LOCUS       NM_013052               1687 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Rattus norvegicus tyrosine 3-monooxygenase/tryptophan
            5-monooxygenase activation protein, eta (Ywhah), mRNA.
ACCESSION   NM_013052
VERSION     NM_013052.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1687)
  AUTHORS   Wan,S., Wang,S., Yang,X., Cui,Y., Guan,H., Xiao,W. and Liu,F.
  TITLE     Regulation of H9C2 cell hypertrophy by 14-3-3eta via inhibiting
            glycolysis
  JOURNAL   PLoS One 19 (7), e0307696 (2024)
   PUBMED   39038022
  REMARK    GeneRIF: Regulation of H9C2 cell hypertrophy by 14-3-3eta via
            inhibiting glycolysis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1687)
  AUTHORS   Hu,T., Yu,W.P., Wang,X.Q., Wang,Z.Y., Xu,Z.Q., Hu,F.J., Liu,J.C.,
            Yu,F. and Wang,L.J.
  TITLE     Activation of PPAR-alpha attenuates myocardial ischemia/reperfusion
            injury by inhibiting ferroptosis and mitochondrial injury via
            upregulating 14-3-3eta
  JOURNAL   Sci Rep 14 (1), 15246 (2024)
   PUBMED   38956068
  REMARK    GeneRIF: Activation of PPAR-alpha attenuates myocardial
            ischemia/reperfusion injury by inhibiting ferroptosis and
            mitochondrial injury via upregulating 14-3-3eta.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1687)
  AUTHORS   Nguyen,N.M., Meyer,D., Meyer,L., Chand,S., Jagadesan,S.,
            Miravite,M., Guda,C., Yelamanchili,S.V. and Pendyala,G.
  TITLE     Identification of YWHAH as a Novel Brain-Derived Extracellular
            Vesicle Marker Post Long-Term Midazolam Exposure during Early
            Development
  JOURNAL   Cells 12 (6), 966 (2023)
   PUBMED   36980307
  REMARK    GeneRIF: Identification of YWHAH as a Novel Brain-Derived
            Extracellular Vesicle Marker Post Long-Term Midazolam Exposure
            during Early Development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1687)
  AUTHORS   Chen,S., Lu,F.F., Seeman,P. and Liu,F.
  TITLE     Quantitative proteomic analysis of human substantia nigra in
            Alzheimer's disease, Huntington's disease and Multiple sclerosis
  JOURNAL   Neurochem Res 37 (12), 2805-2813 (2012)
   PUBMED   22926577
REFERENCE   5  (bases 1 to 1687)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   6  (bases 1 to 1687)
  AUTHORS   Tang,S.J., Suen,T.C., McInnes,R.R. and Buchwald,M.
  TITLE     Association of the TLX-2 homeodomain and 14-3-3eta signaling
            proteins
  JOURNAL   J Biol Chem 273 (39), 25356-25363 (1998)
   PUBMED   9738002
REFERENCE   7  (bases 1 to 1687)
  AUTHORS   Wakui,H., Wright,A.P., Gustafsson,J. and Zilliacus,J.
  TITLE     Interaction of the ligand-activated glucocorticoid receptor with
            the 14-3-3 eta protein
  JOURNAL   J Biol Chem 272 (13), 8153-8156 (1997)
   PUBMED   9079630
REFERENCE   8  (bases 1 to 1687)
  AUTHORS   Martin,H., Rostas,J., Patel,Y. and Aitken,A.
  TITLE     Subcellular localisation of 14-3-3 isoforms in rat brain using
            specific antibodies
  JOURNAL   J Neurochem 63 (6), 2259-2265 (1994)
   PUBMED   7964746
REFERENCE   9  (bases 1 to 1687)
  AUTHORS   Watanabe,M., Isobe,T., Ichimura,T., Kuwano,R., Takahashi,Y.,
            Kondo,H. and Inoue,Y.
  TITLE     Molecular cloning of rat cDNAs for the zeta and theta subtypes of
            14-3-3 protein and differential distributions of their mRNAs in the
            brain
  JOURNAL   Brain Res Mol Brain Res 25 (1-2), 113-121 (1994)
   PUBMED   7984035
REFERENCE   10 (bases 1 to 1687)
  AUTHORS   Watanabe,M., Isobe,T., Okuyama,T., Ichimura,T., Kuwano,R.,
            Takahashi,Y. and Kondo,H.
  TITLE     Molecular cloning of cDNA to rat 14-3-3 eta chain polypeptide and
            the neuronal expression of the mRNA in the central nervous system
  JOURNAL   Brain Res Mol Brain Res 10 (2), 151-158 (1991)
   PUBMED   1649368
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Nov 26, 2020 this sequence version replaced NM_013052.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D17445.1, BC081825.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071, SAMN12840105
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-261               JAXUCZ010000014.1  81929942-81930202   c
            262-1687            JAXUCZ010000014.1  81920819-81922244   c
FEATURES             Location/Qualifiers
     source          1..1687
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..1687
                     /gene="Ywhah"
                     /gene_synonym="14-3-3e"
                     /note="tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
                     activation protein, eta"
                     /db_xref="GeneID:25576"
                     /db_xref="RGD:3978"
     exon            1..261
                     /gene="Ywhah"
                     /gene_synonym="14-3-3e"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..915
                     /gene="Ywhah"
                     /gene_synonym="14-3-3e"
                     /note="14-3-3 protein eta-subtype; tyrosine
                     3-monooxygenase/tryptophan 5-monooxygenase activation
                     protein, eta polypeptide"
                     /codon_start=1
                     /product="14-3-3 protein eta"
                     /protein_id="NP_037184.1"
                     /db_xref="GeneID:25576"
                     /db_xref="RGD:3978"
                     /translation="MGDREQLLQRARLAEQAERYDDMASAMKAVTELNEPLSNEDRNL
                     LSVAYKNVVGARRSSWRVISSIEQKTMADGNEKKLEKVKAYREKIEKELETVCNDVLA
                     LLDKFLIKNCNDFQYESKVFYLKMKGDYYRYLAEVASGEKKNSVVEASEAAYKEAFEI
                     SKEHMQPTHPIRLGLALNFSVFYYEIQNAPEQACLLAKQAFDDAIAELDTLNEDSYKD
                     STLIMQLLRDNLTLWTSDQQDEEAGEGN"
     exon            262..1687
                     /gene="Ywhah"
                     /gene_synonym="14-3-3e"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcagccagc tagcgagaag gcgcgagcgg cggcgcagcc agcagcctcc cgccagccgg
       61 cgagccagtg cgcgtgcgcg gcggcggcct cggcggcgac cgggaagcgg acgggcgggc
      121 gagcgagcga gcaggcggtg cgggcgtgcg aggcgaggcc gagtcgcgag cgacatgggg
      181 gaccgagagc agctgctgca gcgggcgcga ctggcggagc aggcggagcg ctacgacgac
      241 atggcctccg ccatgaaggc ggtgacagag ctgaatgaac ctctatctaa tgaagataga
      301 aatctcctct ctgtggccta caagaatgta gttggtgcca ggcgatcttc ttggagggtt
      361 attagtagca ttgagcagaa aaccatggca gatgggaatg agaagaagct ggagaaagtc
      421 aaagcctatc gggagaagat tgagaaggag ctggagacag tttgcaatga tgtcttggct
      481 ctgctcgaca agttccttat caagaactgc aatgattttc agtacgagag caaggtgttc
      541 tacctgaaaa tgaagggcga ttactaccgc tacctggcag aggtggcttc tggggagaag
      601 aaaaacagtg tggttgaagc ttctgaggca gcgtataagg aagccttcga aatcagcaaa
      661 gagcacatgc agccaacaca ccccatccgg cttggcctgg ccctcaattt ttctgtgttc
      721 tactatgaga tccagaatgc accagagcag gcctgcctct tagccaaaca agccttcgat
      781 gatgctatag ctgagctgga cacattaaac gaggattcct ataaggactc cactctcatc
      841 atgcagttgc tgcgagacaa cctcaccctc tggacgagcg accagcagga tgaagaagcc
      901 ggagaaggca actgaagacc catcaggtcc ctggcccttc ctttacccac cacccccatt
      961 atcactgatt cttccttgcc acaatcacta tatctagtgc taaacctatc tgtattggca
     1021 gcacagctat tcagatctgc cctcctgtcc cttgggaagc agtttcagat aaaccttcat
     1081 gggcatttgc tggactgatg gttgctttga gccacagagc gctccctttt tgaattgtgc
     1141 agagaagtgt gttctgaacg aggcatttta ttatgtctgt tgatctgtag caaatccatg
     1201 tgatggtaat tgagtgtaga aaggagaatt agccaacaca ggctatggct gctatttaaa
     1261 acaagctgat agtgtgttgt taagcagtac atctcgtgca tgcaaaaatg aatttgaccc
     1321 tctcacccct tctttcagct aatggaaact gacacacgac aacttgttcc ttcaccatca
     1381 gctttataaa ctgtttctcg tgagctttca gcggcccctg ctgtgcctct ttaaattatg
     1441 atgtgcgcac accttctttt caatgcaatg catcagaggt ttttgatatg tgtaactttt
     1501 tttttggttg tgattaagaa tcatggattt attttttgta actctttggc tattgttctt
     1561 gtgtaccctg acagcatcat gtgtgtcaac ctgtgtcaat catgatgggt ggttatgaaa
     1621 tgccagattg ctaaaataaa tgttttggac ttaaaaagag taaataaatg ctgctttggg
     1681 gatatta
//
