LOCUS       NM_031603               2042 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus tyrosine 3-monooxygenase/tryptophan
            5-monooxygenase activation protein, epsilon (Ywhae), mRNA.
ACCESSION   NM_031603
VERSION     NM_031603.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2042)
  AUTHORS   He,Q.Q., Wu,X., Liu,X.P., Yang,X.J., Yuan,Z.M. and Zhang,Y.
  TITLE     14-3-3 epsilon plays an important role in testicular germ cell
            apoptosis: A functional proteomic study of experimental varicocele
  JOURNAL   Andrologia 51 (6), e13275 (2019)
   PUBMED   30950109
  REMARK    GeneRIF: Study of experimental varicocele in rat model demonstrated
            the pro-apoptotic function of the downregulation of 14-3-3epsilon,
            which may play an important role in germ cell apoptosis induced by
            varicocele.
REFERENCE   2  (bases 1 to 2042)
  AUTHORS   Chen,J., Ou,Y., Yang,Y., Li,W., Xu,Y., Xie,Y. and Liu,Y.
  TITLE     KLHL22 activates amino-acid-dependent mTORC1 signalling to promote
            tumorigenesis and ageing
  JOURNAL   Nature 557 (7706), 585-589 (2018)
   PUBMED   29769719
REFERENCE   3  (bases 1 to 2042)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2042)
  AUTHORS   Sai,Y., Peng,K., Ye,F., Zhao,X., Zhao,Y., Zou,Z., Cao,J. and
            Dong,Z.
  TITLE     14-3-3 Proteins in the regulation of rotenone-induced neurotoxicity
            might be via its isoform 14-3-3epsilon's involvement in autophagy
  JOURNAL   Cell Mol Neurobiol 33 (8), 1109-1121 (2013)
   PUBMED   24002177
  REMARK    GeneRIF: The regulation of 14-3-3 proteins in rotenone-induced
            neurotoxicity might be associated with its isoform 14-3-3epsilon's
            involvement in autophagy.
REFERENCE   5  (bases 1 to 2042)
  AUTHORS   Meng,J., Cui,C., Liu,Y., Jin,M., Wu,D., Liu,C., Wang,E. and Yu,B.
  TITLE     The role of 14-3-3epsilon interaction with phosphorylated Cdc25B at
            its Ser321 in the release of the mouse oocyte from prophase I
            arrest
  JOURNAL   PLoS One 8 (1), e53633 (2013)
   PUBMED   23326474
REFERENCE   6  (bases 1 to 2042)
  AUTHORS   Stewart,S., Sundaram,M., Zhang,Y., Lee,J., Han,M. and Guan,K.L.
  TITLE     Kinase suppressor of Ras forms a multiprotein signaling complex and
            modulates MEK localization
  JOURNAL   Mol Cell Biol 19 (8), 5523-5534 (1999)
   PUBMED   10409742
REFERENCE   7  (bases 1 to 2042)
  AUTHORS   Gao,L., Gu,X.B., Yu,D.S., Yu,R.K. and Zeng,G.
  TITLE     Association of a 14-3-3 protein with CMP-NeuAc:GM1 alpha
            2,3-sialyltransferase
  JOURNAL   Biochem Biophys Res Commun 224 (1), 103-107 (1996)
   PUBMED   8694795
REFERENCE   8  (bases 1 to 2042)
  AUTHORS   Martin,H., Rostas,J., Patel,Y. and Aitken,A.
  TITLE     Subcellular localisation of 14-3-3 isoforms in rat brain using
            specific antibodies
  JOURNAL   J Neurochem 63 (6), 2259-2265 (1994)
   PUBMED   7964746
REFERENCE   9  (bases 1 to 2042)
  AUTHORS   Alam,R., Hachiya,N., Sakaguchi,M., Kawabata,S., Iwanaga,S.,
            Kitajima,M., Mihara,K. and Omura,T.
  TITLE     cDNA cloning and characterization of mitochondrial import
            stimulation factor (MSF) purified from rat liver cytosol
  JOURNAL   J Biochem 116 (2), 416-425 (1994)
   PUBMED   7822263
REFERENCE   10 (bases 1 to 2042)
  AUTHORS   Roseboom,P.H., Weller,J.L., Babila,T., Aitken,A., Sellers,L.A.,
            Moffett,J.R., Namboodiri,M.A. and Klein,D.C.
  TITLE     Cloning and characterization of the epsilon and zeta isoforms of
            the 14-3-3 proteins
  JOURNAL   DNA Cell Biol 13 (6), 629-640 (1994)
   PUBMED   8024705
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 20, 2020 this sequence version replaced NM_031603.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ220393.1, M84416.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               JAXUCZ010000010.1  61082934-61083113
            181-380             JAXUCZ010000010.1  61107165-61107364
            381-487             JAXUCZ010000010.1  61109836-61109942
            488-694             JAXUCZ010000010.1  61110884-61111090
            695-831             JAXUCZ010000010.1  61113533-61113669
            832-2042            JAXUCZ010000010.1  61119408-61120618
FEATURES             Location/Qualifiers
     source          1..2042
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..2042
                     /gene="Ywhae"
                     /gene_synonym="14-3-3e"
                     /note="tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
                     activation protein, epsilon"
                     /db_xref="GeneID:29753"
                     /db_xref="RGD:62000"
     exon            1..180
                     /gene="Ywhae"
                     /gene_synonym="14-3-3e"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..884
                     /gene="Ywhae"
                     /gene_synonym="14-3-3e"
                     /note="14-3-3 epsilon; mitochondrial import stimulation
                     factor (MSF) L subunit; MSF L; mitochondrial import
                     stimulation factor L subunit; tyrosine
                     3-monooxygenase/tryptophan 5-monooxygenase
                     activatioprotein epsilon polypeptide; tyrosine
                     3-monooxygenase/tryptophan 5-monooxygenase activation
                     protein, epsilon polypeptide"
                     /codon_start=1
                     /product="14-3-3 protein epsilon"
                     /protein_id="NP_113791.2"
                     /db_xref="GeneID:29753"
                     /db_xref="RGD:62000"
                     /translation="MDDREDLVYQAKLAEQAERYDEMVESMKKVAGMDVELTVEERNL
                     LSVAYKNVIGARRASWRIISSIEQKEENKGGEDKLKMIREYRQMVETELKLICCDILD
                     VLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDIAM
                     TELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDST
                     LIMQLLRDNLTLWTSDMQGDGEEQNKEALQDVEDENQ"
     exon            181..380
                     /gene="Ywhae"
                     /gene_synonym="14-3-3e"
                     /inference="alignment:Splign:2.1.0"
     exon            381..487
                     /gene="Ywhae"
                     /gene_synonym="14-3-3e"
                     /inference="alignment:Splign:2.1.0"
     exon            488..694
                     /gene="Ywhae"
                     /gene_synonym="14-3-3e"
                     /inference="alignment:Splign:2.1.0"
     exon            695..831
                     /gene="Ywhae"
                     /gene_synonym="14-3-3e"
                     /inference="alignment:Splign:2.1.0"
     exon            832..2042
                     /gene="Ywhae"
                     /gene_synonym="14-3-3e"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcccggattg aggcgccgcc atttttactg ctcggacgcg gagcgagaag ctgagagagt
       61 cggagacgct atccgcttcc atccgtcgtg cagaccctgc cggagccgct gccgctatgg
      121 atgatcggga ggatctggtg taccaggcga agctggcaga gcaggccgag cgatacgacg
      181 aaatggtgga atcaatgaag aaagtagcag gaatggacgt ggagctgaca gttgaagaac
      241 gaaacctttt atctgttgca tataaaaatg tgattggagc cagaagagca tcctggagaa
      301 taatcagcag cattgaacag aaggaagaaa acaagggagg agaggacaaa ttaaagatga
      361 ttcgggagta ccggcaaatg gttgaaactg agctcaagtt aatctgttgt gacattctgg
      421 atgtactgga caagcacctc attccagcag ctaacactgg cgagtccaag gttttctatt
      481 ataaaatgaa aggggactac cacaggtatc tggctgagtt tgccacagga aacgacagga
      541 aggaggcagc agagaacagc cttgtggctt acaaagctgc tagtgacatt gcgatgacag
      601 aacttcctcc aacgcacccc attcgtttag gtcttgctct caacttttcc gtattctact
      661 atgaaattct taattccccc gaccgtgcct gcaggttggc aaaagcagct tttgatgacg
      721 caattgcaga actggacacg ctgagtgaag aaagctataa ggactccaca ctcatcatgc
      781 agctgctacg tgataacctg acgctgtgga cctcagacat gcagggcgat ggtgaagagc
      841 agaataaaga agcgctgcag gatgtggaag atgagaatca gtgagacgta ataaagccaa
      901 caagagaaac catctctgac taccccaccc cacccctgcc cttggaagtt ccccattgtc
      961 actgagaacc accaaatttg actttcacat ttggtctcag aatttaggtt cctgccctgt
     1021 tgtttttctt tctttttctt ttttttctcc cctccccttt tttaaaacaa acagttttca
     1081 gaagttctta aggcaagagt gaatttctgt ggattttact ggtcccagct ttaggttctt
     1141 tacgacacta acaggactgc atagaggctt tttcagcatt actgtattgt ctccggccac
     1201 atgtggcaag atcatcatta gaaatggaaa tgacatttga gagccattag acttctaggt
     1261 gatgcatcta agaaagatta atcacacaat agaggcatat gcgctgtcat ttttcctttt
     1321 tttaattgtt aaattgaatt ttataccaat gtttaaactt aaattgggtg ttagcttgag
     1381 gtgttttggg ggagtttgcg gtaatggttt tgctgtaacg tgtgtttgga actctgctga
     1441 agggctgctg aaaagcacgg tgctggtaac agtccaacag tccgcggctg ctcattcttg
     1501 ccgactcctc cctctgacgc aggttagcat tgaaggtggt atggaagcct gcatgcgtgt
     1561 tcaactcttc ctcttccctc ctcctcggcc tccctcatcc cttcctcctt cgctcgctca
     1621 acctcttttg ttcagtatgt gtaacttgaa gctaatttgt actactggat atctgactgg
     1681 agccacagat acagatctgt attgttctta ctgaaacaca gcatggaatt aacattaaac
     1741 ttaaataaaa caaacctaaa ttaaaaatgc caaatatatt atgcctccat cctttatact
     1801 tctaaaataa aatctctagt ccaaacatat ttgacagtat tgtttgtctg aatgtgaaaa
     1861 tatcccccat tttatcccat aaatcatttg tttcccaatg atgtgtattt gggggtgggg
     1921 tagggaaatt gcttgtaatc tggtgttgaa caactaagtc agtagattgt cctgtctttc
     1981 aaaccagtta gcaacacaat atttatgttt aaatttatca ttaaagtaca acaatcattt
     2041 aa
//
