LOCUS       NM_053682               3006 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus YME1-like 1 ATPase (Yme1l1), mRNA.
ACCESSION   NM_053682
VERSION     NM_053682.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3006)
  AUTHORS   Shi,H., Rampello,A.J. and Glynn,S.E.
  TITLE     Engineered AAA+ proteases reveal principles of proteolysis at the
            mitochondrial inner membrane
  JOURNAL   Nat Commun 7, 13301 (2016)
   PUBMED   27786171
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3006)
  AUTHORS   Hartmann,B., Wai,T., Hu,H., MacVicar,T., Musante,L.,
            Fischer-Zirnsak,B., Stenzel,W., Graf,R., van den Heuvel,L.,
            Ropers,H.H., Wienker,T.F., Hubner,C., Langer,T. and Kaindl,A.M.
  TITLE     Homozygous YME1L1 mutation causes mitochondriopathy with optic
            atrophy and mitochondrial network fragmentation
  JOURNAL   Elife 5, e16078 (2016)
   PUBMED   27495975
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3006)
  AUTHORS   Stiburek,L., Cesnekova,J., Kostkova,O., Fornuskova,D., Vinsova,K.,
            Wenchich,L., Houstek,J. and Zeman,J.
  TITLE     YME1L controls the accumulation of respiratory chain subunits and
            is required for apoptotic resistance, cristae morphogenesis, and
            cell proliferation
  JOURNAL   Mol Biol Cell 23 (6), 1010-1023 (2012)
   PUBMED   22262461
REFERENCE   4  (bases 1 to 3006)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 3006)
  AUTHORS   Coppola,M., Pizzigoni,A., Banfi,S., Bassi,M.T., Casari,G. and
            Incerti,B.
  TITLE     Identification and characterization of YME1L1, a novel
            paraplegin-related gene
  JOURNAL   Genomics 66 (1), 48-54 (2000)
   PUBMED   10843804
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081751.1.
            
            On Sep 16, 2004 this sequence version replaced NM_053682.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081751.1, AF151784.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3006
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.3"
     gene            1..3006
                     /gene="Yme1l1"
                     /gene_synonym="FtsH1"
                     /note="YME1-like 1 ATPase"
                     /db_xref="GeneID:114217"
                     /db_xref="RGD:620764"
     exon            1..199
                     /gene="Yme1l1"
                     /gene_synonym="FtsH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..2314
                     /gene="Yme1l1"
                     /gene_synonym="FtsH1"
                     /note="ATP-dependent metalloprotease YME1L1; meg-4;
                     YME1-like protein 1; ATP-dependent metalloprotease FtsH1
                     homolog"
                     /codon_start=1
                     /product="ATP-dependent zinc metalloprotease YME1L1"
                     /protein_id="NP_446134.2"
                     /db_xref="GeneID:114217"
                     /db_xref="RGD:620764"
                     /translation="MFSLSSTVQPQVTVPLSHLINAFHSPKNISVSVNTSASPKQHRD
                     TVAEHEAPSSEPVLNLRDLGLSELKIGQTDKLVENLLPGFYKDKRVSSCWHTSHISAQ
                     SFFENKYGHLDMFSTLRSSSLYRQHPKTLQSICSDLQNFPVFIQSRGFKTLKSRTRRL
                     QSTSERLAEAQNIAPSFVKGFLLRDRGTDLESLDKLMKTKNIPEVHQDAFKTGFAEGF
                     LKAQALTQKTNDSLRRTRLILFVLLLFGIYGLLKNPFLSVRFRTTTGLDSAVDPVQMK
                     NVTFEHVKGVEEAKQELQEVVEFLKNPQKFTVLGGKLPKGILLVGPPGTGKTLLARAV
                     AGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIES
                     PMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPD
                     VKGRTEILKWYLNKIKFDKSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVT
                     MKELEFSKDKILMGPERRSVEIDNKNKTITAYHESGHAIIAYYTKDAMPINKATIMPR
                     GPTLGHVSLLPENDRWNETRAQLLAQMDVSMGGRVAEELIFGTDHITTGASSDFDNAT
                     KIAKRMVTKFGMSEKLGVMTYSDTGKLSPETQSAIEQEIRILLRESYERAKHILKTHA
                     KEHKNLAEALLTYETLDAKEIQIVLEGKKLEVR"
     exon            200..331
                     /gene="Yme1l1"
                     /gene_synonym="FtsH1"
                     /inference="alignment:Splign:2.1.0"
     exon            332..494
                     /gene="Yme1l1"
                     /gene_synonym="FtsH1"
                     /inference="alignment:Splign:2.1.0"
     exon            495..593
                     /gene="Yme1l1"
                     /gene_synonym="FtsH1"
                     /inference="alignment:Splign:2.1.0"
     exon            594..703
                     /gene="Yme1l1"
                     /gene_synonym="FtsH1"
                     /inference="alignment:Splign:2.1.0"
     exon            704..854
                     /gene="Yme1l1"
                     /gene_synonym="FtsH1"
                     /inference="alignment:Splign:2.1.0"
     exon            855..938
                     /gene="Yme1l1"
                     /gene_synonym="FtsH1"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1021
                     /gene="Yme1l1"
                     /gene_synonym="FtsH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1112
                     /gene="Yme1l1"
                     /gene_synonym="FtsH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1265
                     /gene="Yme1l1"
                     /gene_synonym="FtsH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1398
                     /gene="Yme1l1"
                     /gene_synonym="FtsH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1461
                     /gene="Yme1l1"
                     /gene_synonym="FtsH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1574
                     /gene="Yme1l1"
                     /gene_synonym="FtsH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1730
                     /gene="Yme1l1"
                     /gene_synonym="FtsH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1882
                     /gene="Yme1l1"
                     /gene_synonym="FtsH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2009
                     /gene="Yme1l1"
                     /gene_synonym="FtsH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..2083
                     /gene="Yme1l1"
                     /gene_synonym="FtsH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2170
                     /gene="Yme1l1"
                     /gene_synonym="FtsH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..2981
                     /gene="Yme1l1"
                     /gene_synonym="FtsH1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagctgtcgg gaagggaagc catttttttg tttttgggag gagtaaggaa gaaactggga
       61 gaagagcgaa ggaaaataaa gagaaaataa aagggcttag cccctttcct ttgagctgat
      121 ttaggaagca gtttcagctg gcgggaaagg tcccgagggc ccagagatgt tctccctgtc
      181 gagcactgtg cagcctcagg ttacagttcc tctcagtcat ctcatcaatg ccttccattc
      241 accaaaaaat atatccgttt ccgtcaatac atctgcttct ccaaaacagc atcgagatac
      301 agttgctgag catgaagctc ccagtagtga gcctgtgctt aatttaaggg accttggatt
      361 atctgaattg aaaattggac agactgataa actggtagaa aatttacttc ctggatttta
      421 taaagacaaa agagtttctt cctgttggca tacatctcat atctcggcac agtccttttt
      481 tgaaaataaa tatggtcact tagatatgtt cagtacatta cgttcctcta gcttgtacag
      541 gcaacatcca aaaactcttc agagcatttg ttcagatctt cagaattttc cagttttcat
      601 acagtctcgt ggtttcaaaa ctttgaagtc aaggacacgg cgtttgcaat ctacttctga
      661 aagattagca gaagcacaga atatagcacc atcatttgtg aaggggtttc ttttgcggga
      721 cagaggaaca gatcttgaga gtttggacaa acttatgaaa actaaaaaca tacctgaagt
      781 tcaccaagat gcatttaaaa ctggttttgc agagggtttt ctcaaagctc aagctcttac
      841 acagaagacc aatgattcct taaggcgaac tcgtctgatt ctctttgttt tgctcctgtt
      901 tggcatttat ggactcttaa aaaatccatt tttatctgtg cgcttccgga caactacagg
      961 acttgattct gcagtagacc ctgtccagat gaaaaatgtc acttttgaac atgttaaagg
     1021 ggtggaggag gccaaacaag aattacagga agtggttgaa ttcttgaaaa acccacagaa
     1081 gtttactgtg cttggaggta aacttcccaa aggaattctc ttagtggggc caccaggaac
     1141 agggaagacc cttcttgccc gagctgtggc aggagaagct gatgttcctt tttattatgc
     1201 ttctggatca gaattcgatg agatgtttgt gggtgtagga gccagcagga tcagaaatct
     1261 ttttagagaa gcaaaagcaa atgctccttg tgttatattc attgatgaat tggattctgt
     1321 tggtgggaag agaattgaat ctccaatgca tccatattca aggcagacta tcaatcaact
     1381 tcttgccgaa atggatggtt tcaaacctaa tgaaggagta atcattatag gtgccacaaa
     1441 tttcccagag gcattagata atgccttaat acgtcctggt cgttttgata tgcaagttac
     1501 agttccaagg ccagatgtga agggtcgtac tgaaattttg aaatggtatc ttaataaaat
     1561 aaagtttgat aaatctgttg atccagaaat catagctcga ggaactgttg ggttttctgg
     1621 agcagagttg gagaatcttg tgaaccaagc tgcattaaag gcagcagttg atggaaaaga
     1681 aatggttacc atgaaggaac tagagttttc caaggataaa attctaatgg gaccagaaag
     1741 aagaagtgtg gaaattgata acaaaaacaa aactataaca gcctatcatg aatctggtca
     1801 tgctattatt gcatattaca caaaggatgc aatgccaatc aataaagcta caatcatgcc
     1861 acgagggccc acacttggac atgtatcact gttgcctgag aatgacagat ggaatgaaac
     1921 tagagcccag ctgcttgcac agatggatgt tagtatggga ggaagagtgg cagaggaact
     1981 catatttgga accgatcata ttacaactgg tgcttctagt gattttgata atgcaacaaa
     2041 aattgcaaag aggatggtta ccaaatttgg aatgagtgaa aagcttggag ttatgaccta
     2101 cagtgataca ggaaagctaa gtcctgaaac tcaatcggcc attgaacaag aaataagaat
     2161 ccttctacgg gaatcatatg aacgagcaaa acatatcctg aaaacacatg cgaaagaaca
     2221 taagaacctg gccgaggcgt tgctgaccta tgagactttg gatgccaaag agattcaaat
     2281 tgttcttgag gggaagaaat tagaagtgag atgataactc tgttgatatt gctggtttta
     2341 ttacaagaat atacttagtc ctacagtctc ctttgcaaca cttccaaccc ccacttctga
     2401 cttggtatct aattccagga tgtgaaacac tttgtcagtc ttctgttcca ttatttgatt
     2461 ttggttattc ctgtggtgat actcattgga gattagtaac ctataacaag tacacgaaaa
     2521 gataaataaa gagctgtcag gattaaagtc aattgaaaaa tgtcaatcat ggtgaaagta
     2581 agcaatcatt ttgtggttga ttactccaag tgagtaaaaa ttgtgccttt atgtactggt
     2641 aagtatggtt ttttttttct ttgcaagcta aatttgaaaa tctatcatct cctgatggta
     2701 acatttctct ttggggaaac aaatgccatg gataaaccat ttctacttat atcagtagaa
     2761 atgccattaa gatgtactta attttgttct tgattgacca tgtaaaatgg cctttaaaag
     2821 aagctatttg aattgtaaat ataaatatat actcagaatt taaatgattg taatggttta
     2881 aaaatgcaca tgtatgccca ttttctttca gatattacta tctcactgac aaaatttgtt
     2941 tcagaacaac agtattttat gaagtaaaca agtaaattat aaaaaaaaaa aaaaaaaaaa
     3001 aaaaaa
//
