LOCUS       NM_001304352            5748 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus zinc finger and BTB domain containing 4 (Zbtb4),
            mRNA.
ACCESSION   NM_001304352 XM_006220704 XM_006246843
VERSION     NM_001304352.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5748)
  AUTHORS   Buck-Koehntop,B.A. and Defossez,P.A.
  TITLE     On how mammalian transcription factors recognize methylated DNA
  JOURNAL   Epigenetics 8 (2), 131-137 (2013)
   PUBMED   23324617
  REMARK    Review article
REFERENCE   2  (bases 1 to 5748)
  AUTHORS   Sasai,N., Nakao,M. and Defossez,P.A.
  TITLE     Sequence-specific recognition of methylated DNA by human
            zinc-finger proteins
  JOURNAL   Nucleic Acids Res 38 (15), 5015-5022 (2010)
   PUBMED   20403812
REFERENCE   3  (bases 1 to 5748)
  AUTHORS   Yamada,D., Perez-Torrado,R., Filion,G., Caly,M., Jammart,B.,
            Devignot,V., Sasai,N., Ravassard,P., Mallet,J., Sastre-Garau,X.,
            Schmitz,M.L. and Defossez,P.A.
  TITLE     The human protein kinase HIPK2 phosphorylates and downregulates the
            methyl-binding transcription factor ZBTB4
  JOURNAL   Oncogene 28 (27), 2535-2544 (2009)
   PUBMED   19448668
REFERENCE   4  (bases 1 to 5748)
  AUTHORS   Filion,G.J., Zhenilo,S., Salozhin,S., Yamada,D., Prokhortchouk,E.
            and Defossez,P.A.
  TITLE     A family of human zinc finger proteins that bind methylated DNA and
            repress transcription
  JOURNAL   Mol Cell Biol 26 (1), 169-181 (2006)
   PUBMED   16354688
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before Jan 21, 2015 this sequence version replaced
            XM_006246843.2, XM_006220704.2.
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data because no single transcript was available for the full length
            of the gene. The extent of this transcript is supported by
            transcript alignments and orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.35546.1,
                                           SRR26360194.1527943.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-183               JAXUCZ010000010.1  54984286-54984468
            184-250             JAXUCZ010000010.1  54993731-54993797
            251-1278            JAXUCZ010000010.1  54994165-54995192
            1279-5746           JAXUCZ010000010.1  54995746-55000213
            5747-5748           JAXUCZ010000010.1  55000214-55000215
FEATURES             Location/Qualifiers
     source          1..5748
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..5748
                     /gene="Zbtb4"
                     /note="zinc finger and BTB domain containing 4"
                     /db_xref="GeneID:287441"
                     /db_xref="RGD:1307184"
     exon            1..183
                     /gene="Zbtb4"
                     /inference="alignment:Splign:2.1.0"
     exon            184..250
                     /gene="Zbtb4"
                     /inference="alignment:Splign:2.1.0"
     exon            251..1278
                     /gene="Zbtb4"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..3214
                     /gene="Zbtb4"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 4"
                     /protein_id="NP_001291281.1"
                     /db_xref="GeneID:287441"
                     /db_xref="RGD:1307184"
                     /translation="MPPPAEVTDPSHAPAVLRQLNEQRLRGLFCDVTLIAGDTKFPAH
                     RSVLAASSPFFREALLASAPLPLPPVTGGSAPSPATTTAASSSSSPPPPASPHSSSPP
                     RVLELPGVPAAAFSDVLNFIYSARLALPGGGGDGAAVAEIGALGRRLGISRLQGLGEG
                     GDTWVPPAPSSMVTSEPNEDSLGPGLRTDGGWEGDKAEPLTPDSQPRRPFPCPRCGKS
                     FIHPKRLQTHEAQCRRGSNTRGSAGLGPGGSGPGGPAGVDASALPQPVSFRDGPEHVV
                     KVVGGHVLYVCAACERSYVTLSSLKRHSNVHSWRRKYPCRYCEKVFALAEYRTKHEVW
                     HTGERRYQCIFCWETFVTYYNLKTHQRAFHGISPGLLASEKTPNGGYKPKLNTLKLYR
                     LLPMRAAKRPYKTYSQGAPEAPLSPSLHTPVPAVMPASPQPLLPSVPEPGPPHSVITF
                     AHPAPSVIVHGSSSSGAAGGGPVGTGGSQAASVITYTTPPRPPKKREYPPPPPEPAAT
                     PTSPASTAVIPATAAGPATATEEAKGRNLRAGRTLTYTAKPVGGVSGSGGSPTGTGRG
                     SSQLQAPPPLCQITVRIGEEAIVKRRISETDLRPGELSGEEVEESEEEEEEEEEEDQE
                     DQEESKAGGEDQLWRPYYSYKPKRKAGATASGLSGLPRGRRPPRWRQKLERRGWEETP
                     AVEGPGGRGRGERRHRCGDCAQAFATLRKLRKHQEAHSGGSHNSRTGRRSSTRFTCPH
                     CAKVCKTAAALNRHGQRHAVERPGGTPTPVIAYSKGSIGTRPTDVKEEAPQEMQVSSS
                     SGEAGGGSAAAAAAEASESASLQDPVISGGEEPPVAGGGGYVYPPVQEFPLALIGGSR
                     DPGAGKGKPGNEGPVGASEGNRMEEMGTAKVTFYPEPYPLVYGPQLLAAYPYNFSNLA
                     ALPVALNMVLPDEKGGGALPFLPGVFGYAVNPQTAPPTPPTPPPPLPLPVPPKGVGEM
                     TGVERTQKGDVG"
     exon            1279..5748
                     /gene="Zbtb4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgctgggag ggcgatggcg taggagccag gcagagaggg ggaggggtgg ccctctgagc
       61 gccccagagt tggggtgtgc agggtgcgca gtgcgagcag ggacccagaa ccgccgcgcc
      121 gtcggggcag ggttgttgct gtgagtcctg gagattgtac ctcctgcggt gctgtggggc
      181 aagaaggaaa aggccagact ggagggactt gctgagccac tacactgctc catgttggct
      241 atgctctcag gctggcatca tgccaccccc tgcagaggtg acggacccat cccatgctcc
      301 agctgtcctg cgccagctca atgagcagcg gctccgtggc ctcttctgtg acgtcaccct
      361 catagcagga gacaccaagt tccctgctca ccgcagtgtg ctggccgcct ctagtccttt
      421 cttcagagaa gctctactag cttcagcccc actgcccctc ccaccagtta ctggtggctc
      481 agcccccagc cctgcaacca ccacagctgc ctcctcttca tcctctcctc cccctccagc
      541 ctctcctcat tcttcatctc ctcctcgggt gctagagttg cccggggtcc cagcagctgc
      601 cttctctgat gtcctcaact tcatctatag tgcccggctt gcactccctg gtggtggcgg
      661 ggatggggca gctgtggcag agattggagc tctgggccgg aggctgggta tctctcggct
      721 acagggcctg ggggaaggag gtgacacttg ggtaccacct gccccatctt ccatggtcac
      781 ctcagagcct aatgaggata gtttggggcc agggcttaga acagatggag gatgggaagg
      841 tgacaaagct gagcccctga ctcctgactc acagccccgg cggccctttc cttgcccccg
      901 atgtggaaaa agcttcatcc atcccaagcg actgcagacc cacgaggctc agtgtcgacg
      961 agggtccaac actcgggggt ctgcagggct gggacctggg ggctctggcc ctggaggtcc
     1021 tgcaggagtg gacgcctcag ccctgccaca accagtgagc ttcagagatg gccctgagca
     1081 tgtggtgaag gttgtgggcg gccatgtgct ctatgtgtgt gcagcctgtg agcgttccta
     1141 cgtgaccctg tccagcctga agcggcacag caatgtacac tcatggcgga ggaagtaccc
     1201 ctgccgctac tgtgagaagg tgtttgccct ggctgagtac cgcaccaagc atgaggtgtg
     1261 gcacactggg gaacgcaggt accagtgcat cttctgctgg gaaacctttg tgacctatta
     1321 taacctgaag acccaccagc gagccttcca tggcattagc cctggcctcc tagccagtga
     1381 gaagacaccc aatggaggct acaagcccaa gcttaatacc ctcaagctgt accgcctgct
     1441 ccctatgcgg gcagccaagc ggccctacaa gacctacagt cagggagccc ctgaggcccc
     1501 tctttctcca agcctccaca caccggtccc cgccgtaatg ccagccagcc cccaacccct
     1561 actcccatcc gtcccagaac ctggtcctcc ccactctgtc atcacctttg ctcatccagc
     1621 tccctcagtc attgtccacg ggagcagtag tagtggtgca gctgggggtg gaccagtcgg
     1681 cacaggaggg tcccaagctg cctcagtcat cacttatacg actcccccaa gaccccccaa
     1741 gaaacgagag tacccacctc ctccccctga gcctgcagca acacccacca gcccagcctc
     1801 caccgctgtc atcccagcca cagctgcagg gccagccaca gccacagagg aggccaaggg
     1861 ccggaatctg cgggctggga ggactctgac ttacacagcc aaacccgtgg gtggggtgag
     1921 tgggagtggg ggttccccca cagggacagg ccgaggctct tctcagcttc aggctccacc
     1981 tccactgtgt cagatcactg tgcgaattgg ggaagaggcc attgtcaagc gccgcatctc
     2041 agaaactgac ctacgtccgg gagaactgag tggagaggaa gtagaggaga gcgaggaaga
     2101 ggaggaagaa gaggaggagg aggaccagga ggaccaagag gaatcgaagg ctggagggga
     2161 agatcagctt tggagaccct actattcata taagcctaag cgcaaggctg gagctactgc
     2221 cagcgggctg agcggactgc cccgaggacg aagaccacct cgctggaggc aaaagctgga
     2281 acgaaggggc tgggaggaaa ccccagcagt ggagggccca ggaggacgag gacgtggtga
     2341 gcgtaggcac cgttgtgggg actgtgccca ggcttttgcc actctgagga agctgagaaa
     2401 gcaccaggaa gctcatagcg ggggctcgca caactctagg actggcagga ggtcttccac
     2461 ccgtttcacc tgtccccact gtgccaaggt gtgcaagacg gcagctgctc tgaaccgaca
     2521 tgggcagagg catgctgtgg agcggcctgg gggcactccc acacctgtca ttgcctattc
     2581 caaaggcagc attggcacca ggcccactga tgtcaaggag gaagcccccc aagagatgca
     2641 agtgtcctca tccagtggag aggcaggcgg tggtagtgct gctgctgctg ctgctgaagc
     2701 ttctgagtct gcctcactcc aggacccggt catctctggg ggtgaggaac ccccagtagc
     2761 aggtgggggt ggctatgtat acccacctgt gcaggaattt cccctggccc tgataggagg
     2821 tagccgggat cccggtgctg gcaaaggaaa acctgggaat gaggggccag tgggagcttc
     2881 cgagggaaac cggatggagg agatggggac tgccaaagtc accttctacc ctgaacccta
     2941 cccacttgtc tatggccccc agctccttgc tgcctaccct tacaacttca gcaacttggc
     3001 tgctctccca gttgctctca acatggtcct acctgatgaa aagggtggtg gggcccttcc
     3061 cttccttccg ggggtctttg gctatgcagt gaatcctcaa acagcaccac ctactccacc
     3121 aaccccacct ccccctcttc ctctgccagt tccccctaag ggagtagggg aaatgacagg
     3181 ggttgagaga acccagaagg gggatgtggg gtgagcacca aggccagatc ccccctctta
     3241 ccagatgcca ccctccctga gtccctcttc cctctccccc cagctccctg gcctccctgt
     3301 cctttgggag ccccataaca ttcttgtgca gggatttggg ggcccctgga gctcaggagt
     3361 caggctgctt tgtgtgattg tagtttcccc attccctgag aagggatttt gggttgttcc
     3421 ctctcagtct tctccaggga atggcccctg tgaggggcag agccagctcc catcccttct
     3481 ccagcccttg ggcaactgag caatatactt ctctgagtct ctacttacag ccccaccagc
     3541 tctgaatgtc taacctgctc ccctaattgg taagcctagg gggaaaccat ctatctctct
     3601 cacctaatga tgcctgctca ttctgacgct gtctctaagc ccttccccag atgcttccta
     3661 gcacattcca ttctttgtgg cccaaggcct ggaccagacc attgtgatat ctgacccacc
     3721 agcctggaag catggctttg gattccgttc ttcccaaggt gggtttctct gtccttgttt
     3781 ctttcatatt aagatgccat gccttccttg gcttccatgc ctttggatct tccatattcc
     3841 ttcctgcact ccgagacttt ggagatggcc taacccattc caggtcataa ggaggcagga
     3901 ggtgtcctat ggctgagcac tttttcaata cagggcaggg aaatcttggg ccctaccttt
     3961 accccaagtc cagtgacccc agattcttcc aagacaaaag aggtgaatag atcataactc
     4021 ttctggcctt tatatgtggc tgctttggga ataacccaaa ttcgagcacc aggtatgaag
     4081 tactccatac agaatggaga agagaatcta ctttctccgt gtcaacccct cactatggtt
     4141 tcttctagat tagaccaaat agccagagaa actgatgggg gtttgatgtg tgggtaagcc
     4201 caagatctgc acagaacctc caccctcacc tttattccgt ctcctctgat gtcactgtcc
     4261 tcaccaatca ctccagatgg ttttaaggga accatcttcc tcttctggtg ggctttgggg
     4321 tatccccacc aactctgcct ccaaaacagc accttatacc ccatctcaag tctcccacac
     4381 ccaaagatcc cagcctagga atggggcaca gggattttta aatagtccct aatccctaat
     4441 ttgcactagt taaccctggt caggggtcct atgtttcctt ccagtaggga caatagagaa
     4501 atgtttgttc ctaattccct ttgaaaatgg ggcctccctg acctgatgtg tgattagatg
     4561 gatatttcca atatacccat ctcccctccc ccacaaagaa agaaccagct cacaaaggga
     4621 gagccaattt gggggaacaa atttgatgtg ggagttagag gagtatgatt tcaaaaggag
     4681 aaagactgtt ttaatcaaaa tgacagtctt tcagctactg ttttctgggg ccaagatggc
     4741 tgccctctga cttgctatgg agagggcaag atcatggctt ttggagggag gtgagtttgg
     4801 gaaggccagg agcatcctcc tgcctcctcc taacctccaa gtatacagaa ggggaggttt
     4861 ttgacaggct tcctgaatgt taaccacgga gggggtcact ccacccctcc tctgtctctt
     4921 tgcacttttc ttggtcttgg ctacagcctg agtgaagaat ttcctactga atgtaccaag
     4981 ttccagtttt taagggggga aaagtttcaa acagggaaaa atggaaaaaa aaaagaaaaa
     5041 aaatcactaa aaactcccat aaatcttgtt tctggcactt tagaaaaact gcaaaaaata
     5101 cataataaag aatacatata tatatctaca cacaaattat atatataaat atatctatat
     5161 atacagcgga accacaagag agactgagga aggcctgaag gcagggggca gagatgacaa
     5221 aggtcccctc taccttcatt gccctcctct gaggaagtct tgagagaagg ggtaaaaatg
     5281 aactggggaa tttgaatttc agaatagatc aaaattctga ccatttggaa gaattgagat
     5341 tataaatggg ttttgttttt gtttttaata agggtaaaga caatagcttc cagaatttgg
     5401 tgacaaacag ttgtggcaaa gcagaaactt aaaaatatat atctgagctg gaaggtctcc
     5461 atatcctgag tttcaggtgc tgggagtttg ggattttgca attttgtcat ttggaggtga
     5521 tcaagtcttg tcagtttgtg ccctctttcc ccatgtgacc tggggagaag ggaaaaagtg
     5581 ggaagctact ggttctgtgc cacagcacgc aagatttaga attttacaga ctctagctct
     5641 atacgtagtg aggacccaga tttagagaat ctgaccaata tttatctcca gatttgtgtg
     5701 ttttcaattc tctaggccaa taaatcaaca agacaaatga actctgct
//
