LOCUS       NM_001024756            3104 bp    mRNA    linear   ROD 30-OCT-2023
DEFINITION  Rattus norvegicus YTH N6-methyladenosine RNA binding protein F1
            (Ythdf1), mRNA.
ACCESSION   NM_001024756 XM_215979
VERSION     NM_001024756.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3104)
  AUTHORS   Huang Y, Yang Y, Ye C, Liu Z and Wei F.
  TITLE     The m6A Reader YTHDF1 Improves Sevoflurane-Induced Neuronal
            Pyroptosis and Cognitive Dysfunction Through Augmenting CREB-BDNF
            Signaling
  JOURNAL   Neurochem Res 48 (12), 3625-3638 (2023)
   PUBMED   37572160
  REMARK    GeneRIF: The m[6]A Reader YTHDF1 Improves Sevoflurane-Induced
            Neuronal Pyroptosis and Cognitive Dysfunction Through Augmenting
            CREB-BDNF Signaling.
REFERENCE   2  (bases 1 to 3104)
  AUTHORS   Wang H, Fu L, Li Y, Wei L, Gu X, Li H, Li J and Wen S.
  TITLE     m6A methyltransferase WTAP regulates myocardial ischemia
            reperfusion injury through YTHDF1/FOXO3a signaling
  JOURNAL   Apoptosis 28 (5-6), 830-839 (2023)
   PUBMED   36894806
  REMARK    GeneRIF: m6A methyltransferase WTAP regulates myocardial ischemia
            reperfusion injury through YTHDF1/FOXO3a signaling.
REFERENCE   3  (bases 1 to 3104)
  AUTHORS   Xing Y, Cheng D, Shi C and Shen Z.
  TITLE     The protective role of YTHDF1-knock down macrophages on the immune
            paralysis of severe sepsis rats with ECMO
  JOURNAL   Microvasc Res 137, 104178 (2021)
   PUBMED   34015275
  REMARK    GeneRIF: The protective role of YTHDF1-knock down macrophages on
            the immune paralysis of severe sepsis rats with ECMO.
REFERENCE   4  (bases 1 to 3104)
  AUTHORS   Zeng Y, Huang T, Zuo W, Wang D, Xie Y, Wang X, Xiao Z, Chen Z, Liu
            Q, Liu N and Xiao Y.
  TITLE     Integrated analysis of m6A mRNA methylation in rats with
            monocrotaline-induced pulmonary arterial hypertension
  JOURNAL   Aging (Albany NY) 13 (14), 18238-18256 (2021)
   PUBMED   34310344
  REMARK    GeneRIF: Integrated analysis of m(6)A mRNA methylation in rats with
            monocrotaline-induced pulmonary arterial hypertension.
REFERENCE   5  (bases 1 to 3104)
  AUTHORS   Zhuang M, Li X, Zhu J, Zhang J, Niu F, Liang F, Chen M, Li D, Han P
            and Ji SJ.
  TITLE     The m6A reader YTHDF1 regulates axon guidance through translational
            control of Robo3.1 expression
  JOURNAL   Nucleic Acids Res 47 (9), 4765-4777 (2019)
   PUBMED   30843071
REFERENCE   6  (bases 1 to 3104)
  AUTHORS   Xu C, Liu K, Ahmed H, Loppnau P, Schapira M and Min J.
  TITLE     Structural Basis for the Discriminative Recognition of
            N6-Methyladenosine RNA by the Human YT521-B Homology Domain Family
            of Proteins
  JOURNAL   J Biol Chem 290 (41), 24902-24913 (2015)
   PUBMED   26318451
REFERENCE   7  (bases 1 to 3104)
  AUTHORS   Wang X, Zhao BS, Roundtree IA, Lu Z, Han D, Ma H, Weng X, Chen K,
            Shi H and He C.
  TITLE     N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency
  JOURNAL   Cell 161 (6), 1388-1399 (2015)
   PUBMED   26046440
REFERENCE   8  (bases 1 to 3104)
  AUTHORS   Wang X, Lu Z, Gomez A, Hon GC, Yue Y, Han D, Fu Y, Parisien M, Dai
            Q, Jia G, Ren B, Pan T and He C.
  TITLE     N6-methyladenosine-dependent regulation of messenger RNA stability
  JOURNAL   Nature 505 (7481), 117-120 (2014)
   PUBMED   24284625
REFERENCE   9  (bases 1 to 3104)
  AUTHORS   Baltz AG, Munschauer M, Schwanhausser B, Vasile A, Murakawa Y,
            Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E,
            Bonneau R, Selbach M, Dieterich C and Landthaler M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   10 (bases 1 to 3104)
  AUTHORS   Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein
            C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J and
            Hentze MW.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097360.1.
            
            On Jun 10, 2005 this sequence version replaced XM_215979.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097360.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3104
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q43"
     gene            1..3104
                     /gene="Ythdf1"
                     /note="YTH N6-methyladenosine RNA binding protein F1"
                     /db_xref="GeneID:296467"
                     /db_xref="RGD:1308932"
     exon            1..171
                     /gene="Ythdf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..1824
                     /gene="Ythdf1"
                     /note="YTH domain family 1; YTH domain family protein 1;
                     YTH domain family, member 1; YTH N(6)-methyladenosine RNA
                     binding protein 1"
                     /codon_start=1
                     /product="YTH domain-containing family protein 1"
                     /protein_id="NP_001019927.1"
                     /db_xref="GeneID:296467"
                     /db_xref="RGD:1308932"
                     /translation="MSATSVDPQRTKGQENKVQNGSLHQKDAVHDNDFEPYLSGQSNP
                     SNSYPSMSDPYLSSYYPPSIGFPYSLSEAPWSTAGDPPIPYLTTYGQLSNGDHHFMHD
                     AVFGQPGGLGNNIYQHRFNFFPENPAFSAWGTSGSQGQQTQSSAYGSSYTYPPSSLGG
                     TVVDGQTGFHSDTLNKAPGMNSLEQGMVGLKIGDVTTSAVKTVGSVVNSVALTGVLSG
                     NGGTNVNMPVSKPTSWAAIASKPAKPQPKMKTKSGPIVGGTLPPPPIKHNMDIGTWDN
                     KGPAPKASAPQQTPSPQAAPQPQQVAQPLPVQPPPLVQPQYQSPQQPLQPRWVAPRNR
                     NAAFGQSGGANSDSNSVGSAQPTSAPSVESHPVLEKLKAAHSYNPKEFDWNLKSGRVF
                     IIKSYSEDDIHRSIKYSIWCSTEHGNKRLDGAFRSMSSKGPVYLLFSVNGSGHFCGVA
                     EMKSPVDYGTSAGVWSQDKWKGKFDVKWIFVKDVPNNQLRHIRLENNDNKPVTNSRDT
                     QEVPLEKAKQVLKIIASYKHTTSIFDDFSHYEKRQEEEEVVRKERQNRNKQ"
     exon            172..196
                     /gene="Ythdf1"
                     /inference="alignment:Splign:2.1.0"
     exon            197..276
                     /gene="Ythdf1"
                     /inference="alignment:Splign:2.1.0"
     exon            277..1797
                     /gene="Ythdf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..3082
                     /gene="Ythdf1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcgtgccta cagctgccgc cgcgcccggc cgcgcccgtg gagttggtgg cggggcacgg
       61 gaccgcgcgc ggcgtgacag gcccggcctc gcgggaggcc cgagccggcg gcgccggggt
      121 cccgcgccgc gctgttcatg aagcatgtcg gccaccagcg tggaccccca gagaacaaaa
      181 ggacaagaga ataaagtaca aaatggttct ttgcatcaga aggatgcagt tcatgacaat
      241 gactttgagc cctacctttc tggacagtcc aatccgagta acagttaccc ctcgatgagt
      301 gatccttacc tgtccagcta ctacccacca tccattggat ttccttactc cctcagcgag
      361 gcaccatggt ccactgcagg ggaccctccc atcccgtatc tcactaccta tggacaactt
      421 agtaatggag accatcactt catgcacgat gctgtttttg ggcaacctgg gggtctgggg
      481 aacaacattt accagcacag gtttaatttt ttccctgaaa accctgcatt ctcagcatgg
      541 gggacaagtg gttctcaggg gcagcagact cagagctcag cctatgggag cagttacact
      601 tacccaccaa gctcccttgg tggcacagtt gttgatgggc agacaggttt tcacagtgac
      661 accctcaaca aggcccctgg gatgaacagt ctggagcagg gcatggttgg cctgaagatt
      721 ggagatgtta ccacctctgc agttaaaaca gtgggttcag ttgtcaacag tgtggcactg
      781 actggtgtcc tttctggcaa tggtgggaca aatgtaaaca tgccagtttc aaaaccaact
      841 tcatgggcag ccattgccag caagcctgca aaaccacagc ctaagatgaa aacgaagagt
      901 gggccgatag tagggggtac gctgcctcct ccacctataa agcataacat ggacattggt
      961 acttgggata acaagggccc tgctccgaag gcctcagccc cccagcagac accatccccc
     1021 caggctgctc cacagccaca gcaggtagct cagcctctcc ctgttcagcc cccacctttg
     1081 gtccagccac agtatcagag ccctcagcag ccacttcaac cccgctgggt ggctcctcga
     1141 aacagaaatg cagcatttgg gcagagtgga ggggccaaca gtgacagtaa ctctgttgga
     1201 agtgctcagc ctacttctgc cccaagtgta gaatcccacc ctgtcctgga gaaactgaaa
     1261 gctgcccaca gctataaccc taaagagttc gactggaatc ttaagagtgg gcgggtgttc
     1321 atcatcaaga gctattctga ggacgacatc caccgctcca tcaagtactc catctggtgt
     1381 agtactgaac atggcaacaa gcgcctggat ggcgccttcc gctccatgag cagcaagggg
     1441 cctgtttatc tgctcttcag tgtcaatggg agtggacatt tctgtggggt ggcagaaatg
     1501 aagtcccctg tggactacgg caccagtgct ggggtctggt ctcaggacaa gtggaagggg
     1561 aagtttgatg tgaagtggat ttttgtcaag gatgtgccca ataatcaact gcggcacatc
     1621 agactggaga ataacgacaa caagcctgtc acaaactccc gtgacacgca ggaggtgccc
     1681 ttagaaaaag caaaacaagt gctgaagatt attgcctcct ataagcacac aacctccatc
     1741 tttgacgact tttctcatta tgagaagcgc caggaggaag aggaggtagt gcgcaaggaa
     1801 aggcagaatc gaaacaaaca ataaggacaa gccggtttgt ttttggttaa tggttgactt
     1861 tgaaaacaga gttttaaagc tgtatgcttg gtgctgtctc cgagtcagct ccagtgtcgt
     1921 cctcgtgcgg ggttgattgt tgcatcttta tctttgtagt tcatttttgc cagatggatc
     1981 tgcattcatt tgtatttttc tatgtattat aatattgtag aactcactaa taaaggagta
     2041 ttttgtttgt cagcttatca gtcagattga cctaatgcaa aatataaata ttcttcaaaa
     2101 caaaacacct aatacatccc aaagatattt ttattttggc agaaattatg ttcttattct
     2161 tatatctagt catttactat ccctatagga tacttcatat ttcttgccct ctcctgcttt
     2221 acagcaaaca gcccattcag catgtgctgt tgtcgtctcc tcacagtact gaagtggctt
     2281 gccattttac tatctgtggt atccatcatt gctgacctgc cctcttgagt ttcctactag
     2341 acaggtaact tttagtttta agtgtgccca cagctgtcta tggacaagcg ttccatagtt
     2401 tagtgcccac acagagcggt gctccagttc tccttgccac cgtctgccac tgcatgaggt
     2461 tcgggctctg tggcaaggaa ctagaaggtg ttttaagtct ggttcagcat ttcgacattc
     2521 ttagttgttc gtagatcatt tttagttgtc ctctttcttc tcttgagaat cctgatgctg
     2581 tcttaagttt ttataccagt aacgctaagc tttaaatgta ggatctgata gtacaggcag
     2641 tgtgatggat gctgctgccg actgtaaatt tcactgtgtg tctaattttt tttcctgttg
     2701 aatgggtgaa aaaagcaaaa aacaaaaaat cctttagaaa acaaatttgc tatcatgttt
     2761 tgtggaatga ggagcctcgg aggagctcac cgccacctgg agttggagtt tagcatgaaa
     2821 gtggtgctca tgcccgacgc cctcgcatac tgaatctgca cgcgcccact gtagaggatc
     2881 cttactgtct tagagagcag ataccttctg aaactattta ctccaaaaga ccctctgagt
     2941 taacatttaa gctgtattat ttagacttgt atttagaacg tgtcacttcc tcgagctgtt
     3001 actgcctgta cggagtcacg gacaacatcg gatacctgtc ctctaggaga atacaagcct
     3061 taataaacac ctgttgagca aaaaaaaaaa aaaaaaaaaa aaaa
//
