LOCUS       NM_001037652            2134 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus zinc finger DHHC-type palmitoyltransferase 6
            (Zdhhc6), mRNA.
ACCESSION   NM_001037652 XM_342065
VERSION     NM_001037652.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2134)
  AUTHORS   Abrami L, Dallavilla T, Sandoz PA, Demir M, Kunz B, Savoglidis G,
            Hatzimanikatis V and van der Goot FG.
  TITLE     Identification and dynamics of the human ZDHHC16-ZDHHC6
            palmitoylation cascade
  JOURNAL   Elife 6, e27826 (2017)
   PUBMED   28826475
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2134)
  AUTHORS   Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK,
            Vidal-Puig A and Teleman AA.
  TITLE     Regulation of mitochondrial morphology and function by
            stearoylation of TFR1
  JOURNAL   Nature 525 (7567), 124-128 (2015)
   PUBMED   26214738
REFERENCE   3  (bases 1 to 2134)
  AUTHORS   Fredericks GJ, Hoffmann FW, Rose AH, Osterheld HJ, Hess FM, Mercier
            F and Hoffmann PR.
  TITLE     Stable expression and function of the inositol 1,4,5-triphosphate
            receptor requires palmitoylation by a DHHC6/selenoprotein K complex
  JOURNAL   Proc Natl Acad Sci U S A 111 (46), 16478-16483 (2014)
   PUBMED   25368151
REFERENCE   4  (bases 1 to 2134)
  AUTHORS   Ohno Y, Kashio A, Ogata R, Ishitomi A, Yamazaki Y and Kihara A.
  TITLE     Analysis of substrate specificity of human DHHC protein
            acyltransferases using a yeast expression system
  JOURNAL   Mol Biol Cell 23 (23), 4543-4551 (2012)
   PUBMED   23034182
REFERENCE   5  (bases 1 to 2134)
  AUTHORS   Fairbank M, Huang K, El-Husseini A and Nabi IR.
  TITLE     RING finger palmitoylation of the endoplasmic reticulum Gp78 E3
            ubiquitin ligase
  JOURNAL   FEBS Lett 586 (16), 2488-2493 (2012)
   PUBMED   22728137
REFERENCE   6  (bases 1 to 2134)
  AUTHORS   Gorleku OA, Barns AM, Prescott GR, Greaves J and Chamberlain LH.
  TITLE     Endoplasmic reticulum localization of DHHC palmitoyltransferases
            mediated by lysine-based sorting signals
  JOURNAL   J Biol Chem 286 (45), 39573-39584 (2011)
   PUBMED   21926431
REFERENCE   7  (bases 1 to 2134)
  AUTHORS   Ohno Y, Kihara A, Sano T and Igarashi Y.
  TITLE     Intracellular localization and tissue-specific distribution of
            human and yeast DHHC cysteine-rich domain-containing proteins
  JOURNAL   Biochim Biophys Acta 1761 (4), 474-483 (2006)
   PUBMED   16647879
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC107928.1.
            
            On Dec 9, 2005 this sequence version replaced XM_342065.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC107928.1, AY886524.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2134
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..2134
                     /gene="Zdhhc6"
                     /note="zinc finger DHHC-type palmitoyltransferase 6"
                     /db_xref="GeneID:361771"
                     /db_xref="RGD:1304657"
     exon            1..194
                     /gene="Zdhhc6"
                     /inference="alignment:Splign:2.1.0"
     exon            195..664
                     /gene="Zdhhc6"
                     /inference="alignment:Splign:2.1.0"
     CDS             398..1639
                     /gene="Zdhhc6"
                     /EC_number="2.3.1.225"
                     /note="membrane-associated DHHC6 zinc finger protein; zinc
                     finger, DHHC domain containing 6; probable
                     palmitoyltransferase ZDHHC6; zinc finger, DHHC-type
                     containing 6"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC6"
                     /protein_id="NP_001032741.1"
                     /db_xref="GeneID:361771"
                     /db_xref="RGD:1304657"
                     /translation="MSTLCSVIKFENLQDLRRLCHWGPIIALGVIAICSTMAMIDSVL
                     WYWPLHTTGGSVNFIMLINWTVMILYNYFNAMFAGPGFVPRGWKPENPQDSMYLQYCK
                     VCQAYKAPRSHHCRKCNRCVMKMDHHCPWINNCCGHQNHASFTLFLLLAPLGCTHAAF
                     IFVMTMYTQLYNRLSFGWNTVKIDMSAARRDPPPIVPFGLAAFAATLFALGLALGTTI
                     AVGMLFFIQIKIILRNKTSIESWIEEKAKDRIQYYQLDEVFVFPYDMGSKWKNLKQVF
                     TWSGVPEGDGLEWPIREGCHQYSLTIEQLKQKADKRVRSVRYKVVEDYNGACCPLNRG
                     VRTFFTSPCTEEPRIQLQKGELVLATRGLRYWLYGDKILDDSFIEGTSRIRGWFPRNC
                     VEKCPCDGESDPAPEGEKKNR"
     exon            665..756
                     /gene="Zdhhc6"
                     /inference="alignment:Splign:2.1.0"
     exon            757..916
                     /gene="Zdhhc6"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1078
                     /gene="Zdhhc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1132
                     /gene="Zdhhc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1300
                     /gene="Zdhhc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1342
                     /gene="Zdhhc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1488
                     /gene="Zdhhc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1535
                     /gene="Zdhhc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..2103
                     /gene="Zdhhc6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacgcccctg cgtgagccag acacgcgccg gtaggagttg ctcgctcggt tctcgccatc
       61 aggtttcgca ttcggcttac tcaggactga tgtgctcatg acagagctat aaagaggaga
      121 aaatctgttc cggtgagccc aggccgctcc ggaaatgcga tggccgtgga gcgggcaccg
      181 gagaccagac tgagactgtg tttcaaacca accaagattc tcctcctcga gatctggagg
      241 ccaccagtga aaatggcata ctccatatca acaccccgtc atccaaaggc atgacagaca
      301 gctcaggaac acgcgtggac tttttgcaca cagaaatgtg tacacaggaa aaggaaatct
      361 ctagttcttt agaagaaaga agtcattctt caccaaaatg agcacgctct gctcagtaat
      421 caagtttgaa aatcttcaag acttaagaag actgtgtcat tggggtccca taatagccct
      481 gggtgttata gcaatatgtt ccacaatggc catgattgac tctgtcttgt ggtattggcc
      541 cttacataca actggaggaa gtgtgaattt catcatgttg ataaattgga ctgtcatgat
      601 tctttataat tacttcaatg ccatgtttgc tggtcctggc ttcgtccccc ggggctggaa
      661 accggagaat cctcaggata gcatgtatct ccagtattgt aaagtctgcc aagcgtacaa
      721 ggcaccacgt tcacatcatt gcagaaagtg taacagatgt gtaatgaaga tggaccacca
      781 ctgtccctgg atcaataact gctgtggtca ccagaaccat gcgtccttca cactcttcct
      841 gctgctggcc cctctgggct gcacccatgc tgctttcatc tttgtgatga ccatgtacac
      901 acagctctat aaccggctct ccttcgggtg gaacacagtc aagattgaca tgagtgcagc
      961 caggagagac cctcctccaa ttgttccttt tggattggct gcgtttgctg ccaccttgtt
     1021 tgccttggga ttagctctgg gaacaaccat agctgttggg atgttgtttt tcatacagat
     1081 aaaaattatt ctcagaaaca aaacttctat tgaatcatgg atcgaagaga aggctaaaga
     1141 tcggatccag tattaccagc tggatgaagt cttcgtgttc ccttacgata tgggaagtaa
     1201 atggaagaac ttgaagcagg tgtttacatg gtcgggagtc cctgaaggag atggacttga
     1261 gtggccaata cgagagggct gtcaccagta cagcctaaca atagagcagt tgaaacaaaa
     1321 agcagacaag agagtcagaa gtgtccgcta taaggtcgta gaagactata atggtgcctg
     1381 ttgccctttg aaccgaggag tcagaacctt cttcacaagc ccctgcactg aggagcctcg
     1441 gattcagctg cagaaagggg agctcgtctt agcaacccga gggttacgat actggttgta
     1501 tggagacaaa attcttgatg attccttcat agaaggtact tcaagaataa gagggtggtt
     1561 tcctagaaac tgtgtagaaa agtgcccctg tgatggagag tcagatccag ccccagaggg
     1621 cgagaagaag aacagatagc cacggttaaa gtgagatcat tacgtcttca ttacttgaaa
     1681 atccacacat agtacctgag aattatgcaa caagcctact atgcctaagg tattttcctc
     1741 aaagatgccc tcgtgccatg acttcagaaa tttttattac cattttgaaa cagaagccat
     1801 tctgcatatg cctttgaagt cctgccatct tcccacttct tcctactaaa ggaaggccat
     1861 tccagccaag taagccagct gccctttctg tctgctgcac ctgtgacttc acctgcaggt
     1921 ctgattccca cctggacagg agcatcttgc atgtgcttat tctgtttctt cctcagttga
     1981 catttcctcc ataatctaga gactgtaaaa cctgtcagat tcagtgtaaa ctcaaatttt
     2041 gttactttta ataatgcaaa ttttgtcaaa ttcaataaag gtcaatggat gttctgtaaa
     2101 ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
