LOCUS       NM_001047099            2922 bp    mRNA    linear   ROD 27-FEB-2024
DEFINITION  Rattus norvegicus YTH N6-methyladenosine RNA binding protein F2
            (Ythdf2), mRNA.
ACCESSION   NM_001047099 XM_001063404 XM_039109797 XM_232772
VERSION     NM_001047099.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2922)
  AUTHORS   Chen,H., Guo,S., Li,R., Yang,L., Wang,R., Jiang,Y. and Hao,Y.
  TITLE     YTHDF2-regulated matrilin-3 mitigates post-reperfusion hemorrhagic
            transformation in ischemic stroke via the PI3K/AKT pathway
  JOURNAL   J Neuropathol Exp Neurol 83 (3), 194-204 (2024)
   PUBMED   38230623
  REMARK    GeneRIF: YTHDF2-regulated matrilin-3 mitigates post-reperfusion
            hemorrhagic transformation in ischemic stroke via the PI3K/AKT
            pathway.
REFERENCE   2  (bases 1 to 2922)
  AUTHORS   Chen,Y., Liu,X., Li,L., He,X., Zheng,F., Zhang,Y., Gao,H., Jin,Z.,
            Wu,D., Wang,Q., Tao,H., Zhao,Y., Liu,W. and Zou,L.
  TITLE     Methyltransferase-like 3 aggravates endoplasmic reticulum stress in
            preeclampsia by targeting TMBIM6 in YTHDF2-dependent manner
  JOURNAL   Mol Med 29 (1), 19 (2023)
   PUBMED   36747144
  REMARK    GeneRIF: Methyltransferase-like 3 aggravates endoplasmic reticulum
            stress in preeclampsia by targeting TMBIM6 in YTHDF2-dependent
            manner.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2922)
  AUTHORS   Li,J., Yao,H., Huang,J., Li,C., Zhang,Y., Xu,R., Wang,Z., Long,Z.,
            Tang,J. and Wang,L.
  TITLE     METTL3 promotes prostatic hyperplasia by regulating PTEN expression
            in an m6A-YTHDF2-dependent manner
  JOURNAL   Cell Death Dis 13 (8), 723 (2022)
   PUBMED   35985997
  REMARK    GeneRIF: METTL3 promotes prostatic hyperplasia by regulating PTEN
            expression in an m(6)A-YTHDF2-dependent manner.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2922)
  AUTHORS   Park,O.H., Ha,H., Lee,Y., Boo,S.H., Kwon,D.H., Song,H.K. and
            Kim,Y.K.
  TITLE     Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP
            Complex
  JOURNAL   Mol Cell 74 (3), 494-507 (2019)
   PUBMED   30930054
REFERENCE   5  (bases 1 to 2922)
  AUTHORS   Winkler,R., Gillis,E., Lasman,L., Safra,M., Geula,S., Soyris,C.,
            Nachshon,A., Tai-Schmiedel,J., Friedman,N., Le-Trilling,V.T.K.,
            Trilling,M., Mandelboim,M., Hanna,J.H., Schwartz,S. and
            Stern-Ginossar,N.
  TITLE     m6A modification controls the innate immune response to infection
            by targeting type I interferons
  JOURNAL   Nat Immunol 20 (2), 173-182 (2019)
   PUBMED   30559377
  REMARK    Erratum:[Nat Immunol. 2019 Jan 11;:. PMID: 30635652]
REFERENCE   6  (bases 1 to 2922)
  AUTHORS   Li,F., Zhao,D., Wu,J. and Shi,Y.
  TITLE     Structure of the YTH domain of human YTHDF2 in complex with an
            m(6)A mononucleotide reveals an aromatic cage for m(6)A recognition
  JOURNAL   Cell Res 24 (12), 1490-1492 (2014)
   PUBMED   25412658
REFERENCE   7  (bases 1 to 2922)
  AUTHORS   Wang,X., Lu,Z., Gomez,A., Hon,G.C., Yue,Y., Han,D., Fu,Y.,
            Parisien,M., Dai,Q., Jia,G., Ren,B., Pan,T. and He,C.
  TITLE     N6-methyladenosine-dependent regulation of messenger RNA stability
  JOURNAL   Nature 505 (7481), 117-120 (2014)
   PUBMED   24284625
REFERENCE   8  (bases 1 to 2922)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   9  (bases 1 to 2922)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   10 (bases 1 to 2922)
  AUTHORS   Dominissini,D., Moshitch-Moshkovitz,S., Schwartz,S.,
            Salmon-Divon,M., Ungar,L., Osenberg,S., Cesarkas,K.,
            Jacob-Hirsch,J., Amariglio,N., Kupiec,M., Sorek,R. and Rechavi,G.
  TITLE     Topology of the human and mouse m6A RNA methylomes revealed by
            m6A-seq
  JOURNAL   Nature 485 (7397), 201-206 (2012)
   PUBMED   22575960
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000162.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001047099.3.
            
            On or before Mar 4, 2021 this sequence version replaced
            XM_039109797.1, NM_001047099.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166407.1, SRR8487230.21589.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132263 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-349               JACYVU010000162.1  58954979-58955327   c
            350-374             JACYVU010000162.1  58954518-58954542   c
            375-454             JACYVU010000162.1  58953830-58953909   c
            455-2038            JACYVU010000162.1  58947291-58948874   c
            2039-2922           JACYVU010000162.1  58930730-58931613   c
FEATURES             Location/Qualifiers
     source          1..2922
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2922
                     /gene="Ythdf2"
                     /note="YTH N6-methyladenosine RNA binding protein F2"
                     /db_xref="GeneID:313053"
                     /db_xref="RGD:1311321"
     exon            1..349
                     /gene="Ythdf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             323..2062
                     /gene="Ythdf2"
                     /note="YTH domain family protein 2; YTH domain family 2;
                     YTH domain family, member 2; YTH N(6)-methyladenosine RNA
                     binding protein 2"
                     /codon_start=1
                     /product="YTH domain-containing family protein 2"
                     /protein_id="NP_001040564.2"
                     /db_xref="GeneID:313053"
                     /db_xref="RGD:1311321"
                     /translation="MSASSLLEQRPKGQGNKVQNGSVHQKDGLNDDDFEPYLSPQARP
                     NNAYTAMSDSYLPSYYSPSIGFSYSLGEAAWSTGGDTAMPYLTSYGQLSNGEPHFLPD
                     AMFGQPGALGSTPFLGQHGFNFFPSGIDFSAWGNNSSQGQSTQSSGYSSNYAYAPSSL
                     GGAMIDGQSAFANETLNKAPGMNTIDQGMAALKLGSTEVASSVPKVVGSAVGSGSITS
                     NIVASSSLPPATIAPPKPASWADIASKPAKQQPKLKTKNGIAGSSLPPPPIKHNMDIG
                     TWDNKGPVAKAPSQALVQNIGQPTQGSPQPVGQQANNSPPVTQTSVGQQTQPLPPPPP
                     QPAQLSVQQQAAQPTRWVAPRNRGSGFGHNGVDGNGVGQSQAGSGSTPSEPHPVLEKL
                     RSINNYNPKDFDWNLKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMN
                     GKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWIFVKDVPNS
                     QLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYKHTTSIFDDFSHYEKRQEE
                     EESVKKERQGRGK"
     exon            350..374
                     /gene="Ythdf2"
                     /inference="alignment:Splign:2.1.0"
     exon            375..454
                     /gene="Ythdf2"
                     /inference="alignment:Splign:2.1.0"
     exon            455..2038
                     /gene="Ythdf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2922
                     /gene="Ythdf2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgggttagtg aatgtgagag tcagcgctcg cgccgcgcgc gccgcccgtc tctgccgctc
       61 ggctcccaca tcccggctgt gagaggcggg cgcgcgcgcc agagcataga gacgggcgtt
      121 gagctgtccg gctagagcgt cgctgaatcg gagccggagc ccgagccgcg cgctgtgtct
      181 ccgctgcgtc cgccgaggct ccgagtgtca gggacaaaag ccgccgccgc gccctctgct
      241 cctgccgccg gggctcatcc gccgccgccg ccgtgctgac gaggagtccg ccaccgacgt
      301 taccagtgag gatccgagag ccatgtcggc cagcagcctc ttggagcaga gaccaaaagg
      361 tcaaggaaac aaagtacaaa atggttctgt gcatcaaaag gatggtctaa atgatgatga
      421 tttcgaacct tacttgagcc cacaggcaag gccgaataat gcatatactg ccatgtcaga
      481 ctcctactta cccagttact acagcccctc tattggcttt tcctattctt tgggtgaagc
      541 tgcttggtct actggaggtg acacagccat gccctatcta acttcttatg gacaactgag
      601 caacggagag ccccactttc taccagatgc aatgtttggg caaccaggag ccctaggtag
      661 cactccattt cttggtcagc atggttttaa tttttttccc agtgggattg acttctcagc
      721 atggggaaat aacagttctc agggacagtc tactcaaagc tctggatata gtagcaatta
      781 tgcttatgca cccagctcct taggtggagc catgattgat ggacagtcag cttttgccaa
      841 tgagaccctc aataaagctc ctggcatgaa tactatagac caagggatgg cagcactgaa
      901 actaggtagc acagaagttg cgagcagtgt tcccaaagtt gtaggctctg ctgttggtag
      961 tgggtccatc actagtaaca ttgtggcttc tagcagtttg cctccagcta ctattgctcc
     1021 tccaaaacca gcatcttggg ctgatattgc tagcaaacct gcaaaacaac aacctaagct
     1081 gaagaccaag aatggcattg caggatcaag tcttccaccg cccccaataa agcataacat
     1141 ggatattgga acttgggata acaagggtcc tgtggcaaaa gccccctcac aggctttggt
     1201 tcaaaatata ggtcagccaa cccagggatc tcctcagcct gtaggacagc aggccaataa
     1261 tagcccacca gtgactcaga catcagtagg gcaacagaca cagccattgc ctccacctcc
     1321 accacagcct gctcagctct cagtccagca gcaggcagct cagccaactc gctgggtagc
     1381 acctcggaac cgtggcagtg ggttcggtca taatggggtg gatggtaatg gagtaggaca
     1441 gtctcaggcg ggttctggat ctactccttc agagcctcac ccagtgttgg agaaacttcg
     1501 gtccattaat aactataacc ctaaagattt cgactggaat ctgaaacacg gccgggtttt
     1561 catcattaag agctactctg aggacgatat ccaccgttcc attaagtata atatctggtg
     1621 cagcacagag catggtaaca agagactgga tgccgcctat cgttccatga acgggaaggg
     1681 tcccgtgtac ttacttttca gtgtcaacgg cagtggacac ttctgtggag ttgcagagat
     1741 gaaatctgct gtggactaca acacatgtgc aggtgtgtgg tcccaggaca aatggaaggg
     1801 tcgttttgac gtcagatgga tttttgtgaa ggacgttccc aatagccaac tgcgacacat
     1861 tcgtctagag aacaacgaga ataaaccagt gaccaactct agggacactc aggaagtgcc
     1921 tctggaaaaa gctaagcagg tgttgaaaat catagccagc tacaagcaca ccacttccat
     1981 ttttgatgac ttctcacact atgagaaacg ccaagaggaa gaagaaagtg ttaaaaagga
     2041 acgtcaaggc cgtgggaaat aaaaagcggt tctgcataga ctgcagcaac ggttgcgtct
     2101 gcttatccta agaggacacg atgacctgca agaaaattag gacttttttt cttaatttca
     2161 ttgacttcag agacaattgc aaacttgcag tttaagtatt ggaatttcac aaaagacata
     2221 ggacttaact ggaaaatggg gaaaaaaaaa aaggaaaaaa gaaaaaccta aacaaaaatt
     2281 ccctctaggt agtttaggta aaaaaaaaaa atgtcccttt tattttggct ttggttgtga
     2341 ttcagagcat aatgctttgg gttggttttt tttttttttt tttttttttt tgtcttttta
     2401 ctatattttt cggattttta agtccgtaag tgcatacaat tttctctaat ttttaaaccc
     2461 tttcctcctc ccattttgac atttgcactt ggagaacact tgagttgcgc agattttggg
     2521 tgtccacccc agaaagtggg aatttgattt ttcccttccg aactggaaga aaatttttat
     2581 gaagaatttt tgtctaggaa agtttaataa cagtgttagc caaggttgag tctgtaaggg
     2641 tggttcattt ctctgaccct ttgttactca aagtaaagtg ctcggagtcc taagaaatgt
     2701 tctgttcttg tgtattatac tgattaagtc aggattaatt tgatttcaaa gctaagaaca
     2761 gtggtaaaaa cttgttttca gaaatgcatt ttggaagaga aaatattgta aacatgtagt
     2821 gaatgtttct tcagtttctt gttcagccaa tgaggaaagg gcattgcctt tctttttacc
     2881 attaatcact tctcaataaa cgtgagatcc tgttgagcat ca
//
