LOCUS       NM_001401285            3822 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus zinc finger and BTB domain containing 18
            (Zbtb18), transcript variant 2, mRNA.
ACCESSION   NM_001401285
VERSION     NM_001401285.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3822)
  AUTHORS   Yang,H., Zhang,Z., Ding,X., Jiang,X., Tan,L., Lin,C., Xu,L., Li,G.,
            Lu,L., Qin,Z., Feng,X. and Li,M.
  TITLE     RP58 knockdown contributes to hypoxia-ischemia-induced pineal
            dysfunction and circadian rhythm disruption in neonatal rats
  JOURNAL   J Pineal Res 75 (1), e12885 (2023)
   PUBMED   37183291
  REMARK    GeneRIF: RP58 knockdown contributes to hypoxia-ischemia-induced
            pineal dysfunction and circadian rhythm disruption in neonatal
            rats.
REFERENCE   2  (bases 1 to 3822)
  AUTHORS   Enzo,E., Santinon,G., Pocaterra,A., Aragona,M., Bresolin,S.,
            Forcato,M., Grifoni,D., Pession,A., Zanconato,F., Guzzo,G.,
            Bicciato,S. and Dupont,S.
  TITLE     Aerobic glycolysis tunes YAP/TAZ transcriptional activity
  JOURNAL   EMBO J 34 (10), 1349-1370 (2015)
   PUBMED   25796446
REFERENCE   3  (bases 1 to 3822)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   4  (bases 1 to 3822)
  AUTHORS   Okado,H., Ohtaka-Maruyama,C., Sugitani,Y., Fukuda,Y., Ishida,R.,
            Hirai,S., Miwa,A., Takahashi,A., Aoki,K., Mochida,K., Suzuki,O.,
            Honda,T., Nakajima,K., Ogawa,M., Terashima,T., Matsuda,J.,
            Kawano,H. and Kasai,M.
  TITLE     The transcriptional repressor RP58 is crucial for cell-division
            patterning and neuronal survival in the developing cortex
  JOURNAL   Dev Biol 331 (2), 140-151 (2009)
   PUBMED   19409883
REFERENCE   5  (bases 1 to 3822)
  AUTHORS   Takahashi,A., Hirai,S., Ohtaka-Maruyama,C., Miwa,A., Hata,Y.,
            Okabe,S. and Okado,H.
  TITLE     Co-localization of a novel transcriptional repressor simiRP58 with
            RP58
  JOURNAL   Biochem Biophys Res Commun 368 (3), 637-642 (2008)
   PUBMED   18262495
REFERENCE   6  (bases 1 to 3822)
  AUTHORS   Kang,J.S., Yang,Y.C., Liu,H.L., Li,Y.H., Du,Y.C. and Li,R.X.
  TITLE     Cloning and Distribution of rRP58, A Novel Neuronal Gene
  JOURNAL   Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 33 (5),
            563-568 (2001)
   PUBMED   12040400
REFERENCE   7  (bases 1 to 3822)
  AUTHORS   Meng,G., Inazawa,J., Ishida,R., Tokura,K., Nakahara,K., Aoki,K. and
            Kasai,M.
  TITLE     Structural analysis of the gene encoding RP58, a sequence-specific
            transrepressor associated with heterochromatin
  JOURNAL   Gene 242 (1-2), 59-64 (2000)
   PUBMED   10721697
REFERENCE   8  (bases 1 to 3822)
  AUTHORS   Aoki,K., Meng,G., Suzuki,K., Takashi,T., Kameoka,Y., Nakahara,K.,
            Ishida,R. and Kasai,M.
  TITLE     RP58 associates with condensed chromatin and mediates a
            sequence-specific transcriptional repression
  JOURNAL   J Biol Chem 273 (41), 26698-26704 (1998)
   PUBMED   9756912
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1105680.1, BG376882.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               JAXUCZ010000013.1  91973933-91974094
            163-3822            JAXUCZ010000013.1  91976399-91980058
FEATURES             Location/Qualifiers
     source          1..3822
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q25"
     gene            1..3822
                     /gene="Zbtb18"
                     /gene_synonym="Rp58; Zfp238; Znf238"
                     /note="zinc finger and BTB domain containing 18"
                     /db_xref="GeneID:64619"
                     /db_xref="RGD:621548"
     exon            1..162
                     /gene="Zbtb18"
                     /gene_synonym="Rp58; Zfp238; Znf238"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..1745
                     /gene="Zbtb18"
                     /gene_synonym="Rp58; Zfp238; Znf238"
                     /note="isoform 2 is encoded by transcript variant 2;
                     rRP58; 58 kDa repressor protein; zinc finger protein 238;
                     transcriptional repressor RP58; zinc finger and BTB
                     domain-containing protein 18"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 18
                     isoform 2"
                     /protein_id="NP_001388214.1"
                     /db_xref="GeneID:64619"
                     /db_xref="RGD:621548"
                     /translation="MCPKGYEDSMEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQF
                     RAHRAVLASCSMYFHLFYKDQLDKRDIVHLNSDIVTAPAFALLLEFMYEGKLQFKDLP
                     IEDVLAAASYLHMYDIVKVCKKKLKEKATTEADSTKKEEDASSCSDKVESLSDGSSHM
                     AGDLPSDEDEGEDDKLNILPSKRDLAAEPGNMWMRLPSDAAGIPQAGGEAEPHATAAG
                     KTVASPCSSTESLSQRSVTSVRDSADVDCVLDLSVKSSLSGVENLNSSYFSSQDVLRS
                     NLVQVKVEKEASCDESDVGTNDYDMEHSTVKESVSANNRVQYEPAHLAPLREDSVLRE
                     LDREDKASDDEMMTPESERVQVEGGMESSLLPYVSNILSPAGQIFMCPLCNKVFPSPH
                     ILQIHLSTHFREQDGIRSKPAADVNVPTCSLCGKTFSCMYTLKRHERTHSGEKPYTCT
                     QCGKSFQYSHNLSRHAVVHTREKPHACKWCERRFTQSGDLYRHIRKFHCELVNSLSVK
                     SEALSLPTVRDWTLEDSSQELWK"
     exon            163..3822
                     /gene="Zbtb18"
                     /gene_synonym="Rp58; Zfp238; Znf238"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgtgtgcg gatctgtggt ggggaaggta tctcgttcct ctccaacatc atctccactt
       61 tgcatctgtc tctcttagtc tgcttttttt ccaccgatgt aacagacctg cagccagcaa
      121 gactccgagg gaaggactta atcaagttta tgtgtcctaa aggttatgaa gacagtatgg
      181 agttcccaga ccacagcaga catttgctgc agtgtctgag cgagcagagg caccagggct
      241 ttctttgtga ctgcactgtt ctggtgggag atgcccagtt ccgggcacac cgagctgtac
      301 tggcttcatg cagcatgtat ttccacctct tttacaagga ccagctggac aaaagagaca
      361 ttgttcatct gaacagcgac attgtgacag cccccgcttt cgctctcctg cttgaattca
      421 tgtacgaagg gaaactccag ttcaaagact tgcccattga ggacgtgcta gcagctgcca
      481 gttatctcca catgtatgac attgtcaaag tctgcaaaaa gaagctgaaa gagaaagcta
      541 ccacagaggc agacagcacc aaaaaagaag aagatgcttc aagttgttcg gataaagtcg
      601 agagcctctc ggacggcagc agccacatgg caggtgatct gcccagtgat gaagacgaag
      661 gcgaagatga caaattgaac attctaccca gcaaaaggga cttggcagct gagcctggga
      721 acatgtggat gcgattgccc tcagacgcag caggcatccc ccaggctggc ggagaggccg
      781 agccacacgc cacagcagct ggaaaaacag tagccagccc ctgcagctca acagagtctt
      841 tgtcccagag gtctgtcacc tccgtgaggg attcggcaga tgttgactgt gtgctggacc
      901 tgtctgtcaa gtccagcctt tcaggagttg aaaatctgaa cagctcttat ttctcttcac
      961 aggacgtgct gagaagcaac ctggtgcagg tgaaggtgga gaaagaggca tcctgtgatg
     1021 agagtgatgt tggcactaat gactatgaca tggaacatag cactgtgaaa gagagtgtga
     1081 gcgctaacaa cagggtacag tatgagccgg cccacctggc tcctctgagg gaggactcgg
     1141 tcttaaggga gctggatcgg gaggacaaag ccagcgacga tgagatgatg accccagaga
     1201 gcgagcgggt gcaggtggaa ggaggcatgg agagcagtct gcttccctat gtctccaata
     1261 tcctgagccc cgcgggccag atcttcatgt gccccctgtg caacaaagtc ttccccagcc
     1321 cccacatcct gcagatccac ctgagcacgc acttccgcga gcaggatggc atccgcagca
     1381 agcctgccgc cgatgtcaat gtgcccacgt gctctctgtg tgggaagact ttctcctgca
     1441 tgtacaccct caagcgccac gagaggactc actcagggga gaagccctac acgtgcaccc
     1501 agtgcggcaa gagtttccag tactcacaca acctgagccg ccacgccgtg gtgcacaccc
     1561 gtgagaagcc ccatgcctgc aagtggtgcg agcgcaggtt cacgcagtcc ggagacctgt
     1621 acagacacat ccgcaagttc cactgtgagt tggtgaactc cttgtcggtc aaaagtgaag
     1681 cactgagctt gcccactgtc agagactgga ccttagaaga tagctctcaa gaactttgga
     1741 aataatttta tatatatata tataaattat atatatatat atacatatat atacatagat
     1801 ctctatatag ttgtggtacg gtctaaaagc agtcttgttt cctggaactg aaaagttgga
     1861 atcttgtttt gcactttaga ataatagcat gagaatctca ctaatttagc attctgataa
     1921 agaaactaga gaagtcacaa gtagagagct gtctttcttt tgagggttag gccaagttag
     1981 ccaataaaac cttctcaaca aatgggtctg tcgcagaacg cctcacacgg cttacttttg
     2041 tacacactgc attgtcttga gcactttcct tgtgctccac actgtttagt tttgttttgt
     2101 tttcagagta gaaatcccct ccagtttata gcctctttat atgtctcaaa ttgcatgaat
     2161 attttctggc tgttggaaac ctgaatgctt ttagacccaa atggaaaatt tctgaaatgc
     2221 tggattatct atttttaaac aagcagttga cttaaaactt tctgtggcaa cttctggttt
     2281 tctgatggtc cccagtgaga gaaatctgac agtacactgg gtcactggga ctgtctctgt
     2341 gaaggtttgc ttgagatgaa aaggatattg cagcttcagc agtgttgaac tgtgtgttta
     2401 aaatgtgaat tactgttctt gtatactgta attgattacg cgggctgggg gggtcaaaga
     2461 acttgacagg ttgtgttgat gctcttagtt gagtcttgaa aagtaaatat taacgctaca
     2521 gaaatgcatg agtttcaata tattttttgt ctttgtttgc attgtataac tttaacgagt
     2581 gagtttaaaa ttatttaatt tccttagaaa aatagcacca tttgggaaaa aaaactggtg
     2641 ttacgaagaa cataaatgca ctgtttttat ttttattttt attttatata atttaaattg
     2701 acttttccca cgtctttaag tttgaaactg ttaagctgaa taaaaactta agctgcaaat
     2761 cgataacttc gctacattac aaggagcata gaaatgttta caaacggctt acagaattgc
     2821 atgtgcaggg tccatccaca ccacacttgt aattgcacag aacccatgcc agctcagagt
     2881 ttaggtgtac acacgtaccc agccgagtga ttttagagta actactgcac aaattgacaa
     2941 taggtcatag gtcattctct ctctctcccc cccttttgct tcccttttct ttttctcccc
     3001 tatttccttt ccttccccct accccctaac tcatgaaaag actctatgga ctgaaaagcc
     3061 ccaggctgaa aggactgaac tgccttgatt gacatgggga agggggttag tagactgtgt
     3121 atcggcagca caggctgcag ctcgacgtgt gggtctgatg gccagcgtgc agggcagagc
     3181 attttgcaca ctgtttgttt tcctgtcttg cacttacaaa taaggtctat gggagtagca
     3241 tggaaaacgg ttgttgtttt tccctttttc ttttttaatt gcttttgttt aaaatttgat
     3301 cgccttaact actgtaaaca tagcctattt ttgtgcttaa gatactgaat ggaaaactcc
     3361 attgtgtgtt gctggactgt tttggaaata tttggtcaaa tgtatgttaa tttggctgta
     3421 atggcattta aagcaagcaa acaaacaaac aaaaaaagct gtgaaaatgg ccttggagca
     3481 ttatctttag ttacttgaag agtttctggg ttttttttta atacagttta tgttaaaata
     3541 atctttatta atttagagaa gacaatcaat gtctgtgaaa gaacggactc tttggatttt
     3601 tttttttttt ttgtggtcat tgtgagtgat tgctttttct tttccttagt ttcacattct
     3661 tcctttgttg taaatcttag actgacatct agctttgaca atcatagtat gttttatttc
     3721 ctgaggggga ataacttaca atactgttta gttttgtact attggtgtgt tggtgaattt
     3781 ttaaactgtg tgctaactgc aataaattat atgaactgag aa
//
