LOCUS       NM_145096               1735 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus zinc finger DHHC-type palmitoyltransferase 2
            (Zdhhc2), mRNA.
ACCESSION   NM_145096 XM_001064977
VERSION     NM_145096.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1735)
  AUTHORS   Woolfrey,K.M., Sanderson,J.L. and Dell'Acqua,M.L.
  TITLE     The palmitoyl acyltransferase DHHC2 regulates recycling endosome
            exocytosis and synaptic potentiation through palmitoylation of
            AKAP79/150
  JOURNAL   J Neurosci 35 (2), 442-456 (2015)
   PUBMED   25589740
  REMARK    GeneRIF: knockdown of DHHC2 in rat hippocampal neurons disrupted
            exocytosis from recycling endosomes, enlargement of dendritic
            spines, AKAP recruitment to spines, and potentiation of
            AMPAR-mediated synaptic currents.
REFERENCE   2  (bases 1 to 1735)
  AUTHORS   Lai,J. and Linder,M.E.
  TITLE     Oligomerization of DHHC protein S-acyltransferases
  JOURNAL   J Biol Chem 288 (31), 22862-22870 (2013)
   PUBMED   23793055
REFERENCE   3  (bases 1 to 1735)
  AUTHORS   Ohno,Y., Kashio,A., Ogata,R., Ishitomi,A., Yamazaki,Y. and
            Kihara,A.
  TITLE     Analysis of substrate specificity of human DHHC protein
            acyltransferases using a yeast expression system
  JOURNAL   Mol Biol Cell 23 (23), 4543-4551 (2012)
   PUBMED   23034182
REFERENCE   4  (bases 1 to 1735)
  AUTHORS   Zeidman,R., Buckland,G., Cebecauer,M., Eissmann,P., Davis,D.M. and
            Magee,A.I.
  TITLE     DHHC2 is a protein S-acyltransferase for Lck
  JOURNAL   Mol Membr Biol 28 (7-8), 473-486 (2011)
   PUBMED   22034844
REFERENCE   5  (bases 1 to 1735)
  AUTHORS   Greaves,J., Carmichael,J.A. and Chamberlain,L.H.
  TITLE     The palmitoyl transferase DHHC2 targets a dynamic membrane cycling
            pathway: regulation by a C-terminal domain
  JOURNAL   Mol Biol Cell 22 (11), 1887-1895 (2011)
   PUBMED   21471008
REFERENCE   6  (bases 1 to 1735)
  AUTHORS   Noritake,J., Fukata,Y., Iwanaga,T., Hosomi,N., Tsutsumi,R.,
            Matsuda,N., Tani,H., Iwanari,H., Mochizuki,Y., Kodama,T.,
            Matsuura,Y., Bredt,D.S., Hamakubo,T. and Fukata,M.
  TITLE     Mobile DHHC palmitoylating enzyme mediates activity-sensitive
            synaptic targeting of PSD-95
  JOURNAL   J Cell Biol 186 (1), 147-160 (2009)
   PUBMED   19596852
REFERENCE   7  (bases 1 to 1735)
  AUTHORS   Sharma,C., Yang,X.H. and Hemler,M.E.
  TITLE     DHHC2 affects palmitoylation, stability, and functions of
            tetraspanins CD9 and CD151
  JOURNAL   Mol Biol Cell 19 (8), 3415-3425 (2008)
   PUBMED   18508921
REFERENCE   8  (bases 1 to 1735)
  AUTHORS   Zhang,J., Planey,S.L., Ceballos,C., Stevens,S.M. Jr., Keay,S.K. and
            Zacharias,D.A.
  TITLE     Identification of CKAP4/p63 as a major substrate of the palmitoyl
            acyltransferase DHHC2, a putative tumor suppressor, using a novel
            proteomics method
  JOURNAL   Mol Cell Proteomics 7 (7), 1378-1388 (2008)
   PUBMED   18296695
REFERENCE   9  (bases 1 to 1735)
  AUTHORS   Ohno,Y., Kihara,A., Sano,T. and Igarashi,Y.
  TITLE     Intracellular localization and tissue-specific distribution of
            human and yeast DHHC cysteine-rich domain-containing proteins
  JOURNAL   Biochim Biophys Acta 1761 (4), 474-483 (2006)
   PUBMED   16647879
REFERENCE   10 (bases 1 to 1735)
  AUTHORS   Fukata,M., Fukata,Y., Adesnik,H., Nicoll,R.A. and Bredt,D.S.
  TITLE     Identification of PSD-95 palmitoylating enzymes
  JOURNAL   Neuron 44 (6), 987-996 (2004)
   PUBMED   15603741
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Nov 27, 2020 this sequence version replaced NM_145096.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY886521.1, AF228917.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760476,
                                           SAMN11044071 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-348               JAXUCZ010000016.1  58581169-58581516   c
            349-375             JAXUCZ010000016.1  58555701-58555727   c
            376-470             JAXUCZ010000016.1  58554456-58554550   c
            471-591             JAXUCZ010000016.1  58546970-58547090   c
            592-661             JAXUCZ010000016.1  58545465-58545534   c
            662-694             JAXUCZ010000016.1  58544658-58544690   c
            695-815             JAXUCZ010000016.1  58538830-58538950   c
            816-948             JAXUCZ010000016.1  58536708-58536840   c
            949-1075            JAXUCZ010000016.1  58532254-58532380   c
            1076-1168           JAXUCZ010000016.1  58531810-58531902   c
            1169-1281           JAXUCZ010000016.1  58520330-58520442   c
            1282-1354           JAXUCZ010000016.1  58518431-58518503   c
            1355-1735           JAXUCZ010000016.1  58513441-58513821   c
FEATURES             Location/Qualifiers
     source          1..1735
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.1"
     gene            1..1735
                     /gene="Zdhhc2"
                     /gene_synonym="DHHC2; srec"
                     /note="zinc finger DHHC-type palmitoyltransferase 2"
                     /db_xref="GeneID:246326"
                     /db_xref="RGD:628681"
     exon            1..348
                     /gene="Zdhhc2"
                     /gene_synonym="DHHC2; srec"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..1322
                     /gene="Zdhhc2"
                     /gene_synonym="DHHC2; srec"
                     /EC_number="2.3.1.225"
                     /note="rec; acyltransferase ZDHHC2; membrane-associated
                     DHHC2 zinc finger protein; DHHC-2; zinc finger DHHC
                     domain-containing protein 2; zinc finger, DHHC domain
                     containing 2; small rec; zinc finger, DHHC-type containing
                     2"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC2"
                     /protein_id="NP_659564.3"
                     /db_xref="GeneID:246326"
                     /db_xref="RGD:628681"
                     /translation="MAPSGPGGVRRRCRRVLYWIPVVFISLLLGWSYYAYAIQLCIVS
                     MENIGEQVVCLMAYHLLFAMFVWSYWKTIFTLPMNPSKEFHLSYAEKELLEREPRGEA
                     HQEVLRRAAKDLPIYTRTMSGAIRYCDRCRLIKPDRCHHCSVCDKCILKMDHHCPWVN
                     NCVGFSNYKFFLLFLAYSLLYCLFIAATDLQYFIRFWTNGLPDTQAKFHIMFLFFAAA
                     MFSVSLSSLFGYHCWLVSKNKSTLEAFRNPVFRHGTDKNGFSLGFSKNMRQVFGDEKK
                     YWLLPIFSSQGDGCSFPTCLVNQDPEQPSTPAGLNSTAKNPENHQFPAKPLRESQSHL
                     LTDSQTWTENSSNSGRCKAGMSNPALTMENET"
     exon            349..375
                     /gene="Zdhhc2"
                     /gene_synonym="DHHC2; srec"
                     /inference="alignment:Splign:2.1.0"
     exon            376..470
                     /gene="Zdhhc2"
                     /gene_synonym="DHHC2; srec"
                     /inference="alignment:Splign:2.1.0"
     exon            471..591
                     /gene="Zdhhc2"
                     /gene_synonym="DHHC2; srec"
                     /inference="alignment:Splign:2.1.0"
     exon            592..661
                     /gene="Zdhhc2"
                     /gene_synonym="DHHC2; srec"
                     /inference="alignment:Splign:2.1.0"
     exon            662..694
                     /gene="Zdhhc2"
                     /gene_synonym="DHHC2; srec"
                     /inference="alignment:Splign:2.1.0"
     exon            695..815
                     /gene="Zdhhc2"
                     /gene_synonym="DHHC2; srec"
                     /inference="alignment:Splign:2.1.0"
     exon            816..948
                     /gene="Zdhhc2"
                     /gene_synonym="DHHC2; srec"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1075
                     /gene="Zdhhc2"
                     /gene_synonym="DHHC2; srec"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1168
                     /gene="Zdhhc2"
                     /gene_synonym="DHHC2; srec"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1281
                     /gene="Zdhhc2"
                     /gene_synonym="DHHC2; srec"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1354
                     /gene="Zdhhc2"
                     /gene_synonym="DHHC2; srec"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1735
                     /gene="Zdhhc2"
                     /gene_synonym="DHHC2; srec"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagccgccgc ctcagcccgg cggagcagcg ggagtccgcg gcgcccgctc gccgccgcgg
       61 gatggggagc tagcgccacg gcggccgcgg tggccgcagc acagccggcc gccgcccccg
      121 ggcctgtccc gccgggtgct ccgggagccc cgagcccggc cccgagccag gcccgcgggc
      181 ggcggcggcg gaggagctgg gcaggtgtat gcggctggaa gatggcgccc tcgggccccg
      241 gtggcgtgag gcggcggtgc cggcgggtgc tctactggat ccctgtggtg ttcatcagct
      301 tgcttctggg ctggtcctac tatgcttacg cgatccagct gtgcatagtg tccatggaaa
      361 acattggtga acaagttgtg tgcctcatgg cttatcatct acttttcgca atgtttgtct
      421 ggtcatactg gaaaaccatt tttacattgc ccatgaatcc ttcaaaagaa ttccatctct
      481 cttatgcaga gaaagaattg ctggagagag agccaagagg agaagcccat caggaagttc
      541 tgaggcgagc agccaaagac cttcccatct acaccaggac catgtccggc gcgatccgat
      601 attgtgacag atgccgactt ataaagccag accgctgcca tcactgttcc gtctgtgata
      661 aatgtatttt gaagatggac catcattgcc catgggtgaa caattgtgtt ggattttcaa
      721 attataaatt cttcctcctt ttcttggctt actctctgct gtactgcctt ttcattgctg
      781 ctacagattt acagtatttt atcagatttt ggacaaatgg tctccctgat actcaagcca
      841 agttccatat tatgttttta ttctttgctg cagctatgtt ttctgtcagc ttgtcctctc
      901 tttttggtta tcattgctgg ctagtcagca aaaataaatc tacattagag gcattcagaa
      961 atccagtatt tagacatgga acagataaga acggattcag cttgggtttc agtaaaaaca
     1021 tgcgacaagt ttttggcgat gagaagaagt attggctgtt accaatattt tcaagtcaag
     1081 gtgatggctg ttcctttcca acttgccttg ttaaccagga tcctgaacaa ccttccactc
     1141 ctgcaggact aaattcaaca gcgaaaaatc ctgaaaacca tcagtttcct gcaaagccgt
     1201 tgagagagtc acagagccac ctccttacgg attctcagac ctggacagag aacagttcaa
     1261 actccgggag atgcaaagcc ggtatgagca accctgcatt aactatggag aacgagactt
     1321 aactctacaa tcaaaataaa accactcttg taaagtacca aggctgtgga agactggaac
     1381 aagcttccaa ttggatggca ccattggcca attgtccctt tggctaaata tgcgaatttt
     1441 gtcttcagtg atggggatca aacacagcac tatcaagaat ttcaagtaat caccaaactg
     1501 atgcttaaaa cagaacactg tttattccaa tatatagact tctgtaacta atacaaatta
     1561 ctattaacct tcaaaagtaa ttaaaaaaat attttttgcc aaaaactgag aataagttta
     1621 tgggccagtt ttcattcaga tattcgggtt gtctaatttg tcacataatc tcattatttg
     1681 gtattctgtt ttagaaaatt taggttaatc ttaagattta aaatttttca agtca
//
