggccccgagt tctctgtatg agccttcagg gcaggatgtc tgcagacatc
     1261 atactcagtg gccgcaagca cagcagcctt gtgggcagat ggagctggcc agcagacggg
     1321 gccatgagca cttcatggac ctagggccac aggcacttgt catttctgtg tgtactgcca
     1381 ggagaagcag tcccgggagg ccatcctgac catcctgacc caggatgtct cgtgggctgc
     1441 gagcacccac agcacaggtg ccgttgcttc ttggtcatga aggaagccag cacagcagct
     1501 gctggggtcc tgctggccca tccccagcgc acttcttact ggaaggggtt tccacagaga
     1561 ctctggcttg gagggctctg acacctagca ctgaacagtc aaagcggctt ccagaacact
     1621 ccatgctgcc ccagaacggg catcctttga cccttccagc aagtctgtgt gtgctcatct
     1681 gtgtgtctgt gtggtgtgtg tgcgtgagca tgtgtcagaa tcagcagtgt tgttcaagca
     1741 cgcgtgtggt agacaagctg tctttcagac tccagtgttt cagggaagtg ggacgcactg
     1801 ctggcccttg ctggcctcct atgaatgtat cctccagtgt ccagatccaa agaacaggca
     1861 tgcctgcgca tgggcccggc ctcctgcttt tatttcactg aaaacttagt gtttgagggc
     1921 atggagctga ggttttgttg ttccagccaa actagccact gcaacattct ctcaacaagg
     1981 aaagtggtag ccctgtgctg agacccagca ctgtggggca ggggctgtgg ggagctcagc
     2041 atgagaagcc gccttgggcc cctttggaga ggtgctgcag gctgagacag cccggtgcct
     2101 gagctatcaa gagtggggac atgtgactat ttctttaccc atggcacttc agtcagtgga
     2161 cccttggtgt gggcttagaa ttatgtcagc acacacagct cccctcaggg gacttgcctt
     2221 aaactcgtag gttgtccttt gctgctgggt gaaagcagtc tgacagaagc tggggacttc
     2281 cgagagtgtt ctcccatgca gacaccagtg tttcccttct gggaccagct gcctttctgt
     2341 ccccgtgaca ccatgactgt tctttcggtg tcagtcgctt gtgccctgcc cttgtctggg
     2401 ctcctatgct actgaggtga acccggggga cctgagccct ctcatgcagt gagcaaactc
     2461 tggggcctga gtccctgcag agggacatcg tggcttcaga ttgtctctgc gttcctttgc
     2521 acatgtgtct gggcatgtag gctctggcag tctcaccctc cagtgtggag tccgtggcgg
     2581 tgaatccaag ctgagtatac ttgacttttc aattcctcag tgtgattttc tatgaaataa
     2641 agtaacccgt ccacagttc
//
