LOCUS       NM_001416726            1535 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Rattus norvegicus Y box binding protein 1 (Ybx1), transcript
            variant 1, mRNA.
ACCESSION   NM_001416726 XM_008764058
VERSION     NM_001416726.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1535)
  AUTHORS   Zhang,M., Xing,J., Zhao,S., Lu,M., Liu,Y., Lin,L., Gao,W., Chen,L.,
            Li,W., Shang,J., Zhou,J., Yin,X. and Zhu,X.
  TITLE     Exosomal YB-1 facilitates ovarian restoration by
            MALAT1/miR-211-5p/FOXO3 axis
  JOURNAL   Cell Biol Toxicol 40 (1), 29 (2024)
   PUBMED   38700571
  REMARK    GeneRIF: Exosomal YB-1 facilitates ovarian restoration by
            MALAT1/miR-211-5p/FOXO3 axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1535)
  AUTHORS   Zhang,H., Zheng,W., Li,D. and Zheng,J.
  TITLE     MiR-379-5p Promotes Chondrocyte Proliferation via Inhibition of
            PI3K/Akt Pathway by Targeting YBX1 in Osteoarthritis
  JOURNAL   Cartilage 13 (1), 19476035221074024 (2022)
   PUBMED   35255737
  REMARK    GeneRIF: MiR-379-5p Promotes Chondrocyte Proliferation via
            Inhibition of PI3K/Akt Pathway by Targeting YBX1 in Osteoarthritis.
REFERENCE   3  (bases 1 to 1535)
  AUTHORS   Tuerxun,T., Li,X., Lou,F., Wang,X. and Ma,L.
  TITLE     YBX1 Protects against Apoptosis Induced by Oxygen-Glucose
            Deprivation/Reoxygenation in PC12 Cells via Activation of the
            AKT/GSK3beta Pathway
  JOURNAL   Folia Biol (Praha) 67 (4), 150-157 (2021)
   PUBMED   35151240
  REMARK    GeneRIF: YBX1 Protects against Apoptosis Induced by Oxygen-Glucose
            Deprivation/Reoxygenation in PC12 Cells via Activation of the
            AKT/GSK3beta Pathway.
REFERENCE   4  (bases 1 to 1535)
  AUTHORS   Cao,X., Zhu,N., Zhang,Y., Chen,Y., Zhang,J., Li,J., Hao,P., Gao,C.
            and Li,L.
  TITLE     Y-box protein 1 promotes hypoxia/reoxygenation- or
            ischemia/reperfusion-induced cardiomyocyte apoptosis via
            SHP-1-dependent STAT3 inactivation
  JOURNAL   J Cell Physiol 235 (11), 8187-8198 (2020)
   PUBMED   31967332
  REMARK    GeneRIF: Y-box protein 1 promotes hypoxia/reoxygenation- or
            ischemia/reperfusion-induced cardiomyocyte apoptosis via
            SHP-1-dependent STAT3 inactivation.
REFERENCE   5  (bases 1 to 1535)
  AUTHORS   Chen,X., Li,A., Sun,B.F., Yang,Y., Han,Y.N., Yuan,X., Chen,R.X.,
            Wei,W.S., Liu,Y., Gao,C.C., Chen,Y.S., Zhang,M., Ma,X.D., Liu,Z.W.,
            Luo,J.H., Lyu,C., Wang,H.L., Ma,J., Zhao,Y.L., Zhou,F.J., Huang,Y.,
            Xie,D. and Yang,Y.G.
  TITLE     5-methylcytosine promotes pathogenesis of bladder cancer through
            stabilizing mRNAs
  JOURNAL   Nat Cell Biol 21 (8), 978-990 (2019)
   PUBMED   31358969
REFERENCE   6  (bases 1 to 1535)
  AUTHORS   Lasham,A., Moloney,S., Hale,T., Homer,C., Zhang,Y.F., Murison,J.G.,
            Braithwaite,A.W. and Watson,J.
  TITLE     The Y-box-binding protein, YB1, is a potential negative regulator
            of the p53 tumor suppressor
  JOURNAL   J Biol Chem 278 (37), 35516-35523 (2003)
   PUBMED   12835324
  REMARK    GeneRIF: may protect cells from p53-mediated apoptosis
REFERENCE   7  (bases 1 to 1535)
  AUTHORS   Fukada,T. and Tonks,N.K.
  TITLE     Identification of YB-1 as a regulator of PTP1B expression:
            implications for regulation of insulin and cytokine signaling
  JOURNAL   EMBO J 22 (3), 479-493 (2003)
   PUBMED   12554649
  REMARK    GeneRIF: Data show that Y box-binding protein-1 (YB-1) is a
            regulator of protein tyrosine phosphatase 1B (PTP1B) expression,
            and highlight PTP1B as a critical regulator of insulin- and
            cytokine-mediated signal transduction.
REFERENCE   8  (bases 1 to 1535)
  AUTHORS   Cheng,S., Alfonso-Jaume,M.A., Mertens,P.R. and Lovett,D.H.
  TITLE     Tumour metastasis suppressor, nm23-beta, inhibits gelatinase A
            transcription by interference with transactivator Y-box protein-1
            (YB-1)
  JOURNAL   Biochem J 366 (Pt 3), 807-816 (2002)
   PUBMED   12010125
  REMARK    GeneRIF: nm23-beta binds to YB-1 and inhibits MMP2 transcription
REFERENCE   9  (bases 1 to 1535)
  AUTHORS   Zou,Y., Evans,S., Chen,J., Kuo,H.C., Harvey,R.P. and Chien,K.R.
  TITLE     CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5
            homeobox gene pathway
  JOURNAL   Development 124 (4), 793-804 (1997)
   PUBMED   9043061
REFERENCE   10 (bases 1 to 1535)
  AUTHORS   Ozer,J., Faber,M., Chalkley,R. and Sealy,L.
  TITLE     Isolation and characterization of a cDNA clone for the CCAAT
            transcription factor EFIA reveals a novel structural motif
  JOURNAL   J Biol Chem 265 (36), 22143-22152 (1990)
   PUBMED   1967130
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Feb 15, 2023 this sequence version replaced XM_008764058.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC103637.1, SRR22399492.1224982.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676807 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-300               JAXUCZ010000005.1  138183889-138184188 c
            301-364             JAXUCZ010000005.1  138183426-138183489 c
            365-398             JAXUCZ010000005.1  138174885-138174918 c
            399-488             JAXUCZ010000005.1  138172694-138172783 c
            489-791             JAXUCZ010000005.1  138172050-138172352 c
            792-874             JAXUCZ010000005.1  138171561-138171643 c
            875-1152            JAXUCZ010000005.1  138168261-138168538 c
            1153-1535           JAXUCZ010000005.1  138167444-138167826 c
FEATURES             Location/Qualifiers
     source          1..1535
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1535
                     /gene="Ybx1"
                     /gene_synonym="Byb1; CBF-A; Cbfa; Dbpb; Ef1a; EFI-A; Msy1;
                     Nsep1; YB-1; Yb1"
                     /note="Y box binding protein 1"
                     /db_xref="GeneID:500538"
                     /db_xref="RGD:61843"
     exon            1..300
                     /gene="Ybx1"
                     /gene_synonym="Byb1; CBF-A; Cbfa; Dbpb; Ef1a; EFI-A; Msy1;
                     Nsep1; YB-1; Yb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1121
                     /gene="Ybx1"
                     /gene_synonym="Byb1; CBF-A; Cbfa; Dbpb; Ef1a; EFI-A; Msy1;
                     Nsep1; YB-1; Yb1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclease-sensitive element-binding protein 1; enhancer
                     factor 1 subunit A; enhancer factor 1 alpha; DNA binding
                     protein B; CCAAT-binding transcription factor 1 subunit A;
                     Y box transcription factor; enhancer factor I subunit A;
                     CCAAT-binding transcription factor I subunit A"
                     /codon_start=1
                     /product="Y-box-binding protein 1 isoform 1"
                     /protein_id="NP_001403655.1"
                     /db_xref="GeneID:500538"
                     /db_xref="RGD:61843"
                     /translation="MSSEAETQQPPAAPAAALSAADTKPGSTGSGAGSGGPGGLTSAA
                     PAGGDKKVIATKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKYLRSVG
                     DGETVEFDVVEGEKGAEAANVTGPGGVPVQGSKYAADRNHYRRYPRRRGPPRNYQQNY
                     QNSESGEKNEGSESAPEGQAQQRRPYRRRRFPPYYMRRPYARRPQYSNPPVQGEVMEG
                     ADNQGAGEQGRPVRQNMYRGYRPRFRSVHFRGPPRQRQPREDGNEEDKENQGDETQGQ
                     QPPQRRYRRNFNYRRRRPENPKPQDGKETKAADPPAENSSAPEAEQGGAE"
     exon            301..364
                     /gene="Ybx1"
                     /gene_synonym="Byb1; CBF-A; Cbfa; Dbpb; Ef1a; EFI-A; Msy1;
                     Nsep1; YB-1; Yb1"
                     /inference="alignment:Splign:2.1.0"
     exon            365..398
                     /gene="Ybx1"
                     /gene_synonym="Byb1; CBF-A; Cbfa; Dbpb; Ef1a; EFI-A; Msy1;
                     Nsep1; YB-1; Yb1"
                     /inference="alignment:Splign:2.1.0"
     exon            399..488
                     /gene="Ybx1"
                     /gene_synonym="Byb1; CBF-A; Cbfa; Dbpb; Ef1a; EFI-A; Msy1;
                     Nsep1; YB-1; Yb1"
                     /inference="alignment:Splign:2.1.0"
     exon            489..791
                     /gene="Ybx1"
                     /gene_synonym="Byb1; CBF-A; Cbfa; Dbpb; Ef1a; EFI-A; Msy1;
                     Nsep1; YB-1; Yb1"
                     /inference="alignment:Splign:2.1.0"
     exon            792..874
                     /gene="Ybx1"
                     /gene_synonym="Byb1; CBF-A; Cbfa; Dbpb; Ef1a; EFI-A; Msy1;
                     Nsep1; YB-1; Yb1"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1152
                     /gene="Ybx1"
                     /gene_synonym="Byb1; CBF-A; Cbfa; Dbpb; Ef1a; EFI-A; Msy1;
                     Nsep1; YB-1; Yb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1535
                     /gene="Ybx1"
                     /gene_synonym="Byb1; CBF-A; Cbfa; Dbpb; Ef1a; EFI-A; Msy1;
                     Nsep1; YB-1; Yb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctagttcga tcggtagcgg gagcggagag cggaccccag agagccctga gagccccacc
       61 gccgccgccg gcctagtcac catcacaccc gggaggagcc gcagccgtcg ccgccggccc
      121 cagtcaccat caccgcaacc atgagcagcg aggccgagac ccagcagccg cccgccgccc
      181 ccgccgccgc cctcagcgcc gccgacacca agcccggctc cacgggcagc ggcgcgggta
      241 gtggcggccc gggcggcctc acatcggcgg cgcccgccgg cggggacaag aaggtcatcg
      301 caacgaaggt tttgggaaca gtaaaatggt tcaatgtaag gaacggatac ggtttcatca
      361 acaggaatga caccaaggaa gacgtatttg tacaccagac ggccataaag aagaataacc
      421 ccaggaagta ccttcgcagt gtaggagatg gagagactgt ggagtttgat gttgttgaag
      481 gagaaaaggg tgcggaggca gctaatgtta caggccctgg tggagttcca gttcaaggca
      541 gtaaatacgc agcagaccgt aaccattata gacgctatcc acgtcgtagg ggtcctccac
      601 gcaattacca gcaaaattac cagaatagtg agagtgggga aaagaatgaa ggatcggaaa
      661 gcgctcctga aggccaggcc caacaacgcc ggccctatcg caggcgaagg ttcccacctt
      721 actacatgcg gagaccctat gcgcgtcgac cacagtattc caacccccct gtgcaaggag
      781 aagtgatgga gggtgctgac aaccagggtg caggagagca aggtagacca gtgagacaga
      841 atatgtatcg gggttacaga ccacgattcc gcagtgttca tttcaggggc cctcctcgcc
      901 aaagacagcc tagagaggat ggcaatgaag aggacaaaga aaatcaagga gatgagaccc
      961 aaggtcagca gccacctcaa cgtcggtatc gccgcaactt caattaccga cgcagacgcc
     1021 cagagaaccc taaaccacaa gatggcaaag agacaaaagc agccgatcca ccagctgaga
     1081 attcgtccgc tcccgaggct gagcagggcg gggctgagta aatgccggct taccatctct
     1141 accatcatcc ggtttggtca tccaacaaga agaaatgaat atgaaattcc agcaataaga
     1201 aatgaacaaa gattggagct gaagacctta agtgcttgct ttttgcccgt tgaccagatc
     1261 cactagaact gtctgcatta tctatgcagc atggggtttt tattattttt acctaaagat
     1321 gtctcttttt ggtaatgaca aacgtgtttt ttaagaaaaa aaaaaaaggc ctggtttttc
     1381 tcaatacacc tttaacggtt tttaaattgt ttcatatctg gtcaagttga gatttttaag
     1441 aacttcattt ttaatttgta ataaagttta caacttgatt ttttcaaaaa agtcaacaaa
     1501 ctgcaagcac ctgttaataa aggtcttaaa taata
//
