LOCUS       NM_133564               1692 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus Z-DNA binding protein 1 (Zbp1), mRNA.
ACCESSION   NM_133564 XM_001054526 XM_342594
VERSION     NM_133564.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1692)
  AUTHORS   Shi,K., Wang,X., Ke,Z. and Li,J.
  TITLE     The role of ZBP1 in eccentric exercise-induced skeletal muscle
            necroptosis
  JOURNAL   J Muscle Res Cell Motil 44 (4), 311-323 (2023)
   PUBMED   37889396
  REMARK    GeneRIF: The role of ZBP1 in eccentric exercise-induced skeletal
            muscle necroptosis.
REFERENCE   2  (bases 1 to 1692)
  AUTHORS   Guo,H., Chen,R., Li,P., Yang,Q. and He,Y.
  TITLE     ZBP1 mediates the progression of Alzheimer's disease via pyroptosis
            by regulating IRF3
  JOURNAL   Mol Cell Biochem 478 (12), 2849-2860 (2023)
   PUBMED   36964897
  REMARK    GeneRIF: ZBP1 mediates the progression of Alzheimer's disease via
            pyroptosis by regulating IRF3.
REFERENCE   3  (bases 1 to 1692)
  AUTHORS   Qiannan-Di, Qianqian-Jiang, Jiahui-Sun, Haowei-Fu and Qian-Xu.
  TITLE     LncRNA PVT1 mediates the progression of liver necroptosis via ZBP1
            promoter methylation under nonylphenol exposure
  JOURNAL   Sci Total Environ 844, 157185 (2022)
   PUBMED   35803419
  REMARK    GeneRIF: LncRNA PVT1 mediates the progression of liver necroptosis
            via ZBP1 promoter methylation under nonylphenol exposure.
REFERENCE   4  (bases 1 to 1692)
  AUTHORS   Urbanska,A.S., Janusz-Kaminska,A., Switon,K., Hawthorne,A.L.,
            Perycz,M., Urbanska,M., Bassell,G.J. and Jaworski,J.
  TITLE     ZBP1 phosphorylation at serine 181 regulates its dendritic
            transport and the development of dendritic trees of hippocampal
            neurons
  JOURNAL   Sci Rep 7 (1), 1876 (2017)
   PUBMED   28500298
  REMARK    GeneRIF: Ser181 ZBP1 phosphorylation was essential for the proper
            dendritic branching of hippocampal neurons that were cultured in
            vitro and for the proper ZBP1 dendritic distribution and motility.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1692)
  AUTHORS   Kim,H.H., Lee,S.J., Gardiner,A.S., Perrone-Bizzozero,N.I. and
            Yoo,S.
  TITLE     Different motif requirements for the localization zipcode element
            of beta-actin mRNA binding by HuD and ZBP1
  JOURNAL   Nucleic Acids Res 43 (15), 7432-7446 (2015)
   PUBMED   26152301
  REMARK    GeneRIF: Both ZBP1 and HuD bind the zipcode element in rat
            beta-actin mRNA's 3' UTR. Differences between HuD and ZBP1 were
            observed in their binding preference to the element.
REFERENCE   6  (bases 1 to 1692)
  AUTHORS   Burckstummer,T., Baumann,C., Bluml,S., Dixit,E., Durnberger,G.,
            Jahn,H., Planyavsky,M., Bilban,M., Colinge,J., Bennett,K.L. and
            Superti-Furga,G.
  TITLE     An orthogonal proteomic-genomic screen identifies AIM2 as a
            cytoplasmic DNA sensor for the inflammasome
  JOURNAL   Nat Immunol 10 (3), 266-272 (2009)
   PUBMED   19158679
REFERENCE   7  (bases 1 to 1692)
  AUTHORS   Ha,S.C., Kim,D., Hwang,H.Y., Rich,A., Kim,Y.G. and Kim,K.K.
  TITLE     The crystal structure of the second Z-DNA binding domain of human
            DAI (ZBP1) in complex with Z-DNA reveals an unusual binding mode to
            Z-DNA
  JOURNAL   Proc Natl Acad Sci U S A 105 (52), 20671-20676 (2008)
   PUBMED   19095800
REFERENCE   8  (bases 1 to 1692)
  AUTHORS   Takaoka,A., Wang,Z., Choi,M.K., Yanai,H., Negishi,H., Ban,T.,
            Lu,Y., Miyagishi,M., Kodama,T., Honda,K., Ohba,Y. and Taniguchi,T.
  TITLE     DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of
            innate immune response
  JOURNAL   Nature 448 (7152), 501-505 (2007)
   PUBMED   17618271
REFERENCE   9  (bases 1 to 1692)
  AUTHORS   Rothenburg,S., Schwartz,T., Koch-Nolte,F. and Haag,F.
  TITLE     Complex regulation of the human gene for the Z-DNA binding protein
            DLM-1
  JOURNAL   Nucleic Acids Res 30 (4), 993-1000 (2002)
   PUBMED   11842111
REFERENCE   10 (bases 1 to 1692)
  AUTHORS   Schwartz,T., Behlke,J., Lowenhaupt,K., Heinemann,U. and Rich,A.
  TITLE     Structure of the DLM-1-Z-DNA complex reveals a conserved family of
            Z-DNA-binding proteins
  JOURNAL   Nat Struct Biol 8 (9), 761-765 (2001)
   PUBMED   11524677
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On or before Feb 13, 2013 this sequence version replaced
            XM_342594.2, XM_001054526.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ302054.1, SRR26643288.17096.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                JAXUCZ010000003.1  182421984-182422017 c
            35-274              JAXUCZ010000003.1  182420127-182420366 c
            275-466             JAXUCZ010000003.1  182418981-182419172 c
            467-634             JAXUCZ010000003.1  182417105-182417272 c
            635-838             JAXUCZ010000003.1  182415551-182415754 c
            839-1054            JAXUCZ010000003.1  182414172-182414387 c
            1055-1231           JAXUCZ010000003.1  182412967-182413143 c
            1232-1692           JAXUCZ010000003.1  182411665-182412125 c
FEATURES             Location/Qualifiers
     source          1..1692
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..1692
                     /gene="Zbp1"
                     /gene_synonym="Dlm1"
                     /note="Z-DNA binding protein 1"
                     /db_xref="GeneID:171091"
                     /db_xref="RGD:619956"
     CDS             1..1230
                     /gene="Zbp1"
                     /gene_synonym="Dlm1"
                     /note="tumor stroma and activated macrophage protein
                     DLM-1"
                     /codon_start=1
                     /product="Z-DNA-binding protein 1"
                     /protein_id="NP_598248.1"
                     /db_xref="GeneID:171091"
                     /db_xref="RGD:619956"
                     /translation="MAEASVDLGTGDNLEQKILQVLSDAGSPVQIDQLLKKLQVPKKI
                     LNQVLYRLKKEGRVSSPAPATWSLGGDGASGDGAPEIPEDSAAQPSLEERILRFLETK
                     GPQRALHIAKALGMTTAKEVNPILYSMRNKHLLTVSDTQMWTIYRSSQEGQERACSGV
                     GQESPAVIYQQNPINMICQQGPNSLISISNSKAIQIGHGNVMSRQTICGDPGPGTPHH
                     APLPVLEDAAAQDTPPGTHGAQLIHLNKSMLRRVQLGHGNEMNLERDPVEHPIFSFSS
                     SPPESTTTADPETAFNMQTPEPGPHPEGGTTQIVHIKSCLLEDTTVGNNNKMTIHRRS
                     KGGAKESADSQELKEDTGASSEATPPRSCLHTPSDSTLLTSELTAMALGDGSPQITES
                     MLREDEVQAAETCQTQD"
     exon            1..34
                     /gene="Zbp1"
                     /gene_synonym="Dlm1"
                     /inference="alignment:Splign:2.1.0"
     exon            35..274
                     /gene="Zbp1"
                     /gene_synonym="Dlm1"
                     /inference="alignment:Splign:2.1.0"
     exon            275..466
                     /gene="Zbp1"
                     /gene_synonym="Dlm1"
                     /inference="alignment:Splign:2.1.0"
     exon            467..634
                     /gene="Zbp1"
                     /gene_synonym="Dlm1"
                     /inference="alignment:Splign:2.1.0"
     exon            635..838
                     /gene="Zbp1"
                     /gene_synonym="Dlm1"
                     /inference="alignment:Splign:2.1.0"
     exon            839..1054
                     /gene="Zbp1"
                     /gene_synonym="Dlm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1231
                     /gene="Zbp1"
                     /gene_synonym="Dlm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1692
                     /gene="Zbp1"
                     /gene_synonym="Dlm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcggagg cttctgtgga cctgggcacg ggagacaacc tggagcagaa gatcctgcag
       61 gtgttgagtg atgctggtag tcctgtgcag atcgaccagc tgttgaagaa gttacaagtg
      121 cccaagaaaa tcctcaacca agtcctttac cgcctgaaga aagagggccg agtgtcctcg
      181 ccggcgccag cgacgtggtc cttaggtgga gatggggctt ccggagatgg ggctcccgag
      241 atccctgagg actccgctgc ccagcctagc cttgaagaaa ggatattaag attcctggag
      301 actaaagggc cccagagggc cctgcatatc gccaaggctc tgggaatgac gacggccaaa
      361 gaagtgaacc ccatcctgta ttccatgagg aataagcacc ttctgaccgt gtctgacaca
      421 cagatgtgga ccatctaccg ctcaagccag gaaggccaag agcgagcttg ttccggagtc
      481 ggacaagagt cccctgcggt tatttaccag caaaatccga tcaacatgat ctgccaacaa
      541 ggacccaaca gcctcatctc tatttccaac tcaaaagcca tccagattgg ccatgggaat
      601 gttatgtcaa gacagacaat ctgtggtgac ccaggtcccg ggactcctca ccacgcccct
      661 ctacccgtgc tagaggatgc tgctgctcag gacacgcccc ctggtaccca cggagctcaa
      721 ctcatccacc tgaacaagtc catgctccga cgtgtgcagc tcggccacgg caacgagatg
      781 aacctcgaga gggatccagt ggaacacccc attttcagct ttagtagtag ccccccagag
      841 tcaaccacca ctgcagaccc agaaactgca ttcaacatgc aaacacctga gccaggccct
      901 caccctgagg gaggcacaac ccagatagtc cacatcaaat cctgcttgct agaggacacg
      961 accgtcggca acaacaacaa gatgaccatc caccgtaggt caaagggtgg agccaaggag
     1021 tctgcagaca gccaagaact gaaagaagac acaggtgcaa gttctgaagc cacgccaccc
     1081 agaagctgct tgcacacacc cagcgactcc accctgctca cctctgagct gacagctatg
     1141 gctctgggag atggcagccc ccagatcaca gaatctatgc ttagagagga tgaagtgcag
     1201 gccgcagaaa cctgtcagac gcaggactga ggccagaaag caatggagcc acaagaccat
     1261 agacctctct gccaccatga gccaaaccaa cctttcctgc ctcaagatca atgaatcaat
     1321 caatacatcg atcagtcaac catatgagcc agttgtacca ctcctgggtg ttcaccggaa
     1381 gggaaaagtc aacacagaga gacgtctgca tatccatgca gacggtggtc ctgttcccag
     1441 cagataagag atggaaccaa ccttgctgtc ccgcagtaaa agatgggcga atgtggagta
     1501 gcacacagcc atgaaaaata ctgaggttgt cattggctgg aagaagatga caccagagac
     1561 caccacgtta agtgaatgaa agccatctta gaatgacaac ggtcacgtct tcctctcttt
     1621 tgtggctcct ggactttatg atagattcct ggaatcatac acagatgtga cattaaagta
     1681 cacgtgacac ca
//
