LOCUS       NP_446134                715 aa            linear   ROD 27-APR-2025
DEFINITION  ATP-dependent zinc metalloprotease YME1L1 [Rattus norvegicus].
ACCESSION   NP_446134
VERSION     NP_446134.2
DBSOURCE    REFSEQ: accession NM_053682.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 715)
  AUTHORS   Shi,H., Rampello,A.J. and Glynn,S.E.
  TITLE     Engineered AAA+ proteases reveal principles of proteolysis at the
            mitochondrial inner membrane
  JOURNAL   Nat Commun 7, 13301 (2016)
   PUBMED   27786171
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 715)
  AUTHORS   Hartmann,B., Wai,T., Hu,H., MacVicar,T., Musante,L.,
            Fischer-Zirnsak,B., Stenzel,W., Graf,R., van den Heuvel,L.,
            Ropers,H.H., Wienker,T.F., Hubner,C., Langer,T. and Kaindl,A.M.
  TITLE     Homozygous YME1L1 mutation causes mitochondriopathy with optic
            atrophy and mitochondrial network fragmentation
  JOURNAL   Elife 5, e16078 (2016)
   PUBMED   27495975
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 715)
  AUTHORS   Stiburek,L., Cesnekova,J., Kostkova,O., Fornuskova,D., Vinsova,K.,
            Wenchich,L., Houstek,J. and Zeman,J.
  TITLE     YME1L controls the accumulation of respiratory chain subunits and
            is required for apoptotic resistance, cristae morphogenesis, and
            cell proliferation
  JOURNAL   Mol Biol Cell 23 (6), 1010-1023 (2012)
   PUBMED   22262461
REFERENCE   4  (residues 1 to 715)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (residues 1 to 715)
  AUTHORS   Coppola,M., Pizzigoni,A., Banfi,S., Bassi,M.T., Casari,G. and
            Incerti,B.
  TITLE     Identification and characterization of YME1L1, a novel
            paraplegin-related gene
  JOURNAL   Genomics 66 (1), 48-54 (2000)
   PUBMED   10843804
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081751.1.
            
            On Sep 16, 2004 this sequence version replaced NP_446134.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081751.1, AF151784.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..715
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.3"
     Protein         1..715
                     /product="ATP-dependent zinc metalloprotease YME1L1"
                     /note="ATP-dependent metalloprotease YME1L1; meg-4;
                     YME1-like protein 1; ATP-dependent metalloprotease FtsH1
                     homolog"
                     /calculated_mol_wt=79681
     Region          31..54
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q925S8.1)"
     Site            238..258
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q925S8.1)"
     Region          <274..709
                     /region_name="HflB"
                     /note="ATP-dependent Zn proteases [Posttranslational
                     modification, protein turnover, chaperones]; COG0465"
                     /db_xref="CDD:440233"
     CDS             1..715
                     /gene="Yme1l1"
                     /gene_synonym="FtsH1"
                     /coded_by="NM_053682.2:167..2314"
                     /db_xref="GeneID:114217"
                     /db_xref="RGD:620764"
ORIGIN      
        1 mfslsstvqp qvtvplshli nafhspknis vsvntsaspk qhrdtvaehe apssepvlnl
       61 rdlglselki gqtdklvenl lpgfykdkrv sscwhtshis aqsffenkyg hldmfstlrs
      121 sslyrqhpkt lqsicsdlqn fpvfiqsrgf ktlksrtrrl qstserlaea qniapsfvkg
      181 fllrdrgtdl esldklmktk nipevhqdaf ktgfaegflk aqaltqktnd slrrtrlilf
      241 vlllfgiygl lknpflsvrf rtttgldsav dpvqmknvtf ehvkgveeak qelqevvefl
      301 knpqkftvlg gklpkgillv gppgtgktll aravageadv pfyyasgsef demfvgvgas
      361 rirnlfreak anapcvifid eldsvggkri espmhpysrq tinqllaemd gfkpnegvii
      421 igatnfpeal dnalirpgrf dmqvtvprpd vkgrteilkw ylnkikfdks vdpeiiargt
      481 vgfsgaelen lvnqaalkaa vdgkemvtmk elefskdkil mgperrsvei dnknktitay
      541 hesghaiiay ytkdampink atimprgptl ghvsllpend rwnetraqll aqmdvsmggr
      601 vaeelifgtd hittgassdf dnatkiakrm vtkfgmsekl gvmtysdtgk lspetqsaie
      661 qeirillres yerakhilkt hakehknlae alltyetlda keiqivlegk klevr
//
