LOCUS       NM_001025696            2466 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus tyrosyl-tRNA synthetase 1 (Yars1), mRNA.
ACCESSION   NM_001025696 XM_232760
VERSION     NM_001025696.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2466)
  AUTHORS   Tsukahara,T., Yamagishi,S., Neyama,H. and Ueda,H.
  TITLE     Tyrosyl-tRNA synthetase: A potential kyotorphin synthetase in
            mammals
  JOURNAL   Peptides 101, 60-68 (2018)
   PUBMED   29289698
  REMARK    GeneRIF: conclusion is further supported by a positive correlation
            across brain regions between TyrRS expression and
            arginine-accelerated KTP production.
REFERENCE   2  (bases 1 to 2466)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC098795.1.
            
            On Jul 22, 2005 this sequence version replaced XM_232760.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098795.1, SRR8487227.103329.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2466              BC098795.1         1-2466
FEATURES             Location/Qualifiers
     source          1..2466
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2466
                     /gene="Yars1"
                     /gene_synonym="Yars"
                     /note="tyrosyl-tRNA synthetase 1"
                     /db_xref="GeneID:313047"
                     /db_xref="RGD:1307616"
     exon            1..205
                     /gene="Yars1"
                     /gene_synonym="Yars"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1735
                     /gene="Yars1"
                     /gene_synonym="Yars"
                     /EC_number="6.1.1.1"
                     /note="tyrosyl-tRNA synthetase, cytoplasmic; tyrRS;
                     tyrosyl--tRNA ligase"
                     /codon_start=1
                     /product="tyrosine--tRNA ligase, cytoplasmic"
                     /protein_id="NP_001020867.2"
                     /db_xref="GeneID:313047"
                     /db_xref="RGD:1307616"
                     /translation="MQPDGTSVTVPGTRRRRRTRKGRGCRLSAGNRESGAMGDAPSPE
                     EKLHLITRNLQEVLGEEKLKEILKERELKVYWGTATTGKPHVAYFVPMSKIADFLKAG
                     CEVTILFADLHAYLDNMKAPWELLELRTSYYENVIKAMLESIGVPLEKLKFTKGTDYQ
                     LSKEYTLDVYRLSSLVTQHDAKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQ
                     FGGIDQRKIFTFAEKYLPTLGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKED
                     VKKKLKKAFCEPGNVENNGVLSFVKHVLFPLKSEFVILRDEKWGGNKTYTIYQELEKD
                     FAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPTAKGPAK
                     SSEPEEIIPSRLDIRVGKILSVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEE
                     LQDRLVVVLCNLKPQKMRGVDSQGMLLCASVEGVSRQVEPLDPPAGSAPGERVFVQGY
                     EKGQPDEELKPKKKVFEKLQADFKISDDCVAQWKQTNFMTKLGFVSCKSLKGGNIS"
     exon            206..352
                     /gene="Yars1"
                     /gene_synonym="Yars"
                     /inference="alignment:Splign:2.1.0"
     exon            353..528
                     /gene="Yars1"
                     /gene_synonym="Yars"
                     /inference="alignment:Splign:2.1.0"
     exon            529..658
                     /gene="Yars1"
                     /gene_synonym="Yars"
                     /inference="alignment:Splign:2.1.0"
     exon            659..739
                     /gene="Yars1"
                     /gene_synonym="Yars"
                     /inference="alignment:Splign:2.1.0"
     exon            740..832
                     /gene="Yars1"
                     /gene_synonym="Yars"
                     /inference="alignment:Splign:2.1.0"
     exon            833..968
                     /gene="Yars1"
                     /gene_synonym="Yars"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1054
                     /gene="Yars1"
                     /gene_synonym="Yars"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1190
                     /gene="Yars1"
                     /gene_synonym="Yars"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1288
                     /gene="Yars1"
                     /gene_synonym="Yars"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1482
                     /gene="Yars1"
                     /gene_synonym="Yars"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1624
                     /gene="Yars1"
                     /gene_synonym="Yars"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..2440
                     /gene="Yars1"
                     /gene_synonym="Yars"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggatctag gcctatcaag cggagctacg agctcagctg atgcaacctg acgggactag
       61 cgtgacagtt cccggcacgc ggagacggcg gcgaacgagg aaagggcgcg ggtgccggct
      121 gagcgcggga aaccgagaga gcggagccat gggggatgct ccaagccctg aggagaagct
      181 acaccttatc acccggaacc tgcaggaggt tctgggggaa gagaagctga aggagatact
      241 gaaggagcgg gaacttaaag tttactgggg cacggctacc accgggaagc cacacgtggc
      301 ctactttgta cccatgtcca agattgctga cttcttgaag gcagggtgtg aggtaaccat
      361 cctgtttgca gaccttcatg catacctgga caacatgaaa gctccctggg aacttctaga
      421 acttcgaacc agttactacg aaaatgtgat caaggcaatg ctggagagta ttggtgtgcc
      481 cttggagaag ctcaagttta ccaaaggcac cgactaccag ctcagcaaag agtacacact
      541 ggatgtgtac cggctgtcct ccctggtcac acaacatgat gccaagaaag ccggggctga
      601 ggtcgtaaag caggtggagc accctttgct gagtggtctg ttgtatcccg gtctgcaggc
      661 cttagacgaa gagtacttaa aagtagatgc ccagtttggc ggtattgatc agaggaagat
      721 ttttaccttt gcagagaagt atctccccac acttggctac tcaaaacggg tccatctgat
      781 gaaccccatg gttcctgggt taactgggag caaaatgagc tcatcagaag aggagtccaa
      841 aatcgacctc cttgatcgga aggaggatgt gaagaaaaag ctgaagaagg ccttctgtga
      901 gcccggcaac gtggagaaca atggggtgct gtccttcgtc aagcacgtcc tctttcctct
      961 caagtctgag tttgtgatcc tgagagatga gaagtggggt ggaaacaaaa cctacaccat
     1021 ttaccaggag ctggaaaagg actttgctgc tgaggttgta caccctggag acctaaagaa
     1081 ttctgttgaa gtcgccctga acaagttgct ggaccccatt cgagaaaagt ttaatacccc
     1141 agccctgaag aagctggcca gtgctgccta ccctgatcct tcaaagcaga agcctactgc
     1201 caaaggccct gccaagagtt cagaaccaga ggagatcatc ccatcccggc tggacatccg
     1261 tgtgggcaaa atcctcagcg tggaaaagca cccagatgca gatagcctgt atgtggagaa
     1321 gattgatgtg ggggaagccg aacccaggac tgtggtgagc ggcctcgtgc agtttgtgcc
     1381 caaagaagaa ctacaggacc gactggtggt ggtgctgtgc aacctgaaac cccagaagat
     1441 gagaggagtg gactcccagg gcatgctact gtgtgcttct gtagaagggg taagccgcca
     1501 ggtggaacct ctggaccctc ctgcaggctc tgcccctggt gaacgggtat ttgtacaggg
     1561 ctatgagaag ggccaacctg acgaggagct caagcccaag aagaaagtct ttgagaagct
     1621 gcaggccgac tttaagattt ctgatgactg cgtcgcacag tggaagcaaa ccaacttcat
     1681 gaccaagctg ggctttgtct cctgtaaatc actaaaaggg ggcaacatca gctagccgct
     1741 cggctgctcc caccatcctg tctgccggtc gttccacctc tcacccgctc ccatctcagg
     1801 acactgaagc accggtctgg actgctgact agacgcagga cttggaaagg gacagctcac
     1861 cttcctacca tgtgggctca tcccgcctgg ctgaaaggag acggagtgcc tgggctaagg
     1921 atcttgcctt gcagcaaaca gctctacctt cttcccttgg cagctgactt gagaaatctg
     1981 gtttcaatag aacccacaga aaaagtttat tcctcggtcc ttgtaattgg aaaaacactg
     2041 gttcccaaga ttccatgggg ttttccctgc agctgtacct ctagctgaga tctgttgcct
     2101 ggtctgggct aattacagct tctccccgtc aggaaattgt gggatttgaa aagaagggaa
     2161 aacagcctag aggtctccca agcttcccaa ggctggcagt gttctccagg attgcctgcc
     2221 ctgaggcttg gcaccagagg caggatttgc ccctgctctc ttggggttcc cttgatctgg
     2281 ctaagttggg cactccctaa gcaaaccagc tgtgttagca gcagtgtggg aacggactga
     2341 cacagtgtgg tgctttattc agaatgcgac tactccataa ggcatctcaa tcaaatctct
     2401 caccaccact gtcaaatcca aataaagtgt gtgaacaagg aaaaaaaaaa aaaaaaaaaa
     2461 aaaaaa
//
