LOCUS       NM_001394329            4151 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Rattus norvegicus Yes1 associated transcriptional regulator (Yap1),
            transcript variant 2, mRNA.
ACCESSION   NM_001394329 XM_006242493
VERSION     NM_001394329.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4151)
  AUTHORS   Deng,J., Yang,G., Zhong,N., Liang,L. and Chen,H.
  TITLE     Upregulation of Angiomotin-Like 2 Ameliorates Experimental
            Pulmonary Arterial Hypertension by Inactivating YAP1 Signaling
  JOURNAL   J Cardiovasc Pharmacol 84 (3), 356-369 (2024)
   PUBMED   39027975
  REMARK    GeneRIF: Upregulation of Angiomotin-Like 2 Ameliorates Experimental
            Pulmonary Arterial Hypertension by Inactivating YAP1 Signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4151)
  AUTHORS   Tong,X., Wang,Y., Zhang,H., Liu,P., Wang,C., Liu,H., Zou,R. and
            Niu,L.
  TITLE     Role of YAP in Odontoblast Damage Repair in a Dentin
            Hypersensitivity Model
  JOURNAL   Int Dent J 74 (3), 597-606 (2024)
   PUBMED   38184457
  REMARK    GeneRIF: Role of YAP in Odontoblast Damage Repair in a Dentin
            Hypersensitivity Model.
REFERENCE   3  (bases 1 to 4151)
  AUTHORS   Aravamudhan,A., Dieffenbach,P.B., Choi,K.M., Link,P.A.,
            Meridew,J.A., Haak,A.J., Fredenburgh,L.E. and Tschumperlin,D.J.
  TITLE     Non-canonical IKB kinases regulate YAP/TAZ and pathological
            vascular remodeling behaviors in pulmonary artery smooth muscle
            cells
  JOURNAL   Physiol Rep 12 (7), e15999 (2024)
   PUBMED   38610069
  REMARK    GeneRIF: Non-canonical IKB kinases regulate YAP/TAZ and
            pathological vascular remodeling behaviors in pulmonary artery
            smooth muscle cells.
REFERENCE   4  (bases 1 to 4151)
  AUTHORS   Mengjia,W., Jun,J., Xin,Z., Jiahao,Z. and Jie,G.
  TITLE     GPX4-mediated bone ferroptosis under mechanical stress decreased
            bone formation via the YAP-TEAD signalling pathway
  JOURNAL   J Cell Mol Med 28 (7), e18231 (2024)
   PUBMED   38494855
  REMARK    GeneRIF: GPX4-mediated bone ferroptosis under mechanical stress
            decreased bone formation via the YAP-TEAD signalling pathway.
REFERENCE   5  (bases 1 to 4151)
  AUTHORS   Taiyab,A., Belahlou,Y., Wong,V., Pandi,S., Shekhar,M.,
            Chidambaranathan,G.P. and West-Mays,J.
  TITLE     Understanding the Role of Yes-Associated Protein (YAP) Signaling in
            the Transformation of Lens Epithelial Cells (EMT) and Fibrosis
  JOURNAL   Biomolecules 13 (12), 1767 (2023)
   PUBMED   38136638
  REMARK    GeneRIF: Understanding the Role of Yes-Associated Protein (YAP)
            Signaling in the Transformation of Lens Epithelial Cells (EMT) and
            Fibrosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4151)
  AUTHORS   Hoshino,M., Qi,M.L., Yoshimura,N., Miyashita,T., Tagawa,K.,
            Wada,Y., Enokido,Y., Marubuchi,S., Harjes,P., Arai,N., Oyanagi,K.,
            Blandino,G., Sudol,M., Rich,T., Kanazawa,I., Wanker,E.E., Saitoe,M.
            and Okazawa,H.
  TITLE     Transcriptional repression induces a slowly progressive atypical
            neuronal death associated with changes of YAP isoforms and p73
  JOURNAL   J Cell Biol 172 (4), 589-604 (2006)
   PUBMED   16461361
REFERENCE   7  (bases 1 to 4151)
  AUTHORS   Morin-Kensicki,E.M., Boone,B.N., Howell,M., Stonebraker,J.R.,
            Teed,J., Alb,J.G., Magnuson,T.R., O'Neal,W. and Milgram,S.L.
  TITLE     Defects in yolk sac vasculogenesis, chorioallantoic fusion, and
            embryonic axis elongation in mice with targeted disruption of Yap65
  JOURNAL   Mol Cell Biol 26 (1), 77-87 (2006)
   PUBMED   16354681
REFERENCE   8  (bases 1 to 4151)
  AUTHORS   Murakami,M., Nakagawa,M., Olson,E.N. and Nakagawa,O.
  TITLE     A WW domain protein TAZ is a critical coactivator for TBX5, a
            transcription factor implicated in Holt-Oram syndrome
  JOURNAL   Proc Natl Acad Sci U S A 102 (50), 18034-18039 (2005)
   PUBMED   16332960
REFERENCE   9  (bases 1 to 4151)
  AUTHORS   Sawada,A., Nishizaki,Y., Sato,H., Yada,Y., Nakayama,R.,
            Yamamoto,S., Nishioka,N., Kondoh,H. and Sasaki,H.
  TITLE     Tead proteins activate the Foxa2 enhancer in the node in
            cooperation with a second factor
  JOURNAL   Development 132 (21), 4719-4729 (2005)
   PUBMED   16207754
REFERENCE   10 (bases 1 to 4151)
  AUTHORS   Gavva,N.R., Gavva,R., Ermekova,K., Sudol,M. and Shen,C.J.
  TITLE     Interaction of WW domains with hematopoietic transcription factor
            p45/NF-E2 and RNA polymerase II
  JOURNAL   J Biol Chem 272 (39), 24105-24108 (1997)
   PUBMED   9305852
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Apr 13, 2021 this sequence version replaced XM_006242493.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.21172.1,
                                           SRR26643299.33700.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-489               JAXUCZ010000008.1  13450949-13451437   c
            490-731             JAXUCZ010000008.1  13448441-13448682   c
            732-847             JAXUCZ010000008.1  13420204-13420319   c
            848-961             JAXUCZ010000008.1  13409164-13409277   c
            962-1143            JAXUCZ010000008.1  13399894-13400075   c
            1144-1274           JAXUCZ010000008.1  13387786-13387916   c
            1275-1387           JAXUCZ010000008.1  13384565-13384677   c
            1388-4151           JAXUCZ010000008.1  13380551-13383314   c
FEATURES             Location/Qualifiers
     source          1..4151
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q11"
     gene            1..4151
                     /gene="Yap1"
                     /gene_synonym="Yap; YAP65"
                     /note="Yes1 associated transcriptional regulator"
                     /db_xref="GeneID:363014"
                     /db_xref="RGD:1306035"
     exon            1..489
                     /gene="Yap1"
                     /gene_synonym="Yap; YAP65"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..1623
                     /gene="Yap1"
                     /gene_synonym="Yap; YAP65"
                     /note="isoform 2 is encoded by transcript variant 2;
                     yorkie homolog; 65 kDa Yes-associated protein; protein
                     yorkie homolog; yes-associated protein YAP65 homolog;
                     transcriptional coactivator YAP1; yes-associated protein
                     1"
                     /codon_start=1
                     /product="transcriptional coactivator YAP1 isoform 2"
                     /protein_id="NP_001381258.1"
                     /db_xref="GeneID:363014"
                     /db_xref="RGD:1306035"
                     /translation="MEPAQQPPPQPAPQGPAPPSVSPAGTPAAPPAPPAGHQVVHVRG
                     DSETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDAGTAGA
                     LTPQHVRAHSSPASLQLGAGTLTASGVVSGPAATPAAQHLRQSSFEIPDDVPLPAGWE
                     MAKTSSGQRYFLNHNDQTTTWQDPRKAMLSQLNVPTSASPAVPQTLMNSASGPLPDGW
                     EQAMTQDGEVYYINHKNKTTSWLDPRLDPRFAMNQRITQSAPVKQPPPLAPQSPQGGV
                     LGGGSSNQQQQIQLQQLQMEKERLRLKQQELFRQELALRSQLPSLEQDGGTQNAVSSP
                     GMTQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSIPRTPDDFLNSVDEMDTG
                     DTISQSTLPSQQSRFPDYLEALPGTNVDLGTLEGDAMNIEGEELMPSLQEALSSEILD
                     VESVLAATKLDKESFLTWL"
     exon            490..731
                     /gene="Yap1"
                     /gene_synonym="Yap; YAP65"
                     /inference="alignment:Splign:2.1.0"
     exon            732..847
                     /gene="Yap1"
                     /gene_synonym="Yap; YAP65"
                     /inference="alignment:Splign:2.1.0"
     exon            848..961
                     /gene="Yap1"
                     /gene_synonym="Yap; YAP65"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1143
                     /gene="Yap1"
                     /gene_synonym="Yap; YAP65"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1274
                     /gene="Yap1"
                     /gene_synonym="Yap; YAP65"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1387
                     /gene="Yap1"
                     /gene_synonym="Yap; YAP65"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..4151
                     /gene="Yap1"
                     /gene_synonym="Yap; YAP65"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcctcgcaa ctttttagtt tgggcgtcta gagccgaagt ttctgtctca gttgggacgc
       61 cgccgcggcc cggggcaaag aaagggagga aggaaggagc tcacgaaggg gaggggaggg
      121 ggcctcgggc aaggagtgca gggcgatgcg ggcgcgcgac gcagcccccc gaacctgagc
      181 gcagcgcccc gagcgtcgaa cgaggccgca gccatggagc ccgcgcaaca gccgccgccc
      241 cagccggccc cgcaaggccc cgcgccgccg tcggtgtctc cggccgggac ccccgcggcc
      301 ccgcccgcac ccccggcggg tcaccaggtc gtgcacgtcc gcggggactc ggagaccgac
      361 ctggaagcgc ttttcaacgc cgtcatgaac cccaagacgg ccaacgtgcc acagaccgtg
      421 cccatgaggc ttcgcaagct gcccgactcc ttcttcaagc cgcctgagcc caagtcccac
      481 tcgcgacagg ccagtaccga tgcgggcact gctggagccc tgactcccca gcacgttcga
      541 gctcactcgt ctccagcctc cctgcagctg ggggccggga cactcacggc cagtggtgtt
      601 gtctctggcc cggccgccac ccctgctgct caacatctca gacagtcttc ctttgagatc
      661 cctgatgatg taccattgcc agcaggctgg gagatggcca agacctcttc tggtcagaga
      721 tacttcttaa atcacaatga tcagacaaca acatggcagg acccccggaa ggccatgctc
      781 tcccaactga acgttcctac atctgccagc ccagcagtgc cccagacgct gatgaactct
      841 gcctcagggc ctcttcctga tggatgggag caagccatga ctcaggatgg agaagtttac
      901 tacataaacc ataagaacaa gaccacatcc tggctggacc caaggcttga ccctcgtttt
      961 gccatgaacc agaggatcac tcagagtgct ccagtgaagc agcccccacc cttggctccc
     1021 cagagcccac agggaggcgt cctgggtgga ggcagctcaa accagcagca gcagatacag
     1081 ctgcagcagc tacagatgga gaaggagagg ctgcgattga aacagcagga gttatttcgg
     1141 caggaattag ctctccgcag ccagttgccc tcactggagc aggatggagg gactcagaat
     1201 gcagtgtctt ctcccgggat gactcaggaa ttgaggacaa tgacaaccaa tagttcagat
     1261 ccctttctta acagtggcac ctatcactct agagatgaga gcacagacag tggcctcagc
     1321 atgagcagct acagcatccc tcggacccca gacgacttcc tgaacagcgt ggatgaaatg
     1381 gacacaggag acaccatcag ccagagcacc ctgccgtccc agcagagccg cttccctgat
     1441 tacctggagg ccctccctgg gacaaatgtg gaccttggca cactggaagg agatgcaatg
     1501 aacatagaag gggaggagct gatgcccagc cttcaggaag cgctgagttc cgaaatcctg
     1561 gatgtggagt ctgtgttggc tgccaccaag ttagataaag aaagctttct cacgtggtta
     1621 tagagctgtc cggagccact ctccgggtct gtgaaggatc cacagagcct aaggtgtgca
     1681 ctcctgcatt cagataagcc agtgggtgat tctctggcta acacagaaca ggtgaccagt
     1741 gtccagcggg gatcatccac tgttgctctg ctcttctctg ccattgctgc tcttaggttg
     1801 ctgacctctt cacggccacc cctaaagaac cagaaccaca aatagccaga gccctttgtt
     1861 tcctttgctc tggcagctgt gctctctggg ttgtggggag cctgtcgata acagatgccc
     1921 ggcctcctcc actggtcttc acccatcctc aactgaaccc caggctgggt ctgaaatgct
     1981 ttatgcgtct gttcaagaca cggtttcttc agctgccttt ggcccttggg tccaacaagc
     2041 cagacgcgtg gcatctgatc tcacggaaga ccggaagatg gcaaagaccc atgccgaaga
     2101 ctgatggact tcctgtttct ttttttagtc ataccattag gcacatagtg acctggattt
     2161 tatcttagaa gctcatgagg catgggacag tttccataga aatacattaa ttatgccaca
     2221 tactctaggt taggtttgaa tggatatttt ctgtgggtgt tttggttggt ttttctgttt
     2281 tcttttctgt ggttggtttt ggtggaacgt aggcaactta atgaagtcat tcatagctgt
     2341 agcttggggt gggcagtacc attcttttgg gggaaatcta tatttctcga ctttttaaca
     2401 tcctatttaa atcttggctg tctcctctct acgtatgtac acactcttct gatgtctgtg
     2461 gtagtgtgta gcagagtgtg tcttgataag tgtttccttc gctcctagtt tactgttgaa
     2521 atggtagcct tgagcatatg catttagaca tcttagttat gtttcacgga tagttgaaat
     2581 tctggttggg gcaatctgca ggtgtttgag gagggtggga gggagggagg gaaggagggc
     2641 agtgttatag aaagggctct ggttgtgggt aaagccagga agagctctcc agccctctgc
     2701 actgcggcag tgaggataga agccaccagt ggcctcactc ccttggactg attccgttgt
     2761 gcagtctcag agctttgagc tttggagagg caggccttcc ttccgcctcg gcctcggctg
     2821 tccactcaga tacttttgag tattgactgt cacctacaag atcagtctta ggaaacctca
     2881 cgtgcctgtg ttcagtggac cctggggtag ggcgaagaat gctgtgaggc cttggctggc
     2941 cagtaaagtg aacagacagt aagtgtgcgg gggtggctga acttagcaaa gggctagagc
     3001 gaagcatgat tatggcttta tttttacaag aagaaagatt actagagtat gtgtctccaa
     3061 gagtaatgat ggtttccaaa gagtattttt taaaggaaca aaataggcgt gaattaactc
     3121 tgcgtataag ctatgacgta atagttggtt gtgaattgca gtcgctgcac cagttagcac
     3181 ctctcattta gagtctttga gtgcttctag aagagtccct tattttcaag ggttcataat
     3241 gaacaacaac aacaacaaat tttcccctgg ctaaagctgc taactataaa aattgtcagc
     3301 ttaggaagat agaaatcttg tattttggcc ttttgagtag tatagcgcaa gaatgaagta
     3361 gaaaagtttt atttagtact ttgagtgctc aaaaaatgca atcagtgtat tatatatgat
     3421 tcataggtca gtcatttgag gccatcaact caaggctttt aatcagaacc aagctgaaga
     3481 ttcacccttg aatctagtct ggggaaacaa ccacgggagg atgcattgac tttagaacag
     3541 agaggaaact ctaactgaaa actgcgcaga tggatggtcc gcagcagtgt ggggattcac
     3601 agataatagg catgctgagt gcccatgatt ctccaggaaa ctccagaaca aaggaccaca
     3661 tcttctgtgg gcagagtagc ctcagtgtgg ggagggggag ggcaggtggg catgggctgg
     3721 tgagaggtag cagagccctg ttactgttag aaaagctttt atgaacttaa tttctcttcc
     3781 ttaaagactt cgctctcatc ttgctcccag taaagttttt cctaactttc cagctgctta
     3841 acctccctca caaagtgaaa tgtgtcacct tccttctccc tcagcatggt gtgcctggtt
     3901 atacctcaat gtccagcagc cctggtgcct gacagtgcct ctgactttat caaaccctcc
     3961 gtgctgactg tgggagaccc gagcaccttt tctctcactg aatttgaatc acagcctcaa
     4021 cgtagtcttc ttgttgtgtc caacagtgtt taatgcttcc tggctgtagt gggtagcatg
     4081 cagataagaa tttaactggt tattcttgaa tttcttttac aataaaccaa tttttataat
     4141 cttaaaatgt a
//
