LOCUS       NM_013011               1795 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus tyrosine 3-monooxygenase/tryptophan
            5-monooxygenase activation protein, zeta (Ywhaz), mRNA.
ACCESSION   NM_013011 NM_013054
VERSION     NM_013011.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1795)
  AUTHORS   Popov,I.K., Hiatt,S.M., Whalen,S., Keren,B., Ruivenkamp,C., van
            Haeringen,A., Chen,M.J., Cooper,G.M., Korf,B.R. and Chang,C.
  TITLE     A YWHAZ Variant Associated With Cardiofaciocutaneous Syndrome
            Activates the RAF-ERK Pathway
  JOURNAL   Front Physiol 10, 388 (2019)
   PUBMED   31024343
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1795)
  AUTHORS   Yang,J., Joshi,S., Wang,Q., Li,P., Wang,H., Xiong,Y., Xiao,Y.,
            Wang,J., Parker-Thornburg,J., Behringer,R.R. and Yu,D.
  TITLE     14-3-3zeta loss leads to neonatal lethality by microRNA-126
            downregulation-mediated developmental defects in lung vasculature
  JOURNAL   Cell Biosci 7, 58 (2017)
   PUBMED   29118970
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1795)
  AUTHORS   Chen,M., Hu,W., Xiong,C.L., Qu,Z., Yin,C.Q., Wang,Y.H., Luo,C.L.,
            Guan,Q., Yuan,C.H. and Wang,F.B.
  TITLE     miR-22 targets YWHAZ to inhibit metastasis of hepatocellular
            carcinoma and its down-regulation predicts a poor survival
  JOURNAL   Oncotarget 7 (49), 80751-80764 (2016)
   PUBMED   27811373
REFERENCE   4  (bases 1 to 1795)
  AUTHORS   Hansraj,N.Z., Xiao,L., Wu,J., Chen,G., Turner,D.J., Wang,J.Y. and
            Rao,J.N.
  TITLE     Posttranscriptional regulation of 14-3-3zeta by RNA-binding protein
            HuR modulating intestinal epithelial restitution after wounding
  JOURNAL   Physiol Rep 4 (13) (2016)
   PUBMED   27401462
  REMARK    GeneRIF: Results indicate that HuR induces 14-3-3zeta translation
            via interaction with its 3' UTR and that 14-3-3zeta is necessary
            for stimulation of intestinal epithelial cell migration after
            wounding.
REFERENCE   5  (bases 1 to 1795)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1795)
  AUTHORS   Brunet,A., Bonni,A., Zigmond,M.J., Lin,M.Z., Juo,P., Hu,L.S.,
            Anderson,M.J., Arden,K.C., Blenis,J. and Greenberg,M.E.
  TITLE     Akt promotes cell survival by phosphorylating and inhibiting a
            Forkhead transcription factor
  JOURNAL   Cell 96 (6), 857-868 (1999)
   PUBMED   10102273
REFERENCE   7  (bases 1 to 1795)
  AUTHORS   Murakami,K., Situ,S.Y. and Eshete,F.
  TITLE     A gene variation of 14-3-3 zeta isoform in rat hippocampus
  JOURNAL   Gene 179 (2), 245-249 (1996)
   PUBMED   8972907
REFERENCE   8  (bases 1 to 1795)
  AUTHORS   Watanabe,M., Isobe,T., Ichimura,T., Kuwano,R., Takahashi,Y.,
            Kondo,H. and Inoue,Y.
  TITLE     Molecular cloning of rat cDNAs for the zeta and theta subtypes of
            14-3-3 protein and differential distributions of their mRNAs in the
            brain
  JOURNAL   Brain Res Mol Brain Res 25 (1-2), 113-121 (1994)
   PUBMED   7984035
REFERENCE   9  (bases 1 to 1795)
  AUTHORS   Alam,R., Hachiya,N., Sakaguchi,M., Kawabata,S., Iwanaga,S.,
            Kitajima,M., Mihara,K. and Omura,T.
  TITLE     cDNA cloning and characterization of mitochondrial import
            stimulation factor (MSF) purified from rat liver cytosol
  JOURNAL   J Biochem 116 (2), 416-425 (1994)
   PUBMED   7822263
REFERENCE   10 (bases 1 to 1795)
  AUTHORS   Roseboom,P.H., Weller,J.L., Babila,T., Aitken,A., Sellers,L.A.,
            Moffett,J.R., Namboodiri,M.A. and Klein,D.C.
  TITLE     Cloning and characterization of the epsilon and zeta isoforms of
            the 14-3-3 proteins
  JOURNAL   DNA Cell Biol 13 (6), 629-640 (1994)
   PUBMED   8024705
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 27, 2020 this sequence version replaced NM_013011.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070941.1, U37252.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN12840107
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                JAXUCZ010000007.1  69848653-69848702   c
            51-355              JAXUCZ010000007.1  69845757-69846061   c
            356-479             JAXUCZ010000007.1  69830798-69830921   c
            480-643             JAXUCZ010000007.1  69830022-69830185   c
            644-739             JAXUCZ010000007.1  69829845-69829940   c
            740-1795            JAXUCZ010000007.1  69826404-69827459   c
FEATURES             Location/Qualifiers
     source          1..1795
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..1795
                     /gene="Ywhaz"
                     /gene_synonym="14-3-3z"
                     /note="tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
                     activation protein, zeta"
                     /db_xref="GeneID:25578"
                     /db_xref="RGD:3980"
     exon            1..50
                     /gene="Ywhaz"
                     /gene_synonym="14-3-3z"
                     /inference="alignment:Splign:2.1.0"
     exon            51..355
                     /gene="Ywhaz"
                     /gene_synonym="14-3-3z"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..799
                     /gene="Ywhaz"
                     /gene_synonym="14-3-3z"
                     /note="KCIP-1; protein kinase C inhibitor protein 1;
                     tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
                     activation protein, zeta polypeptide; mitochondrial import
                     stimulation factor S1 subunit"
                     /codon_start=1
                     /product="14-3-3 protein zeta/delta"
                     /protein_id="NP_037143.2"
                     /db_xref="GeneID:25578"
                     /db_xref="RGD:3980"
                     /translation="MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLL
                     SVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLE
                     KFLIPNASQPESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEM
                     QPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIM
                     QLLRDNLTLWTSDTQGDEAEAGEGGEN"
     exon            356..479
                     /gene="Ywhaz"
                     /gene_synonym="14-3-3z"
                     /inference="alignment:Splign:2.1.0"
     exon            480..643
                     /gene="Ywhaz"
                     /gene_synonym="14-3-3z"
                     /inference="alignment:Splign:2.1.0"
     exon            644..739
                     /gene="Ywhaz"
                     /gene_synonym="14-3-3z"
                     /inference="alignment:Splign:2.1.0"
     exon            740..1795
                     /gene="Ywhaz"
                     /gene_synonym="14-3-3z"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagagactg ccgagccggg tccgtgtgcc gccacccact ccggacacag aatatccagt
       61 tatggataaa aatgagctgg tgcagaaggc caagctggcc gagcaggcag agcgatacga
      121 tgacatggca gcctgcatga agtctgtcac tgagcaagga gccgagctgt ctaacgagga
      181 gaggaacctt ctctctgttg cttataaaaa cgttgtagga gcccgtaggt catcttggag
      241 ggtcgtctcg agtattgagc agaagacgga aggtgctgag aaaaagcagc agatggctcg
      301 agaatacaga gagaagatcg agacggagct gagggacatc tgcaacgacg tactgtctct
      361 tttggaaaag ttcttgatcc ccaatgcttc gcagccagaa agcaaagtct tctatttgaa
      421 aatgaagggt gactactacc gctacttggc tgaggttgct gctggtgatg acaagaaagg
      481 aattgtggac cagtcacagc aagcatacca agaagcattt gaaatcagca aaaaggagat
      541 gcagccgaca caccccatca gactgggtct ggccctcaac ttctctgtgt tctactatga
      601 gatcctgaac tccccagaga aagcctgctc tcttgcaaaa acagcttttg atgaagccat
      661 tgctgaactt gatacattaa gtgaagagtc gtacaaagac agcacgctaa taatgcagtt
      721 actgagagac aacttgacat tgtggacatc ggatacccaa ggagacgaag cagaagcggg
      781 agaaggaggg gaaaattaac cggccttcca acctttgtct gcctcattct aaaatttaca
      841 cagtagacca tttgtcatcc atgctgtccc acagatagtt tttttgttta cgatttatga
      901 caggtttatg ttacttctat ttgaatttct atatttccca tgtggtttta tgttttaata
      961 ttaggggagt agagccagtt aactttaggg agttactcgt tttcatcttg aggtggccaa
     1021 tatgggatgt ggaattttta catgagttac acatgtttgg catagttagt acttttggtc
     1081 cattgtggct tcagaagggc cagtgttcaa actgcttcca tgtctaagca aagaaaactg
     1141 cctacatatt ggtgtgtgct ggcggggaat aaacaggata atgggtccag tcatgagtgt
     1201 agtctgtgtg ggtactgtaa ggcttggagc acttgtgagg ctgggacacg aacaccctgt
     1261 ggatgcacgc taagaccgtg tgtctgcgtg cacacccttg accacagctc cagaagttgt
     1321 ctgtagacaa agttgtgacc caatttactc tgataagggc agaaacggtt cacattccat
     1381 tatttgtaaa gttacctgct gtttgctttc attatttttg ctacacattt tatttgtatt
     1441 taaatgtttt aggcaatcta agaacaaatg taaaagtaaa gatgcagtac aaacgagttg
     1501 cttggtgttc ccggctccat gcggatcaag cacagcggta aacaaaatcc catgtattta
     1561 actttttttt ttaagttttt tgttttgttt tgtttttgct tttgtgattt tttttctctt
     1621 tttgatactt gcctaacatg catgtgctgt aaaaatagtt aacagggaaa taacttgaga
     1681 tgacggctag ctttgtttta atgtcttatg aaattttcat gaacaatcca agcataattg
     1741 ttaagaacac atgtattaaa gttcatgtaa gtggaataaa agttttatga atgga
//
