LOCUS       NM_013053               2099 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Rattus norvegicus tyrosine 3-monooxygenase/tryptophan
            5-monooxygenase activation protein, theta (Ywhaq), mRNA.
ACCESSION   NM_013053
VERSION     NM_013053.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2099)
  AUTHORS   Chen,S., Lu,F.F., Seeman,P. and Liu,F.
  TITLE     Quantitative proteomic analysis of human substantia nigra in
            Alzheimer's disease, Huntington's disease and Multiple sclerosis
  JOURNAL   Neurochem Res 37 (12), 2805-2813 (2012)
   PUBMED   22926577
REFERENCE   2  (bases 1 to 2099)
  AUTHORS   Fan,J., Zhang,N., Yin,G., Zhang,Z., Cheng,G., Qian,W., Long,H. and
            Cai,W.
  TITLE     Edaravone protects cortical neurons from apoptosis by inhibiting
            the translocation of BAX and Increasing the interaction between
            14-3-3 and p-BAD
  JOURNAL   Int J Neurosci 122 (11), 665-674 (2012)
   PUBMED   22757651
REFERENCE   3  (bases 1 to 2099)
  AUTHORS   Hoxhaj,G., Najafov,A., Toth,R., Campbell,D.G., Prescott,A.R. and
            MacKintosh,C.
  TITLE     ZNRF2 is released from membranes by growth factors and, together
            with ZNRF1, regulates the Na+/K+ATPase
  JOURNAL   J Cell Sci 125 (Pt 19), 4662-4675 (2012)
   PUBMED   22797923
  REMARK    Erratum:[J Cell Sci. 2022 Mar 15;135(6):jcs259936. doi:
            10.1242/jcs.259936.. PMID: 35267011]
REFERENCE   4  (bases 1 to 2099)
  AUTHORS   Hsu,P.H., Miaw,S.C., Chuang,C.C., Chang,P.Y., Fu,S.J., Jow,G.M.,
            Chiu,M.M. and Jeng,C.J.
  TITLE     14-3-3theta; is a binding partner of rat Eag1 potassium channels
  JOURNAL   PLoS One 7 (7), e41203 (2012)
   PUBMED   22911758
  REMARK    GeneRIF: 14-3-3theta; is a binding partner of rEag1 and may
            modulate the functional expression of the K(+) channel in neurons.
REFERENCE   5  (bases 1 to 2099)
  AUTHORS   Memos,N., Kataki,A., Chatziganni,E., Nikolopoulou,M., Skoulakis,E.,
            Consoulas,C., Zografos,G. and Konstadoulakis,M.
  TITLE     Alternations of 14-3-3 theta; and beta protein levels in brain
            during experimental sepsis
  JOURNAL   J Neurosci Res 89 (9), 1409-1418 (2011)
   PUBMED   21618583
  REMARK    GeneRIF: Results showed that sepsis alters the expression of the
            14-3-3 theta; isoform in a time-, cell-, and topography-dependent
            manner, with the hippocampus, Purkinje cells, and glia-like cells
            showed intense immunohistochemical reactivity.
REFERENCE   6  (bases 1 to 2099)
  AUTHORS   Choi,S.J., Park,S.Y. and Han,T.H.
  TITLE     14-3-3tau associates with and activates the MEF2D transcription
            factor during muscle cell differentiation
  JOURNAL   Nucleic Acids Res 29 (13), 2836-2842 (2001)
   PUBMED   11433030
REFERENCE   7  (bases 1 to 2099)
  AUTHORS   Berruti,G.
  TITLE     A novel rap1/B-Raf/14-3-3 theta protein complex is formed in vivo
            during the morphogenetic differentiation of postmeiotic male germ
            cells
  JOURNAL   Exp Cell Res 257 (1), 172-179 (2000)
   PUBMED   10854065
REFERENCE   8  (bases 1 to 2099)
  AUTHORS   Leo,C.P., Hsu,S.Y., Chun,S.Y., Bae,H.W. and Hsueh,A.J.
  TITLE     Characterization of the antiapoptotic Bcl-2 family member myeloid
            cell leukemia-1 (Mcl-1) and the stimulation of its message by
            gonadotropins in the rat ovary
  JOURNAL   Endocrinology 140 (12), 5469-5477 (1999)
   PUBMED   10579309
REFERENCE   9  (bases 1 to 2099)
  AUTHORS   Perego,L. and Berruti,G.
  TITLE     Molecular cloning and tissue-specific expression of the mouse
            homologue of the rat brain 14-3-3 theta protein: characterization
            of its cellular and developmental pattern of expression in the male
            germ line
  JOURNAL   Mol Reprod Dev 47 (4), 370-379 (1997)
   PUBMED   9211421
REFERENCE   10 (bases 1 to 2099)
  AUTHORS   Watanabe,M., Isobe,T., Ichimura,T., Kuwano,R., Takahashi,Y.,
            Kondo,H. and Inoue,Y.
  TITLE     Molecular cloning of rat cDNAs for the zeta and theta subtypes of
            14-3-3 protein and differential distributions of their mRNAs in the
            brain
  JOURNAL   Brain Res Mol Brain Res 25 (1-2), 113-121 (1994)
   PUBMED   7984035
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D17614.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D17614.1, BC062409.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760396, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2099
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q16"
     gene            1..2099
                     /gene="Ywhaq"
                     /gene_synonym="14-3-3t"
                     /note="tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
                     activation protein, theta"
                     /db_xref="GeneID:25577"
                     /db_xref="RGD:3979"
     exon            1..45
                     /gene="Ywhaq"
                     /gene_synonym="14-3-3t"
                     /inference="alignment:Splign:2.1.0"
     exon            46..379
                     /gene="Ywhaq"
                     /gene_synonym="14-3-3t"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..823
                     /gene="Ywhaq"
                     /gene_synonym="14-3-3t"
                     /note="14-3-3 protein tau; tyrosine
                     3-monooxygenase/tryptophan 5-monooxygenase activation
                     protein, theta polypeptide"
                     /codon_start=1
                     /product="14-3-3 protein theta"
                     /protein_id="NP_037185.1"
                     /db_xref="GeneID:25577"
                     /db_xref="RGD:3979"
                     /translation="MEKTELIQKAKLAEQAERYDDMATCMKAVTEQGAELSNEERNLL
                     SVAYKNVVGGRRSAWRVISSIEQKTDTSDKKLQLIKDYREKVESELRSICTTVLELLD
                     KYLIANATNPESKVFYLKMKGDYFRYLAEVACGDDRKQTIENSQGAYQEAFDISKKEM
                     QPTHPIRLGLALNFSVFYYEILNNPELACTLAKTAFDEAIAELDTLNEDSYKDSTLIM
                     QLLRDNLTLWTSDSAGEECDAAEGAEN"
     exon            380..503
                     /gene="Ywhaq"
                     /gene_synonym="14-3-3t"
                     /inference="alignment:Splign:2.1.0"
     exon            504..667
                     /gene="Ywhaq"
                     /gene_synonym="14-3-3t"
                     /inference="alignment:Splign:2.1.0"
     exon            668..763
                     /gene="Ywhaq"
                     /gene_synonym="14-3-3t"
                     /inference="alignment:Splign:2.1.0"
     exon            764..2099
                     /gene="Ywhaq"
                     /gene_synonym="14-3-3t"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agatcaaagt ggtgggactc gcgtcgcggc cgcggagact agaaggagga ctccggatcc
       61 ggctcggcgc tcgccctcgc tcgccatgga gaagaccgag ctgatccaga aggccaagct
      121 ggccgagcag gccgagcgct acgacgacat ggccacctgc atgaaagccg tgacggagca
      181 gggcgccgag ctgtccaacg aggagcgcaa cctgctatct gtggcctaca agaacgtggt
      241 cgggggccgc aggtccgcct ggagggtcat ctcgagcatt gagcagaaga ccgatacctc
      301 ggacaagaag ttgcagctga tcaaggacta tcgggagaaa gtggagtctg agctgaggtc
      361 catctgcacc acggtcctgg aattgttgga taagtattta atagccaatg caactaatcc
      421 agagagtaag gtcttctatc tgaaaatgaa gggagattat ttccggtatc ttgctgaagt
      481 cgcttgtggt gatgatcgaa aacaaacgat agaaaattcc caaggagcct accaagaggc
      541 atttgatata agcaagaaag agatgcaacc tacacatccg atccgcctgg ggctggctct
      601 taacttttct gtattttact atgagatcct taataatccc gagcttgcct gcacactggc
      661 taaaacggct tttgatgaag ccatcgccga gcttgataca ctgaatgaag actcctacaa
      721 agacagcacc ctcatcatgc agttgcttag agacaactta acattatgga catcagacag
      781 tgcaggagaa gaatgtgatg cagctgaggg ggctgagaac taaaggcatc caggacacca
      841 acctccttcc cctcaagaaa acctttttac atctccattc cttattccac ttggatttcc
      901 tctagcaagg aagcccattc atgtgtatgg ggtcaactgt ttatagtctt ttcacactgc
      961 agctttggga aaactccatc ccttggtttg tgttgtctcc accttcctgg tgtgcagtta
     1021 ctgctgtaga aaagtatcaa tagcttcatt tcatataaac acgagtaact tccagacact
     1081 tgtgtagagg actgacagca catttggtat ttaagtaatc tgaaccagtt ctgcaagtga
     1141 ctgtgttttg tattactgtg aagatatgga aatggtagtg cattacaatt taaagtgatt
     1201 gtaataataa cgtcttgatt tctacattcc ttttctgaac tttcttgggg gtttcctttc
     1261 agaagcaact tttccatgct cttactacaa attccttttt agtaggaatc cagaagtgtt
     1321 agattgaatg ggaaagcgct taatgcatcc gggcttgggg gtcacagatt gaaatgtctc
     1381 ctgtgtcaca ttctggaggt tacatctgtc tgtgacaaca gggcgtttcc ttatgcattc
     1441 ttcatttgct gctgtttaag ttgacaactt ccttcccaat aaaaattcac ttacacctcc
     1501 tgccttcgta gctctggtat tcactttacc ttgtgacaga agtagcatgt tgctgccaga
     1561 atacaagcat tgctttgggc aaattaaaat gcatgtcctt tcttaataca ctaggaagga
     1621 gaaataaagt acacaagtcc aagtctaaac tttagtactt ttccatgcag atttgtgcac
     1681 atgtgagggg gtatccagtt tgtccagtga ttgttcttta gagagttgga ccactatatt
     1741 gtgtgtttgc taatcattga ctgtagtccc aaaaaagcct tgtgaaaatg ttatgcccta
     1801 tgtaacagca gagtaacata aaataaaact acattttata aaaccattta ttatggcttt
     1861 gtaacagttg catacccata ttttaagaac agacaaattt actacttttt gaagtttgtt
     1921 gctatttctc tttatgtaac atataatggt gatatccata tttctgcatt gtggtacact
     1981 tgtctagggt gcctggcact gtaaaattgg actatatttc tccagatagc ctcatgggtt
     2041 gtcttcctca gatgtaatga taactggtta ggtgtcatgt gtaataaagt gaacatttg
//
