LOCUS       NM_001039099            1921 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus zinc finger, DHHC-type containing 1 (Zdhhc1),
            mRNA.
ACCESSION   NM_001039099 XM_214680
VERSION     NM_001039099.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1921)
  AUTHORS   Zhou,Q., Lin,H., Wang,S., Wang,S., Ran,Y., Liu,Y., Ye,W., Xiong,X.,
            Zhong,B., Shu,H.B. and Wang,Y.Y.
  TITLE     The ER-associated protein ZDHHC1 is a positive regulator of DNA
            virus-triggered, MITA/STING-dependent innate immune signaling
  JOURNAL   Cell Host Microbe 16 (4), 450-461 (2014)
   PUBMED   25299331
REFERENCE   2  (bases 1 to 1921)
  AUTHORS   Oku,S., Takahashi,N., Fukata,Y. and Fukata,M.
  TITLE     In silico screening for palmitoyl substrates reveals a role for
            DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in
            its targeting to Rab5-positive endosomes
  JOURNAL   J Biol Chem 288 (27), 19816-19829 (2013)
   PUBMED   23687301
  REMARK    GeneRIF: In silico screening for palmitoyl substrates reveals a
            role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin
            palmitoylation in its targeting to Rab5-positive endosomes.
REFERENCE   3  (bases 1 to 1921)
  AUTHORS   Ohno,Y., Kashio,A., Ogata,R., Ishitomi,A., Yamazaki,Y. and
            Kihara,A.
  TITLE     Analysis of substrate specificity of human DHHC protein
            acyltransferases using a yeast expression system
  JOURNAL   Mol Biol Cell 23 (23), 4543-4551 (2012)
   PUBMED   23034182
REFERENCE   4  (bases 1 to 1921)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 1921)
  AUTHORS   Ohno,Y., Kihara,A., Sano,T. and Igarashi,Y.
  TITLE     Intracellular localization and tissue-specific distribution of
            human and yeast DHHC cysteine-rich domain-containing proteins
  JOURNAL   Biochim Biophys Acta 1761 (4), 474-483 (2006)
   PUBMED   16647879
REFERENCE   6  (bases 1 to 1921)
  AUTHORS   Fukata,M., Fukata,Y., Adesnik,H., Nicoll,R.A. and Bredt,D.S.
  TITLE     Identification of PSD-95 palmitoylating enzymes
  JOURNAL   Neuron 44 (6), 987-996 (2004)
   PUBMED   15603741
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY886520.1.
            
            [WARNING] On Oct 24, 2024 this sequence was replaced by
            NM_001039099.2.
            
            On Jan 17, 2006 this sequence version replaced XM_214680.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY886520.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1921
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..1921
                     /gene="Zdhhc1"
                     /note="zinc finger, DHHC-type containing 1"
                     /db_xref="GeneID:291967"
                     /db_xref="RGD:1589775"
     exon            1..19
                     /gene="Zdhhc1"
                     /inference="alignment:Splign:2.1.0"
     exon            20..152
                     /gene="Zdhhc1"
                     /inference="alignment:Splign:2.1.0"
     exon            153..232
                     /gene="Zdhhc1"
                     /inference="alignment:Splign:2.1.0"
     exon            233..279
                     /gene="Zdhhc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             280..1746
                     /gene="Zdhhc1"
                     /EC_number="2.3.1.225"
                     /note="membrane-associated DHHC1 zinc finger protein; zinc
                     finger, DHHC domain containing 1; probable
                     palmitoyltransferase ZDHHC1"
                     /codon_start=1
                     /product="palmitoyltransferase ZDHHC1"
                     /protein_id="NP_001034188.1"
                     /db_xref="GeneID:291967"
                     /db_xref="RGD:1589775"
                     /translation="MNICNKPSNKTAPEKNVWTAPSQDSGPSPELQGQRSRRNGWSWP
                     PHPLQIVAWLLYLFFAVIGFGVLVPLLPHHWVPAGYACMGAIFAGHLVVHLTAVSIDP
                     ADANVRDKSYSGPLPIFNRSQHAHVIEDLHCNLCDVDVSARSKHCSACNKCVCGFDHH
                     CKWLNNCVGERNYRLFLHSVASALLGVLLLVLVATYVFVEFFVNPMRLRTNQHFEVLK
                     NHTDVWFVFLPAAPVETQAPAILALAALLILLGLLSTALLGHLLCFHIYLMWHKLTTY
                     EYIVQHRPAQEAKETHKELESCPRKMRSIQEMEFYMRTFSHVRPEPSGQARPAALNAN
                     PSQFLATQGQVEPPLPSSSDTLALPPRIQPQEKRKRRVYRLPRSGTMDRELRLPKLRD
                     TGTPSRHASPSSDSTSASPAHAGCSVDAYSSASAESMEEIPVAQTRLGSAALGAPGAG
                     GRESRLALQARLPAVFVSPSSGEPGTPEAVKMACLSGD"
     exon            280..522
                     /gene="Zdhhc1"
                     /inference="alignment:Splign:2.1.0"
     exon            523..698
                     /gene="Zdhhc1"
                     /inference="alignment:Splign:2.1.0"
     exon            699..800
                     /gene="Zdhhc1"
                     /inference="alignment:Splign:2.1.0"
     exon            801..925
                     /gene="Zdhhc1"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1084
                     /gene="Zdhhc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1197
                     /gene="Zdhhc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1280
                     /gene="Zdhhc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1374
                     /gene="Zdhhc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1453
                     /gene="Zdhhc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1903
                     /gene="Zdhhc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgcaac cacgcgcagg cattcatcct gaagtcgtgg gcaagtggta cctctctgga
       61 ccaacagtat cctcatttgg agtcaaagct acccctacga ctatttgcag caagccttag
      121 gatgatgatt cctcctgcct taggactctg ggctgggtgt ggtggcacat gcctgtcatc
      181 ctggccctga ggaggatcag gtagatcaag accagctatg gcaacatagt gaatattttc
      241 aagtcagcga acattcactg agcatctact gtatacaaga tgaacatctg caacaaaccc
      301 tccaacaaga cagcccctga gaagaatgtg tggacagcgc cctcacagga cagtggacct
      361 tccccagaac tgcagggcca gcggtcccga cggaatggat ggagctggcc cccccaccca
      421 ctccagattg tggcctggct gctctacctc ttcttcgcag tgattggctt tggggtcctt
      481 gttcccctcc tgcctcacca ctgggtgcct gctggctatg cttgcatggg tgccatcttt
      541 gctggccacc ttgtggtgca cctgactgct gtctccatcg atccagcaga tgccaatgtg
      601 cgggacaaga gctattctgg acccctgcct atcttcaacc gcagccagca cgcacatgtc
      661 attgaagatc tacactgcaa cctgtgtgac gtggatgtga gtgcgcgatc caaacactgc
      721 agtgcctgca ataaatgtgt atgtggcttc gatcatcatt gcaagtggct taacaactgc
      781 gtgggcgaga ggaactaccg gctctttcta cacagtgtgg catctgcttt actgggtgtt
      841 ctgctcctgg tgctggtggc cacttatgtc tttgtggagt tctttgtcaa ccccatgcgc
      901 cttcgcacca accaacactt tgaagtcttg aagaatcaca cagatgtgtg gtttgtgttc
      961 ttgccggctg cccctgtgga gacccaggct cctgccatcc tggccctggc tgccctactc
     1021 atccttctgg gcctgctttc tacagccctg cttggccact tgctctgctt ccacatttat
     1081 ttaatgtggc acaagctcac cacctacgaa tacattgtgc agcaccgacc agctcaggaa
     1141 gcaaaggaga cccacaagga gcttgagtca tgtccccgca agatgcggtc cattcaggag
     1201 atggagttct acatgaggac cttcagccat gtgcgtccag agccctctgg gcaggccagg
     1261 ccagcagcat taaatgccaa tccttcccag tttcttgcca cacaaggcca agtggaacca
     1321 ccactgccct cctcctcaga cacactggct ctgcctccac ggatccaacc ccaggaaaag
     1381 aggaagcggc gagtatatag attgcccagg tctgggacca tggaccgaga gctccggctg
     1441 cccaagctac gtgacactgg gactcctagc cgccacgcta gcccttcctc tgattccacc
     1501 agtgccagcc cagcacatgc tggttgctct gtagacgcct actcctcggc atcagcggaa
     1561 tccatggaag agatcccagt ggcccagacc cgcctgggca gtgccgcact gggtgcccca
     1621 ggagccgggg gccgagagtc taggctggct ctacaggcac gtttgcctgc tgtttttgtg
     1681 agcccaagca gtggcgagcc cggaacacct gaggcggtga agatggcttg ccttagtggg
     1741 gactagaggc aggagggcct tgcagggacg tctgaccact ctatgcaaca ccccatattc
     1801 gccgcaatga gtgcacttta gggatcagcg ttccttaccc aagactcagc aatatctgct
     1861 ccaccagccc tgatgcccca ataaactttt tttttaatgc tttaaaaaaa aaaaaaaaaa
     1921 a
//
