LOCUS       NM_001398725            4913 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus zinc finger CCCH-type containing, antiviral 1
            (Zc3hav1), transcript variant 1, mRNA.
ACCESSION   NM_001398725 XM_006236295
VERSION     NM_001398725.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4913)
  AUTHORS   Barkauskaite,E., Jankevicius,G. and Ahel,I.
  TITLE     Structures and Mechanisms of Enzymes Employed in the Synthesis and
            Degradation of PARP-Dependent Protein ADP-Ribosylation
  JOURNAL   Mol Cell 58 (6), 935-946 (2015)
   PUBMED   26091342
  REMARK    Review article
REFERENCE   2  (bases 1 to 4913)
  AUTHORS   Karlberg,T., Klepsch,M., Thorsell,A.G., Andersson,C.D., Linusson,A.
            and Schuler,H.
  TITLE     Structural basis for lack of ADP-ribosyltransferase activity in
            poly(ADP-ribose) polymerase-13/zinc finger antiviral protein
  JOURNAL   J Biol Chem 290 (12), 7336-7344 (2015)
   PUBMED   25635049
REFERENCE   3  (bases 1 to 4913)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4913)
  AUTHORS   Vyas,S., Matic,I., Uchima,L., Rood,J., Zaja,R., Hay,R.T., Ahel,I.
            and Chang,P.
  TITLE     Family-wide analysis of poly(ADP-ribose) polymerase activity
  JOURNAL   Nat Commun 5, 4426 (2014)
   PUBMED   25043379
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4913)
  AUTHORS   Charron,G., Li,M.M., MacDonald,M.R. and Hang,H.C.
  TITLE     Prenylome profiling reveals S-farnesylation is crucial for membrane
            targeting and antiviral activity of ZAP long-isoform
  JOURNAL   Proc Natl Acad Sci U S A 110 (27), 11085-11090 (2013)
   PUBMED   23776219
REFERENCE   6  (bases 1 to 4913)
  AUTHORS   Chen,G., Guo,X., Lv,F., Xu,Y. and Gao,G.
  TITLE     p72 DEAD box RNA helicase is required for optimal function of the
            zinc-finger antiviral protein
  JOURNAL   Proc Natl Acad Sci U S A 105 (11), 4352-4357 (2008)
   PUBMED   18334637
REFERENCE   7  (bases 1 to 4913)
  AUTHORS   Guo,X., Ma,J., Sun,J. and Gao,G.
  TITLE     The zinc-finger antiviral protein recruits the RNA processing
            exosome to degrade the target mRNA
  JOURNAL   Proc Natl Acad Sci U S A 104 (1), 151-156 (2007)
   PUBMED   17185417
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2022 Aug 2;119(31):e2211135119.
            doi: 10.1073/pnas.2211135119.. PMID: 35878045]
REFERENCE   8  (bases 1 to 4913)
  AUTHORS   Liu,L., Chen,G., Ji,X. and Gao,G.
  TITLE     ZAP is a CRM1-dependent nucleocytoplasmic shuttling protein
  JOURNAL   Biochem Biophys Res Commun 321 (3), 517-523 (2004)
   PUBMED   15358138
  REMARK    GeneRIF: Results demonstrate that ZAP is predominantly localized in
            the cytoplasm at steady state but shuttles between the nucleus and
            the cytoplasm in a CRM1-dependent manner.
REFERENCE   9  (bases 1 to 4913)
  AUTHORS   Bick,M.J., Carroll,J.W., Gao,G., Goff,S.P., Rice,C.M. and
            MacDonald,M.R.
  TITLE     Expression of the zinc-finger antiviral protein inhibits alphavirus
            replication
  JOURNAL   J Virol 77 (21), 11555-11562 (2003)
   PUBMED   14557641
  REMARK    GeneRIF: expression inhibits the replication of multiple members of
            the Alphavirus genus within the Togaviridae, including Sindbis
            virus, Semliki Forest virus, Ross River virus, and Venezuelan
            equine encephalitis virus
REFERENCE   10 (bases 1 to 4913)
  AUTHORS   Gao,G., Guo,X. and Goff,S.P.
  TITLE     Inhibition of retroviral RNA production by ZAP, a CCCH-type zinc
            finger protein
  JOURNAL   Science 297 (5587), 1703-1706 (2002)
   PUBMED   12215647
  REMARK    GeneRIF: Expression of the gene caused a profound and specific loss
            of viral messenger RNAs from the cytoplasm without affecting the
            levels of nuclear mRNAs; findings suggests the existence of a
            previously unknown machinery for the inhibition of virus
            replication
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Dec 22, 2021 this sequence version replaced XM_006236295.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.18933.1,
                                           SRR26643294.17766.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760400,
                                           SAMEA5760475 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-646               JAXUCZ010000004.1  68028708-68029353   c
            647-782             JAXUCZ010000004.1  68013721-68013856   c
            783-1035            JAXUCZ010000004.1  68008446-68008698   c
            1036-2046           JAXUCZ010000004.1  68002968-68003978   c
            2047-2142           JAXUCZ010000004.1  68002609-68002704   c
            2143-2266           JAXUCZ010000004.1  68001381-68001504   c
            2267-2441           JAXUCZ010000004.1  67997100-67997274   c
            2442-2562           JAXUCZ010000004.1  67992846-67992966   c
            2563-2665           JAXUCZ010000004.1  67989718-67989820   c
            2666-2750           JAXUCZ010000004.1  67986006-67986090   c
            2751-2881           JAXUCZ010000004.1  67985206-67985336   c
            2882-3015           JAXUCZ010000004.1  67984701-67984834   c
            3016-4913           JAXUCZ010000004.1  67979055-67980952   c
FEATURES             Location/Qualifiers
     source          1..4913
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q23"
     gene            1..4913
                     /gene="Zc3hav1"
                     /gene_synonym="ARTD13; PARP13; Zap"
                     /note="zinc finger CCCH-type containing, antiviral 1"
                     /db_xref="GeneID:252832"
                     /db_xref="RGD:628694"
     exon            1..646
                     /gene="Zc3hav1"
                     /gene_synonym="ARTD13; PARP13; Zap"
                     /inference="alignment:Splign:2.1.0"
     CDS             339..3284
                     /gene="Zc3hav1"
                     /gene_synonym="ARTD13; PARP13; Zap"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger CCCH-type antiviral protein 1; rZAP; inactive Poly
                     [ADP-ribose] polymerase 13; zinc finger antiviral protein;
                     CCCH-type zinc finger antiviral protein (Zap);
                     ADP-ribosyltransferase diphtheria toxin-like 13; zinc
                     finger CCCH type, antiviral 1"
                     /codon_start=1
                     /product="zinc finger CCCH-type antiviral protein 1
                     isoform 1"
                     /protein_id="NP_001385654.1"
                     /db_xref="GeneID:252832"
                     /db_xref="RGD:628694"
                     /translation="MADPGVCCFITKILCAHGGRMTLEELLGEIRLPEAQLYELLETA
                     GPDRFVLLETGGQAGITRSVVATTRARVCRRKYCQRPCDSLHLCKLNLLGRCHYAQSQ
                     RNLCKYSHDVLSEQNFQILKNHELSGLNQEELACLLVQSDPFFLPEICKSYKGEGRKQ
                     TCGQPQPCERLHICEHFTRGNCSYLNCLRSHNLMDRKVLTIMREHGLSPDVVQNIQDI
                     CNNKHARRNPPGTRAAHPHRRGGAHRDRSKSRDRFLHNSLEFLSPVVSPLGSGPPSPD
                     VTSCKDSLEDVSVDVTQKFKYLGTHDRAQLSPVSSKAAGVQGPSQMRASQEFSEDGNL
                     DDIFSRNRSDSSSSRASAAKVAQRNEAVAMKMGMEVKGKKEAPDIDRVPFLNSYIDGV
                     TMEKASVSGIPGKKFTANDLENLLLLNDTWKNVAKPQDLQTTGRITDSGQDKAFLQSK
                     YGGNPVWASASTHNAPNGSSQIMDETPNVSKSSTSGFAIKPAIAGGKEAVYSGVQSPR
                     SQVLAMPGETTTPVQSNRLPQSPLSSSSHRAAASGSPGKNSTHTSVSPAIESSRMTSD
                     PDEYLLRYILNPLFRMDNHGPKEICQDHLYKGCQQSHCDRSHFHLPYRWQMFVYTTWR
                     DFQDMESIEQAYCDPHVELILIENHQINFQKMTCDSYPIRRLSTPSYEEKPLSAVFAT
                     KWIWYWKNEFNEYIQYGNESPGHTSSDINSAYLESFFQSCPRGVLPFQAGSQKYELSF
                     QGMIQTNIASKTQRHVVRRPVFVSSNDVEQKRRAPDHQPVTPKADALNSIPQKNASTV
                     LPNEYEFLELNDQDVEYVTVSEQFKASMKPFKIVRIKRIWNQKLWDAFERKKEKMKNK
                     NEMLLFHAACRAHVDYICKNNFEWILHGSRETRYGKGNYFAKEAIYSHKNCSYDIRNI
                     VMFVARVLVGNVIEGNMTFSSPPALYDSCVDTRLNPSVFVIFRKEQIYPEYLIEYVES
                     EKEKGCIIS"
     exon            647..782
                     /gene="Zc3hav1"
                     /gene_synonym="ARTD13; PARP13; Zap"
                     /inference="alignment:Splign:2.1.0"
     exon            783..1035
                     /gene="Zc3hav1"
                     /gene_synonym="ARTD13; PARP13; Zap"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..2046
                     /gene="Zc3hav1"
                     /gene_synonym="ARTD13; PARP13; Zap"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2142
                     /gene="Zc3hav1"
                     /gene_synonym="ARTD13; PARP13; Zap"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2266
                     /gene="Zc3hav1"
                     /gene_synonym="ARTD13; PARP13; Zap"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2441
                     /gene="Zc3hav1"
                     /gene_synonym="ARTD13; PARP13; Zap"
                     /inference="alignment:Splign:2.1.0"
     exon            2442..2562
                     /gene="Zc3hav1"
                     /gene_synonym="ARTD13; PARP13; Zap"
                     /inference="alignment:Splign:2.1.0"
     exon            2563..2665
                     /gene="Zc3hav1"
                     /gene_synonym="ARTD13; PARP13; Zap"
                     /inference="alignment:Splign:2.1.0"
     exon            2666..2750
                     /gene="Zc3hav1"
                     /gene_synonym="ARTD13; PARP13; Zap"
                     /inference="alignment:Splign:2.1.0"
     exon            2751..2881
                     /gene="Zc3hav1"
                     /gene_synonym="ARTD13; PARP13; Zap"
                     /inference="alignment:Splign:2.1.0"
     exon            2882..3015
                     /gene="Zc3hav1"
                     /gene_synonym="ARTD13; PARP13; Zap"
                     /inference="alignment:Splign:2.1.0"
     exon            3016..4913
                     /gene="Zc3hav1"
                     /gene_synonym="ARTD13; PARP13; Zap"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atctttactt cctctcttcc ctgtagcagc ctcgcagtcc ggagctccgg ggacctcacg
       61 tctagcctgg aaccgagggt gccgcggcac ggcggacctg ccggcgaaag gttgcttgct
      121 tcccattcgc tctcccgcgc ggctaacttt aaatctgacc ccgggacctg gccggtgagg
      181 tcgggcctcg cgacgccacc gccggagttg gaaagcgaaa ccgctctgcg ctaggagcgg
      241 caccgcccgc gtccgcccct ggggccgcgt gtaagtttcg attctccgta aagccgagtc
      301 ccgcgcagcg gcccgagcgg cggcagccat agcgcgccat ggcagatccc ggggtatgct
      361 gtttcatcac caagatcctg tgcgcccacg ggggccgtat gaccctggag gaactgctgg
      421 gtgagatcag gctccccgag gcgcagctct acgagctgct ggagacggcg gggcccgatc
      481 gcttcgtgct attggagact ggaggccagg ccgggatcac tcggtctgta gtggctacta
      541 ctcgagcccg cgtctgccgt cggaagtact gccagagacc ctgcgacagc ctgcacctct
      601 gcaagcttaa tctgctcggc cggtgccact atgcacagtc tcagcggaac ctctgcaaat
      661 attctcacga tgttctctcg gaacagaact tccagatcct gaagaatcat gagctctctg
      721 ggcttaacca agaggagcta gcttgcctcc tggtccaaag cgaccctttt ttcctgcccg
      781 agatatgcaa gagttacaaa ggagagggcc gaaaacagac ctgcgggcag ccacagccat
      841 gcgagagact ccacatctgt gagcacttca cccggggcaa ctgcagttac ctcaactgtc
      901 tcaggtctca caacctgatg gacagaaagg tgttgaccat catgagggag cacgggctga
      961 gtcctgatgt ggtccagaac atccaggaca tctgcaacaa caaacacgcc aggaggaacc
     1021 cgcctggcac gagagctgcc catccacacc gcagaggcgg cgcacacaga gacagaagca
     1081 aaagcagaga ccgcttcctt cacaacagtc tagaatttct ctcacctgtt gtctcacctc
     1141 tgggatctgg tccgcctagc ccagatgtca ccagctgtaa agattccctg gaggatgtgt
     1201 ctgtggatgt cacccagaag ttcaagtact tggggacgca cgaccgtgcg cagctctccc
     1261 cagtctcatc taaggctgct ggtgttcaag gacccagtca aatgagagca agccaggagt
     1321 tttcagagga tgggaatcta gatgacatat tttctaggaa tcgttctgat tcatcatcaa
     1381 gtcgagcctc cgctgccaag gtggcacaaa gaaatgaagc tgtggccatg aaaatgggca
     1441 tggaggtcaa gggcaagaag gaggctccag acatcgatcg ggtcccattt ttaaatagtt
     1501 atattgatgg ggtgaccatg gaaaaagcat cggtctcagg aattccaggc aaaaagttca
     1561 cagccaatga tctggaaaat ttgctattac ttaacgacac ttggaagaat gtggctaagc
     1621 cccaggatct gcagaccaca ggcagaatca ctgacagtgg ccaagacaag gcattcctgc
     1681 agagtaaata tggaggaaac ccagtgtggg caagtgcatc cacccataat gccccaaatg
     1741 gctctagtca aattatggat gaaactccta atgtctctaa aagtagtacc agtggttttg
     1801 ccataaaacc agcaattgct ggaggaaaag aagcagtcta ttctggagtt cagagtccga
     1861 gaagccaggt cctagctatg cctggggaga ctactacccc tgtacagagc aacaggctgc
     1921 ctcagtcgcc tctgtcttcc tcaagccaca gagctgcagc ctctgggagc cctggcaaga
     1981 actccaccca tacctctgtg agcccagcca tcgagtcttc aaggatgaca tcagaccccg
     2041 atgagtatct cctacgctac atcctaaatc ctttatttag gatggataat catggcccga
     2101 aggaaatctg tcaggaccat ctgtacaagg gctgtcaaca gagccactgc gacaggagtc
     2161 acttccatct gccctaccgg tggcagatgt tcgtatatac cacttggagg gacttccagg
     2221 acatggagtc tatcgaacag gcctattgtg atccccacgt tgaactcatt ttgatagaaa
     2281 accatcagat caatttccag aaaatgacct gtgactccta ccccatccga cgcctctcca
     2341 ctccctcata tgaggaaaag ccacttagtg ctgtcttcgc caccaagtgg atttggtatt
     2401 ggaagaatga atttaatgaa tatatccagt atgggaatga gagcccaggc cacaccagct
     2461 ctgacatcaa ctctgcgtac ctggagtctt tcttccagtc ttgtcccagg ggagttttgc
     2521 cattccaggc tggttcacag aagtacgagt taagctttca agggatgatt cagacaaata
     2581 tagcttccaa gactcaaagg catgttgtca gaaggccagt atttgtttct tcgaacgatg
     2641 tggagcagaa gagaagagct ccagatcatc agccagtgac gcccaaggca gatgctctga
     2701 attctattcc ccagaagaat gctagcactg ttttgcccaa cgaatatgag tttctagaac
     2761 tcaatgacca ggatgtggag tatgtcacag taagcgaaca gtttaaagca tccatgaaac
     2821 ctttcaagat tgtgagaata aagcggatat ggaaccaaaa actctgggac gcttttgaaa
     2881 ggaagaagga aaagatgaaa aataaaaacg agatgctcct gtttcacgcc gcatgccgtg
     2941 cccatgtgga ttatatctgt aagaataatt tcgagtggat cctacatgga agtcgggaga
     3001 ccagatatgg aaaaggaaat tattttgcaa aagaagccat ctattcccac aagaattgtt
     3061 catatgatat cagaaacatt gttatgttcg tagcccgagt cctggttgga aacgtcattg
     3121 aagggaatat gacgttcagt agccctcctg cactctatga cagctgcgtg gacaccaggc
     3181 tgaatccctc cgtctttgtc attttccgga aagaacagat ttacccagag tatctgattg
     3241 agtatgtgga atcagagaaa gagaaaggtt gcataattag ttagaaatga catatactat
     3301 gccgaaacca ttcttttgcc gtcttggacc aaatcatccc cagatagtag ataggcttct
     3361 acattccctt gctacattac cgaacgtctt aaaccggctc cttgcttctc ccaaccgcct
     3421 tgtacatcat tcctaagtcc atttttacct ccccagtacc aaccattctg gtgttcttat
     3481 agttcttggt gcctttgcat ctaagtcatt ggtctagatg aacttttctg tcagttttta
     3541 ccacctacta ggcagtatct gttttgttta atattcaaag tgcatacaat cacattaatt
     3601 aaaaaaatca gatttactgt aatataagag agaaatataa agtcataact tcggcacgac
     3661 tttaagtcct aagacatgat ggagtcgtca gattgcttcc gtttaccatg aatcagtatg
     3721 agcttataag aaaagaattg gaggaacatg gaaaagcagg gacgtgttta gacattagag
     3781 taaagactaa acgacacacg ttaattgcaa atgtcagcaa ctatctgtac atggtaagaa
     3841 cgaaatatct tcattgaaat aaaaatacag cacaaaagaa cttacagatt gtcgaaacag
     3901 caagaatgaa gaggtacatt cttgcagacg agctgtaggt catacgcgaa tgtcgaaaga
     3961 gacattcaaa actcgaatag ggcgcagagt aatttcttat tgtgaggaac tgcccaatgt
     4021 attgaaagac gcatagctgg ctctcacatg ccaggagcgc cctccttcgc ccgaagtcat
     4081 ggcaaccaca gaccctacta gacctggtca tcctttgaaa ggtagatctt ttataacatc
     4141 ttttgccatc ttgagattta taggtgatac aatctacatt tgagtttatt ctgacttaat
     4201 ttagtgccct acttgtgtga taaatggaaa ctcagaactc taatggacac aaactgtgag
     4261 ggctcaggct tgactatgct accagcttca aatcctgcga actctcacta ggaataggtt
     4321 tgccttaaga gtccagcagg ggcagcttcc tgagctgaat gaagtgcagg acatgaagat
     4381 taaagggatg tgtgacagaa cacagggtta ggcaggtaca gcatagcagg ctttgcaccg
     4441 catctgtcag tggtgaagga gagggcaaaa tcactttagc tgaaatgata gataaaaaag
     4501 acgggacaaa ttacagtctg tctcagagga atcaaaggat tctttctcag acaagttgta
     4561 ggtcctgcat aatacatgtc cagcaggaca ttagacagtc gtaaaggtgc aggacggttt
     4621 gtgtgtggga ctgacccatc cacacacagc agggcgtttg ttctgcctca ggctgcatct
     4681 actcggtgag gttagtaaac ttcagattca aaaccaacag ccatcactct ctaatatgct
     4741 acagtggaaa ccactgatct agttaatggc agcactcttg gatcaactca attgttactt
     4801 ccactgtttt acaactgaat aagccagatc cttgcctctc aagccccgtt tttaacaatt
     4861 ccttgattta taatcctcct tctttgctca ataaaaagaa aaaagtaatt tga
//
