LOCUS       NM_001077671            2567 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus zinc finger CCCH type containing 12A (Zc3h12a),
            mRNA.
ACCESSION   NM_001077671 XM_001057109 XM_233517
VERSION     NM_001077671.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2567)
  AUTHORS   Li,M., Yang,J., Zhao,Y., Song,Y., Yin,S., Guo,J., Zhang,H.,
            Wang,K., Wei,L., Li,S. and Xu,W.
  TITLE     MCPIP1 inhibits Hepatitis B virus replication by destabilizing
            viral RNA and negatively regulates the virus-induced innate
            inflammatory responses
  JOURNAL   Antiviral Res 174, 104705 (2020)
   PUBMED   31926181
REFERENCE   2  (bases 1 to 2567)
  AUTHORS   Zhang,Y., Huang,T., Jiang,L., Gao,J., Yu,D., Ge,Y. and Lin,S.
  TITLE     MCP-induced protein 1 attenuates sepsis-induced acute lung injury
            by modulating macrophage polarization via the JNK/c-Myc pathway
  JOURNAL   Int Immunopharmacol 75, 105741 (2019)
   PUBMED   31323531
  REMARK    GeneRIF: With the help of a cecal ligation puncture-induced model
            of acute lung injury (ALI) in rats, we demonstrated that MCPIP1
            overexpression induced by MG132 can alleviate sepsis-induced
            pathologic changes, increase in water content and protein leakage
            in the lungs, and induction of systemic inflammatory mediators, and
            thereby improve the 7-day mortality rate in sepsis-induced ALI.
REFERENCE   3  (bases 1 to 2567)
  AUTHORS   Tyka,K., Jorns,A., Turatsinze,J.V., Eizirik,D.L., Lenzen,S. and
            Gurgul-Convey,E.
  TITLE     MCPIP1 regulates the sensitivity of pancreatic beta-cells to
            cytokine toxicity
  JOURNAL   Cell Death Dis 10 (1), 29 (2019)
   PUBMED   30631045
  REMARK    GeneRIF: Since MCPIP1 expression undergoes fluctuations in islets
            during type 1 diabetes development in the IDDM rat and regulates
            the beta-cell fate upon exposure to proinflammatory cytokines,
            manipulations of its expression and activity might open new
            perspectives for type 1 diabetes treatment.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2567)
  AUTHORS   Nakatsuka,Y., Vandenbon,A., Mino,T., Yoshinaga,M., Uehata,T.,
            Cui,X., Sato,A., Tsujimura,T., Suzuki,Y., Sato,A., Handa,T.,
            Chin,K., Sawa,T., Hirai,T. and Takeuchi,O.
  TITLE     Pulmonary Regnase-1 orchestrates the interplay of epithelium and
            adaptive immune systems to protect against pneumonia
  JOURNAL   Mucosal Immunol 11 (4), 1203-1218 (2018)
   PUBMED   29695841
REFERENCE   5  (bases 1 to 2567)
  AUTHORS   Li,M., Yan,K., Wei,L., Yang,Y., Qian,Q. and Xu,W.
  TITLE     MCPIP1 inhibits coxsackievirus B3 replication by targeting viral
            RNA and negatively regulates virus-induced inflammation
  JOURNAL   Med Microbiol Immunol 207 (1), 27-38 (2018)
   PUBMED   29043433
REFERENCE   6  (bases 1 to 2567)
  AUTHORS   Younce,C.W., Azfer,A. and Kolattukudy,P.E.
  TITLE     MCP-1 (monocyte chemotactic protein-1)-induced protein, a recently
            identified zinc finger protein, induces adipogenesis in 3T3-L1
            pre-adipocytes without peroxisome proliferator-activated receptor
            gamma
  JOURNAL   J Biol Chem 284 (40), 27620-27628 (2009)
   PUBMED   19666473
REFERENCE   7  (bases 1 to 2567)
  AUTHORS   Matsushita,K., Takeuchi,O., Standley,D.M., Kumagai,Y., Kawagoe,T.,
            Miyake,T., Satoh,T., Kato,H., Tsujimura,T., Nakamura,H. and
            Akira,S.
  TITLE     Zc3h12a is an RNase essential for controlling immune responses by
            regulating mRNA decay
  JOURNAL   Nature 458 (7242), 1185-1190 (2009)
   PUBMED   19322177
REFERENCE   8  (bases 1 to 2567)
  AUTHORS   Niu,J., Azfer,A., Zhelyabovska,O., Fatma,S. and Kolattukudy,P.E.
  TITLE     Monocyte chemotactic protein (MCP)-1 promotes angiogenesis via a
            novel transcription factor, MCP-1-induced protein (MCPIP)
  JOURNAL   J Biol Chem 283 (21), 14542-14551 (2008)
   PUBMED   18364357
REFERENCE   9  (bases 1 to 2567)
  AUTHORS   Liang,J., Wang,J., Azfer,A., Song,W., Tromp,G., Kolattukudy,P.E.
            and Fu,M.
  TITLE     A novel CCCH-zinc finger protein family regulates proinflammatory
            activation of macrophages
  JOURNAL   J Biol Chem 283 (10), 6337-6346 (2008)
   PUBMED   18178554
REFERENCE   10 (bases 1 to 2567)
  AUTHORS   Zhou,L., Azfer,A., Niu,J., Graham,S., Choudhury,M., Adamski,F.M.,
            Younce,C., Binkley,P.F. and Kolattukudy,P.E.
  TITLE     Monocyte chemoattractant protein-1 induces a novel transcription
            factor that causes cardiac myocyte apoptosis and ventricular
            dysfunction
  JOURNAL   Circ Res 98 (9), 1177-1185 (2006)
   PUBMED   16574901
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC127516.1.
            
            On or before Nov 15, 2006 this sequence version replaced
            XM_233517.4, XM_001057109.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC127516.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2567
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2567
                     /gene="Zc3h12a"
                     /gene_synonym="MCPIP-1; Reg1; RGD1306776"
                     /note="zinc finger CCCH type containing 12A"
                     /db_xref="GeneID:313587"
                     /db_xref="RGD:1306776"
     exon            1..61
                     /gene="Zc3h12a"
                     /gene_synonym="MCPIP-1; Reg1; RGD1306776"
                     /inference="alignment:Splign:2.1.0"
     exon            62..538
                     /gene="Zc3h12a"
                     /gene_synonym="MCPIP-1; Reg1; RGD1306776"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1886
                     /gene="Zc3h12a"
                     /gene_synonym="MCPIP-1; Reg1; RGD1306776"
                     /EC_number="3.4.19.12"
                     /note="ribonuclease ZC3H12A; Zinc finger CCCH
                     domain-containing protein 12A; bifunctional
                     endoribonuclease and deubiquitinase ZC3H12A; regnase-1;
                     MCP-induced protein 1; monocyte chemotactic
                     protein-induced protein 1"
                     /codon_start=1
                     /product="endoribonuclease ZC3H12A"
                     /protein_id="NP_001071139.1"
                     /db_xref="GeneID:313587"
                     /db_xref="RGD:1306776"
                     /translation="MSDPCGKKLVQEISPTMSLWGLEDRHSCQGQPQPDQDPVAKEAS
                     ASELQMKVDFFRKLGYSSSEIHSALQKLGVQADTNTVLGELVKHGSATERECQASTDP
                     CPQPPLVPRGGSTPKPSTVEPSLPEEDKESSDLRPVVIDGSNVAMSHGNKEVFSCRGI
                     LLAVNWFLERGHTDITVFVPSWRKEQPRPDVPITDQHILRELEKKKILVFTPSRRVGG
                     KRVVCYDDRFIVKLAYESDGVVVSNDTYRDLQGERQEWKRFIEERLLMYSFVNDKFMP
                     PDDPLGRHGPSLDNFLRKKPLPSEHRKQPCPYGRKCTYGIKCRFFHPERPSRPQRSVA
                     DELRANALLSPPRTPVKDKSSQRPSPASQPNSMSLEAEPGSPDGKKLGTRSSPGPHQE
                     GSTQTCAPAGRSLPVSGGSFGPTEWLPHTLDSLPYTSQECLDSGIGSLESQMSELWGL
                     RGGSPGESGPTRGPYTGYQTYGSKLPAAPAFSPFRQAIGTGHFSVPTDYVPPPPTYPA
                     REYWSEPYPLPPPTPVLQEPQRPRPRASGDPWGRVSDLAKERAGVYTKLCGVFPPHLV
                     EAVMGRFPQLLDPQQLAAEILSYKSQHLSE"
     exon            539..678
                     /gene="Zc3h12a"
                     /gene_synonym="MCPIP-1; Reg1; RGD1306776"
                     /inference="alignment:Splign:2.1.0"
     exon            679..913
                     /gene="Zc3h12a"
                     /gene_synonym="MCPIP-1; Reg1; RGD1306776"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1020
                     /gene="Zc3h12a"
                     /gene_synonym="MCPIP-1; Reg1; RGD1306776"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..2544
                     /gene="Zc3h12a"
                     /gene_synonym="MCPIP-1; Reg1; RGD1306776"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtcagagcc caagactcgg ctccatggac actcttcgga cggcgtcggg cgctcggcgg
       61 ggagttgtga tggacgcatt ccaagaatgt gaaatatgag tgacccctgt gggaagaaac
      121 ttgtccaaga aatcagcccc accatgagtc tgtgggggct tgaggacaga cacagctgcc
      181 aaggtcaacc tcagccagac caggatcctg tggctaaaga ggcctctgct tccgagctgc
      241 agatgaaggt ggactttttc cgtaaactgg gatactcgtc ttctgagatc cacagtgccc
      301 tgcagaagct gggagtccaa gcagacacca acacggtgct gggggagctg gtgaagcacg
      361 gttcagctac tgaacgagag tgccaggcct ccacagaccc ctgcccccag ccccctctgg
      421 tgccccgggg tggaagcacc cccaagcctt ccactgtaga accctcactc ccagaggagg
      481 acaaagagag cagtgacctg agaccagtgg tcatcgacgg aagcaacgtg gccatgagcc
      541 atgggaacaa agaagtcttc tcctgccggg gcattttgct ggctgtgaac tggtttctgg
      601 agcggggcca tacagacatc accgtgtttg tgccatcgtg gaggaaggaa cagcctcggc
      661 cagatgtgcc tatcacagac cagcacattc tgcgggaact agagaaaaag aagatcctgg
      721 tgttcacgcc atccaggcgg gtcggtggca agcgtgtagt gtgctacgat gaccgattca
      781 ttgtgaagct ggcctatgaa tccgacggag tggtggtgtc caatgacaca taccgggacc
      841 tccaaggcga gaggcaggag tggaagcgct tcatcgagga gaggctgctc atgtactcct
      901 tcgtcaatga caagttcatg ccccctgacg accctttagg acgccacggg cctagcctgg
      961 acaacttcct gcgtaagaaa ccactgcctt ctgaacacag gaagcagcca tgtccctatg
     1021 ggagaaaatg tacttatgga atcaagtgcc ggttcttcca cccggagcgg ccaagccgcc
     1081 cccagcgctc tgtggctgat gagctccggg ccaacgccct tctctcgccc cccaggactc
     1141 cagtcaagga caaaagtagc cagaggcctt cccctgcctc tcagcccaac tccatgtccc
     1201 tagaggctga gccaggcagc ccagatggga aaaaactggg taccagatcc tccccaggcc
     1261 cccaccaaga aggctcaaca cagacctgtg ctccggctgg caggagcctc cctgttagtg
     1321 ggggcagctt tgggcccaca gagtggctcc cacacaccct ggactcgctc ccatacacct
     1381 cccaggagtg ccttgattca ggcattggct ccctggagag ccagatgtca gaattgtggg
     1441 ggttgcgagg aggtagccct ggggagtcgg gccccactcg gggtccttat actggttacc
     1501 aaacctatgg atccaagctc cctgcagcgc ctgccttttc tccctttaga caagccatcg
     1561 gtactggcca tttcagtgtc cccaccgact atgtgccccc gccacccacc tacccagcca
     1621 gagagtactg gtctgagcca tacccattgc ccccacccac tccagtcctt caggagcccc
     1681 agagacccag acccagggcc agtggggacc cctggggcag ggtgagcgac ctggccaaag
     1741 aaagggctgg tgtgtatacc aagctgtgtg gtgtctttcc cccacacctg gtagaagctg
     1801 tgatgggtcg tttcccacag ctcctggacc cccagcagct ggccgctgag atcctttctt
     1861 acaagtccca gcacctcagt gagtaaacca gaaggtggct caaggggcta tcaggcatca
     1921 cagatcggtc cccagcccct ggcctaccct ggaagttgga cagagggaca agtggagcag
     1981 gcaagggaat cctcaaacca gataccatag gattggttct ggccctgtgg ccctctatct
     2041 actccccacg ggtcagaagt gatcaccctg ttgatacaca ttgtatctct gtcatttaag
     2101 gagacgctgc cggtcaggcc gtccatccgt ggctgatgcc caaaccctct ttttttctca
     2161 gagggcaggg tagagggtct ggggagcaga ggtctgagct aaaccccatc ctctaccctg
     2221 tccctgggac gccggcacca ccggctagtt gggcaccatg tgcctgccct ctgaggcccc
     2281 cctcaagcca atgcagcctc atccctgttc acagggtgtg aggcttcatg ttagtaagca
     2341 agatgcttgt tttaacccac tcgcccgctc tgcccaccta ccccacccca cacacaccag
     2401 ggctccaagg ccctgtttcc acaccttccc cttccccttc cccacaggtg ggaggacaca
     2461 cgtactacgc catgtacaga gacaggattt aaatgtttta aacgaaaaga tcatcaaaat
     2521 aaaggctatt gccagtcatt tgaaaaaaaa aaaaaaaaaa aaaaaaa
//
