LOCUS       NM_001039340            2904 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus zinc finger DHHC-type palmitoyltransferase 17
            (Zdhhc17), mRNA.
ACCESSION   NM_001039340
VERSION     NM_001039340.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2904)
  AUTHORS   Lemonidis,K., Gorleku,O.A., Sanchez-Perez,M.C., Grefen,C. and
            Chamberlain,L.H.
  TITLE     The Golgi S-acylation machinery comprises zDHHC enzymes with major
            differences in substrate affinity and S-acylation activity
  JOURNAL   Mol Biol Cell 25 (24), 3870-3883 (2014)
   PUBMED   25253725
REFERENCE   2  (bases 1 to 2904)
  AUTHORS   Butland,S.L., Sanders,S.S., Schmidt,M.E., Riechers,S.P., Lin,D.T.,
            Martin,D.D., Vaid,K., Graham,R.K., Singaraja,R.R., Wanker,E.E.,
            Conibear,E. and Hayden,M.R.
  TITLE     The palmitoyl acyltransferase HIP14 shares a high proportion of
            interactors with huntingtin: implications for a role in the
            pathogenesis of Huntington's disease
  JOURNAL   Hum Mol Genet 23 (15), 4142-4160 (2014)
   PUBMED   24705354
REFERENCE   3  (bases 1 to 2904)
  AUTHORS   Ohno,Y., Kashio,A., Ogata,R., Ishitomi,A., Yamazaki,Y. and
            Kihara,A.
  TITLE     Analysis of substrate specificity of human DHHC protein
            acyltransferases using a yeast expression system
  JOURNAL   Mol Biol Cell 23 (23), 4543-4551 (2012)
   PUBMED   23034182
REFERENCE   4  (bases 1 to 2904)
  AUTHORS   Berchtold,L.A., Storling,Z.M., Ortis,F., Lage,K.,
            Bang-Berthelsen,C., Bergholdt,R., Hald,J., Brorsson,C.A.,
            Eizirik,D.L., Pociot,F., Brunak,S. and Storling,J.
  TITLE     Huntingtin-interacting protein 14 is a type 1 diabetes candidate
            protein regulating insulin secretion and beta-cell apoptosis
  JOURNAL   Proc Natl Acad Sci U S A 108 (37), E681-E688 (2011)
   PUBMED   21705657
  REMARK    GeneRIF: Immunohistochemical analysis of pancreatic sections
            demonstrated that HIP14 is almost exclusively expressed in
            insulin-positive cells in islets of Langerhans.
REFERENCE   5  (bases 1 to 2904)
  AUTHORS   Goytain,A., Hines,R.M. and Quamme,G.A.
  TITLE     Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual
            functions, palmitoyl acyltransferase and Mg2+ transport
  JOURNAL   J Biol Chem 283 (48), 33365-33374 (2008)
   PUBMED   18794299
REFERENCE   6  (bases 1 to 2904)
  AUTHORS   Greaves,J., Salaun,C., Fukata,Y., Fukata,M. and Chamberlain,L.H.
  TITLE     Palmitoylation and membrane interactions of the neuroprotective
            chaperone cysteine-string protein
  JOURNAL   J Biol Chem 283 (36), 25014-25026 (2008)
   PUBMED   18596047
REFERENCE   7  (bases 1 to 2904)
  AUTHORS   Ohno,Y., Kihara,A., Sano,T. and Igarashi,Y.
  TITLE     Intracellular localization and tissue-specific distribution of
            human and yeast DHHC cysteine-rich domain-containing proteins
  JOURNAL   Biochim Biophys Acta 1761 (4), 474-483 (2006)
   PUBMED   16647879
REFERENCE   8  (bases 1 to 2904)
  AUTHORS   Fukata,M., Fukata,Y., Adesnik,H., Nicoll,R.A. and Bredt,D.S.
  TITLE     Identification of PSD-95 palmitoylating enzymes
  JOURNAL   Neuron 44 (6), 987-996 (2004)
   PUBMED   15603741
REFERENCE   9  (bases 1 to 2904)
  AUTHORS   Huang,K., Yanai,A., Kang,R., Arstikaitis,P., Singaraja,R.R.,
            Metzler,M., Mullard,A., Haigh,B., Gauthier-Campbell,C.,
            Gutekunst,C.A., Hayden,M.R. and El-Husseini,A.
  TITLE     Huntingtin-interacting protein HIP14 is a palmitoyl transferase
            involved in palmitoylation and trafficking of multiple neuronal
            proteins
  JOURNAL   Neuron 44 (6), 977-986 (2004)
   PUBMED   15603740
REFERENCE   10 (bases 1 to 2904)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY886533.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY886533.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2904
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..2904
                     /gene="Zdhhc17"
                     /note="zinc finger DHHC-type palmitoyltransferase 17"
                     /db_xref="GeneID:366889"
                     /db_xref="RGD:1595790"
     exon            1..71
                     /gene="Zdhhc17"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..1877
                     /gene="Zdhhc17"
                     /EC_number="2.3.1.225"
                     /note="zinc finger, DHHC domain containing 17;
                     membrane-associated DHHC17 zinc finger protein; zinc
                     finger DHHC domain-containing protein 17; zinc finger,
                     DHHC-type containing 17; acyltransferase ZDHHC7;
                     acyltransferase ZDHHC17"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC17"
                     /protein_id="NP_001034429.1"
                     /db_xref="GeneID:366889"
                     /db_xref="RGD:1595790"
                     /translation="MADGPDEYDTETGCVPLLHPEEIKPQSHYNHGYGEPLGRKTHVD
                     DYSTWDIVKATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISK
                     GAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHT
                     SIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTA
                     LHWAVLAGNTTVISLLLEAGGNVDAQNVKGESALDLAKQRKNVWMINHLQEARQAKGY
                     DNPSFLRKLKADKEFRQKVMLGTPFLVIWLVGFIADLNIDSWLIKGLMYGGVWATVQF
                     LSKSFFDHSMHSALPLGIYLATKFWMYVTWFFWFWNDLSFLSIHLPFLANSVALFYNF
                     GKSWKSDPGIIKATEEQKKKTIVELAETGSLDLSIFCSTCLIRKPVRSKHCGVCNRCI
                     AKFDHHCPWVGNCVCAGNHRYFMGYLFFLLFMICWMIYGCVSYWGLHCETTYTKDGFW
                     TYITQIATCSPWMFWMFLNSVFHFMWVAVLLMCQMYQITCLGITTNERMNARRYKHFK
                     VTTTSIESPFNHGCVRNIIDFFEFRCCGLFRPVIVDWTRQYTIEYDQISGSGYQLV"
     exon            72..175
                     /gene="Zdhhc17"
                     /inference="alignment:Splign:2.1.0"
     exon            176..298
                     /gene="Zdhhc17"
                     /inference="alignment:Splign:2.1.0"
     exon            299..376
                     /gene="Zdhhc17"
                     /inference="alignment:Splign:2.1.0"
     exon            377..521
                     /gene="Zdhhc17"
                     /inference="alignment:Splign:2.1.0"
     exon            522..586
                     /gene="Zdhhc17"
                     /inference="alignment:Splign:2.1.0"
     exon            587..749
                     /gene="Zdhhc17"
                     /inference="alignment:Splign:2.1.0"
     exon            750..875
                     /gene="Zdhhc17"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1018
                     /gene="Zdhhc17"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1119
                     /gene="Zdhhc17"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1244
                     /gene="Zdhhc17"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1307
                     /gene="Zdhhc17"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1401
                     /gene="Zdhhc17"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1485
                     /gene="Zdhhc17"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1643
                     /gene="Zdhhc17"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1738
                     /gene="Zdhhc17"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..2887
                     /gene="Zdhhc17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acaccaagat ggcggacggc ccggatgagt acgataccga aacgggctgt gtgccccttc
       61 tccacccgga ggagatcaaa ccacagagcc attataacca tgggtatggt gagcctcttg
      121 ggcggaaaac ccatgttgat gactacagca catgggacat tgtcaaggct acacaatacg
      181 gaatatatga acgctgccga gaattggtgg aagcaggtta tgacgtacgg caaccggaca
      241 aagagaacgt tacacttctt cactgggctg ccatcaataa cagaatagat ttagtcaaat
      301 actatatttc gaaaggtgct attgtggatc aacttggagg agacctgaat tcaactccat
      361 tgcactgggc cacaagacaa ggccatttat ccatggttgt acaactaatg aaatatggtg
      421 cagatccctc attgatcgat ggtgaagggt gcagctgtat ccacttggct gctcagtttg
      481 gacatacctc aattgttgct taccttatag caaaaggaca ggatgtagat atgatggatc
      541 agaacggaat gacaccttta atgtgggcag cttatagaac acatagtgtg gatccaacta
      601 gattgctttt aacattcaat gtttcagtta accttggtga caagtatcac aaaaacactg
      661 ctctgcactg ggcagtccta gcagggaaca ccacagtcat tagtcttctt ctggaagctg
      721 gagggaacgt ggatgcccag aatgtcaagg gcgaatcagc acttgatttg gcaaagcaaa
      781 gaaaaaacgt gtggatgatc aaccatttgc aggaggcaag gcaggcgaag ggttacgaca
      841 acccgtcctt cctcagaaag ctgaaggctg acaaggaatt tcggcagaaa gtaatgctag
      901 gaactccatt cctagtgatt tggctagttg ggtttatagc agacctgaac attgattctt
      961 ggctcattaa agggttaatg tatggtggtg tttgggctac agtacaattt ctttccaagt
     1021 ccttttttga tcattcaatg cacagcgcat tgccccttgg gatatatttg gcaaccaaat
     1081 tctggatgta tgtgacatgg ttcttctggt tttggaatga tctcagcttc ttatccatcc
     1141 acctgccctt cctcgccaac agtgttgctc ttttctacaa ttttggaaag tcttggaaat
     1201 cagatccagg gatcattaaa gctacagaag aacaaaagaa gaagacaata gttgaacttg
     1261 cagagaccgg cagtctggac ctcagtatat tctgcagcac ctgcttgatt cggaagccgg
     1321 tgaggtccaa acactgtggt gtgtgcaacc gctgtatagc gaaatttgat caccattgcc
     1381 catgggtggg taactgtgta tgtgcaggca accatagata ctttatgggc tacctattct
     1441 tcttgctttt tatgatctgc tggatgattt atggttgtgt ttcttactgg ggacttcact
     1501 gtgagaccac gtacacgaag gatggcttct ggacatatat tactcagatt gccacatgct
     1561 ctccttggat gttttggatg tttctgaaca gtgtgtttca tttcatgtgg gtggccgtgc
     1621 tactcatgtg tcagatgtac cagataacat gtttaggtat tactacaaat gaaagaatga
     1681 atgccaggag atacaagcac tttaaagtta caacaacatc tatagagagc ccattcaacc
     1741 atggatgtgt aaggaatatt atagacttct ttgaatttcg atgctgtggc ctctttcgtc
     1801 ctgttatcgt ggactggacc aggcaataca caatagagta tgaccaaata tcaggatctg
     1861 ggtaccagct ggtgtagcag catccgtatg ccaggaaaca ttgctgctga gtggggcctg
     1921 aagattgtct gtccctgtct ctctccctgg gatccacatc cttggaacaa atagcatgct
     1981 atatgtaggg ctaaccgtga acttgacagc cttcattcag tactttatta acaaaagcaa
     2041 acatggacag aacacactgc cacgtctagg aagaaaagat cataagagga attttcacag
     2101 ttcttaatgt ttgaattcac atcatactct actttttggt tttgttctca taacattttt
     2161 catgaaaatc tgaacttatt ctgttactag agatggcaat actgaggata aatgttgtta
     2221 taactcaaac taaatttacg ttatacagct aaattgtact gtgcagtact tacaagtatt
     2281 gcatttaatc caagaaaatt gtcttaactc gatgactagt attatgtgca ttttagatgt
     2341 acatgtaaat actgtgatga aaatcatgtg gttttattag aggtctgctg tactgtgtcc
     2401 ccaaggcacg ggaaaataat gttcatggaa acgggcttgc tcttctgttg cctccagctc
     2461 ttgggatgct ggcttatttc tagttcagcg aaataatttc tagtgactgt gctctgaggt
     2521 cccatagtct gataataaag cacttgcatg agtatactaa gtcataatat tttgttgaaa
     2581 tttgaagccc tactgcatgc atgatacacc gcatagaatg tatactagca gatgctgtcc
     2641 agagaagcat agattaggtt tgaatttcat gtgcaaaaca gcccaatttt ttaaagagtt
     2701 aaggtggatt ttcaacaaga agcaaaacaa ataagctaat gcaaaatttt ttattaatag
     2761 agataagtgg atatgctttt taaattctga gctgaaaaat aagttgtaga caaaataatg
     2821 gagtctaggc taaaaatgga gcatgatctc tgtacatagc acatgcgaat aaatgaaaag
     2881 ctagggaaaa aaaaaaaaaa aaaa
//
