LOCUS       NM_031692               2435 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus YKT6 v-SNARE homolog (Ykt6), mRNA.
ACCESSION   NM_031692 XM_346467
VERSION     NM_031692.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2435)
  AUTHORS   Ji,J., Yu,Y., Wu,S., Wang,D., Weng,J. and Wang,W.
  TITLE     Different conformational dynamics of SNARE protein Ykt6 among yeast
            and mammals
  JOURNAL   J Biol Chem 299 (8), 104968 (2023)
   PUBMED   37380075
  REMARK    GeneRIF: Different conformational dynamics of SNARE protein Ykt6
            among yeast and mammals.
REFERENCE   2  (bases 1 to 2435)
  AUTHORS   Wu,S., Wang,D., Weng,J., Liu,J. and Wang,W.
  TITLE     A revisit of the conformational dynamics of SNARE protein rYkt6
  JOURNAL   Biochem Biophys Res Commun 503 (4), 2841-2847 (2018)
   PUBMED   30119892
  REMARK    GeneRIF: The un-lipidated rat Ykt6 adopts five major conformational
            states.
REFERENCE   3  (bases 1 to 2435)
  AUTHORS   Dai,Y., Seeger,M., Weng,J., Song,S., Wang,W. and Tan,Y.W.
  TITLE     Lipid Regulated Intramolecular Conformational Dynamics of
            SNARE-Protein Ykt6
  JOURNAL   Sci Rep 6, 30282 (2016)
   PUBMED   27493064
  REMARK    GeneRIF: Dodecylphosphocholine-regulated intramolecular
            conformational dynamics of Ykt6 has been reported.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2435)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2435)
  AUTHORS   Thayanidhi,N., Liang,Y., Hasegawa,H., Nycz,D.C., Oorschot,V.,
            Klumperman,J. and Hay,J.C.
  TITLE     R-SNARE ykt6 resides in membrane-associated protease-resistant
            protein particles and modulates cell cycle progression when
            over-expressed
  JOURNAL   Biol Cell 104 (7), 397-417 (2012)
   PUBMED   22443861
  REMARK    GeneRIF: The ykt6 particles/aggregates may represent ykt6 engaged
            in a non-SNARE function(s) or else nonfunctional, stored and/or
            excess ykt6.
REFERENCE   6  (bases 1 to 2435)
  AUTHORS   Xu,Y., Martin,S., James,D.E. and Hong,W.
  TITLE     GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is
            implicated in traffic in the early cisternae of the Golgi apparatus
  JOURNAL   Mol Biol Cell 13 (10), 3493-3507 (2002)
   PUBMED   12388752
  REMARK    GeneRIF: Data suggest that GS15 exists in a distinct SNARE complex
            that contains syntaxin5, GS28, and Ykt6, and may be involved in
            both ER-to-Golgi and intra-Golgi transport.
REFERENCE   7  (bases 1 to 2435)
  AUTHORS   Shorter,J., Beard,M.B., Seemann,J., Dirac-Svejstrup,A.B. and
            Warren,G.
  TITLE     Sequential tethering of Golgins and catalysis of SNAREpin assembly
            by the vesicle-tethering protein p115
  JOURNAL   J Cell Biol 157 (1), 45-62 (2002)
   PUBMED   11927603
REFERENCE   8  (bases 1 to 2435)
  AUTHORS   Zhang,T. and Hong,W.
  TITLE     Ykt6 forms a SNARE complex with syntaxin 5, GS28, and Bet1 and
            participates in a late stage in endoplasmic reticulum-Golgi
            transport
  JOURNAL   J Biol Chem 276 (29), 27480-27487 (2001)
   PUBMED   11323436
REFERENCE   9  (bases 1 to 2435)
  AUTHORS   Catchpoole,D.R. and Wanjin,H.
  TITLE     Characterization of the sequence and expression of a Ykt6
            prenylated SNARE from rat
  JOURNAL   DNA Cell Biol 18 (2), 141-145 (1999)
   PUBMED   10073573
REFERENCE   10 (bases 1 to 2435)
  AUTHORS   McNew,J.A., Sogaard,M., Lampen,N.M., Machida,S., Ye,R.R.,
            Lacomis,L., Tempst,P., Rothman,J.E. and Sollner,T.H.
  TITLE     Ykt6p, a prenylated SNARE essential for endoplasmic reticulum-Golgi
            transport
  JOURNAL   J Biol Chem 272 (28), 17776-17783 (1997)
   PUBMED   9211930
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Sep 29, 2022 this sequence version replaced NM_031692.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.159073.1,
                                           SRR22399489.1649514.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-223               JAXUCZ010000014.1  85046189-85046411
            224-306             JAXUCZ010000014.1  85049465-85049547
            307-407             JAXUCZ010000014.1  85051246-85051346
            408-512             JAXUCZ010000014.1  85052390-85052494
            513-578             JAXUCZ010000014.1  85052749-85052814
            579-680             JAXUCZ010000014.1  85054406-85054507
            681-2435            JAXUCZ010000014.1  85055593-85057347
FEATURES             Location/Qualifiers
     source          1..2435
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..2435
                     /gene="Ykt6"
                     /note="YKT6 v-SNARE homolog"
                     /db_xref="GeneID:64351"
                     /db_xref="RGD:70897"
     exon            1..223
                     /gene="Ykt6"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..716
                     /gene="Ykt6"
                     /note="prenylated SNARE protein; YKT6 homolog"
                     /codon_start=1
                     /product="synaptobrevin homolog YKT6"
                     /protein_id="NP_113880.2"
                     /db_xref="GeneID:64351"
                     /db_xref="RGD:70897"
                     /translation="MKLYSLSVFYKGEPKAVLLKAAYDVSSFSFFQRSSVQEFMTFTS
                     QLIVERSAKGSRASVKEQEYLCHVYVRSDSLAGVVIADSEYPSRVAFTLLEKVLDEFS
                     KQVDRIDWPVGSPATIHYTALDGHLSRYQNPREADPMSKVQAELDETKIILHNTMESL
                     LERGEKLDDLVSKSEVLGTQSKAFYKTARKQNSCCAIM"
     exon            224..306
                     /gene="Ykt6"
                     /inference="alignment:Splign:2.1.0"
     exon            307..407
                     /gene="Ykt6"
                     /inference="alignment:Splign:2.1.0"
     exon            408..512
                     /gene="Ykt6"
                     /inference="alignment:Splign:2.1.0"
     exon            513..578
                     /gene="Ykt6"
                     /inference="alignment:Splign:2.1.0"
     exon            579..680
                     /gene="Ykt6"
                     /inference="alignment:Splign:2.1.0"
     exon            681..2435
                     /gene="Ykt6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctaggaggaa gaagccggcc cggccccgtc agcagccggc cgcggctgtt ctgaggaact
       61 gcggccgcgc tcccgtgagc gggtctgggg tccagcgggc agcccgaagg tgcggcgcca
      121 tgaagctgta cagccttagt gtcttttaca aaggcgaacc aaaagcggtg cttctcaaag
      181 ccgcgtacga tgtgtcttcc ttcagtttct tccagaggtc cagtgttcag gaattcatga
      241 cctttacaag tcaactgatt gtggaacgat cggcgaaagg cagcagagct tctgttaaag
      301 aacaagagta cctttgccat gtctacgtcc ggagtgacag tctggcaggt gtggtcattg
      361 ctgacagcga atacccttcc agagtggcct ttaccttgct ggagaaggta ctagatgaat
      421 tctccaagca ggtcgataga atagactggc cagtaggatc ccctgctaca atccattaca
      481 cagccctaga tggccacctt agtagatacc agaacccccg ggaggctgat cccatgagta
      541 aagtgcaggc cgaactggat gagaccaaaa tcattctgca caacaccatg gagtctttgt
      601 tagagcgagg cgagaagctt gatgacttgg tatccaaatc agaagtcctg ggaacacagt
      661 cgaaagcctt ctataaaact gcccggaaac aaaactcatg ctgtgcaatc atgtgacata
      721 gcccacagag gcaggcgctg gatcgtcacg tcacttcaac ccctggagac aagcaacatc
      781 ctagaagagg atctggagcc aggcagactg tctactttta tttgacgttc ccaagaggaa
      841 tggaggaacg atttaggggg gacatcgacg ttcatgtgtg tggttgtgac tatgggaaaa
      901 aatttgagct caaagatgta atgttgggaa aatgaaacca taaactttta agtggctctt
      961 ataggtgctg aaggacttat tctcagctaa ccctggaagg ctctatggga gggaatcttt
     1021 ttcctgatcc ttggtatgac ttaggatttc atttgtgcat taacaatatt aactgtccgg
     1081 tgaatggggt ggggggaggg gcccgggtga tagggcaggg tttgaacact ccaacattct
     1141 actgccttgc actgtggggg ctgggagaag tcaccatggc cggtaacagg cagtggtcac
     1201 tgggtcttac atgtttagct tgcctgtctg ctaggactgg catttgtcag gaacagggcc
     1261 catcctaagt acctttatcc actactacaa aaatgactta tatgaggtac ttagaaaggg
     1321 ccaagctggg caggatgtgt aaggacagtt ttatcagcta gcagactgcg tgtgggctgg
     1381 ggctgttctg gcgttgggag ggtcgctggg agtgtccaac tttggggaag aagcagatgc
     1441 aggtgccttc agtgtccagt gtggaggaac actcacctgg acttgcagtt gggctttgaa
     1501 catcaagatc aaagtatcgg gtgctgcacc tctcaaagct ggtttgattt gtctctgtgc
     1561 ccacaagatt gttctggcaa ctgcctgggg cttatgtgtc agacaagtca ttcttgtggg
     1621 taccaggaca agtgccagca gcctccacat ttccactgcc cacctctggt ctgaccagct
     1681 ctgtctcaca agcccttccc aaccagacag ctgcagggtg gaggatgctg aggggttggt
     1741 ctgagctggt accattgcca gcacagccta cagggtaaac ccagaatgtg ccaggttcca
     1801 catcacctct tcatgttctg ctgtgcacag gctatatccg agaaaccctg tctccccaaa
     1861 agccactgct gggatgctgg cctctgagtt ttgagccaga gttgtctcac tctgatgatc
     1921 cctaccctga gcctgctgag ctgccctcag aatgcccata tggggagggg gacatctact
     1981 atggcttcca aaaatcccca ctagttgctg tacctatttc tctggatact gctagccaaa
     2041 gggctcaggc tccccctaga gtggcctgcc cacgtaattt tcccactgcc acagaccttt
     2101 ccaacccagg gtccctggac ggcacagtgc tgctggcact tgtggtgtaa taagtggcct
     2161 gggtgcgcgt ctttctcttg ttgctctggg ggtcctggga ggagtagagg tgggtggagg
     2221 tagaagtttg tgggggaaag gtaacctttg cctacgtgtg gctgtctaca gggtctgctc
     2281 gcttaccctg cagtggatga gttgtcctgt gtttcccatc cccccaccat attctaatgt
     2341 taaatcactt ggcaagagtg tattttaata atgcctaatt cctctatgtt ctgtctgaag
     2401 gtttctgtcc aaataaaatt gtcttttgaa attca
//
