LOCUS       NM_001013181            2306 bp    mRNA    linear   ROD 19-JUN-2023
DEFINITION  Rattus norvegicus zinc finger and BTB domain containing 16
            (Zbtb16), mRNA.
ACCESSION   NM_001013181 XM_345936
VERSION     NM_001013181.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2306)
  AUTHORS   Shi SM, Liu TT, Wei XQ, Sun GH, Yang L and Zhu JF.
  TITLE     GCN5 regulates ZBTB16 through acetylation, mediates osteogenic
            differentiation, and affects orthodontic tooth movement
  JOURNAL   Biochem Cell Biol 101 (3), 235-245 (2023)
   PUBMED   36786377
  REMARK    GeneRIF: GCN5 regulates ZBTB16 through acetylation, mediates
            osteogenic differentiation, and affects orthodontic tooth movement.
REFERENCE   2  (bases 1 to 2306)
  AUTHORS   Liska F, Landa V, Zidek V, Mlejnek P, Silhavy J, Simakova M, Strnad
            H, Trnovska J, Skop V, Kazdova L, Starker CG, Voytas DF, Izsvak Z,
            Mancini M, Seda O, Kren V and Pravenec M.
  TITLE     Downregulation of Plzf Gene Ameliorates Metabolic and Cardiac
            Traits in the Spontaneously Hypertensive Rat
  JOURNAL   Hypertension 69 (6), 1084-1091 (2017)
   PUBMED   28396530
REFERENCE   3  (bases 1 to 2306)
  AUTHORS   Liska F, Peterkova R, Peterka M, Landa V, Zidek V, Mlejnek P,
            Silhavy J, Simakova M, Kren V, Starker CG, Voytas DF, Izsvak Z and
            Pravenec M.
  TITLE     Targeting of the Plzf Gene in the Rat by Transcription
            Activator-Like Effector Nuclease Results in Caudal Regression
            Syndrome in Spontaneously Hypertensive Rats
  JOURNAL   PLoS One 11 (10), e0164206 (2016)
   PUBMED   27727328
  REMARK    GeneRIF: All homozygous PLZF gene mutated animals exhibited
            manifestations of a caudal regression syndrome including tail
            anomalies and serious size reduction and deformities of long bones,
            and oligo- or polydactyly on the hindlimbs.
            Erratum:[PLoS One. 2020 Jan 16;15(1):e0228139. PMID: 31945126]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2306)
  AUTHORS   Yachie N, Petsalaki E, Mellor JC, Weile J, Jacob Y, Verby M, Ozturk
            SB, Li S, Cote AG, Mosca R, Knapp JJ, Ko M, Yu A, Gebbia M, Sahni
            N, Yi S, Tyagi T, Sheykhkarimli D, Roth JF, Wong C, Musa L, Snider
            J, Liu YC, Yu H, Braun P, Stagljar I, Hao T, Calderwood MA,
            Pelletier L, Aloy P, Hill DE, Vidal M and Roth FP.
  TITLE     Pooled-matrix protein interaction screens using Barcode Fusion
            Genetics
  JOURNAL   Mol Syst Biol 12 (4), 863 (2016)
   PUBMED   27107012
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2306)
  AUTHORS   Simpson MT, Venkatesh I, Callif BL, Thiel LK, Coley DM, Winsor KN,
            Wang Z, Kramer AA, Lerch JK and Blackmore MG.
  TITLE     The tumor suppressor HHEX inhibits axon growth when prematurely
            expressed in developing central nervous system neurons
  JOURNAL   Mol Cell Neurosci 68, 272-283 (2015)
   PUBMED   26306672
  REMARK    GeneRIF: This study idnetifed that the ZBTB16 as inhibitors of
            neurite outgrowth.
REFERENCE   6  (bases 1 to 2306)
  AUTHORS   Koken MH, Reid A, Quignon F, Chelbi-Alix MK, Davies JM, Kabarowski
            JH, Zhu J, Dong S, Chen S, Chen Z, Tan CC, Licht J, Waxman S, de
            The H and Zelent A.
  TITLE     Leukemia-associated retinoic acid receptor alpha fusion partners,
            PML and PLZF, heterodimerize and colocalize to nuclear bodies
  JOURNAL   Proc Natl Acad Sci U S A 94 (19), 10255-10260 (1997)
   PUBMED   9294197
REFERENCE   7  (bases 1 to 2306)
  AUTHORS   Dong S, Zhu J, Reid A, Strutt P, Guidez F, Zhong HJ, Wang ZY, Licht
            J, Waxman S, Chomienne C, Chen Z, Zelent A and Chen SJ.
  TITLE     Amino-terminal protein-protein interaction motif (POZ-domain) is
            responsible for activities of the promyelocytic leukemia zinc
            finger-retinoic acid receptor-alpha fusion protein
  JOURNAL   Proc Natl Acad Sci U S A 93 (8), 3624-3629 (1996)
   PUBMED   8622986
REFERENCE   8  (bases 1 to 2306)
  AUTHORS   Reid A, Gould A, Brand N, Cook M, Strutt P, Li J, Licht J, Waxman
            S, Krumlauf R and Zelent A.
  TITLE     Leukemia translocation gene, PLZF, is expressed with a speckled
            nuclear pattern in early hematopoietic progenitors
  JOURNAL   Blood 86 (12), 4544-4552 (1995)
   PUBMED   8541544
REFERENCE   9  (bases 1 to 2306)
  AUTHORS   Chen SJ, Zelent A, Tong JH, Yu HQ, Wang ZY, Derre J, Berger R,
            Waxman S and Chen Z.
  TITLE     Rearrangements of the retinoic acid receptor alpha and
            promyelocytic leukemia zinc finger genes resulting from
            t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia
  JOURNAL   J Clin Invest 91 (5), 2260-2267 (1993)
   PUBMED   8387545
REFERENCE   10 (bases 1 to 2306)
  AUTHORS   Dagg,C.P.
  TITLE     Combined action of fluorouracil and two mutant genes on limb
            development in the mouse
  JOURNAL   J Exp Zool 164 (3), 479-489 (1967)
   PUBMED   6068186
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY781102.1.
            
            On Apr 20, 2005 this sequence version replaced XM_345936.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY781102.1, AY781103.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476, SAMN16676807
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2306
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="PD/Cub"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..2306
                     /gene="Zbtb16"
                     /gene_synonym="Lx; Plzf; Zfp145; Znf145"
                     /note="zinc finger and BTB domain containing 16"
                     /db_xref="GeneID:353227"
                     /db_xref="RGD:727921"
     exon            1..71
                     /gene="Zbtb16"
                     /gene_synonym="Lx; Plzf; Zfp145; Znf145"
                     /inference="alignment:Splign:2.1.0"
     exon            72..1428
                     /gene="Zbtb16"
                     /gene_synonym="Lx; Plzf; Zfp145; Znf145"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..2182
                     /gene="Zbtb16"
                     /gene_synonym="Lx; Plzf; Zfp145; Znf145"
                     /note="Polydactyly-luxate syndrome; promyelocytic leukemia
                     zinc finger; zinc finger protein 145; zinc finger and BTB
                     domain containing 16 protein"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein
                     16"
                     /protein_id="NP_001013199.1"
                     /db_xref="GeneID:353227"
                     /db_xref="RGD:727921"
                     /translation="MDLTKMGMIQLQNPSHPTGLLCKANQMRLAGTLCDVVIMVDSQE
                     FHAHRTVLACTSKMFEILFHRNSQHYTLDFLSPKTFQQILEYAYTATLQAKAEDLDDL
                     LYAAEILEIEYLEEQCLKILETIQASDDNDTEATMADGGGEEEEDRKARYLKNIFISK
                     HSGEESGYANVAGQSLPGPMVDQSPSVSTSFGLSAMSPTKAAVDSLMTIGQSLLQGAL
                     QPPAGPEEPTLAGGGRHPGVAEVHMEMMQVDEAPGQDSPGAAESSVSGGMGDKLEERS
                     KEGPGTPTRGSVITSARELHYGREESGEQLSPPVEAGQGPPGRQESLAPPVEKHLGIY
                     SVLPNHKADAVLSMPSSVTSGLHVQPALAVSMDFSTYGGLLPQGFIQRELFSKLGELA
                     VGMKAESRPLGEQCSVCGVELPDNEAVEQHRKLHSGMKTYGCELCGKRFLDSLRLRMH
                     LLAHSAGAKAFVCDQCGAQFSKEDALETHRQTHTGTDMAVFCLLCGKRFQAQSALQQH
                     MEVHAGVRSYICSECNRTFPSHTALKRHLRSHTGDHPYECEFCGSCFRDESTLKSHKR
                     IHTGEKPYECNGCGKKFSLKHQLETHYRVHTGEKPFECKLCHQRSRDYSAMIKHLRTH
                     NGASPYQCTICTEYCPSLSSMQKHMKGHKPEEIPPDWRIEKTYLYLCYV"
     exon            1429..1526
                     /gene="Zbtb16"
                     /gene_synonym="Lx; Plzf; Zfp145; Znf145"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1613
                     /gene="Zbtb16"
                     /gene_synonym="Lx; Plzf; Zfp145; Znf145"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1784
                     /gene="Zbtb16"
                     /gene_synonym="Lx; Plzf; Zfp145; Znf145"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1952
                     /gene="Zbtb16"
                     /gene_synonym="Lx; Plzf; Zfp145; Znf145"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2306
                     /gene="Zbtb16"
                     /gene_synonym="Lx; Plzf; Zfp145; Znf145"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttccccgatc caggcacacc cctaaccccc caggcacgca cacccacccc aagctcccgg
       61 ctctgcaagc gacccctctg ctggccccga agcccaccct gccccacctt gcagagcaga
      121 gaaggaaaga gagccccatg cctgagccca ggggagcatc atggatctga caaagatggg
      181 tatgatccaa ctgcagaacc ctagccaccc cacggggctg ctgtgcaagg ccaatcagat
      241 gcgactggcc gggactttgt gcgatgtggt catcatggtg gacagtcagg agttccatgc
      301 ccaccggacg gtgctagcct gcaccagcaa gatgtttgag atcctcttcc accggaacag
      361 ccagcactac accctggact tcctctcgcc gaaaaccttc cagcagatcc tcgagtatgc
      421 ctacacagcc acactgcaag ccaaagcaga ggacctggat gacctgctgt acgcagctga
      481 gatcctagag atcgagtacc tggaggagca gtgcctgaag atcctggaga ccatccaagc
      541 atctgatgac aatgacacag aagccaccat ggccgacggt gggggcgaag aagaagagga
      601 ccgtaaggct cgatacctca agaacatctt catctcgaag cattccggcg aggagagcgg
      661 ctatgccaat gtggctggac agagcctccc tgggcccatg gtagaccaga gcccctcggt
      721 ctccacctct tttggtctct cagccatgag tcctaccaag gcagcagtgg acagtttgat
      781 gaccatagga cagtcactcc tgcaaggagc tcttcagcca cctgcagggc ctgaggaacc
      841 cacactggca gggggtgggc ggcaccctgg ggtggctgag gtgcatatgg agatgatgca
      901 ggtagatgaa gcccccggcc aggacagccc tggggcagct gagtctagcg tctcaggagg
      961 gatgggggac aagcttgaag agaggagcaa agaggggcct gggaccccca ctagaggcag
     1021 tgtcatcacc agtgctaggg agctgcacta tgggagagag gagagtggtg agcagctctc
     1081 accccctgtt gaagctggcc agggaccccc tggacgacag gagtccctgg caccaccagt
     1141 ggagaagcat ttgggcatct actcagtgtt gcccaaccac aaggccgatg ccgtgttgag
     1201 catgccgtct tcagtgacat ctggtctcca tgtgcaacct gccctggcag tctccatgga
     1261 cttcagcacc tatgggggtc tgctgcctca gggcttcatc cagagggagc tgttcagcaa
     1321 gctaggtgag ctggccgtgg gcatgaaggc ggagagccgt cctctcgggg agcagtgcag
     1381 tgtgtgtggg gtcgaacttc cggacaacga ggccgtggag cagcacagga agctgcacag
     1441 tgggatgaag acatacggat gcgaactctg tggaaaacgg ttcctggata gtttgcgact
     1501 gagaatgcat ttactggctc attcagcggg tgccaaagcc tttgtatgtg atcagtgtgg
     1561 cgcccagttc tcaaaggaag atgccctgga gacacacaga cagacccata ctggcacgga
     1621 catggctgtc ttctgtctgc tgtgtgggaa gcgctttcag gcacagagtg cactccagca
     1681 acacatggag gtccacgcag gcgtgcgcag ctatatctgc agcgagtgca accgcacctt
     1741 ccccagccac acggctctca agcgccacct tcgctcacat acaggtgacc acccatatga
     1801 gtgtgagttc tgtggcagct gcttccggga tgagagcaca ctcaagagcc acaagcgcat
     1861 ccacacaggg gagaagccct atgagtgtaa tggctgtggc aagaagttca gcctcaagca
     1921 ccagctggag acgcactaca gggttcacac aggtgagaag ccctttgagt gcaaactctg
     1981 ccaccagcgc tcccgagact actcggccat gatcaagcac ctgagaacac acaatggtgc
     2041 ctcaccctac caatgcacca tctgcacgga atactgcccc agcctctcct ccatgcagaa
     2101 gcacatgaag ggccacaagc cggaggagat cccgcctgac tggaggatag agaagacata
     2161 cctctacctg tgttatgtgt gaatggggga cacacccctc cccccaacat atggtagagc
     2221 catggcagga gccagcaaag gcaagctaga gcgagacaaa gtggaaagac tgtggagaaa
     2281 aggaataaca gaaaagaaaa ggggaa
//
