LOCUS       NM_001413578            5365 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus zinc finger DHHC-type palmitoyltransferase 3
            (Zdhhc3), transcript variant 1, mRNA.
ACCESSION   NM_001413578 XM_008766714
VERSION     NM_001413578.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5365)
  AUTHORS   Murphy,J. and Kolandaivelu,S.
  TITLE     Palmitoylation of Progressive Rod-Cone Degeneration (PRCD)
            Regulates Protein Stability and Localization
  JOURNAL   J Biol Chem 291 (44), 23036-23046 (2016)
   PUBMED   27613864
REFERENCE   2  (bases 1 to 5365)
  AUTHORS   Lemonidis,K., Gorleku,O.A., Sanchez-Perez,M.C., Grefen,C. and
            Chamberlain,L.H.
  TITLE     The Golgi S-acylation machinery comprises zDHHC enzymes with major
            differences in substrate affinity and S-acylation activity
  JOURNAL   Mol Biol Cell 25 (24), 3870-3883 (2014)
   PUBMED   25253725
REFERENCE   3  (bases 1 to 5365)
  AUTHORS   Lai,J. and Linder,M.E.
  TITLE     Oligomerization of DHHC protein S-acyltransferases
  JOURNAL   J Biol Chem 288 (31), 22862-22870 (2013)
   PUBMED   23793055
REFERENCE   4  (bases 1 to 5365)
  AUTHORS   Oku,S., Takahashi,N., Fukata,Y. and Fukata,M.
  TITLE     In silico screening for palmitoyl substrates reveals a role for
            DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in
            its targeting to Rab5-positive endosomes
  JOURNAL   J Biol Chem 288 (27), 19816-19829 (2013)
   PUBMED   23687301
  REMARK    GeneRIF: In silico screening for palmitoyl substrates reveals a
            role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin
            palmitoylation in its targeting to Rab5-positive endosomes.
REFERENCE   5  (bases 1 to 5365)
  AUTHORS   Ohno,Y., Kashio,A., Ogata,R., Ishitomi,A., Yamazaki,Y. and
            Kihara,A.
  TITLE     Analysis of substrate specificity of human DHHC protein
            acyltransferases using a yeast expression system
  JOURNAL   Mol Biol Cell 23 (23), 4543-4551 (2012)
   PUBMED   23034182
REFERENCE   6  (bases 1 to 5365)
  AUTHORS   Greaves,J., Salaun,C., Fukata,Y., Fukata,M. and Chamberlain,L.H.
  TITLE     Palmitoylation and membrane interactions of the neuroprotective
            chaperone cysteine-string protein
  JOURNAL   J Biol Chem 283 (36), 25014-25026 (2008)
   PUBMED   18596047
REFERENCE   7  (bases 1 to 5365)
  AUTHORS   Fang,C., Deng,L., Keller,C.A., Fukata,M., Fukata,Y., Chen,G. and
            Luscher,B.
  TITLE     GODZ-mediated palmitoylation of GABA(A) receptors is required for
            normal assembly and function of GABAergic inhibitory synapses
  JOURNAL   J Neurosci 26 (49), 12758-12768 (2006)
   PUBMED   17151279
REFERENCE   8  (bases 1 to 5365)
  AUTHORS   Ohno,Y., Kihara,A., Sano,T. and Igarashi,Y.
  TITLE     Intracellular localization and tissue-specific distribution of
            human and yeast DHHC cysteine-rich domain-containing proteins
  JOURNAL   Biochim Biophys Acta 1761 (4), 474-483 (2006)
   PUBMED   16647879
REFERENCE   9  (bases 1 to 5365)
  AUTHORS   Fukata,M., Fukata,Y., Adesnik,H., Nicoll,R.A. and Bredt,D.S.
  TITLE     Identification of PSD-95 palmitoylating enzymes
  JOURNAL   Neuron 44 (6), 987-996 (2004)
   PUBMED   15603741
REFERENCE   10 (bases 1 to 5365)
  AUTHORS   Uemura,T., Mori,H. and Mishina,M.
  TITLE     Isolation and characterization of Golgi apparatus-specific GODZ
            with the DHHC zinc finger domain
  JOURNAL   Biochem Biophys Res Commun 296 (2), 492-496 (2002)
   PUBMED   12163046
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 3, 2022 this sequence version replaced XM_008766714.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.37937.1,
                                           SRR26643292.36050.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-199               JAXUCZ010000008.1  131650800-131650998 c
            200-529             JAXUCZ010000008.1  131635493-131635822 c
            530-654             JAXUCZ010000008.1  131624531-131624655 c
            655-751             JAXUCZ010000008.1  131620073-131620169 c
            752-833             JAXUCZ010000008.1  131619385-131619466 c
            834-964             JAXUCZ010000008.1  131616731-131616861 c
            965-5365            JAXUCZ010000008.1  131602663-131607063 c
FEATURES             Location/Qualifiers
     source          1..5365
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..5365
                     /gene="Zdhhc3"
                     /note="zinc finger DHHC-type palmitoyltransferase 3"
                     /db_xref="GeneID:301081"
                     /db_xref="RGD:1309041"
     exon            1..199
                     /gene="Zdhhc3"
                     /inference="alignment:Splign:2.1.0"
     exon            200..529
                     /gene="Zdhhc3"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..1222
                     /gene="Zdhhc3"
                     /EC_number="2.3.1.225"
                     /note="isoform 1 is encoded by transcript variant 1;
                     palmitoyltransferase ZDHHC3; zinc finger, DHHC domain
                     containing 3; zinc finger, DHHC-type containing 3;
                     acyltransferase ZDHHC3; zinc finger DHHC domain-containing
                     protein 3"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC3 isoform 1"
                     /protein_id="NP_001400507.1"
                     /db_xref="GeneID:301081"
                     /db_xref="RGD:1309041"
                     /translation="MMLIPTHHFRDIERKPEYLQPEKCAPPPFPGPVGTMWFIRDGCG
                     IACAIVTWFLVLYAEFVVLFVMLIPSRDYAYSIINGIVFNLLAFLALASHCRAMLTDP
                     GAVPKGNATKEFIESLQLKPGQVVYKCPKCCSIKPDRAHHCSVCKRCIRKMDHHCPWV
                     NNCVGENNQKYFVLFTMYIALISLHALIMVGFHFLHCFEEDWTKCSSFSPPTTVILLI
                     LLCFEALLFLIFTSVMFGTQVHSICTDETGIERLQRSKQPREQSGSWKSVQEAFGGEF
                     SLNWFNPFTRPCQPEIPIDKGLVRQVSSLSNMDNVETAEGQLEETKDRDPVEVLGE"
     exon            530..654
                     /gene="Zdhhc3"
                     /inference="alignment:Splign:2.1.0"
     exon            655..751
                     /gene="Zdhhc3"
                     /inference="alignment:Splign:2.1.0"
     exon            752..833
                     /gene="Zdhhc3"
                     /inference="alignment:Splign:2.1.0"
     exon            834..964
                     /gene="Zdhhc3"
                     /inference="alignment:Splign:2.1.0"
     exon            965..5365
                     /gene="Zdhhc3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcccgcgcg gtggccgctc ccgcagccgc ggctgccgcc actgcctgga gctccatggg
       61 cctctccttc gcgccgcccc gtgtgaggcc gagtccggca agccgtggcg cccggtgccc
      121 gagccatcgc ggacgctgga ggctgggccc cggggcaaca gcaggcggcg cgggactacg
      181 agctgcctcc agattgacga tgccagtatg gacagaatag cttatgatgc ttatccccac
      241 tcatcacttc cgagacattg aacggaaacc agaatacctc cagccagaga agtgtgcccc
      301 acctcccttc cctggccccg tgggaaccat gtggtttatc cgcgatggct gtggcatcgc
      361 ctgtgccatt gtcacctggt ttctggtcct ctatgcagag tttgtagtcc tctttgtcat
      421 gctgattcca tcccgagact acgcatacag tatcatcaac ggaattgtgt tcaacctgct
      481 ggccttcttg gctctggcct cccactgccg ggccatgctg acggaccccg gggcagtgcc
      541 caaaggaaat gccactaaag agttcatcga gagccttcag ctgaagcctg ggcaggtggt
      601 gtacaagtgt cccaagtgct gcagcatcaa gcccgaccgg gcacaccact gcagtgtttg
      661 taagcggtgc attcgcaaga tggaccacca ctgtccttgg gtcaacaact gtgtcggcga
      721 gaacaaccag aagtactttg tcctgttcac aatgtacata gctctcattt ccttgcacgc
      781 cctcatcatg gtgggattcc acttcctgca ttgctttgaa gaagactgga caaagtgcag
      841 ctccttctca ccgcccacca ctgttatcct gctcatcctg ctgtgttttg aggccctgct
      901 cttcctcatt ttcacatcag tgatgtttgg gacccaagtg cactccatct gcacagatga
      961 gacgggcatt gaacgcctcc aacgatcaaa acagcccagg gagcagtcgg gcagctggaa
     1021 gtcggtccag gaggcttttg gtggggaatt ttccctgaat tggttcaacc ctttcaccag
     1081 accttgtcaa ccagagatac ccatcgacaa gggcttggta cggcaagtgt catctctgtc
     1141 aaacatggac aacgtggaaa cagctgaggg ccaattggaa gagacaaaag acagggaccc
     1201 tgtggaggta cttggtgaat agaggtcact gagagtaaga tgccaacagt gcctgctacc
     1261 ctgatgagtg ttaccaactg tcacccccac cttttttttc tgctaggatt ggggtagggg
     1321 gtggtgggag ggcagtagag ggtacaggag agaagggtct ttgagttcct cttagcagga
     1381 tgtgctagaa gggatggtca ttaacacttc tccaggccta ttctctgtcc agcaagggaa
     1441 atggtgacca ggatgtcagg gtaggggatc cacttctgct tcttgagggc tctcttgggg
     1501 aggctgaaga tcttggggaa gggatactaa catcaaggaa gaccagcctg gaatgctaga
     1561 gagactccag ccatttccag gaaagggatt ccttggctgg ctggctggct ggctggctgg
     1621 ctgggaatca gaacaaagga ggggctgctg agcctgtctt caggacttag gcttggttga
     1681 cagagcaccc cacacatctg tgtgcatgca tacacatgtg cagagcctac ccaaatggaa
     1741 acaagcctga gttatgacag taccatcatc ctatagatac tagacacttc cctgacacaa
     1801 caatgcagcc agcctttctg tgacacaagc atgcattacc agaagagcta agtaaagaca
     1861 tatattaaac tcctggaaaa aaaagtctag taagatatgg ggacaggtgc aaccagaaat
     1921 ggcggacctt tgcattttag agcagctcct aagatggtgc cccacagaaa actgcattcc
     1981 tagacctagt gacacatgcc ttatccccaa catttagagg aggcagccag tctctgtctg
     2041 gcgaggctgg tccacatggt tccagcaaca tagtgaaacc ctgtcttaaa aacaacaaaa
     2101 gaagaactgt gtggtggtca agacacgcag actgcttaaa ccaggaagac cccagacact
     2161 gctctcccag gatgagcttg gacctagtct gctcactgga gcttgaggta cctggcttta
     2221 ctgacagtct gggcaacctc ctgcacaccc catccattat tgcagtggtt gccaaagcag
     2281 cagcttctgc agtctaacca gttagtctca agaaacacac ccaactcccc aacccactcc
     2341 ttgaactatt ccccagtgtt cctgggccaa cagaacccat ggcctcagtg acatgagtca
     2401 gtcgaggtac tgtcccagga ccctgagaaa ggatcgctgt gaggagccaa gtggtccaat
     2461 tcttgggcag cgtcctaggt cgtccctcag acttgagcat tagcagctgt ggcctacttc
     2521 accccactgc gagtgcactt cctccaagca ggtctgctct aacgtctatt agcaataacg
     2581 tgaggaaccc aagttggccc taacgttgct ggcactgtgt gcagagaact gtcctctggt
     2641 gcagggaccc caaccccaaa cagagctgga tagcctatgt gctggatcat aaccagagat
     2701 tccacaccag ggagaaagca gggctagtga ctgggtcccc aaggagcagc agttaaaaga
     2761 aggaggagct tcagcgtctg gatttgttaa ctaaatgccc tcccacactg aggcagaaac
     2821 tagtcttcct tggggacaac ttggcctgca gcagaggtac ctcccagccc gcagccattt
     2881 gtttccaaag tgcttttcct ggaaaggttg aagtgtgcat tttgctctta caggtttaga
     2941 tcttccacac tcctcggcaa gcccattacc atgtcaggcc tcagccatat tgctcccatg
     3001 tccaggagat acggacagcc aggatcatgt aggtagtagt ctgtccagcc ccggatcttg
     3061 tgccttcaca ccagaacaca atgactttct ctccagggtg actcatgaga ttctactcag
     3121 cactgcagct gataaaaaga ggcccagtgt ttctaggcca gaggctgctt gcacacctgc
     3181 ctctcggttt gaatgaaagt tctttggtct acctctgtgg ctagaggtgc ctgttttttt
     3241 agcaggagat cctagcccaa agcactggac agcatccttc ctctcaggtc tagtgtgtaa
     3301 aacaagtgtc acacagactc taacagtggt ttcatggggt tactaactga cccttcttgg
     3361 ccccaacata cacagaggtc atgccacaag cacataccag acatctgcat ggcccagagg
     3421 tgggcatctg ggcaaaagga gtgaggactt gaggttttct ggtttcgggt gaatgaagga
     3481 gtgatgacaa gttttatatt aacttaacac aatctaaagg tatttgggaa gagggatctc
     3541 agttgagaaa atgcctctaa ggttggcctt tacacaaatg tgcagtgcat tctcttcgtt
     3601 gatgtaggag gaccaggtcc agtgtgagtt gtgccacatc cgggctggtg gttctggctg
     3661 gtgtaagaaa acatgatggg caggctttga ggagcaagcc agtaagcagc acttctctgt
     3721 gacctctgca ttagcccatg cctccagggt cccgccctaa cttccctcag agatggactg
     3781 ttacctgtaa gatgcaatca accctctcct ccccagatcg cttttggtca tcgtgttttt
     3841 tcacagcaac agaaacccta agacaagaat ggcctttgaa tacaccaaac actccttatt
     3901 caatctgtac tcagtacctc tggaattcat gtccactcag aactacagcc cttgagagag
     3961 gctgaccatc acgaagatgg cccagaccaa ggaggccaac ccactggaga gagctcctgg
     4021 atccatgaag ttcagagaca atgactctcc ccagattaag ttaagcagca tgctggtgta
     4081 aaagaaaaat taactcggga ccacttagcc atcttaaagt tgccagagtt taattcaaag
     4141 cacagtgata catgagcaga tccctttaca gcatagtaaa gcacagactc cagggaacag
     4201 ggaaggatac cttgcttctt cagatgttgt cactggccat agactcttac ttaaggaaag
     4261 ggcctccctc ccctggccca tctagagcaa gaggggcctc acgccagcgt ggggcctgct
     4321 tccgagagga cggagcccta gggtaagagc ttgtagcacc tggtcaagga ccagctccac
     4381 gatgcttcct acaggacttc cagcacagcc tccaggcacc cctggacttg atagaatcca
     4441 tggtgtagat ggaagatgcc tctggcactt ctctatctgg gctctggata tggttctgaa
     4501 tccagatgac agtggcactg tcttctgagg ccacagttcc taaatatgta tttgagatgt
     4561 ctgcctatgt atgacatgtg cttaggtaac ctggctccct ggagctactg ccggtggtta
     4621 cattggcctt tgagctctgt cttttgctgg gctggctctt gaatctgcct tcatatgagt
     4681 aatcaaaatt taatcatttc tttttttttt ttttttcccg gagctgggga ccgaacccag
     4741 ggccttgcgc ttcctaggca agcgctctac cactgagcta aatccccaac ccctaaaatt
     4801 taatcatttc tgacctgaga gctaaatgca atttaggaaa tgctaacatg cttaccaagg
     4861 ctcagagcca atcagggctc ctgcctccat ctcaatggta tcagatgggc tactttgtga
     4921 tgagaacgac cttctcggca tgaacctctt tcacttgtct ggaaataaac ttgacaatga
     4981 acttcctggg tccagttttc actggggtgc attctatctg gaaattgatg gtctttccgg
     5041 gcggcaccgt cctagaaaat tcaaaggcat acagtcagcc aaaggtgcca cagcaagaaa
     5101 aactgcatga ggaaccaggc aggcatctgg gaaatccctg tgctgcagaa ccagtgaaac
     5161 agtcctcagc tgtaagacaa gatggctggc tggaatggct gctttccagc tacgcaagtc
     5221 acaaaccctc ctgagagccc tcaggagcaa gtttcatgat gactctacaa aaaagtgttg
     5281 tctaacccta ggtattcaag atggcaaata catgagagta tattaggctc tgaggccctg
     5341 ccccaatact actgaactga atgta
//
