LOCUS       NM_001012002            2277 bp    mRNA    linear   ROD 05-MAR-2024
DEFINITION  Rattus norvegicus zeta chain of T cell receptor associated protein
            kinase 70 (Zap70), mRNA.
ACCESSION   NM_001012002 XM_217382
VERSION     NM_001012002.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2277)
  AUTHORS   Xuan,J., Zhang,J., He,J., Zhao,K., Miao,S., Chen,G. and Wei,S.
  TITLE     RNA-Sequencing Analysis and Expression of Lymphocyte-Specific
            Protein Tyrosine Kinase, Linker for Activation of T Cells, and
            70-kDa T-Cell Receptor Zeta-Chain Associated Protein Kinase in Rat
            Liver Transplant Rejection
  JOURNAL   Exp Clin Transplant 21 (12), 961-972 (2023)
   PUBMED   38263783
  REMARK    GeneRIF: RNA-Sequencing Analysis and Expression of
            Lymphocyte-Specific Protein Tyrosine Kinase, Linker for Activation
            of T Cells, and 70-kDa T-Cell Receptor Zeta-Chain Associated
            Protein Kinase in Rat Liver Transplant Rejection.
REFERENCE   2  (bases 1 to 2277)
  AUTHORS   Liang,Y., Cucchetti,M., Roncagalli,R., Yokosuka,T., Malzac,A.,
            Bertosio,E., Imbert,J., Nijman,I.J., Suchanek,M., Saito,T.,
            Wulfing,C., Malissen,B. and Malissen,M.
  TITLE     The lymphoid lineage-specific actin-uncapping protein Rltpr is
            essential for costimulation via CD28 and the development of
            regulatory T cells
  JOURNAL   Nat Immunol 14 (8), 858-866 (2013)
   PUBMED   23793062
REFERENCE   3  (bases 1 to 2277)
  AUTHORS   Chiang,Y.J., Ho,K.C., Sun,C.T., Chiu,J.J., Lee,F.J., Liao,F.,
            Yang-Yen,H.F. and Yen,J.J.
  TITLE     CBAP functions as a novel component in chemokine-induced
            ZAP70-mediated T-cell adhesion and migration
  JOURNAL   PLoS One 8 (4), e61761 (2013)
   PUBMED   23620790
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2277)
  AUTHORS   Lesourne,R., Zvezdova,E., Song,K.D., El-Khoury,D., Uehara,S.,
            Barr,V.A., Samelson,L.E. and Love,P.E.
  TITLE     Interchangeability of Themis1 and Themis2 in thymocyte development
            reveals two related proteins with conserved molecular function
  JOURNAL   J Immunol 189 (3), 1154-1161 (2012)
   PUBMED   22732588
REFERENCE   5  (bases 1 to 2277)
  AUTHORS   Hatterer,E., Benon,A., Chounlamountri,N., Watrin,C., Angibaud,J.,
            Jouanneau,E., Boudin,H., Honnorat,J., Pellier-Monnin,V. and
            Noraz,N.
  TITLE     Syk kinase is phosphorylated in specific areas of the developing
            nervous system
  JOURNAL   Neurosci Res 70 (2), 172-182 (2011)
   PUBMED   21354221
  REMARK    GeneRIF: ZAP-70 is present in neurons of different structures
            including the cerebellum, the hippocampus, the visual system and
            the olfactory system.
REFERENCE   6  (bases 1 to 2277)
  AUTHORS   Negishi,I., Motoyama,N., Nakayama,K., Nakayama,K., Senju,S.,
            Hatakeyama,S., Zhang,Q., Chan,A.C. and Loh,D.Y.
  TITLE     Essential role for ZAP-70 in both positive and negative selection
            of thymocytes
  JOURNAL   Nature 376 (6539), 435-438 (1995)
   PUBMED   7630421
REFERENCE   7  (bases 1 to 2277)
  AUTHORS   Gauen,L.K., Zhu,Y., Letourneur,F., Hu,Q., Bolen,J.B., Matis,L.A.,
            Klausner,R.D. and Shaw,A.S.
  TITLE     Interactions of p59fyn and ZAP-70 with T-cell receptor activation
            motifs: defining the nature of a signalling motif
  JOURNAL   Mol Cell Biol 14 (6), 3729-3741 (1994)
   PUBMED   8196616
REFERENCE   8  (bases 1 to 2277)
  AUTHORS   Chan,A.C., van Oers,N.S., Tran,A., Turka,L., Law,C.L., Ryan,J.C.,
            Clark,E.A. and Weiss,A.
  TITLE     Differential expression of ZAP-70 and Syk protein tyrosine kinases,
            and the role of this family of protein tyrosine kinases in TCR
            signaling
  JOURNAL   J Immunol 152 (10), 4758-4766 (1994)
   PUBMED   8176201
REFERENCE   9  (bases 1 to 2277)
  AUTHORS   Arpaia,E., Shahar,M., Dadi,H., Cohen,A. and Roifman,C.M.
  TITLE     Defective T cell receptor signaling and CD8+ thymic selection in
            humans lacking zap-70 kinase
  JOURNAL   Cell 76 (5), 947-958 (1994)
   PUBMED   8124727
REFERENCE   10 (bases 1 to 2277)
  AUTHORS   Chan,A.C., Iwashima,M., Turck,C.W. and Weiss,A.
  TITLE     ZAP-70: a 70 kd protein-tyrosine kinase that associates with the
            TCR zeta chain
  JOURNAL   Cell 71 (4), 649-662 (1992)
   PUBMED   1423621
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089855.1.
            
            On Feb 11, 2005 this sequence version replaced XM_217382.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089855.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN06680412
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2277
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q21"
     gene            1..2277
                     /gene="Zap70"
                     /gene_synonym="Srk"
                     /note="zeta chain of T cell receptor associated protein
                     kinase 70"
                     /db_xref="GeneID:301348"
                     /db_xref="RGD:3983"
     exon            1..99
                     /gene="Zap70"
                     /gene_synonym="Srk"
                     /inference="alignment:Splign:2.1.0"
     exon            100..510
                     /gene="Zap70"
                     /gene_synonym="Srk"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1953
                     /gene="Zap70"
                     /gene_synonym="Srk"
                     /EC_number="2.7.10.2"
                     /note="syk-related protein tyrosine kinase; zeta-chain
                     (TCR) associated protein kinase 70"
                     /codon_start=1
                     /product="tyrosine-protein kinase ZAP-70"
                     /protein_id="NP_001012002.1"
                     /db_xref="GeneID:301348"
                     /db_xref="RGD:3983"
                     /translation="MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLG
                     GYVLSLVHDVRFHHFPIERQLNGTYAIAGGKAHCGPAELCQFYSQDPDGLPCNLRKPC
                     NRPPGLEPQPGVFDCLRDAMVRDYVRQTWKLEGDALEQAIISQAPQVEKLIATTAHER
                     MPWYHSSLTREEAERKLYSGQQTDGKFLLRPRKEQGTYALSLVYGKTVYHYLISQDKA
                     GKYCIPEGTKFDTLWQLVEYLKLKADGLIYRLKEVCPNSSASAEAAAPTLPAHPSTFT
                     QPHRRIDTLNSDGYTPEPARLDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRENLLV
                     ADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQSTEKADKDEMMREAQIMHQLDNPY
                     IVRLIGVCQAEALMLVMEMAGGGPLHKFLIGKKEEIPVSNVAELLHQVAMGMKYLEEK
                     NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINF
                     RKFSSRSDVWSYGVTMWEAFSYGQKPYKKMKGPEVLDFIKQGKRMECPPECPPEMYAL
                     MSDCWIYKWEDRPDFVAVEQRMRTYYYSMASRAEGPPQCEQVAEAACG"
     exon            511..671
                     /gene="Zap70"
                     /gene_synonym="Srk"
                     /inference="alignment:Splign:2.1.0"
     exon            672..810
                     /gene="Zap70"
                     /gene_synonym="Srk"
                     /inference="alignment:Splign:2.1.0"
     exon            811..895
                     /gene="Zap70"
                     /gene_synonym="Srk"
                     /inference="alignment:Splign:2.1.0"
     exon            896..939
                     /gene="Zap70"
                     /gene_synonym="Srk"
                     /inference="alignment:Splign:2.1.0"
     exon            940..991
                     /gene="Zap70"
                     /gene_synonym="Srk"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1175
                     /gene="Zap70"
                     /gene_synonym="Srk"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1382
                     /gene="Zap70"
                     /gene_synonym="Srk"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1575
                     /gene="Zap70"
                     /gene_synonym="Srk"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1716
                     /gene="Zap70"
                     /gene_synonym="Srk"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1829
                     /gene="Zap70"
                     /gene_synonym="Srk"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..2209
                     /gene="Zap70"
                     /gene_synonym="Srk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaaaagtg ttggtgagaa aaagtgcacc agggacagca ggccttgcgg ctaggccctg
       61 ccgtgctctg tgagctgtgg tagcgtcgag ggtgtccagg gcccagcgat gcccgacccc
      121 gcggcgcatc tgccattctt ctacggaagc atttcgcggg ccgaggccga ggagcacctg
      181 aagctggcag gcatggccga cggactgttc ctcctgcgcc agtgcctgcg ctcgctgggc
      241 ggctacgtgc tgtcgctagt acacgacgtg cgcttccacc atttccccat cgagcgccaa
      301 ctcaatggca cgtacgccat cgcgggcggc aaggcgcact gcggcccggc cgagctctgc
      361 cagttctact cgcaggaccc cgacggactg ccctgcaatc tgcgtaagcc atgcaaccgg
      421 ccgccgggac ttgagcctca gcccggggtc ttcgactgcc tgcgcgatgc tatggtgcgg
      481 gactacgtgc gccagacctg gaaactggag ggtgatgcac tagagcaggc catcatcagc
      541 caggccccac aggtggagaa gctcattgct accacagccc acgagcgaat gccctggtac
      601 cacagcagcc tgactcgcga ggaggctgag cgcaaactct attctggcca gcagaccgac
      661 ggcaagttcc tgctgagacc ccggaaggag cagggcacat atgcgctgtc cctggtctac
      721 gggaaaactg tgtaccacta tctcatcagc caggacaagg ctggcaagta ctgtatcccc
      781 gaaggcacca agtttgatac gctctggcag ctggtggagt acctgaagct gaaggcagat
      841 ggactcattt atcgcctgaa ggaggtctgt cccaacagca gtgccagcgc cgaagctgct
      901 gcacccacgc tcccagccca cccatccaca ttcactcagc ctcacagacg aattgatacc
      961 ctgaactcag acggatacac ccctgaacca gcacgcttag acaagccacg accgatgccc
     1021 atggacacga gcgtgtacga gagcccctac agcgaccccg aggaactcaa ggacaagaag
     1081 ctcttcctga agcgagagaa cctcctcgtg gccgacatcg aacttggttg cggcaacttt
     1141 ggctcagtgc gccagggagt ctaccgcatg cgcaagaagc agatcgacgt ggccatcaag
     1201 gtgctaaagc agagcacaga gaaagctgac aaggatgaga tgatgcggga ggcccagatc
     1261 atgcatcagc tcgacaaccc ctacattgtg cggctcatcg gcgtgtgcca ggcagaggcg
     1321 ctcatgctgg tcatggagat ggcaggaggc gggccactgc acaagttcct gattggaaaa
     1381 aaggaggaga tcccggtgag caacgtggct gaactgctgc accaggtggc catgggcatg
     1441 aagtatttgg aggagaagaa ctttgtgcac cgtgacctgg cagcccggaa tgttctactg
     1501 gtcaatcggc actatgccaa gatcagcgac tttggcctgt ccaaggcact gggtgctgat
     1561 gacagctatt acacagcccg ttctgcaggg aagtggcctc tgaagtggta cgcaccagaa
     1621 tgcatcaact tccggaagtt ctccagccgc agtgatgtct ggagctatgg ggtcaccatg
     1681 tgggaggcct tctcctatgg ccagaagccc tacaagaaga tgaagggccc tgaggtcctg
     1741 gatttcatca agcagggtaa gaggatggaa tgccctccag agtgtccgcc cgaaatgtac
     1801 gcgcttatga gtgactgctg gatatacaag tgggaggatc gtcccgattt cgtggctgtg
     1861 gaacaacgaa tgaggaccta ttactacagc atggctagcc gggcagaggg acccccacag
     1921 tgtgaacagg tggccgaggc tgcatgtggc tgagccccaa gcctccctac cctcagcctt
     1981 gcttagttag ccttactctc tctgcacagg atgggctgta ttcaggagcc caatcgaccg
     2041 tcccatgtga ttctccccgc ctcatggctg gggctgatgg gacactggta aacatcacca
     2101 gtgggccgag agtgtatgtg ctcccaaatc tacttccgct atttctgtgg gagctcagag
     2161 tcctccaggg gtcactgtca ttcatcggaa taaactccac ttctctttaa aaaaaaaaaa
     2221 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
