LOCUS       NM_001033951            3449 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus zinc finger CCCH type containing 14 (Zc3h14),
            transcript variant 1, mRNA.
ACCESSION   NM_001033951
VERSION     NM_001033951.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3449)
  AUTHORS   Bienkowski,R.S., Banerjee,A., Rounds,J.C., Rha,J., Omotade,O.F.,
            Gross,C., Morris,K.J., Leung,S.W., Pak,C., Jones,S.K.,
            Santoro,M.R., Warren,S.T., Zheng,J.Q., Bassell,G.J., Corbett,A.H.
            and Moberg,K.H.
  TITLE     The Conserved, Disease-Associated RNA Binding Protein dNab2
            Interacts with the Fragile X Protein Ortholog in Drosophila Neurons
  JOURNAL   Cell Rep 20 (6), 1372-1384 (2017)
   PUBMED   28793261
REFERENCE   2  (bases 1 to 3449)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 3449)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 3449)
  AUTHORS   Pak,C., Garshasbi,M., Kahrizi,K., Gross,C., Apponi,L.H., Noto,J.J.,
            Kelly,S.M., Leung,S.W., Tzschach,A., Behjati,F., Abedini,S.S.,
            Mohseni,M., Jensen,L.R., Hu,H., Huang,B., Stahley,S.N., Liu,G.,
            Williams,K.R., Burdick,S., Feng,Y., Sanyal,S., Bassell,G.J.,
            Ropers,H.H., Najmabadi,H., Corbett,A.H., Moberg,K.H. and Kuss,A.W.
  TITLE     Mutation of the conserved polyadenosine RNA binding protein,
            ZC3H14/dNab2, impairs neural function in Drosophila and humans
  JOURNAL   Proc Natl Acad Sci U S A 108 (30), 12390-12395 (2011)
   PUBMED   21734151
REFERENCE   5  (bases 1 to 3449)
  AUTHORS   Leung,S.W., Apponi,L.H., Cornejo,O.E., Kitchen,C.M.,
            Valentini,S.R., Pavlath,G.K., Dunham,C.M. and Corbett,A.H.
  TITLE     Splice variants of the human ZC3H14 gene generate multiple isoforms
            of a zinc finger polyadenosine RNA binding protein
  JOURNAL   Gene 439 (1-2), 71-78 (2009)
   PUBMED   19303045
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB097077.1.
            
            [WARNING] On Oct 24, 2024 this sequence was replaced by
            NM_001033951.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB097077.1, AB097075.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3449
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..3449
                     /gene="Zc3h14"
                     /gene_synonym="Npuk68"
                     /note="zinc finger CCCH type containing 14"
                     /db_xref="GeneID:192359"
                     /db_xref="RGD:621850"
     exon            1..130
                     /gene="Zc3h14"
                     /gene_synonym="Npuk68"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..2305
                     /gene="Zc3h14"
                     /gene_synonym="Npuk68"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger CCCH domain-containing protein 14; nuclear protein
                     UKp83/UKp68; nuclear protein UKp68"
                     /codon_start=1
                     /product="zinc finger CCCH domain-containing protein 14
                     isoform 1"
                     /protein_id="NP_001029123.1"
                     /db_xref="GeneID:192359"
                     /db_xref="RGD:621850"
                     /translation="MEIGTEISRKIRSAIKGKLQELGAYVDEELPDYIMVMVANKKSQ
                     DQMTEDLSLFLGNNTIRFTVWLHGVLDKLRSVTTEPSSLKSPDTSIFDSNVPSNKSSF
                     SRGDERRHEAAIPPLAVSSSRPEKRDSRVSTSSQEHKSTNVRHSYDDGASTRLMSTVK
                     PLREPAPSEDVIDIKPEPDDLIDEDLNFVQENSLSQKKPTVTLTYGSSRPSIEIYRPP
                     ASRNADTGTHLNRPQLQQQQSSTHTAKQLDGQSSQVYEAGRLCEPEVLGSVEDTYSPF
                     FRNNLDKMNIEEENFRKRKLPVVSSVVKVKRFSHDGEEEEEDEDYGTRVGSLSSSVSV
                     PAKPERRPSLPPSKQANKNLILKAISEAQESVTKTTNYPAVPQKQTLPVAPRTRTSQE
                     EVLAEMVQGQNRAPRISPPVKEEEAKGDNAEKIEGTQQRQLLSRLQIDPVTVDTMELS
                     QDYYDMESMVHADTRSFILKKPKLSEEIVVTPNQDSGMKTADALRVLSGHLMQTRDLV
                     QPDKPASPKFIVTLDGVPSPPGYMSDQEEEMCFEGMKPVNQTSASNKGLRGLLHPQQL
                     HLLSRQLEDPDGSFSNAEMTDLSVAQKPEKLLERCKYWPACKNGDECVYHHPISPCKA
                     FPNCKFAEKCLFVHPNCKYDAKCTKADCPFTHMSRRGPVLTPKPAVSSPAPSSNGQFC
                     RYFPACKKMECPFYHPKHCRFNTQCTRPDCTFYHPTITVPPRHALKWIRPQTSE"
     exon            131..173
                     /gene="Zc3h14"
                     /gene_synonym="Npuk68"
                     /inference="alignment:Splign:2.1.0"
     exon            174..288
                     /gene="Zc3h14"
                     /gene_synonym="Npuk68"
                     /inference="alignment:Splign:2.1.0"
     exon            289..329
                     /gene="Zc3h14"
                     /gene_synonym="Npuk68"
                     /inference="alignment:Splign:2.1.0"
     exon            330..525
                     /gene="Zc3h14"
                     /gene_synonym="Npuk68"
                     /inference="alignment:Splign:2.1.0"
     exon            526..955
                     /gene="Zc3h14"
                     /gene_synonym="Npuk68"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1116
                     /gene="Zc3h14"
                     /gene_synonym="Npuk68"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1217
                     /gene="Zc3h14"
                     /gene_synonym="Npuk68"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1373
                     /gene="Zc3h14"
                     /gene_synonym="Npuk68"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1448
                     /gene="Zc3h14"
                     /gene_synonym="Npuk68"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1608
                     /gene="Zc3h14"
                     /gene_synonym="Npuk68"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1841
                     /gene="Zc3h14"
                     /gene_synonym="Npuk68"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1962
                     /gene="Zc3h14"
                     /gene_synonym="Npuk68"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2099
                     /gene="Zc3h14"
                     /gene_synonym="Npuk68"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2298
                     /gene="Zc3h14"
                     /gene_synonym="Npuk68"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..3422
                     /gene="Zc3h14"
                     /gene_synonym="Npuk68"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctaggggg gcaggctgca gggtggcagc ccgcggcggg ttccaggtaa ccgaggcgcc
       61 gcgcagtgtt gacctggccg cccgccgccg agccatggaa atcggcaccg agatcagccg
      121 caagatccgg agtgccatta aggggaaatt acaagaatta ggagcttacg tggatgaaga
      181 acttcctgat tacattatgg tgatggtggc caacaagaaa agtcaggacc aaatgacaga
      241 ggacctgtcc ctgtttctag ggaacaacac aattcgattc accgtatggc tccatggtgt
      301 attagataaa cttcgttctg ttacaactga gccctctagt ctaaagtctc ctgataccag
      361 catctttgat agtaacgtgc cttcaaacaa gagcagtttt agtcggggag atgagagaag
      421 gcatgaagct gccattcctc cccttgccgt ttctagctct agacctgaga aaagggattc
      481 cagagtttct acaagttcac aggagcacaa atccactaac gtcagacatt catatgatga
      541 tggagcttcc accaggctaa tgtcaacagt gaaacctttg agggagccag caccctctga
      601 agatgtgatt gatatcaagc cagaaccaga tgatctcatt gatgaagacc tcaattttgt
      661 gcaggagaat tccttatctc agaaaaaacc tacagtgaca cttacatacg gttcttctcg
      721 cccttctata gaaatttatc gaccacctgc aagtagaaat gcagacactg gtactcattt
      781 aaacaggccg caacttcagc agcagcaaag cagtacccat actgccaagc agctggatgg
      841 acagagcagc caggtgtatg aagcaggacg gttgtgtgaa ccagaagtac ttggcagcgt
      901 agaagatact tatagccctt tcttcagaaa caacttggat aaaatgaata ttgaggagga
      961 aaactttcgg aagagaaagt tgcctgtggt aagttcagtt gttaaagtaa aaagatttag
     1021 ccatgatgga gaagaggagg aagaagatga ggattatggg acccgggtag gaagcttgtc
     1081 cagcagtgtg tcagtaccag caaaacctga gaggagacct tctcttccac cttctaaaca
     1141 agctaacaag aatctaattt tgaaggctat ctctgaagct caagagtctg taacaaaaac
     1201 aactaactat cctgcagttc cacagaaaca gacacttcca gttgctccta gaactcgaac
     1261 ttctcaagaa gaagtgctcg cagaaatggt ccaggggcaa aacagggccc ccagaataag
     1321 ccccccagtt aaagaagagg aagcaaaagg agataatgca gaaaaaattg aaggaactca
     1381 acagaggcaa ttgttatccc gactgcaaat tgatccagta acggtagaca caatggagct
     1441 gagtcaagat tactatgaca tggaatccat ggtccatgca gacacaagat catttattct
     1501 gaagaagcca aagctgtctg aggaaatagt agtgacacca aaccaggatt cggggatgaa
     1561 gactgcagat gcccttcggg tcctttcagg acaccttatg cagacacgag atcttgtaca
     1621 accagataaa cctgcaagtc ccaagtttat agtgacgctg gatggtgtcc ccagcccccc
     1681 aggatacatg tcagatcaag aggaggagat gtgctttgaa ggaatgaaac ccgtaaacca
     1741 aacttcagcc tcaaacaagg gactcagagg cctcctccac ccacagcagt tgcatttgct
     1801 gagcaggcag cttgaggacc cagatggtag cttttccaac gccgagatga ctgacctgag
     1861 tgtggcacag aaaccagaaa aactcctgga gcgctgcaag tactggcctg cttgtaaaaa
     1921 tggggatgag tgtgtgtacc atcaccccat ttcaccttgc aaagcctttc ccaactgtaa
     1981 atttgctgag aaatgtttgt ttgtgcatcc aaattgtaaa tatgacgcaa agtgtactaa
     2041 agcagattgt cccttcactc acatgagtag aagaggtcca gtactgactc caaaaccagc
     2101 agtgtcgtca ccagcgccat cttctaatgg ccagttctgc cgttacttcc ctgcctgtaa
     2161 gaaaatggag tgtcccttct accaccccaa acactgtagg tttaataccc agtgtacaag
     2221 accagactgt acgttttatc accccactat tactgtgcca ccaagacatg ccttgaaatg
     2281 gattcgacct caaaccagtg aatgatgccc tagtcctacc tggcagaaga tcatgcagtt
     2341 tgaaagcttc cgtcttctga tgagagatgt tctacagaac ttgtcacgtc tttgaaattt
     2401 agaatatatt gctttcataa tatgaatttt actgcccaac tgaagtgtct aatttttcaa
     2461 atttgtaagt ttattaagtg gtttcaacct tttttgtttg ttcgttttga ctatgaaaaa
     2521 gacagtttaa agaaaagcca attttattaa acactgcggc atgtttgtac attgctgttg
     2581 aacatcattt ttggtaatgg tgctgcagct tagggctgtg gtgctgtggg agggccagtg
     2641 tcctcagaac tgaagcactt tttactttcc ccaaagataa tgcagtgtct gtaacccagc
     2701 gtggaaacag tggccagact ttgaaactga ggcagctttg gaacaactag tttaaatttt
     2761 ctttttaatg tctgaatgaa tttgctccga gaagaataat acagactttt aattttgagt
     2821 gctactttgg tagagtggac tgaggtcccg tgcctttctg aaagtaagta gtgacatggt
     2881 catatagggt aaacatagtt ggaatgacaa tgcaaaaatg gatgaacaat tctttgaaat
     2941 gctcccattt actattagct tataattttt aaatagtttt ggagggacta cattatcaca
     3001 aaattataca aaaagtttta caggcatatg tacaggaagt atcagaaaac agactttgaa
     3061 ctcacaagaa taaaaatata catatatatt cccatattct gaaaaatatt gtcagaaata
     3121 actccacaga aaatatactt atgttactac taaagatcat tcttgaaatg tagaagttga
     3181 gatttaagtg gtatatttta aatgacagaa ctatataatt gcagagatag taagggtaaa
     3241 cttcacaata ggatgaacct tggcctactg tattatggag ttttatgtgt ggttttgaaa
     3301 ttgttaaggc aagatgtgtc atgttttaga attaaataac agacaactga tttcaaaaac
     3361 ttgttttaaa aattaaagtg taaaaggtgg ttagcaaagg ggataataaa agttcaaaca
     3421 ttaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
