LOCUS       NP_113791                255 aa            linear   ROD 29-MAR-2024
DEFINITION  14-3-3 protein epsilon [Rattus norvegicus].
ACCESSION   NP_113791
VERSION     NP_113791.2
DBSOURCE    REFSEQ: accession NM_031603.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 255)
  AUTHORS   He,Q.Q., Wu,X., Liu,X.P., Yang,X.J., Yuan,Z.M. and Zhang,Y.
  TITLE     14-3-3 epsilon plays an important role in testicular germ cell
            apoptosis: A functional proteomic study of experimental varicocele
  JOURNAL   Andrologia 51 (6), e13275 (2019)
   PUBMED   30950109
  REMARK    GeneRIF: Study of experimental varicocele in rat model demonstrated
            the pro-apoptotic function of the downregulation of 14-3-3epsilon,
            which may play an important role in germ cell apoptosis induced by
            varicocele.
REFERENCE   2  (residues 1 to 255)
  AUTHORS   Chen,J., Ou,Y., Yang,Y., Li,W., Xu,Y., Xie,Y. and Liu,Y.
  TITLE     KLHL22 activates amino-acid-dependent mTORC1 signalling to promote
            tumorigenesis and ageing
  JOURNAL   Nature 557 (7706), 585-589 (2018)
   PUBMED   29769719
REFERENCE   3  (residues 1 to 255)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 255)
  AUTHORS   Sai,Y., Peng,K., Ye,F., Zhao,X., Zhao,Y., Zou,Z., Cao,J. and
            Dong,Z.
  TITLE     14-3-3 Proteins in the regulation of rotenone-induced neurotoxicity
            might be via its isoform 14-3-3epsilon's involvement in autophagy
  JOURNAL   Cell Mol Neurobiol 33 (8), 1109-1121 (2013)
   PUBMED   24002177
  REMARK    GeneRIF: The regulation of 14-3-3 proteins in rotenone-induced
            neurotoxicity might be associated with its isoform 14-3-3epsilon's
            involvement in autophagy.
REFERENCE   5  (residues 1 to 255)
  AUTHORS   Meng,J., Cui,C., Liu,Y., Jin,M., Wu,D., Liu,C., Wang,E. and Yu,B.
  TITLE     The role of 14-3-3epsilon interaction with phosphorylated Cdc25B at
            its Ser321 in the release of the mouse oocyte from prophase I
            arrest
  JOURNAL   PLoS One 8 (1), e53633 (2013)
   PUBMED   23326474
REFERENCE   6  (residues 1 to 255)
  AUTHORS   Stewart,S., Sundaram,M., Zhang,Y., Lee,J., Han,M. and Guan,K.L.
  TITLE     Kinase suppressor of Ras forms a multiprotein signaling complex and
            modulates MEK localization
  JOURNAL   Mol Cell Biol 19 (8), 5523-5534 (1999)
   PUBMED   10409742
REFERENCE   7  (residues 1 to 255)
  AUTHORS   Gao,L., Gu,X.B., Yu,D.S., Yu,R.K. and Zeng,G.
  TITLE     Association of a 14-3-3 protein with CMP-NeuAc:GM1 alpha
            2,3-sialyltransferase
  JOURNAL   Biochem Biophys Res Commun 224 (1), 103-107 (1996)
   PUBMED   8694795
REFERENCE   8  (residues 1 to 255)
  AUTHORS   Martin,H., Rostas,J., Patel,Y. and Aitken,A.
  TITLE     Subcellular localisation of 14-3-3 isoforms in rat brain using
            specific antibodies
  JOURNAL   J Neurochem 63 (6), 2259-2265 (1994)
   PUBMED   7964746
REFERENCE   9  (residues 1 to 255)
  AUTHORS   Alam,R., Hachiya,N., Sakaguchi,M., Kawabata,S., Iwanaga,S.,
            Kitajima,M., Mihara,K. and Omura,T.
  TITLE     cDNA cloning and characterization of mitochondrial import
            stimulation factor (MSF) purified from rat liver cytosol
  JOURNAL   J Biochem 116 (2), 416-425 (1994)
   PUBMED   7822263
REFERENCE   10 (residues 1 to 255)
  AUTHORS   Roseboom,P.H., Weller,J.L., Babila,T., Aitken,A., Sellers,L.A.,
            Moffett,J.R., Namboodiri,M.A. and Klein,D.C.
  TITLE     Cloning and characterization of the epsilon and zeta isoforms of
            the 14-3-3 proteins
  JOURNAL   DNA Cell Biol 13 (6), 629-640 (1994)
   PUBMED   8024705
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 20, 2020 this sequence version replaced NP_113791.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ220393.1, M84416.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..255
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     Protein         1..255
                     /product="14-3-3 protein epsilon"
                     /note="14-3-3 epsilon; mitochondrial import stimulation
                     factor (MSF) L subunit; MSF L; mitochondrial import
                     stimulation factor L subunit; tyrosine
                     3-monooxygenase/tryptophan 5-monooxygenase
                     activatioprotein epsilon polypeptide; tyrosine
                     3-monooxygenase/tryptophan 5-monooxygenase activation
                     protein, epsilon polypeptide"
                     /calculated_mol_wt=29043
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine. /evidence=ECO:0000269|Ref.5;
                     propagated from UniProtKB/Swiss-Prot (P62260.1)"
     Region          4..233
                     /region_name="14-3-3_epsilon"
                     /note="14-3-3 epsilon, an isoform of 14-3-3 protein;
                     cd10020"
                     /db_xref="CDD:206757"
     Site            order(6,10,13..14,16,26,59,62,66,81..82,84..85,88..89,92)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:206757"
     Site            order(50,57,130..131,172,175..176,179,182..183,219..220,
                     223,227,230..231)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:206757"
     Site            50
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P62258; propagated from
                     UniProtKB/Swiss-Prot (P62260.1)"
     Site            57
                     /site_type="other"
                     /note="Interaction with phosphoserine on interacting
                     protein. /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P62260.1)"
     Site            65
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P62260.1)"
     Site            69
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P62258; propagated from
                     UniProtKB/Swiss-Prot (P62260.1)"
     Site            118
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P62258; propagated from
                     UniProtKB/Swiss-Prot (P62260.1)"
     Site            123
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P62258; propagated from
                     UniProtKB/Swiss-Prot (P62260.1)"
     Site            130
                     /site_type="other"
                     /note="Interaction with phosphoserine on interacting
                     protein. /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P62260.1)"
     Site            131
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P62260.1)"
     Site            137
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P62260.1)"
     Site            210
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P62260.1)"
     Site            232
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P62258; propagated from
                     UniProtKB/Swiss-Prot (P62260.1)"
     Region          234..255
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P62260.1)"
     CDS             1..255
                     /gene="Ywhae"
                     /gene_synonym="14-3-3e"
                     /coded_by="NM_031603.2:117..884"
                     /db_xref="GeneID:29753"
                     /db_xref="RGD:62000"
ORIGIN      
        1 mddredlvyq aklaeqaery demvesmkkv agmdveltve ernllsvayk nvigarrasw
       61 riissieqke enkggedklk mireyrqmve telkliccdi ldvldkhlip aantgeskvf
      121 yykmkgdyhr ylaefatgnd rkeaaenslv aykaasdiam telppthpir lglalnfsvf
      181 yyeilnspdr acrlakaafd daiaeldtls eesykdstli mqllrdnltl wtsdmqgdge
      241 eqnkealqdv edenq
//
