LOCUS       NM_054002               2810 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus zinc finger and BTB domain containing 7a
            (Zbtb7a), mRNA.
ACCESSION   NM_054002
VERSION     NM_054002.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2810)
  AUTHORS   Xu,X., Shobuike,T., Shiraki,M., Kamohara,A., Hirata,H.,
            Murayama,M., Mawatari,D., Ueno,M., Morimoto,T., Kukita,T.,
            Mawatari,M. and Kukita,A.
  TITLE     Leukemia/lymphoma-related factor (LRF) or osteoclast zinc finger
            protein (OCZF) overexpression promotes osteoclast survival by
            increasing Bcl-xl mRNA: A novel regulatory mechanism mediated by
            the RNA binding protein SAM68
  JOURNAL   Lab Invest 102 (9), 1000-1010 (2022)
   PUBMED   35474350
  REMARK    GeneRIF: Leukemia/lymphoma-related factor (LRF) or osteoclast zinc
            finger protein (OCZF) overexpression promotes osteoclast survival
            by increasing Bcl-xl mRNA: A novel regulatory mechanism mediated by
            the RNA binding protein SAM68.
REFERENCE   2  (bases 1 to 2810)
  AUTHORS   Ramos Pittol,J.M., Oruba,A., Mittler,G., Saccani,S. and van
            Essen,D.
  TITLE     Zbtb7a is a transducer for the control of promoter accessibility by
            NF-kappa B and multiple other transcription factors
  JOURNAL   PLoS Biol 16 (5), e2004526 (2018)
   PUBMED   29813070
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2810)
  AUTHORS   Liu,X.S., Liu,Z., Gerarduzzi,C., Choi,D.E., Ganapathy,S.,
            Pandolfi,P.P. and Yuan,Z.M.
  TITLE     Somatic human ZBTB7A zinc finger mutations promote cancer
            progression
  JOURNAL   Oncogene 35 (23), 3071-3078 (2016)
   PUBMED   26455326
REFERENCE   4  (bases 1 to 2810)
  AUTHORS   Masuda,T., Wang,X., Maeda,M., Canver,M.C., Sher,F., Funnell,A.P.,
            Fisher,C., Suciu,M., Martyn,G.E., Norton,L.J., Zhu,C., Kurita,R.,
            Nakamura,Y., Xu,J., Higgs,D.R., Crossley,M., Bauer,D.E.,
            Orkin,S.H., Kharchenko,P.V. and Maeda,T.
  TITLE     Transcription factors LRF and BCL11A independently repress
            expression of fetal hemoglobin
  JOURNAL   Science 351 (6270), 285-289 (2016)
   PUBMED   26816381
REFERENCE   5  (bases 1 to 2810)
  AUTHORS   Liu,X.S., Chandramouly,G., Rass,E., Guan,Y., Wang,G., Hobbs,R.M.,
            Rajendran,A., Xie,A., Shah,J.V., Davis,A.J., Scully,R., Lunardi,A.
            and Pandolfi,P.P.
  TITLE     LRF maintains genome integrity by regulating the non-homologous end
            joining pathway of DNA repair
  JOURNAL   Nat Commun 6, 8325 (2015)
   PUBMED   26446488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2810)
  AUTHORS   Maeda,T., Hobbs,R.M., Merghoub,T., Guernah,I., Zelent,A.,
            Cordon-Cardo,C., Teruya-Feldstein,J. and Pandolfi,P.P.
  TITLE     Role of the proto-oncogene Pokemon in cellular transformation and
            ARF repression
  JOURNAL   Nature 433 (7023), 278-285 (2005)
   PUBMED   15662416
REFERENCE   7  (bases 1 to 2810)
  AUTHORS   Liu,C.J., Prazak,L., Fajardo,M., Yu,S., Tyagi,N. and Di Cesare,P.E.
  TITLE     Leukemia/lymphoma-related factor, a POZ domain-containing
            transcriptional repressor, interacts with histone deacetylase-1 and
            inhibits cartilage oligomeric matrix protein gene expression and
            chondrogenesis
  JOURNAL   J Biol Chem 279 (45), 47081-47091 (2004)
   PUBMED   15337766
  REMARK    GeneRIF: LRF is the first transcription factor found to bind
            directly to the COMP gene promoter, to recruit HDAC1, and to
            regulate both COMP gene expression and chondrogenic differentiation
REFERENCE   8  (bases 1 to 2810)
  AUTHORS   Laudes,M., Christodoulides,C., Sewter,C., Rochford,J.J.,
            Considine,R.V., Sethi,J.K., Vidal-Puig,A. and O'Rahilly,S.
  TITLE     Role of the POZ zinc finger transcription factor FBI-1 in human and
            murine adipogenesis
  JOURNAL   J Biol Chem 279 (12), 11711-11718 (2004)
   PUBMED   14701838
REFERENCE   9  (bases 1 to 2810)
  AUTHORS   Lee,D.K., Suh,D., Edenberg,H.J. and Hur,M.W.
  TITLE     POZ domain transcription factor, FBI-1, represses transcription of
            ADH5/FDH by interacting with the zinc finger and interfering with
            DNA binding activity of Sp1
  JOURNAL   J Biol Chem 277 (30), 26761-26768 (2002)
   PUBMED   12004059
REFERENCE   10 (bases 1 to 2810)
  AUTHORS   Kukita,A., Kukita,T., Ouchida,M., Maeda,H., Yatsuki,H. and
            Kohashi,O.
  TITLE     Osteoclast-derived zinc finger (OCZF) protein with POZ domain, a
            possible transcriptional repressor, is involved in
            osteoclastogenesis
  JOURNAL   Blood 94 (6), 1987-1997 (1999)
   PUBMED   10477728
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 26, 2020 this sequence version replaced NM_054002.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D88450.1, SRR26643287.17293.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840105,
                                           SAMN12840106 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               JAXUCZ010000007.1  9227143-9227252     c
            111-1366            JAXUCZ010000007.1  9218632-9219887     c
            1367-2810           JAXUCZ010000007.1  9214493-9215936     c
FEATURES             Location/Qualifiers
     source          1..2810
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..2810
                     /gene="Zbtb7a"
                     /gene_synonym="Lrf; OCZF; Zbtb7"
                     /note="zinc finger and BTB domain containing 7a"
                     /db_xref="GeneID:117107"
                     /db_xref="RGD:620946"
     exon            1..110
                     /gene="Zbtb7a"
                     /gene_synonym="Lrf; OCZF; Zbtb7"
                     /inference="alignment:Splign:2.1.0"
     exon            111..1366
                     /gene="Zbtb7a"
                     /gene_synonym="Lrf; OCZF; Zbtb7"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..1832
                     /gene="Zbtb7a"
                     /gene_synonym="Lrf; OCZF; Zbtb7"
                     /note="leukemia/lymphoma-related factor;
                     osteoclast-derived zinc finger protein"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein
                     7A"
                     /protein_id="NP_446454.2"
                     /db_xref="GeneID:117107"
                     /db_xref="RGD:620946"
                     /translation="MAGGVDGPIGIPFPDHSSDILSGLNEQRTQGLLCDVVILVEGRE
                     FPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSAEALTALMDFAYTATLTVSTA
                     NVGDILSAARLLEIPAVSRVCTDLLERQILAADDVGDAGQPDGAGPTDQRNLLRAKEY
                     LEFFRSNPMNSLPPTAFQWPGFSAPDDDLDATKEAVAAAVAAVAAGDCNGLDFYGPGP
                     PADRPPTGDGEEGDSTPGLWPERDEDAPPGGLFPPPTAPPATTQNGHYGRAGASTGEE
                     EAVALSEAAPEPGDSPGFLSGAAEGEDGDAADVDGLAASTLLQQMMSSVGRAGDSDEE
                     SRPDDKGVMDYYLKYFSGAHEGDVYPAWSQKGEKKIRAKAFQKCPICEKVIQGAGKLP
                     RHIRTHTGEKPYECNICKVRFTRQDKLKVHMRKHTGEKPYLCQQCGAAFAHNYDLKNH
                     MRVHTGLRPYQCDSCCKTFVRSDHLHRHLKKDGCNGVPSRRGRKPRVRGVPPDVPSGA
                     GAPPGLPDAPRNGQEKHFKDEEEDEEEASPDGLGRLNVAGSGGDDGAGGPTVAATEGN
                     FAT"
     exon            1367..2810
                     /gene="Zbtb7a"
                     /gene_synonym="Lrf; OCZF; Zbtb7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccgcccga gcgaggtccg cgccgcgggc tgccccgatc gcgcgtcctc cgggcccggg
       61 tccccgcgag gtaagctgcc tgggctgaag gggagccctc tcccggagag gtgtcgcgga
      121 agatggctgg cggcgtggac ggccccatcg ggatcccgtt cccagaccac agcagcgaca
      181 tcctgagcgg cctgaatgag cagcggactc aggggctgct gtgtgatgtg gtgatcttgg
      241 tggagggacg tgagttcccc acgcatcgct cggtgctggc cgcctgcagt cagtacttca
      301 agaagctgtt cacttcgggc gctgtcgtgg accagcagaa cgtgtacgag attgactttg
      361 tgagcgccga ggcgctgacg gcgctcatgg actttgccta cacagccacg ctcacggtca
      421 gcacggccaa tgtgggcgac atcctgagtg cggcccggct gctggagatc ccggccgtga
      481 gccgagtgtg cactgacctg ctggagcgcc agattcttgc ggccgacgat gtgggggatg
      541 cgggccagcc cgatggggcg ggtcccacgg accagcgcaa cctgctgcgt gccaaggagt
      601 acctggagtt cttccgcagc aaccccatga atagcctgcc ccccactgcc ttccagtggc
      661 ctggcttcag tgcccccgat gacgacctgg atgccaccaa ggaggcagtg gctgccgctg
      721 tggctgctgt ggctgcaggt gactgcaatg gcttagactt ctacggccca gggcctccag
      781 ctgatcggcc cccaacgggc gatggggagg agggtgacag caccccaggg ctgtggcctg
      841 agcgggatga agatgccccg cctggggggc tcttcccgcc tcctactgcc ccgccagcca
      901 ctacacagaa cggccactat ggccgtgcag gggccagcac tggtgaggaa gaagcagtgg
      961 cgctctctga ggccgcccct gagccgggtg actccccggg cttcctgtca ggtgctgcag
     1021 aaggcgagga tggggatgcc gctgatgtgg acgggctagc ggccagcaca ctgctacagc
     1081 agatgatgtc gtccgtgggc cgggcagggg acagtgatga ggagtcccgc ccggacgaca
     1141 agggtgtcat ggactactac ctgaagtact tcagcggagc ccatgagggt gatgtgtacc
     1201 cggcctggtc acagaagggc gagaagaaaa tccgggccaa ggccttccag aagtgcccca
     1261 tttgcgagaa ggtgattcag ggcgcaggca agctgccccg gcacatccgc acgcacaccg
     1321 gcgagaagcc ctatgagtgc aacatctgca aggtccgctt caccagacag gacaagctga
     1381 aggtgcacat gcggaagcac acgggtgaga aaccgtacct gtgccagcag tgcggcgcgg
     1441 ccttcgcaca caactacgac ctgaagaacc acatgcgggt gcacacaggg ctgcgaccgt
     1501 accagtgtga cagctgctgc aagaccttcg tgcgctccga ccacctgcac agacacctca
     1561 agaaggacgg ctgcaatgga gtcccctcgc gccgtggccg caagccccgc gtgcggggtg
     1621 tgccacctga tgtcccctcc ggggctggcg caccccccgg gctcccggat gctccacgca
     1681 atggccagga gaagcacttt aaggacgagg aggaggacga ggaggaggcc agccctgacg
     1741 gcttgggccg cctgaatgta gcgggcagtg gaggagacga tggtgcgggt ggccccacgg
     1801 tggccgccac tgagggtaac ttcgcaacct gactcgtatt aaaacaaacc aaaaacaaaa
     1861 caaaaaacta agaacagaga gaaaccacca cccaccccca gcaccacaag taagcagttc
     1921 tctgtccaga cgccctccat ccatccgcgc ggacatgtgt gcgtgtatat accatggccg
     1981 cgggcgcctg cctttctcag atccttagga tgtggcccca tctgctcctg tgcccctcgc
     2041 cccgtccacc cagaggtccc acccaggggc ccagcctgct cctgctaagg cgagggcgat
     2101 agggtcgcca ggacaggcgc ccagctcctt gctggttggt tttagggggt cttagacaga
     2161 ccttaaatgc tctgtccact atgagtggac gttaaaatgg tccccagctc cccaccctcc
     2221 ttcctcaggg cacttactaa aagagggggg tgtcccctcg ggctccctcc ccgcctgtgg
     2281 cctcacatct ctgcacatcc accatggcca ccactgacat acaaatctat ttattcccaa
     2341 gcctggatgg ccagagcggg gatttggggg gctgctgggg tccctgccac cctctttcac
     2401 ggcacttaga cctgacgggg tccttggggc cactgctcag ggcgaccccc cccaaccttc
     2461 ccatctctgc ttggccatgc cccaccctgt gttcagagat tgaaaattcg tcgttacccc
     2521 gcgccccact ttttaaggca ctttttagat ctatttcccc ttttctcctt aaagacagtt
     2581 tatatagaga tatatataga gagagatata taaaatattc ttttcctcag aggagccggc
     2641 agcagttgtg ggtggacgta gccaagatca gaggtaaccc caggaactca ggcagagaca
     2701 ggcgagggag cgagagaaag gccacagctt aatgtcacaa aacagcaata aaaccccaag
     2761 actttagaaa cacgaaaaca gaacattaaa aaaaaaaaaa aaaaaaaaaa
//
