LOCUS       NM_001108546            4150 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus YTH N6-methyladenosine RNA binding protein F3
            (Ythdf3), mRNA.
ACCESSION   NM_001108546 XM_001054853 XM_001054909 XM_001054965 XM_342217
VERSION     NM_001108546.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4150)
  AUTHORS   Zhang Y, Wang X, Zhang X, Wang J, Ma Y, Zhang L and Cao X.
  TITLE     RNA-binding protein YTHDF3 suppresses interferon-dependent
            antiviral responses by promoting FOXO3 translation
  JOURNAL   Proc Natl Acad Sci U S A 116 (3), 976-981 (2019)
   PUBMED   30591559
REFERENCE   2  (bases 1 to 4150)
  AUTHORS   Li A, Chen YS, Ping XL, Yang X, Xiao W, Yang Y, Sun HY, Zhu Q,
            Baidya P, Wang X, Bhattarai DP, Zhao YL, Sun BF and Yang YG.
  TITLE     Cytoplasmic m6A reader YTHDF3 promotes mRNA translation
  JOURNAL   Cell Res 27 (3), 444-447 (2017)
   PUBMED   28106076
REFERENCE   3  (bases 1 to 4150)
  AUTHORS   Shi H, Wang X, Lu Z, Zhao BS, Ma H, Hsu PJ, Liu C and He C.
  TITLE     YTHDF3 facilitates translation and decay of
            N6-methyladenosine-modified RNA
  JOURNAL   Cell Res 27 (3), 315-328 (2017)
   PUBMED   28106072
REFERENCE   4  (bases 1 to 4150)
  AUTHORS   Wang X, Lu Z, Gomez A, Hon GC, Yue Y, Han D, Fu Y, Parisien M, Dai
            Q, Jia G, Ren B, Pan T and He C.
  TITLE     N6-methyladenosine-dependent regulation of messenger RNA stability
  JOURNAL   Nature 505 (7481), 117-120 (2014)
   PUBMED   24284625
REFERENCE   5  (bases 1 to 4150)
  AUTHORS   Baltz AG, Munschauer M, Schwanhausser B, Vasile A, Murakawa Y,
            Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E,
            Bonneau R, Selbach M, Dieterich C and Landthaler M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 4150)
  AUTHORS   Dominissini D, Moshitch-Moshkovitz S, Schwartz S, Salmon-Divon M,
            Ungar L, Osenberg S, Cesarkas K, Jacob-Hirsch J, Amariglio N,
            Kupiec M, Sorek R and Rechavi G.
  TITLE     Topology of the human and mouse m6A RNA methylomes revealed by
            m6A-seq
  JOURNAL   Nature 485 (7397), 201-206 (2012)
   PUBMED   22575960
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473961.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_342217.3, XM_001054965.1, XM_001054853.1, XM_001054909.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4150
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q24"
     gene            1..4150
                     /gene="Ythdf3"
                     /note="YTH N6-methyladenosine RNA binding protein F3"
                     /db_xref="GeneID:361920"
                     /db_xref="RGD:1305234"
     exon            1..267
                     /gene="Ythdf3"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..2001
                     /gene="Ythdf3"
                     /note="YTH domain family protein 3; YTH domain family 3;
                     YTH domain family, member 3; YTH N(6)-methyladenosine RNA
                     binding protein 3"
                     /codon_start=1
                     /product="YTH domain-containing family protein 3"
                     /protein_id="NP_001102016.1"
                     /db_xref="GeneID:361920"
                     /db_xref="RGD:1305234"
                     /translation="MSATSVDQRPKGQGNKVSVQNGSIHQKDAVNDDDFEPYLSSQTN
                     QNNSYPPMSDPYMPSYYAPSIGFPYSLGEAAWSTAGDQPMPYLTTYGQMSNGEHHYIP
                     DGVFSQPGALGNTPPFLGQHGFNFFPGNADFSTWGTSGSQGQSTQNSAYSSSYGYPPS
                     SLGRAITDGQAGFGNDTLSKVPGISSIEQGMTGLKIGGDLTAAVTKTVGTALSSSGMT
                     SIATNNVPPVSSAAPKPTSWAAIARKPAKPQPKLKPKGSVGIGGSAVPPPPIKHNMNI
                     GTWDEKGSVVKAPPTQPVLPPQTIIQQPQPLIQPPPLVQSQLPQQQPQPPQPQQQQGP
                     QPQAQPHQVQSQQPQLQNRWVAPRNRGTGFNQNNGTGSENFGLGVVPVSASPSSVEVH
                     PVLEKLKAINNYNPKDFDWNLKNGRVFIIKSYSEDDIHRSIKYSIWCSTEHGNKRLDA
                     AYRSLNGKGPLYLLFSVNGSGHFCGVAEMKSVVDYNAYAGVWSQDKWKGKFEVKWIFV
                     KDVPNNQLRHIRLENNDNKPVTNSRDTQEVPLEKAKQVLKIIATFKHTTSIFDDFAHY
                     EKRQEEEEAMRRERNRNKQ"
     exon            268..292
                     /gene="Ythdf3"
                     /inference="alignment:Splign:2.1.0"
     exon            293..378
                     /gene="Ythdf3"
                     /inference="alignment:Splign:2.1.0"
     exon            379..1977
                     /gene="Ythdf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..4150
                     /gene="Ythdf3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagtgggg ctctggagct tgtccgccat tgtgggcccg aggatcggag gacgagcggg
       61 gacgagcagt gtgcaggcgg cgagctcggg ccccttccgc gactcccgag cgcgagcccg
      121 cttcctggag cctacaagag cggcagcggc aaaggcagag cttcgcgagg gcgacagtcg
      181 actgctgtga gtgctctcgg agaggcccag gcggcggcgg ttcctctcgg gttacggtga
      241 agaatgtcag ccactagcgt ggatcagaga cctaaagggc aaggaaataa agtttcagta
      301 caaaatggtt cgattcatca aaaagatgct gtaaatgatg atgattttga gccatactta
      361 agtagccaga caaatcagaa taacagctat ccaccaatgt cagatccata tatgcctagt
      421 tactatgctc catccattgg atttccatat tctcttgggg aagcagcatg gtccacggct
      481 ggagatcagc ccatgccata tctgacaacc tatggacaaa tgagtaatgg agaacatcat
      541 tacataccag atggtgtttt tagtcaacca ggggcattag gaaatacccc tccatttctt
      601 ggtcaacatg gatttaactt ttttcctggt aatgctgatt tctctacatg gggaacaagt
      661 ggatctcagg gacaatcaac acaaaattct gcttatagta gcagttacgg ctatccacct
      721 agttctcttg ggagagctat tactgatgga caggccggat ttggcaatga tactttgagt
      781 aaggtgcctg gcattagtag tattgagcaa ggcatgactg gactgaaaat tggtggtgac
      841 ctgacagctg cagtgacaaa aactgtaggt acagccttga gcagcagtgg tatgactagc
      901 attgcaacca ataatgtgcc ccctgttagc agtgcagcac ctaaaccaac ttcttgggct
      961 gctattgcca gaaagcctgc aaaacctcaa ccgaaactta aacccaaggg cagtgtggga
     1021 attgggggtt ctgctgtgcc accacctcct ataaaacaca atatgaatat tggaacttgg
     1081 gatgaaaagg ggtcagtggt aaaggctcca ccaacccaac cagttctgcc tcctcaaact
     1141 ataatccagc agcctcagcc attaattcaa ccaccaccat tggtgcaaag ccaactgcct
     1201 caacagcagc ctcagccacc acaaccacag cagcaacaag gacctcagcc acaggcccag
     1261 cctcaccaag tgcagtctca acagccacag ttgcagaatc gttgggtagc tcctcggaat
     1321 aggggaaccg gcttcaacca gaacaatgga acaggcagtg aaaactttgg tttaggtgtt
     1381 gtacctgtta gtgcttcacc ttctagtgta gaggtgcatc cagtgctgga aaaactaaag
     1441 gccataaaca attataatcc caaagacttt gattggaacc tgaagaatgg acgtgtgttt
     1501 ataattaaga gctattctga ggatgatata caccgttcca tcaagtactc tatctggtgt
     1561 agtactgagc atggtaataa gcgtttggat gcagcttacc gttccctgaa tgggaaaggc
     1621 ccactctatt tgctcttcag tgtgaatggc agtggacatt tttgtggagt ggctgaaatg
     1681 aagtctgttg tagactataa tgcttatgct ggtgtttggt ctcaggataa atggaagggc
     1741 aaatttgaag ttaaatggat ctttgtcaaa gatgttccca ataaccaatt acgacatatt
     1801 cgcttagaaa ataatgacaa caaaccagta accaattcaa gagacactca agaagtaccc
     1861 ctagaaaaag caaagcaagt gcttaaaata attgctactt tcaagcacac cacctcaatc
     1921 tttgatgact ttgcacatta tgaaaagcgt caagaggagg aggaagccat gcgaagggag
     1981 agaaatagaa acaagcaata accaccgtgt ggagatgtcc tattaaaatg acaacactaa
     2041 tgatgtagac tctggaaatg cctaataagt caaagaagac gttattaaag ctttttgttt
     2101 tctgcttaag gtgacatctt tgaacccttt taacacaaaa ttgactcttc ttgtaatggt
     2161 tttcatcagc gcatctgccc ttattctctc accaaacaca cttgagaact gtaacttcat
     2221 caagcacttt gtgtcctgaa gcttttacca gtacctgctg tcttttgtaa ttatgcatcc
     2281 tagctaaggc acagaagact gaatgaattg caaggattca ttaactcttt gaatttgtta
     2341 agtactaaca gttaaccaat agaagtggtt caatgatgta agagtctcac tgcttcaatc
     2401 ttttcattgt tgtagttttt aaattgtcaa tttttagcta tttgacagat taaaaacaaa
     2461 ataatcatgc catatttagt cctggagttc aagtctgaat gtttatgtga aaaattattg
     2521 tagcaaactt ttaatatggc aaagcaacct tatgctctat tttagccaaa caatacataa
     2581 tctaaaatta tatattagaa catttccctt gtcttcaaac tacttgatgt aacaaaatat
     2641 tgatatgcag cttggtgaat ctcaccaatt aatgcacccc ctcctttcca attatatgta
     2701 cactgagaat atgggttggt ttgagggatt attttgtttc taccacttaa tgaatctcaa
     2761 cattttgagt aaatgtacct cagtctaatc agacttttta tgacctttat aactacattt
     2821 aaaaccctta aattctattt ctgggtgttt gcgagcctga ttgctatcat gaagtaaaaa
     2881 tttattactc taggtattca ctagataaat aaagatagtt cttgtttagt aagcatatac
     2941 tgtttctcaa ctcttctcca gcttttgcag tgtactggca tccttaaaat actttgaaaa
     3001 tatggccttg atccatgaat taaatcagta tctaagtgaa tgtgttgacg ttttattgat
     3061 gagatctata tacatgggaa tacagtatat atctgggtat tcttatagat aatcttttta
     3121 acatcctatt tttttcatta attacatatc aatattaatt ttgtatcttg aaacaaattg
     3181 attttgtata attgaatgtg ttgtgcatct gtatttgatt tgatggcata aggttatgaa
     3241 aataatgtcc ttccccttat aatactgttt tgaaaggaga aagctatgta gaatgatatg
     3301 ttaagggtga aaatagcaat acagtagatt tgaatgtcct tatgatctgc attagttcat
     3361 ttatgtttac atcgtgttta gagatattat catttgctct tgtctttgct cacttcaatt
     3421 caaaagcctc gtgactgata tttctttgaa actttgattt atataatttt tatacaatgt
     3481 cttagaatgt acaaatattg tattttttta ttaaaataca gtatttgtag atgaccatag
     3541 ctacttcaca attacttgtt agtcccagtg tagttatgtc agtgtttact gaagggaaca
     3601 caaaaatatt aatggtttat tacagaatga aaactttctt aaaggaagat tgcacctatt
     3661 ttaccttttt gagactaagc catgaaatct tgtaatatgt ctcttatcta tttataatga
     3721 aagttggcat ttgggtatag tcagcacagc aatgttctat atccttaaga ttgtataagt
     3781 aggacatttt aaagatgaca catgtcattc tggaactcct actagagaaa actgtaaaag
     3841 ggtgaccttg taggaaggag ctgagtcctc cccctgaggt tctctttttc ttggtgcttt
     3901 attagcaact ctggatattt ttataaaact agttacatta taaactaatt cagtcttgtt
     3961 taatttacat taggttttat gtaagaaatg tcattgaaat acccaatgag caggctgatt
     4021 gcagtagact cagacagggc cagtgaatct cagctgagag tctattcgtg gtgaggagaa
     4081 catcccagtg cctttaacct gaatttctaa tcttatgtga aatgggtgca gcattccttt
     4141 ggacaaaagc
//
