LOCUS       NM_001009627            1588 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus tyrosyl-tRNA synthetase 2 (Yars2), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_001009627 XM_213561
VERSION     NM_001009627.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1588)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   2  (bases 1 to 1588)
  AUTHORS   Riley,L.G., Cooper,S., Hickey,P., Rudinger-Thirion,J., McKenzie,M.,
            Compton,A., Lim,S.C., Thorburn,D., Ryan,M.T., Giege,R., Bahlo,M.
            and Christodoulou,J.
  TITLE     Mutation of the mitochondrial tyrosyl-tRNA synthetase gene, YARS2,
            causes myopathy, lactic acidosis, and sideroblastic anemia--MLASA
            syndrome
  JOURNAL   Am J Hum Genet 87 (1), 52-59 (2010)
   PUBMED   20598274
REFERENCE   3  (bases 1 to 1588)
  AUTHORS   Bonnefond,L., Frugier,M., Touze,E., Lorber,B., Florentz,C.,
            Giege,R., Sauter,C. and Rudinger-Thirion,J.
  TITLE     Crystal structure of human mitochondrial tyrosyl-tRNA synthetase
            reveals common and idiosyncratic features
  JOURNAL   Structure 15 (11), 1505-1516 (2007)
   PUBMED   17997975
REFERENCE   4  (bases 1 to 1588)
  AUTHORS   Bonnefond,L., Frugier,M., Giege,R. and Rudinger-Thirion,J.
  TITLE     Human mitochondrial TyrRS disobeys the tyrosine identity rules
  JOURNAL   RNA 11 (5), 558-562 (2005)
   PUBMED   15840810
REFERENCE   5  (bases 1 to 1588)
  AUTHORS   Bonnefond,L., Fender,A., Rudinger-Thirion,J., Giege,R., Florentz,C.
            and Sissler,M.
  TITLE     Toward the full set of human mitochondrial aminoacyl-tRNA
            synthetases: characterization of AspRS and TyrRS
  JOURNAL   Biochemistry 44 (12), 4805-4816 (2005)
   PUBMED   15779907
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088224.1.
            
            On Jan 13, 2005 this sequence version replaced XM_213561.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088224.1, SRR8487227.248967.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1588
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..1588
                     /gene="Yars2"
                     /gene_synonym="CGI-04; RGD1311696"
                     /note="tyrosyl-tRNA synthetase 2"
                     /db_xref="GeneID:287924"
                     /db_xref="RGD:1311696"
     exon            1..767
                     /gene="Yars2"
                     /gene_synonym="CGI-04; RGD1311696"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..1422
                     /gene="Yars2"
                     /gene_synonym="CGI-04; RGD1311696"
                     /EC_number="6.1.1.1"
                     /note="tyrosyl-tRNA synthetase, mitochondrial; tyrRS;
                     tyrosyl-tRNA synthetase 2 (mitochondrial)"
                     /codon_start=1
                     /product="tyrosine--tRNA ligase, mitochondrial"
                     /protein_id="NP_001009627.1"
                     /db_xref="GeneID:287924"
                     /db_xref="RGD:1311696"
                     /translation="MAAPMLRHLCRVPQSGVWTRGPRAVRPGARGMLVAPRARGLFKE
                     FFPESGTKTELPELFDRRRAGSPQTVYCGFDPTGDSLHVGHLLTLLGLFHFQRAGHNV
                     IALVGGSTALLGDPSGRTKEREALSAECVRANARALQRGLETLAANHARLFADGRPWG
                     TFTVLDNAAWFQKQHLMDFLATVGGHFRMGTLLSRLSVQSRLKSPEGMSLAEFFYQVL
                     QAYDFYYLFRHYGCRVQLGGSDQLGNIMSGYEFIHKLTGEDVFGITVPLITSTTGAKL
                     GKSAGNAVWLNREKTSPFELYQFFIRQQDDSVERYLKLFTFLPLPEIDHIMQLHVKEP
                     EKRIAQKRLAAEVTKLVHGQEGLDSAKRCTQALYHSSIEALEVMSDQELKELFKEASF
                     SELVLDPGTSVIDTCRKANAIPDGPRGYRMITEGGVSINHRQVTNPESVLVIGQHILK
                     NGLSLLKIGKRNFYIIKWLQL"
     exon            768..935
                     /gene="Yars2"
                     /gene_synonym="CGI-04; RGD1311696"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1091
                     /gene="Yars2"
                     /gene_synonym="CGI-04; RGD1311696"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1262
                     /gene="Yars2"
                     /gene_synonym="CGI-04; RGD1311696"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1564
                     /gene="Yars2"
                     /gene_synonym="CGI-04; RGD1311696"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcaagatgg cggcgcccat gctgagacac ctgtgccgcg ttccgcagtc aggggtctgg
       61 acacgggggc cgcgtgcggt gcgccctggc gcgcggggaa tgttggtggc accaagggcc
      121 cgcggcctgt tcaaggagtt cttccccgag agcggcacga agacagagct ccccgaactc
      181 tttgaccgcc gcagggcggg ttcgccccag actgtgtact gcggtttcga ccccacgggc
      241 gattcgctgc acgtggggca cctgttaact ttattgggtc tgttccactt ccagcgagcc
      301 ggccacaacg tgatcgcgct cgtgggaggc tccacggctc tcctgggaga ccccagcggc
      361 cggaccaagg agcgcgaggc gctgagcgct gagtgcgtgc gggccaacgc gcgcgccctg
      421 cagcgagggc tggagacctt ggcggccaac cacgcgcgcc tcttcgcgga cgggcggccc
      481 tggggcactt tcacggtgct cgacaatgca gcctggttcc agaagcagca cctaatggat
      541 tttctggcca cggtgggcgg ccacttccgc atgggcactc tgcttagccg gctgagcgtg
      601 cagtcccgtc tcaagagccc agagggcatg agcttggctg agttctttta ccaggtgctc
      661 caggcctatg acttctacta ccttttccgg cactatggat gccgggtcca gctgggcgga
      721 tcagatcagt tgggcaacat catgtctggc tacgagttta tccacaagtt gactggagaa
      781 gatgtgtttg gaatcactgt acctctaatt acaagtacaa ctggagcgaa gctgggaaag
      841 tctgctggca acgcggtttg gctaaacaga gagaaaacat ctccgtttga actttaccag
      901 ttctttatca gacagcaaga tgattctgta gaaaggtacc tgaagctttt cactttcctt
      961 cccctcccag agattgatca tattatgcag ctacatgtca aagaaccaga aaagcgaatt
     1021 gctcagaaac gacttgctgc agaagtaaca aagcttgttc atggacaaga aggtctggac
     1081 tctgcgaaaa ggtgtacaca agccctttac catagcagca tagaggcact ggaggtcatg
     1141 tctgaccaag agttaaagga attgtttaaa gaagcttcat tttctgaatt agttcttgac
     1201 cctggaacga gtgtcataga cacatgccgt aaagcaaatg ccattcctga tggtccccga
     1261 gggtatcgga tgatcacaga aggtggagtc agtataaatc acagacaggt aacaaatcct
     1321 gaaagtgttt tagtaattgg acaacatatt ctcaagaatg gactttcctt acttaaaata
     1381 ggaaaaagga atttctacat tataaaatgg cttcagttgt gaaagctttt gtccaaattt
     1441 gtccatcatc cattttcaaa atgtggaagt cttcagaaac ccaagagtgg atgtatacaa
     1501 ggcccccaca ctatgtaaat acttctgtgc atttcaaaat aaagtgatat ttaattatag
     1561 ttcaaaaaaa aaaaaaaaaa aaaaaaaa
//
