LOCUS       NM_173290               6229 bp    mRNA    linear   ROD 23-JUL-2024
DEFINITION  Rattus norvegicus YY1 transcription factor (Yy1), mRNA.
ACCESSION   NM_173290 XM_001069615
VERSION     NM_173290.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6229)
  AUTHORS   Fu,X., Xiao,P., Luo,X. and Guo,N.
  TITLE     Transcription factor YY1 accelerates hepatic fibrosis development
            by activating NLRP3 inflammasome-mediated pyroptosis
  JOURNAL   Histol Histopathol 39 (8), 1079-1087 (2024)
   PUBMED   38264929
  REMARK    GeneRIF: Transcription factor YY1 accelerates hepatic fibrosis
            development by activating NLRP3 inflammasome-mediated pyroptosis.
REFERENCE   2  (bases 1 to 6229)
  AUTHORS   Fu,X., Luo,X., Xiao,P. and Guo,N.
  TITLE     Yin Yang 1 facilitates the activation, inflammation, and
            extracellular matrix deposition of hepatic stellate cells in
            hepatic fibrosis
  JOURNAL   Pathol Int 74 (4), 197-209 (2024)
   PUBMED   38353379
  REMARK    GeneRIF: Yin Yang 1 facilitates the activation, inflammation, and
            extracellular matrix deposition of hepatic stellate cells in
            hepatic fibrosis.
REFERENCE   3  (bases 1 to 6229)
  AUTHORS   Lu,J., Jin,K., Jiao,J., Liu,R., Mou,T., Chen,B., Zhang,Z.,
            Jiang,C., Zhao,H., Wang,Z., Zhou,R. and Huang,M.
  TITLE     YY1 (Yin-Yang 1), a transcription factor regulating systemic
            inflammation, is involved in cognitive impairment of depression
  JOURNAL   Psychiatry Clin Neurosci 77 (3), 149-159 (2023)
   PUBMED   36436207
  REMARK    GeneRIF: YY1 (Yin-Yang 1), a transcription factor regulating
            systemic inflammation, is involved in cognitive impairment of
            depression.
REFERENCE   4  (bases 1 to 6229)
  AUTHORS   Sun,M., Sun,Y., Ma,J. and Li,K.
  TITLE     YY1 promotes SOCS3 expression to inhibit STAT3-mediated
            neuroinflammation and neuropathic pain
  JOURNAL   Mol Med Rep 23 (2) (2021)
   PUBMED   33300076
  REMARK    GeneRIF: YY1 promotes SOCS3 expression to inhibit STAT3mediated
            neuroinflammation and neuropathic pain.
REFERENCE   5  (bases 1 to 6229)
  AUTHORS   Nakayama,T., Fukutomi,T., Terao,Y. and Akagawa,K.
  TITLE     Syntaxin 1A Gene Is Negatively Regulated in a Cell/Tissue Specific
            Manner by YY1 Transcription Factor, Which Binds to the -183 to -137
            Promoter Region Together with Gene Silencing Factors Including
            Histone Deacetylase
  JOURNAL   Biomolecules 11 (2), 146 (2021)
   PUBMED   33498722
  REMARK    GeneRIF: Syntaxin 1A Gene Is Negatively Regulated in a Cell/Tissue
            Specific Manner by YY1 Transcription Factor, Which Binds to the
            -183 to -137 Promoter Region Together with Gene Silencing Factors
            Including Histone Deacetylase.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6229)
  AUTHORS   Patten,M., Wang,W., Aminololama-Shakeri,S., Burson,M. and Long,C.S.
  TITLE     IL-1 beta increases abundance and activity of the negative
            transcriptional regulator yin yang-1 (YY1) in neonatal rat cardiac
            myocytes
  JOURNAL   J Mol Cell Cardiol 32 (7), 1341-1352 (2000)
   PUBMED   10860774
REFERENCE   7  (bases 1 to 6229)
  AUTHORS   Ko,Y.G., Kang,Y.S., Kim,E.K., Park,S.G. and Kim,S.
  TITLE     Nucleolar localization of human methionyl-tRNA synthetase and its
            role in ribosomal RNA synthesis
  JOURNAL   J Cell Biol 149 (3), 567-574 (2000)
   PUBMED   10791971
REFERENCE   8  (bases 1 to 6229)
  AUTHORS   Bergad,P.L., Towle,H.C. and Berry,S.A.
  TITLE     Yin-yang 1 and glucocorticoid receptor participate in the
            Stat5-mediated growth hormone response of the serine protease
            inhibitor 2.1 gene
  JOURNAL   J Biol Chem 275 (11), 8114-8120 (2000)
   PUBMED   10713133
REFERENCE   9  (bases 1 to 6229)
  AUTHORS   Du,K., Leu,J.I., Peng,Y. and Taub,R.
  TITLE     Transcriptional up-regulation of the delayed early gene HRS/SRp40
            during liver regeneration. Interactions among YY1, GA-binding
            proteins, and mitogenic signals
  JOURNAL   J Biol Chem 273 (52), 35208-35215 (1998)
   PUBMED   9857059
REFERENCE   10 (bases 1 to 6229)
  AUTHORS   Lindenmuth,D.M., van Wijnen,A.J., Hiebert,S., Stein,J.L., Lian,J.B.
            and Stein,G.S.
  TITLE     Subcellular partitioning of transcription factors during osteoblast
            differentiation: developmental association of the AML/CBF
            alpha/PEBP2 alpha-related transcription factor-NMP-2 with the
            nuclear matrix
  JOURNAL   J Cell Biochem 66 (1), 123-132 (1997)
   PUBMED   9215534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Sep 17, 2022 this sequence version replaced NM_173290.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.421359.1,
                                           SRR26360190.1460852.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1071              JAXUCZ010000006.1  133471615-133472685
            1072-1234           JAXUCZ010000006.1  133487015-133487177
            1235-1295           JAXUCZ010000006.1  133493690-133493750
            1296-1454           JAXUCZ010000006.1  133495309-133495467
            1455-6229           JAXUCZ010000006.1  133496101-133500875
FEATURES             Location/Qualifiers
     source          1..6229
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..6229
                     /gene="Yy1"
                     /gene_synonym="NF-E1; NMP-1; NMP1; UCRBP"
                     /note="YY1 transcription factor"
                     /db_xref="GeneID:24919"
                     /db_xref="RGD:3982"
     exon            1..1071
                     /gene="Yy1"
                     /gene_synonym="NF-E1; NMP-1; NMP1; UCRBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             402..1637
                     /gene="Yy1"
                     /gene_synonym="NF-E1; NMP-1; NMP1; UCRBP"
                     /codon_start=1
                     /product="transcriptional repressor protein YY1"
                     /protein_id="NP_775412.1"
                     /db_xref="GeneID:24919"
                     /db_xref="RGD:3982"
                     /translation="MASGDTLYIATDGSEMPAEIVELHEIEVETIPVETIETTVVGEE
                     EDDDEDDEDGGGGDHGGGGGHGHAGHHHHHHHHHHPPMIALQPLVTDDPTQVHHHQEV
                     ILVQTREEVVGGDDSDGLRAEDGFEDQILIPVPAPAGGDDDYIEQTLVTVAAAGKSGG
                     GSSSGGGRVKKGGGKKSGKKSYLGSGAGAAGGGGADPGNKKWEQKQVQIKTLEGEFSV
                     TMWSSDEKKDIDHETVVEEQIIGENSPPDYSEYMTGKKLPPGGIPGIDLSDPKQLAEF
                     ARMKPRKIKEDDAPRTIACPHKGCTKMFRDNSAMRKHLHTHGPRVHVCAECGKAFVES
                     SKLKRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPYVCPFDGCNKKFA
                     QSTNLKSHILTHAKAKNNQ"
     exon            1072..1234
                     /gene="Yy1"
                     /gene_synonym="NF-E1; NMP-1; NMP1; UCRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1295
                     /gene="Yy1"
                     /gene_synonym="NF-E1; NMP-1; NMP1; UCRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1454
                     /gene="Yy1"
                     /gene_synonym="NF-E1; NMP-1; NMP1; UCRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..6229
                     /gene="Yy1"
                     /gene_synonym="NF-E1; NMP-1; NMP1; UCRBP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagtgtggc ggcggcggcg gcggcgagat ctgggctcgg gttgaggagt tggtatttgt
       61 gtggaaggag gcggaggcgc aggaggaagg gggcagcgta acgccgtccc ggagggcggg
      121 aggaggcgcg gccagggcag gcagctgagg caaggctagc caggcgggga gcaggacaag
      181 cagcggccga gcgagcgcgg ggcgcaccga tctcgggagg cggggaagcc ccgcggccgc
      241 cgcgcccgcc ccttcccccg ccgcccgccc cctctccccc cccgcccgct cgctgccttc
      301 ctccctctgc cttccttccc cacggccggc cgcctcctcg cccgccctcc cgcagcccag
      361 gagccgaggc tgccgcggcc gtggcggcgg agccctcagc catggcctcg ggcgacaccc
      421 tctacattgc cacggacggc tcggagatgc cagccgagat cgtggaactg catgagattg
      481 aggtggagac catcccggtg gagactatcg agaccacggt ggtgggcgag gaggaggacg
      541 acgacgaaga cgacgaggat ggtggcggcg gagaccacgg tggcgggggc ggccacgggc
      601 acgctggcca ccaccatcac caccaccacc accaccaccc gcccatgatc gcgctgcagc
      661 cgctggtcac cgacgacccg acccaagtgc accaccacca agaggtgatt ctggtgcaga
      721 cgcgcgagga ggtagtgggt ggcgacgact cggacgggct gcgcgccgag gacgggttcg
      781 aggaccagat cctcattccg gtacccgcgc cggccggcgg agacgacgac tacatcgagc
      841 agacgctggt caccgtggcg gcggccggca agagcggtgg cgggtcttcg tcgggcggcg
      901 gccgcgttaa gaagggcggc ggcaagaaga gtggcaagaa gagttacctg ggcagcgggg
      961 ccggcgcggc gggcggtggc ggcgccgacc cgggtaataa gaagtgggaa cagaagcagg
     1021 tgcagatcaa gaccctggag ggcgagttct cggtcaccat gtggtcttca gatgaaaaaa
     1081 aagatattga ccatgaaaca gtggttgaag agcagatcat tggggagaac tcacctcctg
     1141 attattctga atatatgaca ggcaagaaac tccctcctgg agggatacct ggcattgacc
     1201 tctcagaccc caagcaactg gcagaatttg ccagaatgaa gccaagaaaa attaaagaag
     1261 atgatgctcc aagaacaata gcttgccctc ataaaggctg cacaaagatg ttcagggata
     1321 actctgctat gagaaagcat ctgcacaccc acggtcccag agtccacgtc tgtgcagaat
     1381 gtggcaaagc gttcgttgag agctcaaagc taaaacgaca ccagctggtt catactggag
     1441 aaaagccctt tcagtgcaca ttcgaaggct gcgggaagcg cttttcactg gacttcaatt
     1501 tgcgcacgca tgtgcgaatc cataccggag acaggcccta tgtgtgcccc ttcgacggtt
     1561 gtaataagaa gtttgctcag tcaactaacc tgaaatctca catcttaaca cacgctaaag
     1621 ccaaaaacaa ccagtgaaaa gaagagagaa gaccttctcg accccgggaa gcctcttcag
     1681 gagtgtgatt gggaataaat atgcctctcc tttgtatatt atttctagga agaattttaa
     1741 aaatgaatcc tacacactta agggacatgt tttgataaag tagtaaaaat ttaaaaaaat
     1801 actttaataa gatgacattg ctaagatgct ctatcttgct ctgtaatctc gtttcaaaaa
     1861 caaggtgttt ttgtaaagtg tggtcccaac aggaggacaa ttcatgaact tcgcatcaaa
     1921 agacaattct ttatacaaca gtgctaaaaa tgggacttct tttcacattc ttataaatac
     1981 gaagctcacc tgttgcttac aattttttta attttgtatt ttccaagtgt gcatattgta
     2041 cactttttgg ggatatgctt agtaatgctg tgtgactttc tggagggtga cgacttgctt
     2101 gcggtagatt ttctttaaaa gaatgggcag ttacatgcat acttcaaaag tatttttcct
     2161 gtacaaaaaa aagttatata ggttttgttt gctatcttaa ttttggttgt attctttgat
     2221 gttaacacat tttgtataat tgtatcgtat agctgtattg aatcatgtag tatcaaatat
     2281 tagatgtgat ttaatagtgt taatcaattt aaacccattt tagtcacttt ttttttccca
     2341 aaaatactgc cagatgctga tgttcagtgt gatcctttgc ctgttgagtt acagaaagtg
     2401 gtgctcagtt gtagaatgta ttgtaccttt aacacctgat gtgtgcattc atgtaacgga
     2461 aagggcaaca ataaaatagc gatcctaaag aaagagtatg gcagaaagac ctctgtaagc
     2521 acagccttat tttcctctgt tgtccagaat acttacaatt cttgagcctc ccagaaattg
     2581 gaagctaaat aaagcaactc gagtttcctc tattttgcac tcagtgacag tgactgtgat
     2641 gaggtccgtg cacggacgct tagcatttcc tacacgccct gaattccgag agcaggcagg
     2701 aagcaccccg agctagggaa ctacctcaga gcacacagac ggcccatggc tggcaggatt
     2761 gcccttgata tcctggtgca tgtgggagtg acaggtttgc atggggcctg atgctttctg
     2821 aagggaaggc accgactggc agtgggtacg ccggggagga tgggcctgcc tgttttctcg
     2881 tcactcaggc tgccttcaag agcagtggct ccttggcttg tccagtcgga aacctcagta
     2941 cagtccttat tagatgctat cagatgtagt gattgagtgc ccgtagctgt ttgcttgtag
     3001 acacactaag tgcagagcgg caaggcgatt agattattag gaagttgtac tcagtgagta
     3061 cttgacttgt catgtgtgac ctcttcaatg tatgagtata atttttgaat tttacctagg
     3121 atcaaatacg agacttgtta aatattttat aaactgccgt gatacacaaa atctcattta
     3181 ttcaaaatgc aaacctaact gtctgtcttt ctgtgctgaa tgcttactac aaggtaaaat
     3241 gacaaatacc agattcagtc acaaagaggc cgggagacca accggtcgaa cacttagccc
     3301 aatttcttat ggcctcacca ggaagatttg gtgacctgga aacagtggcc ccatggctct
     3361 ggaattttga agtgccttct gaaccataca tggaaatggt aacttgggat acttgtttta
     3421 tttgtccaga atctgatcca gtgagtagtt gctgggactg agcgtatcag cagacccagc
     3481 cgtgtgctgg aggcaggctt tgctatgcct ggtagtcagg agggcttaag cctaaagggg
     3541 ccccttcaga gccaagtgcc catgtaactc tacaaggcct gggcggagct ccccgctgtg
     3601 cttttgtgag cacccaggcc ttcgctccct accatcgggt tgagccctcc caaatgccct
     3661 gcagtaggag gccagagcca cgttgccctc ccttacccag tgttgtgcta ccctcgagcc
     3721 tgaccctggc acctcaagac ccttgcccaa ggctccacag cagagcagac ctgtgctgcg
     3781 gaacggcctg ccagccccct gcgagtcagg cccacgtgta gagcgaggcc tcatcctctg
     3841 tgccttgatt ccttgggaga tgcccctcgg ccatctcttc tgtccctttc tgagggagca
     3901 gtcatcgtct tcgccctttc tgtgttggca ttgtcttctc agtgtgcagt taacttctgt
     3961 taggagttca tctgggggtt caaagacagc atgatgtgta ggtcctcgct tagggcagcg
     4021 gtgtagggaa ctgacatggc ggcggctaga agaaagctgc ttctcattgg ctttggctga
     4081 aacccatttt gcttgttaga gtttatagtt ttgttataga tgtaatttac taaatttgaa
     4141 atggtgttct aacagtgagt ccattgtcta gacacttaat ctgatttgta agtaataccg
     4201 atagacatat tttcttacat ctgagcagaa ataaatgcat gttctagcaa atgtaatgta
     4261 aaaactccag agactaagtt tacacccaat aggatcttat tttctacttt taaatttgtt
     4321 atttgcccct cttcggtagt ggggttgggg gcatattatc tgttatctgt atgcagagct
     4381 gtcacgccag agtgatgttt atttcccaca gagatgctga gctcacactg ctggttctgt
     4441 gcaggtcctg tgcaatgtgt gtactttgcc cagactcgag gcctgaggga ctgaggaaaa
     4501 ccaagactcc actcccctac cccgcctccc gatttggttt ccacacattg gttcctctga
     4561 atgctgcttg ctttgctaag tttgggcatg taagacctta aggggtggtg tgtgccatgc
     4621 ctgcccatgt ttctaggcag ttttagcttg tgtcttcaca tagatgagag cctactgtct
     4681 gtcagtgaag tgtgtggtgc tccagggata tggtgctggc ctggcttagc acctatctca
     4741 cctttccact ctgcaggact cacctgtggt aaccctcaga tcactgactc gagtgtatgt
     4801 atatctgtgg cccaggaagt tttgcccact ccccaccatc gatggggact tgactactta
     4861 tgcctttcct ctgtgctcca gaattggcat gatttagtca gtcttcggtg ggttttgttt
     4921 gtttttattc tcttgtcatc tagcctacag caagagcagg gactttgggg cgagagcagg
     4981 gagatgagga gagttgtcag tagatgccat ccatgactga cttctaaaag gcattgtcct
     5041 agcagccctt cggtgttggt gtgacttttt ctagagccag gacctgacag atacactgta
     5101 gctgagcata ggaactcaga actccaaagc agatgtgctt gcttgcaaca cttgaaactc
     5161 tagtctctct ttggctggtc agaacaaaag ctactccgtg cttcaaatca caccccagca
     5221 gcattgacca ggttggttgg gtctccaaga tattgggctt gttaactact ctcagggtaa
     5281 gctcagatgc cttggtcgcc tcaagatgtc acaagtacag ggccttcagg tgagcgagta
     5341 gtactgggca ggggagggtg gctgtgtggc tgaggctacc ggcatcattg ggcatacttg
     5401 gtcagtatgg cgccaggaag atcagcctcc agctaggaca gtatgtagac ctcataggaa
     5461 ggggtgggtg gcagatgtga gcaaatgtca caccgtccct gataaaacag tcaaggtttt
     5521 ggaattgagt ggcagtaggt cacaggcagg gtgcaccttc cagactggta caaggtgtgc
     5581 ccggccagcg ttctggagac cattgacggt tagttggcag caccttgctt gacatctcaa
     5641 gagtggcaag tttgggggtt ggggatttag ctcagtggta gagcgcttgc ctaggaagcg
     5701 caaggccctg ggttcggtcc ccagctccgg aaaaaaaaga accaaaaaaa aaaaaaagtg
     5761 gcaagtttga tgatattgac agaagatccc tcggccaccg tgagaaatga ccttggagtt
     5821 gggcagcctc cctgcttgca gccacatggt aactccatac acagcgtaag agaggaaaga
     5881 aggcatcagt accagagtcg cctctttata ctgccagcag ctgttaaact ctgatgtccg
     5941 cgaatggcga gaacagttgt gttttcattt tctgggaact cccataggcc ctggctcaag
     6001 gactttgcat tgtgtgtcat gtacatctct taagtattct ttgctgttct ggaattgtcc
     6061 ttggtttttc cttagcacat agatcataga cacagaaata tcaatagtat ttaaaagcat
     6121 ccgcatcaag catcagatgg cttcgcatcc aggaaaacat aactcggttt gaagcaccac
     6181 gcatgtgtaa catggctcta tacaatacaa taaaaaacgc taatgttaa
//
