LOCUS       NM_019377               2692 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus tyrosine 3-monooxygenase/tryptophan
            5-monooxygenase activation protein, beta (Ywhab), mRNA.
ACCESSION   NM_019377
VERSION     NM_019377.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2692)
  AUTHORS   Feng,L., Dou,C., Wang,J., Jiang,C., Ma,X. and Liu,J.
  TITLE     Upregulated 14-3-3beta aggravates restenosis by promoting cell
            migration following vascular injury in diabetic rats with elevated
            levels of free fatty acids
  JOURNAL   Int J Mol Med 42 (2), 1074-1085 (2018)
   PUBMED   29749466
  REMARK    GeneRIF: The expression of YWHAB was upregulated by oleic acid in a
            concentrationdependent manner in vascular smooth muscle cells.
REFERENCE   2  (bases 1 to 2692)
  AUTHORS   Feng,L., Ma,X., Wang,J. and Tian,Q.
  TITLE     Up-regulation of 14-3-3beta plays a role in intimal hyperplasia
            following carotid artery injury in diabetic Sprague Dawley rats by
            promoting endothelial cell migration and proliferation
  JOURNAL   Biochem Biophys Res Commun 490 (4), 1237-1243 (2017)
   PUBMED   28684312
  REMARK    GeneRIF: The results indicate that hyperglycemia-induced
            up-regulation of YWHAB in endothelial cell plays a significant role
            in intimal hyperplasia following carotid artery injury by enhancing
            endothelial cell proliferation and migration.
REFERENCE   3  (bases 1 to 2692)
  AUTHORS   Lee,D.H., Steinacker,P., Seubert,S., Turnescu,T., Melms,A.,
            Manzel,A., Otto,M. and Linker,R.A.
  TITLE     Role of glial 14-3-3 gamma protein in autoimmune demyelination
  JOURNAL   J Neuroinflammation 12, 187 (2015)
   PUBMED   26438180
  REMARK    GeneRIF: This study reveals that 14-3-3 gamma protein is present in
            oligodendroglial cells and that 14-3-3 gamma deficiency leads to
            more severe chronic EAE with enhanced demyelination.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2692)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2692)
  AUTHORS   Riou,P., Kjaer,S., Garg,R., Purkiss,A., George,R., Cain,R.J.,
            Bineva,G., Reymond,N., McColl,B., Thompson,A.J., O'Reilly,N.,
            McDonald,N.Q., Parker,P.J. and Ridley,A.J.
  TITLE     14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif
            to inhibit G proteins
  JOURNAL   Cell 153 (3), 640-653 (2013)
   PUBMED   23622247
  REMARK    Erratum:[Cell. 2013 May 23;153(5):1164]
REFERENCE   6  (bases 1 to 2692)
  AUTHORS   Ostrerova,N., Petrucelli,L., Farrer,M., Mehta,N., Choi,P., Hardy,J.
            and Wolozin,B.
  TITLE     alpha-Synuclein shares physical and functional homology with 14-3-3
            proteins
  JOURNAL   J Neurosci 19 (14), 5782-5791 (1999)
   PUBMED   10407019
REFERENCE   7  (bases 1 to 2692)
  AUTHORS   York,R.D., Yao,H., Dillon,T., Ellig,C.L., Eckert,S.P.,
            McCleskey,E.W. and Stork,P.J.
  TITLE     Rap1 mediates sustained MAP kinase activation induced by nerve
            growth factor
  JOURNAL   Nature 392 (6676), 622-626 (1998)
   PUBMED   9560161
REFERENCE   8  (bases 1 to 2692)
  AUTHORS   Takai,R., Tanaka,E., Miyazaki,T., Suda,M. and Tashiro,F.
  TITLE     Function of RNH-1/14-3-3 beta gene in cellular differentiation and
            proliferation
  JOURNAL   J Biochem 118 (5), 1045-1053 (1995)
   PUBMED   8749325
REFERENCE   9  (bases 1 to 2692)
  AUTHORS   Watanabe,M., Isobe,T., Ichimura,T., Kuwano,R., Takahashi,Y.,
            Kondo,H. and Inoue,Y.
  TITLE     Molecular cloning of rat cDNAs for the zeta and theta subtypes of
            14-3-3 protein and differential distributions of their mRNAs in the
            brain
  JOURNAL   Brain Res Mol Brain Res 25 (1-2), 113-121 (1994)
   PUBMED   7984035
REFERENCE   10 (bases 1 to 2692)
  AUTHORS   Watanabe,M., Isobe,T., Ichimura,T., Kuwano,R., Takahashi,Y. and
            Kondo,H.
  TITLE     Molecular cloning of rat cDNAs for beta and gamma subtypes of
            14-3-3 protein and developmental changes in expression of their
            mRNAs in the nervous system
  JOURNAL   Brain Res Mol Brain Res 17 (1-2), 135-146 (1993)
   PUBMED   8381897
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NM_019377.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC076502.1, D17446.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               JAXUCZ010000003.1  173079071-173079224
            155-457             JAXUCZ010000003.1  173094492-173094794
            458-581             JAXUCZ010000003.1  173096766-173096889
            582-745             JAXUCZ010000003.1  173098132-173098295
            746-841             JAXUCZ010000003.1  173099077-173099172
            842-2692            JAXUCZ010000003.1  173099658-173101508
FEATURES             Location/Qualifiers
     source          1..2692
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..2692
                     /gene="Ywhab"
                     /note="tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
                     activation protein, beta"
                     /db_xref="GeneID:56011"
                     /db_xref="RGD:61998"
     exon            1..154
                     /gene="Ywhab"
                     /inference="alignment:Splign:2.1.0"
     exon            155..457
                     /gene="Ywhab"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..898
                     /gene="Ywhab"
                     /note="tyrosine 3/tryptophan 5 -monooxygenase activation
                     protein, beta polypeptide; KCIP-1; prepronerve growth
                     factor RNH-1; protein kinase C inhibitor protein 1;
                     tyrosine 3-monooxgenase/tryptophan 5 monooxgenase
                     activation protein, beta polypeptide; 14-3-3 protein
                     beta-subtype; tryosine 3-monooxygenase/tryptophan
                     5-monooxygenase activation protein beta polypeptide;
                     tryosine 3-monooxygenase/tryptophan 5-monooxygenase
                     activation protein gamma; 3-monooxygenase/tryptophan 5
                     monooxygenase activation protein beta polypeptide;
                     tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
                     activation protein, beta polypeptide"
                     /codon_start=1
                     /product="14-3-3 protein beta/alpha"
                     /protein_id="NP_062250.1"
                     /db_xref="GeneID:56011"
                     /db_xref="RGD:61998"
                     /translation="MTMDKSELVQKAKLAEQAERYDDMAAAMKAVTEQGHELSNEERN
                     LLSVAYKNVVGARRSSWRVISSIEQKTERNEKKQQMGKEYREKIEAELQDICSDVLEL
                     LDKYLILNATHAESKVFYLKMKGDYFRYLSEVASGDNKQTTVSNSQQAYQEAFEISKK
                     EMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLNEESYKDSTL
                     IMQLLRDNLTLWTSENQGDEGDAGEGEN"
     exon            458..581
                     /gene="Ywhab"
                     /inference="alignment:Splign:2.1.0"
     exon            582..745
                     /gene="Ywhab"
                     /inference="alignment:Splign:2.1.0"
     exon            746..841
                     /gene="Ywhab"
                     /inference="alignment:Splign:2.1.0"
     exon            842..2692
                     /gene="Ywhab"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgggtagc cactgccgct gccgccgcca ctgcatctac tgtcgccgcc accgccgctg
       61 ccgccagcat cgcctgagga gtgagtccgg gaaggacgta gtcgctgccc ttcgatcttc
      121 ccggaagcgc ctttgctccc tacagtcctc cgcgaaaatg accatggaca aaagtgagct
      181 ggtacagaaa gccaaacttg ctgagcaagc tgagcgttat gatgatatgg ccgcagctat
      241 gaaggctgta acagagcagg gacatgaact ctccaatgaa gagaggaatc tactctctgt
      301 tgcctacaag aatgtggtag gtgcccgccg ttcttcctgg cgagtcatct ccagcatcga
      361 acagaaaaca gagaggaatg agaagaagca gcagatgggc aaggagtacc gtgagaagat
      421 agaggccgag ctgcaggaca tctgcagtga cgttctggag ctgttggaca aatatctcat
      481 tctcaatgct acccatgcag aaagcaaagt gttctactta aaaatgaaag gagactattt
      541 taggtatctt tctgaagttg catctggaga taataaacaa accactgtgt caaactccca
      601 gcaggcgtac caagaagcat ttgaaatcag caagaaagaa atgcagccta cacacccgat
      661 tcgccttggc ctggctctga atttctcagt cttttactat gagattctaa actctcctga
      721 aaaggcctgt agcctggcca aaacggcgtt tgatgaagcc attgctgagt tggacaccct
      781 gaatgaagag tcttacaaag acagcaccct gatcatgcag ctgctaaggg acaatctcac
      841 cctgtggacg tcagaaaacc agggggatga aggagatgct ggagagggag agaactaatg
      901 tctattgagc tctgtgatct gtttggtgtc actgtatcct ccacattatg tccctttgtg
      961 cgataaacaa aaacaaaaaa aatccaatgt ggactttcga tctttcacag cctaagcctt
     1021 gcagaaacgg tccctgggat gaacagctgg tatttgtatc taaaactcag actggtccct
     1081 taaatgccat ggtattttga agtcttgatt tgatcaacat tgacaaggat tactgtgtgt
     1141 ttaattttta caaactgaac actgtgatta cagggcttta taacttagca gagctcttcc
     1201 tggtaggaaa aattgacctg aattatgtgt aactttttgg aaagtttaat ctgatatcaa
     1261 aatggtcact gaaatacaat tctgttgtaa agttgtacag aaagttctag agattctctt
     1321 gtgatgctgg gacttgggcg agatgcttac ccttggcatc ctgagtgtgg taactcacag
     1381 taattctgcc tgtggttgag ggcctgttaa cccttgatca ctttgggctg ttaccactca
     1441 aaagttcatg accgcaaata tctgcagtgt cttctgagga aattcaaaac ctgaaagtga
     1501 acttctttgg ctgataattg ggctgtaaca ccacaaaaag gtcccgtgtt cataccacat
     1561 gtgtgactaa acctttttat tatagcaacg tgttcctgat tagctccatg tgaaaacggg
     1621 gctgttaccc cctagctgaa ggagagggga aagagagaga aagtagtgta tcatataaac
     1681 ggccatacca gttttttgga tgattcttca atgttctgtg gatgcggcct cttgcctgag
     1741 gagcattcct agccttgggg tgggagctgt gacacgtaac attcttctca ccctgtcctt
     1801 ttgacttttg actttttcct ctttaaatgt acagctttct gcttccttgg gtggttttct
     1861 tgggaagcct ttattagtca gtactgtgtg gacagggcgg ggcattgagc acatggtgag
     1921 agctgtgctt taaaggttga gaaagacctt ccagcaccac accctgtctc cctccaggtc
     1981 tcagcacagt tgttcttcat agtatgaccc aaatcgggaa aaaataaagg acttttaagt
     2041 atttgtgatt tcccccattg cacccagccc tgacagtgct ttgtctgtgc ctgtgacaga
     2101 ccctccctcc agtggactca tccagcttcg tcctcagaca cgcctcaaga agacttagaa
     2161 cacagggaag ttgcatggac actacagtag agagaaccaa gaacagccag gccttcagtc
     2221 tcacagtatc acccctctac cttgacattc cgtgtaccca tagctgtaga gttcatccgt
     2281 ttgtccatct gctgaaatat gaaaagaatt catgcactga tttaaacaaa aacaaaaaac
     2341 ccacaaaaaa atttcttctt tctagctgaa cagaaaacgt gcagttaata ctcggcgctt
     2401 gacaagcagc agcgagtgtg gaccaagcct gtctgtatct ggtagctctt cgctctgttt
     2461 tctttcctta ccagtattct gcctaatgtt tgcttccgtg gtggttcttt gcctagcaag
     2521 cacacctgtg gttgtgaaaa tagtatagca aaaagaaaaa gaccccctcc ccacccccag
     2581 ttactgatgt gctagatccg tgtatgtctt ttaaacattc tagtttctcc ttacacagag
     2641 taatcaggac gatgtaaaaa ctcaaaagtg aaataaaaca tcttatcagt ta
//
