LOCUS       NM_001039338            2697 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus zinc finger DHHC-type palmitoyltransferase 5
            (Zdhhc5), mRNA.
ACCESSION   NM_001039338
VERSION     NM_001039338.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2697)
  AUTHORS   Collura,K.M., Niu,J., Sanders,S.S., Montersino,A., Holland,S.M. and
            Thomas,G.M.
  TITLE     The palmitoyl acyltransferases ZDHHC5 and ZDHHC8 are uniquely
            present in DRG axons and control retrograde signaling via the
            Gp130/JAK/STAT3 pathway
  JOURNAL   J Biol Chem 295 (46), 15427-15437 (2020)
   PUBMED   32958558
  REMARK    GeneRIF: The palmitoyl acyltransferases ZDHHC5 and ZDHHC8 are
            uniquely present in DRG axons and control retrograde signaling via
            the Gp130/JAK/STAT3 pathway.
REFERENCE   2  (bases 1 to 2697)
  AUTHORS   Lu,Y., Zheng,Y., Coyaud,E., Zhang,C., Selvabaskaran,A., Yu,Y.,
            Xu,Z., Weng,X., Chen,J.S., Meng,Y., Warner,N., Cheng,X., Liu,Y.,
            Yao,B., Hu,H., Xia,Z., Muise,A.M., Klip,A., Brumell,J.H.,
            Girardin,S.E., Ying,S., Fairn,G.D., Raught,B., Sun,Q. and
            Neculai,D.
  TITLE     Palmitoylation of NOD1 and NOD2 is required for bacterial sensing
  JOURNAL   Science 366 (6464), 460-467 (2019)
   PUBMED   31649195
REFERENCE   3  (bases 1 to 2697)
  AUTHORS   Woodley,K.T. and Collins,M.O.
  TITLE     S-acylated Golga7b stabilises DHHC5 at the plasma membrane to
            regulate cell adhesion
  JOURNAL   EMBO Rep 20 (10), e47472 (2019)
   PUBMED   31402609
REFERENCE   4  (bases 1 to 2697)
  AUTHORS   Brigidi,G.S., Santyr,B., Shimell,J., Jovellar,B. and Bamji,S.X.
  TITLE     Activity-regulated trafficking of the palmitoyl-acyl transferase
            DHHC5
  JOURNAL   Nat Commun 6, 8200 (2015)
   PUBMED   26334723
  REMARK    GeneRIF: DHHC5, to palmitoylate substrates in an activity-dependent
            manner is dependent on changes in its subcellular localization.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2697)
  AUTHORS   Ohno,Y., Kashio,A., Ogata,R., Ishitomi,A., Yamazaki,Y. and
            Kihara,A.
  TITLE     Analysis of substrate specificity of human DHHC protein
            acyltransferases using a yeast expression system
  JOURNAL   Mol Biol Cell 23 (23), 4543-4551 (2012)
   PUBMED   23034182
REFERENCE   6  (bases 1 to 2697)
  AUTHORS   Thomas,G.M., Hayashi,T., Chiu,S.L., Chen,C.M. and Huganir,R.L.
  TITLE     Palmitoylation by DHHC5/8 targets GRIP1 to dendritic endosomes to
            regulate AMPA-R trafficking
  JOURNAL   Neuron 73 (3), 482-496 (2012)
   PUBMED   22325201
  REMARK    GeneRIF: this study identified the first neuronal DHHC5/8
            substrate, define novel mechanisms controlling palmitoylation
            specificity, and suggest further links between dysregulated
            palmitoylation and neuropathological conditions.
REFERENCE   7  (bases 1 to 2697)
  AUTHORS   Kokkola,T., Kruse,C., Roy-Pogodzik,E.M., Pekkinen,J., Bauch,C.,
            Honck,H.H., Hennemann,H. and Kreienkamp,H.J.
  TITLE     Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5
            palmitoyltransferase
  JOURNAL   FEBS Lett 585 (17), 2665-2670 (2011)
   PUBMED   21820437
REFERENCE   8  (bases 1 to 2697)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   9  (bases 1 to 2697)
  AUTHORS   Ohno,Y., Kihara,A., Sano,T. and Igarashi,Y.
  TITLE     Intracellular localization and tissue-specific distribution of
            human and yeast DHHC cysteine-rich domain-containing proteins
  JOURNAL   Biochim Biophys Acta 1761 (4), 474-483 (2006)
   PUBMED   16647879
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY871203.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY871203.1, SRR8487231.100328.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760434 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2697
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..2697
                     /gene="Zdhhc5"
                     /gene_synonym="DHHC-5"
                     /note="zinc finger DHHC-type palmitoyltransferase 5"
                     /db_xref="GeneID:362156"
                     /db_xref="RGD:1589737"
     exon            1..308
                     /gene="Zdhhc5"
                     /gene_synonym="DHHC-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..2352
                     /gene="Zdhhc5"
                     /gene_synonym="DHHC-5"
                     /EC_number="2.3.1.225"
                     /note="zinc finger, DHHC domain containing 5; probable
                     palmitoyltransferase ZDHHC5; membrane-associated DHHC5
                     zinc finger protein; zinc finger DHHC domain-containing
                     protein 5; zinc finger, DHHC-type containing 5"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC5"
                     /protein_id="NP_001034427.1"
                     /db_xref="GeneID:362156"
                     /db_xref="RGD:1589737"
                     /translation="MPAESGKRFKPSKYVPVSAAAIFLVGATTLFFAFTCPGLSLDVS
                     PAVPIYNAIMFLFVLANFSMATFMDPGIFPRAEEDEDKEDDFRAPLYKTVEIKGIQVR
                     MKWCATCRFYRPPRCSHCSVCDNCVEEFDHHCPWVNNCIGRRNYRYFFLFLLSLTAHI
                     MGVFGFGLLYVLCHIEELSGVRTAVTMAVMCVAGLFFIPVAGLTGFHVVLVARGRTTN
                     EQVTGKFRGGVNPFTNGCCNNVSRVLCSSPAPRYLGRPKKEKTIVIRPPFLRPEVSDG
                     QITVKIMDNGIQGELRRTKSKGSLEITESQSADAEPPPPPKPDLSRYTGLRTHLSLAT
                     NEDSSLLGKDSPPTPTMYKYRPGYSSSSTSAAMPHSSSAKLSRGDSLKEPTSIADSSR
                     HPSYRSEPSLEPESFRSPTFGKSFHFDPLSSGSRSSSLKSAQGTGFELGQLQSIRSEG
                     TTSTSYKSLANQTRNGSLSYDSLLTPSDSPDFESVQAGPEPDPPLGYTSPFLSARLAQ
                     QREAERHPRLLPTGPPHREPSPVRYDNLSRHIVASLQEREKLLRQSPPLAGREEEPGL
                     GDSGIQSTPGSGHAPRTSSSSDDSKRSPLSKTPLGRPAVPRFGKPDGLRGRGLGSPEP
                     GTTAPYLGRSMSYSSQKAPSGVSETEEVALQPLLTPKDEVQLKTTYSKSNGQPKSIGS
                     ASPGPGQPPLSSPTRGGVKKVSGVGGTTYEISV"
     exon            309..430
                     /gene="Zdhhc5"
                     /gene_synonym="DHHC-5"
                     /inference="alignment:Splign:2.1.0"
     exon            431..588
                     /gene="Zdhhc5"
                     /gene_synonym="DHHC-5"
                     /inference="alignment:Splign:2.1.0"
     exon            589..761
                     /gene="Zdhhc5"
                     /gene_synonym="DHHC-5"
                     /inference="alignment:Splign:2.1.0"
     exon            762..864
                     /gene="Zdhhc5"
                     /gene_synonym="DHHC-5"
                     /inference="alignment:Splign:2.1.0"
     exon            865..956
                     /gene="Zdhhc5"
                     /gene_synonym="DHHC-5"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1089
                     /gene="Zdhhc5"
                     /gene_synonym="DHHC-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1213
                     /gene="Zdhhc5"
                     /gene_synonym="DHHC-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1326
                     /gene="Zdhhc5"
                     /gene_synonym="DHHC-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..2186
                     /gene="Zdhhc5"
                     /gene_synonym="DHHC-5"
                     /inference="alignment:Splign:2.1.0"
     exon            2187..2680
                     /gene="Zdhhc5"
                     /gene_synonym="DHHC-5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctttccccct cccatgtgct ttccttcatt tgagatcttt tgaccttcat ttttatttgg
       61 gagggggaag ggtgataatt ttacattttc tgttttcccc agttttcttt cctctctgtt
      121 tccctcatcc cattttctta tctgttctgc cgctgtgtgg gcctgggcta tgcggcaggg
      181 cacatcattc atcagagctc caacatgccc gcagagtctg gaaagagatt caaacccagc
      241 aagtatgtac cggtctcagc agccgccata tttctagtgg gagctacaac actcttcttt
      301 gcctttacgt gtccaggact aagcctggat gtgtcacctg cagtgcccat ttacaatgcg
      361 attatgttcc ttttcgtgct ggccaacttc agcatggcca cctttatgga cccaggaatt
      421 ttcccccgag ctgaagaaga cgaagacaaa gaagatgatt tccgagctcc cctttacaaa
      481 acagtggaga tcaagggtat ccaggtgcga atgaaatggt gcgccacctg ccgcttttac
      541 cgccctccta gatgctccca ctgcagtgtc tgtgacaact gtgtggagga atttgatcat
      601 cactgccctt gggtgaacaa ctgtattggt cgcaggaact acagatactt cttccttttc
      661 ctcctttccc tgacagccca catcatgggt gtgtttggct ttggcctcct ttatgtcctc
      721 tgtcacatag aggaactctc aggggtccga actgctgtca caatggcagt gatgtgtgtg
      781 gctggcttgt ttttcatccc tgtagctggc ctcacaggat ttcatgtggt gctggtggcc
      841 aggggacgca caaccaatga acaggttaca ggaaaattcc ggggaggtgt gaatcccttt
      901 accaatggct gttgtaacaa tgttagccgt gtcctctgca gttctccagc acccaggtat
      961 ttggggagac caaagaaaga gaagacaatt gtaatcagac cccctttcct tcgaccagaa
     1021 gtgtcagatg ggcagataac tgtgaagatc atggataatg gcatccaggg agaactgagg
     1081 aggactaagt ctaagggaag cctagagata acagagagcc agtctgcgga tgcggaacct
     1141 ccacctcctc ctaagccaga cctgagccga tacacagggc ttcgaacaca cctcagcctg
     1201 gctactaatg aggatagcag tctcttgggc aaagacagcc cccctacacc taccatgtac
     1261 aagtatcggc caggttacag cagcagtagc acatcagccg ccatgcctca ttcctccagc
     1321 gccaagttga gtcgtggaga cagcttgaag gaaccaactt caattgcaga tagcagccgc
     1381 catcccagct accgctcaga acccagcttg gagccagaga gcttccggtc tcccactttt
     1441 ggcaaaagct ttcattttga tcctttgtcc agtggttcac gatcctccag cctcaagtca
     1501 gctcagggca cgggctttga gctgggccag ttgcagtcca ttcgttcaga gggcaccacc
     1561 tccacctcct ataagagcct ggccaatcag acacgcaatg gaagtctatc ttatgacagc
     1621 ctactcactc cttcagacag ccctgatttt gagtcagtac aggcagggcc tgagccagac
     1681 ccacctttag gctacacctc tcccttcctg tcagcccggc tggcccagca acgggaagcc
     1741 gagaggcacc cacgtttgct gccaactggc ccaccacacc gagagccctc accagtccgt
     1801 tatgacaatc tgtctcgcca catcgtggcc tcccttcagg aacgagagaa gctgctacga
     1861 cagtcacctc cacttgcagg ccgtgaggaa gaaccaggct tgggagactc aggcattcag
     1921 tcaacaccag gctcaggcca tgccccccgt actagttcct cctcagatga ttccaagaga
     1981 tcacccttga gcaagactcc actgggacgc ccagccgtcc cccgttttgg caaaccagat
     2041 gggttaagag gccggggact agggtcccct gaaccaggca caactgcccc ctacctgggc
     2101 cgatcgatgt cctatagcag ccaaaaagcc ccatctggtg tgtctgagac agaggaagta
     2161 gcactgcagc cattactgac acccaaagac gaagtacagc tcaagaccac ctacagcaaa
     2221 tccaatgggc agcccaagag tataggctca gcttcccctg gcccaggcca gccacctctc
     2281 agtagcccca caaggggagg agtcaagaag gtgtcagggg tgggtggcac cacttacgag
     2341 atttctgtgt gaatcttggc gcctcccttc ccccacacct ctgcacctac accaaagggc
     2401 ctcaggtggc caccttcctt ccctcaaggg gctcccctac tttgcatgga cattttttaa
     2461 accaccgatt ccaagaggat gaggcttgtt ttacaaaatg ccatggggtt aaggagagtt
     2521 ggggccctga gactggggtg gcacctcccc ctcctttgat cttttaagac cttcccttcc
     2581 ttgatccctg gaccagactc agtggacatt tgtgcaattg ctcgccctgg agggaaccag
     2641 atcattttta aaccagaaat aatttttttt attattgtta aaaaaaaaaa aaaaaaa
//
