LOCUS       NM_001109267            2100 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus zinc finger CCHC-type containing 17 (Zcchc17),
            transcript variant 1, mRNA.
ACCESSION   NM_001109267 XM_001062322 XM_006238968 XM_575918
VERSION     NM_001109267.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2100)
  AUTHORS   Tomljanovic,Z., Patel,M., Shin,W., Califano,A. and Teich,A.F.
  TITLE     ZCCHC17 is a master regulator of synaptic gene expression in
            Alzheimer's disease
  JOURNAL   Bioinformatics 34 (3), 367-371 (2018)
   PUBMED   29028963
  REMARK    GeneRIF: ZCCHC17 loss is an early driver of lower synaptic gene
            expression in Alzheimer's disease.
REFERENCE   2  (bases 1 to 2100)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 2100)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 2100)
  AUTHORS   Gueydan,C., Wauquier,C., De Mees,C., Huez,G. and Kruys,V.
  TITLE     Identification of ribosomal proteins specific to higher eukaryotic
            organisms
  JOURNAL   J Biol Chem 277 (47), 45034-45040 (2002)
   PUBMED   12202495
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On or before Jul 22, 2021 this sequence version replaced
            XM_006238968.4, NM_001109267.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2056974.1,
                                           SRR22399492.1382515.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                JAXUCZ010000005.1  147984500-147984584 c
            86-206              JAXUCZ010000005.1  147978609-147978729 c
            207-264             JAXUCZ010000005.1  147973812-147973869 c
            265-365             JAXUCZ010000005.1  147963218-147963318 c
            366-457             JAXUCZ010000005.1  147961402-147961493 c
            458-558             JAXUCZ010000005.1  147955833-147955933 c
            559-704             JAXUCZ010000005.1  147953595-147953740 c
            705-2100            JAXUCZ010000005.1  147942789-147944184 c
FEATURES             Location/Qualifiers
     source          1..2100
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2100
                     /gene="Zcchc17"
                     /gene_synonym="RGD1565267"
                     /note="zinc finger CCHC-type containing 17"
                     /db_xref="GeneID:500555"
                     /db_xref="RGD:1565267"
     exon            1..85
                     /gene="Zcchc17"
                     /gene_synonym="RGD1565267"
                     /inference="alignment:Splign:2.1.0"
     exon            86..206
                     /gene="Zcchc17"
                     /gene_synonym="RGD1565267"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..866
                     /gene="Zcchc17"
                     /gene_synonym="RGD1565267"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nucleolar protein of 40 kDa; zinc finger, CCHC domain
                     containing 17; zinc finger CCHC domain-containing protein
                     17"
                     /codon_start=1
                     /product="zinc finger CCHC domain-containing protein 17
                     isoform 1"
                     /protein_id="NP_001102737.1"
                     /db_xref="GeneID:500555"
                     /db_xref="RGD:1565267"
                     /translation="MNSGRPETMENLPALYTIFQGEVAMVTDYGAFIKIPGCRKQGLV
                     HRTHMSSCRVDKPSEIVDVGDKVWVKLIGREMKNDRIKVSLSMKVVNQGTGKDLDPNN
                     VIIEQEERRRRSFQDYTGQKITLEAVLNTTCKKCGCKGHFAKDCFMQPGGTKYSLVPE
                     EEEEKEEAKAEGLEKPDPTKNSSRKRKKEKKKKKHRDRKSSDCDSPDSESDTGKKARH
                     TAKDSKAPKKKKKKKKHKKKHKE"
     exon            207..264
                     /gene="Zcchc17"
                     /gene_synonym="RGD1565267"
                     /inference="alignment:Splign:2.1.0"
     exon            265..365
                     /gene="Zcchc17"
                     /gene_synonym="RGD1565267"
                     /inference="alignment:Splign:2.1.0"
     exon            366..457
                     /gene="Zcchc17"
                     /gene_synonym="RGD1565267"
                     /inference="alignment:Splign:2.1.0"
     exon            458..558
                     /gene="Zcchc17"
                     /gene_synonym="RGD1565267"
                     /inference="alignment:Splign:2.1.0"
     exon            559..704
                     /gene="Zcchc17"
                     /gene_synonym="RGD1565267"
                     /inference="alignment:Splign:2.1.0"
     exon            705..2100
                     /gene="Zcchc17"
                     /gene_synonym="RGD1565267"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccgtgcat tgtgggtgag aacgagcgga gcagattcag tgttcctagg gatgaagcgg
       61 ctgtcctgtt aggagcggac gcggagacgt ttgaattagc tttagcggaa gagaaatgga
      121 ggagccgtag actattaagg atgaattcag gaaggcctga gaccatggaa aacttgcctg
      181 cactgtatac tatttttcaa ggagaggttg ctatggtgac agactatgga gcttttatca
      241 aaatcccagg ctgtcggaag caaggtctgg tccatcgaac tcacatgtcg tcttgtcgag
      301 tggataagcc ttctgagata gtagatgttg gagacaaagt gtgggtgaag cttattggcc
      361 gagagatgaa aaatgataga ataaaagtgt ctctgtccat gaaagttgtc aaccaaggaa
      421 ctgggaaaga cctcgacccc aacaacgtta tcattgagca agaagagagg cgcaggcgat
      481 ccttccagga ctacactggg cagaagatca cccttgaggc cgtcctgaac acgacctgca
      541 agaagtgtgg ctgcaaaggc cactttgcaa aggactgctt catgcagcca ggcggaacca
      601 agtattctct ggtccctgaa gaggaagagg aaaaagagga agcaaaggca gaaggccttg
      661 agaaacctga tcccacaaag aattcttcca ggaagagaaa gaaggaaaag aagaagaaga
      721 aacatagaga caggaagtcg tctgactgtg atagccctga ctctgagagt gacacgggca
      781 agaaggcgag gcacacagca aaagacagca aggctccaaa gaagaaaaag aagaagaaga
      841 aacacaagaa gaagcacaag gaatgatggt ggagcaggcc gcagcagcct tggctcctgc
      901 aaagacttac tagtgagaat gtggcctcct accccactga ctctgtcccc atggtctcgg
      961 atggcttttc ctcatgcagc aagcagattg gggagccaga gggcagctcc caaaatggtt
     1021 tttccttgtt gctcctgatc cctttgcaag tgacccctgc acccatcgca ttcacgagct
     1081 cagtttcttc attcagcaga agggtctagt accaccccgg ctgccactgc cagagctgga
     1141 ttccgttgca ggagtctgtg ctggagccac aggtgctact gtggaggtga gcctggctgt
     1201 ggcggaagag ccaccctgac ctgcctgctg tctggggtgg ttgtgggtgg actctgcggc
     1261 ctctattcgc tcagccaggg cctgtgagga ggacagtgtt tgcagtgacc gctgaaccag
     1321 agatctgtag ccaaggtcat tgctctgctt ctatcactgt gtgactgact ggttccattt
     1381 caggcctctg cttaaattcc tggcataact ggaaacgtgt ttggttttaa actttgcaga
     1441 aggcttcatt cctataatcc ttcctgggtg acttagagac ttaacacatc agttcacaga
     1501 aaacacttaa tatgttatcc aagaccctgg aaagaggcca agcagaggca caaagccaag
     1561 gccactagca ggtcacagct ttcttgagat tacttataaa tcctctcttc cacagtgaag
     1621 acctctttcc cctgggctga ctaggaaacc agtgtttgta acctgaggac ttgctgggca
     1681 tgatgagtgt gtggctctta gcagtcacct cccaccatag tggtccacgc gtggaccttg
     1741 atgtcctgaa cttgtactcc aaagagaggg tgaccacagc ataccacgta gctaatccag
     1801 gactgttgtg tgcaggatgg atgtgaagta gccactcagt gacagccagc tcctctgagc
     1861 aggggcgggt cagtgcaaag gctcgcatag gtgctgctgt ctccgcactg agcccgagac
     1921 tgtccactca gctccttatc agccctgctt cccaggtgac ctgcaggcct tcacttcagc
     1981 actgacacac aggaaagaag accaaaggca gaggcaactg ggtggccttg gctctgcttt
     2041 attgaccttg gagcaccctt tggatacagt tttaaaaaat aaaccacata cacaatggga
//
