LOCUS       NM_133423               2968 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Rattus norvegicus YTH N6-methyladenosine RNA binding protein C1
            (Ythdc1), mRNA.
ACCESSION   NM_133423
VERSION     NM_133423.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2968)
  AUTHORS   Yu,Z., Xia,Y., Li,J., Jiang,J., Li,Y., Li,Y. and Wang,L.
  TITLE     METTL3 mediates m6A modification of lncRNA CRNDE to promote ATG10
            expression and improve brain ischemia/reperfusion injury through
            YTHDC1
  JOURNAL   Biol Direct 19 (1), 92 (2024)
   PUBMED   39407279
  REMARK    GeneRIF: METTL3 mediates m6A modification of lncRNA CRNDE to
            promote ATG10 expression and improve brain ischemia/reperfusion
            injury through YTHDC1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2968)
  AUTHORS   Lin,W., Liu,Y., Zhou,Y., Lin,M., Liu,C., Tang,Y., Wu,B. and Lin,C.
  TITLE     Methyltransferase-like 3 modulates visceral hypersensitivity
            through regulating the nuclear export of circKcnk9 in
            YTHDC1-dependent manner
  JOURNAL   Mol Pain 18, 17448069221144540 (2022)
   PUBMED   36443649
  REMARK    GeneRIF: Methyltransferase-like 3 modulates visceral
            hypersensitivity through regulating the nuclear export of circKcnk9
            in YTHDC1-dependent manner.
REFERENCE   3  (bases 1 to 2968)
  AUTHORS   Zhang,Z., Wang,Q., Zhao,X., Shao,L., Liu,G., Zheng,X., Xie,L.,
            Zhang,Y., Sun,C. and Xu,R.
  TITLE     YTHDC1 mitigates ischemic stroke by promoting Akt phosphorylation
            through destabilizing PTEN mRNA
  JOURNAL   Cell Death Dis 11 (11), 977 (2020)
   PUBMED   33188203
  REMARK    GeneRIF: YTHDC1 mitigates ischemic stroke by promoting Akt
            phosphorylation through destabilizing PTEN mRNA.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2968)
  AUTHORS   Kasowitz,S.D., Ma,J., Anderson,S.J., Leu,N.A., Xu,Y., Gregory,B.D.,
            Schultz,R.M. and Wang,P.J.
  TITLE     Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and
            splicing during mouse oocyte development
  JOURNAL   PLoS Genet 14 (5), e1007412 (2018)
   PUBMED   29799838
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2968)
  AUTHORS   Shima,H., Matsumoto,M., Ishigami,Y., Ebina,M., Muto,A., Sato,Y.,
            Kumagai,S., Ochiai,K., Suzuki,T. and Igarashi,K.
  TITLE     S-Adenosylmethionine Synthesis Is Regulated by Selective
            N6-Adenosine Methylation and mRNA Degradation Involving METTL16 and
            YTHDC1
  JOURNAL   Cell Rep 21 (12), 3354-3363 (2017)
   PUBMED   29262316
REFERENCE   6  (bases 1 to 2968)
  AUTHORS   Heinrich,B., Zhang,Z., Raitskin,O., Hiller,M., Benderska,N.,
            Hartmann,A.M., Bracco,L., Elliott,D., Ben-Ari,S., Soreq,H.,
            Sperling,J., Sperling,R. and Stamm,S.
  TITLE     Heterogeneous nuclear ribonucleoprotein G regulates splice site
            selection by binding to CC(A/C)-rich regions in pre-mRNA
  JOURNAL   J Biol Chem 284 (21), 14303-14315 (2009)
   PUBMED   19282290
REFERENCE   7  (bases 1 to 2968)
  AUTHORS   Stoss,O., Olbrich,M., Hartmann,A.M., Konig,H., Memmott,J.,
            Andreadis,A. and Stamm,S.
  TITLE     The STAR/GSG family protein rSLM-2 regulates the selection of
            alternative splice sites
  JOURNAL   J Biol Chem 276 (12), 8665-8673 (2001)
   PUBMED   11118435
REFERENCE   8  (bases 1 to 2968)
  AUTHORS   Nayler,O., Hartmann,A.M. and Stamm,S.
  TITLE     The ER repeat protein YT521-B localizes to a novel subnuclear
            compartment
  JOURNAL   J Cell Biol 150 (5), 949-962 (2000)
   PUBMED   10973987
REFERENCE   9  (bases 1 to 2968)
  AUTHORS   Hartmann,A.M., Nayler,O., Schwaiger,F.W., Obermeier,A. and Stamm,S.
  TITLE     The interaction and colocalization of Sam68 with the
            splicing-associated factor YT521-B in nuclear dots is regulated by
            the Src family kinase p59(fyn)
  JOURNAL   Mol Biol Cell 10 (11), 3909-3926 (1999)
   PUBMED   10564280
REFERENCE   10 (bases 1 to 2968)
  AUTHORS   Imai,Y., Matsuo,N., Ogawa,S., Tohyama,M. and Takagi,T.
  TITLE     Cloning of a gene, YT521, for a novel RNA splicing-related protein
            induced by hypoxia/reoxygenation
  JOURNAL   Brain Res Mol Brain Res 53 (1-2), 33-40 (1998)
   PUBMED   9473574
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF144731.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF144731.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2968
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p21"
     gene            1..2968
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="YTH N6-methyladenosine RNA binding protein C1"
                     /db_xref="GeneID:170956"
                     /db_xref="RGD:621706"
     CDS             1..2217
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /note="RA301-binding protein; putative splicing factor
                     YT521; splicing factor YT521-B; YTH domain containing 1"
                     /codon_start=1
                     /product="YTH domain-containing protein 1"
                     /protein_id="NP_596914.1"
                     /db_xref="GeneID:170956"
                     /db_xref="RGD:621706"
                     /translation="MAADSREEKDGELNVLDDILTEVPEQDDELYNPESEQDKNEKKG
                     SKRKSERMESIDTKRQKPSIHSRQLISKPLSSSVSNNKRIVSTKGKSVTEYKNEEYQR
                     SERNKRLDADRKIRLSSSSSREPYKSQPEKPCLRKRDSERRAKSPTPDGSERIGLEVD
                     RRASRSSQSSKEEGNSEEYGSDHETGSSASSEQGNNTENEEEGGEEDVEEDEEVDEDG
                     DDDEEVDEDAEEEEDEEEDEEEEDEEEEEEEEEEYEQDERDQKEEGNDYDTRSEASDS
                     GSESVSFTDGSVRSGSGTDGSDEKKKERKRARGISPIVFDRSGSSASESYAGSEKKHE
                     KLSSSVRAVRKDQTSKLKSVLQDARFFLIKSNNHENVSLAKAKGVWSTLPVNEKKLNL
                     AFRSARSVILIFSVRESGKFQGFARLSSESHHGGSPIHWVLPAGMSAKMLGGVFKIDW
                     ICRRELPFTKSAHLTNPWNEHKPVKIGRDGQEIELECGTQLCLLFPPDESIDLYQLIH
                     KMRHKRRMHSQPRSRGRPSRREPVRDVGRRRPEDYDIHNSRKKPRIDYPPEFHQRPGY
                     LKDPRYQEVDSFTNLIPNRRFSGVRRDVFLNGSYNDYVREFHNMGPPPPWQGMPPYPG
                     IEQPPHHPYYQHHAPPPQAHPPYSGHHPVPHEARYRDKRVHDYDMRVDDFLRRTQAVV
                     SGRRSRPRERDRERERDRPRDNRRDRERDRGRDRERERERICDRDRDRGERGRYRR"
     exon            1..28
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            29..130
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            131..459
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            460..892
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            893..982
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1036
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1131
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1240
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1358
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1443
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1610
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1693
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1730
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1794
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1857
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..1992
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..2968
                     /gene="Ythdc1"
                     /gene_synonym="Yt521"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcggccg acagccggga ggagaaagat ggggaactta atgttttaga tgatattttg
       61 actgaagtac cagaacagga tgatgaactg tataatccag agagtgaaca agataaaaat
      121 gagaaaaaag gatcaaaaag aaaaagtgaa agaatggaat ctattgacac caagcgacag
      181 aagccttcta tccattcaag acaactgatt tctaagccac taagctcatc tgttagcaat
      241 aataaaagaa tagttagtac aaaaggaaag tcggttacag aatataaaaa tgaggaatat
      301 caaagatctg aaaggaacaa gcgtctagat gctgatcgaa aaattcgtct gtcaagcagt
      361 tcctctagag aaccttacaa gagtcaacca gaaaaacctt gtctacggaa aagggattct
      421 gaaagaaggg ccaagtctcc tacaccagat ggttctgaga gaattgggct tgaagttgat
      481 agacgtgcaa gcagatccag ccagtcttca aaggaagagg ggaactctga ggagtatggc
      541 tctgaccacg agacaggaag cagtgcttct tctgaacagg gcaacaacac tgagaatgag
      601 gaggaaggag gggaagaaga tgtagaggaa gatgaagagg tagatgaaga tggagatgat
      661 gatgaggaag tggatgaaga tgcggaggag gaggaggacg aggaagaaga tgaggaggag
      721 gaggatgagg aagaagaaga ggaagaggaa gaagaatatg aacaggatga gagagatcag
      781 aaggaagaag ggaatgatta tgacacccgt agtgaggcca gtgattctgg ttctgagtct
      841 gtttccttca cagatggatc tgtcaggtct ggttcaggaa cagatggatc agatgagaaa
      901 aagaaggaaa ggaagagagc tcgaggcata tcacccattg tctttgatag aagtggcagt
      961 tctgcatcag agtcatatgc aggttcagaa aagaagcatg agaaattatc atcttccgtt
     1021 cgtgctgtcc gaaaagatca aaccagtaaa ctcaaatctg tccttcagga tgcaagattt
     1081 ttcctcataa agagtaacaa ccatgagaat gtgtctcttg ccaaagcaaa gggtgtatgg
     1141 tccacattac ctgtaaatga gaagaaatta aatcttgcgt ttagatctgc aaggagtgtt
     1201 atattaatat tttctgtcag ggaaagtgga aagtttcaag gttttgccag attgtcatca
     1261 gaatcgcatc atggtggctc tcctatacat tgggtgcttc cagcaggaat gagtgctaaa
     1321 atgcttggag gtgtttttaa aattgactgg atttgcaggc gtgaattacc ctttactaag
     1381 tcagctcatc tcaccaatcc ctggaatgaa cataagccag taaagattgg acgtgatgga
     1441 caggaaattg aacttgaatg tggaacccag ctttgtcttc tgtttccccc tgatgaaagt
     1501 attgacttgt atcagctcat tcataaaatg cgtcacaaga gaagaatgca ttctcagcct
     1561 cgatcaagag gacgtccatc ccgtcgagaa ccagtccggg atgtgggaag gcgtcgacca
     1621 gaagattatg atattcataa cagcagaaag aaaccaagga ttgactatcc ccctgagttt
     1681 caccagagac cagggtattt aaaggatccc cgataccagg aagttgacag tttcacaaat
     1741 cttattccca acagacgatt ttcaggagtt cgccgagatg tgtttttaaa tgggtcctac
     1801 aatgattatg tgagggaatt tcataacatg ggaccaccgc ctccttggca aggaatgcct
     1861 ccttacccgg gaatagaaca gcctccacac catccctact accagcacca tgccccgcct
     1921 cctcaagccc acccccctta ctcaggacac catccggtac cacatgaagc aagatacaga
     1981 gataaacgag tacatgacta tgatatgagg gttgatgatt tccttcgccg cacacaagcc
     2041 gttgtcagtg gtcggagaag tagaccccga gaaagagatc gggagcgaga gcgagaccgc
     2101 cctagagata acagaagaga tagagagcga gacagaggtc gtgatcgaga aagagagaga
     2161 gaaagaatat gtgatcggga cagagaccga ggggaaagag gtcgttatcg aagataatgt
     2221 gctttttgga agcactgact gaagataaaa aatattgtat tttttttgtg tgtgtttaca
     2281 agtagtaaat ttattttcag ctgtctactt aaagctcatt gtgtagaagg atttattatc
     2341 ttctttgttc caagcatgca gtagaataag aactggaaaa ctcagatccg ccaaaaaatg
     2401 cacagttgac agttgagttg acacttttat tggggcagaa tggaacagtc caagaatgta
     2461 gatattgatt cattctccat aaatgttctt tttacagtgt attcatccta gagttatttt
     2521 gtttgtttgt tttccttctt ttggaccttg gtcaatactg ccatagtatt ttgctttgtg
     2581 tttctatagg tagctgcaca cggttcagta aaaataatgc tgctatcaag tatgcagata
     2641 ttgagtatga tggtttgact atatggcagt gttgtagcag cctctcggtt tctcctcttc
     2701 cctccttttt tttaaaccta taaatccact ttttttttaa gtcttcaatg atgagagcaa
     2761 tattaagaag acattgctat ctaattttta atctttttaa ataaaacgtt cctatgttca
     2821 gtagcatggt cgatgctatt gtttagcctt ccttccaaac tgtacattgg cttggaatgt
     2881 tcagttttgc gtgtgtggca gcagaagata accccacatt ctacattgct actgttttgt
     2941 atgaaataaa ttggtaaaga ttgacact
//
