LOCUS       NM_022296               3375 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Rattus norvegicus xylosyltransferase 2 (Xylt2), mRNA.
ACCESSION   NM_022296
VERSION     NM_022296.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3375)
  AUTHORS   Munns,C.F., Fahiminiya,S., Poudel,N., Munteanu,M.C., Majewski,J.,
            Sillence,D.O., Metcalf,J.P., Biggin,A., Glorieux,F., Fassier,F.,
            Rauch,F. and Hinsdale,M.E.
  TITLE     Homozygosity for frameshift mutations in XYLT2 result in a
            spondylo-ocular syndrome with bone fragility, cataracts, and
            hearing defects
  JOURNAL   Am J Hum Genet 96 (6), 971-978 (2015)
   PUBMED   26027496
REFERENCE   2  (bases 1 to 3375)
  AUTHORS   Kuhn,J., Gotting,C., Beahm,B.J., Bertozzi,C.R., Faust,I., Kuzaj,P.,
            Knabbe,C. and Hendig,D.
  TITLE     Xylosyltransferase II is the predominant isoenzyme which is
            responsible for the steady-state level of xylosyltransferase
            activity in human serum
  JOURNAL   Biochem Biophys Res Commun 459 (3), 469-474 (2015)
   PUBMED   25748573
REFERENCE   3  (bases 1 to 3375)
  AUTHORS   Casanova,J.C., Kuhn,J., Kleesiek,K. and Gotting,C.
  TITLE     Heterologous expression and biochemical characterization of soluble
            human xylosyltransferase II
  JOURNAL   Biochem Biophys Res Commun 365 (4), 678-684 (2008)
   PUBMED   18023272
REFERENCE   4  (bases 1 to 3375)
  AUTHORS   Condac,E., Silasi-Mansat,R., Kosanke,S., Schoeb,T., Towner,R.,
            Lupu,F., Cummings,R.D. and Hinsdale,M.E.
  TITLE     Polycystic disease caused by deficiency in xylosyltransferase 2, an
            initiating enzyme of glycosaminoglycan biosynthesis
  JOURNAL   Proc Natl Acad Sci U S A 104 (22), 9416-9421 (2007)
   PUBMED   17517600
REFERENCE   5  (bases 1 to 3375)
  AUTHORS   Ponighaus,C., Ambrosius,M., Casanova,J.C., Prante,C., Kuhn,J.,
            Esko,J.D., Kleesiek,K. and Gotting,C.
  TITLE     Human xylosyltransferase II is involved in the biosynthesis of the
            uniform tetrasaccharide linkage region in chondroitin sulfate and
            heparan sulfate proteoglycans
  JOURNAL   J Biol Chem 282 (8), 5201-5206 (2007)
   PUBMED   17189265
REFERENCE   6  (bases 1 to 3375)
  AUTHORS   Kuhn,J., Gotting,C., Schnolzer,M., Kempf,T., Brinkmann,T. and
            Kleesiek,K.
  TITLE     First isolation of human UDP-D-xylose: proteoglycan core protein
            beta-D-xylosyltransferase secreted from cultured JAR
            choriocarcinoma cells
  JOURNAL   J Biol Chem 276 (7), 4940-4947 (2001)
   PUBMED   11087729
REFERENCE   7  (bases 1 to 3375)
  AUTHORS   Gotting,C., Kuhn,J., Zahn,R., Brinkmann,T. and Kleesiek,K.
  TITLE     Molecular cloning and expression of human UDP-d-Xylose:proteoglycan
            core protein beta-d-xylosyltransferase and its first isoform XT-II
  JOURNAL   J Mol Biol 304 (4), 517-528 (2000)
   PUBMED   11099377
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC105767.1.
            
            On Oct 16, 2005 this sequence version replaced NM_022296.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC105767.1, AJ295749.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3375
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..3375
                     /gene="Xylt2"
                     /gene_synonym="xylt-II"
                     /note="xylosyltransferase 2"
                     /db_xref="GeneID:64134"
                     /db_xref="RGD:619765"
     exon            1..139
                     /gene="Xylt2"
                     /gene_synonym="xylt-II"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..2599
                     /gene="Xylt2"
                     /gene_synonym="xylt-II"
                     /EC_number="2.4.2.26"
                     /note="peptide O-xylosyltransferase 2; xylosyltransferase
                     II"
                     /codon_start=1
                     /product="xylosyltransferase 2"
                     /protein_id="NP_071632.2"
                     /db_xref="GeneID:64134"
                     /db_xref="RGD:619765"
                     /translation="MVASARVQKLVRRYKLAIATALAILLLQGLVVWSFSGLEEDEPG
                     EKGRQRKPRPLDPGEGSKDTDSSAGRRGSAGRRHGRWRGRAESPGVPVAKVVRAVTSR
                     QRASRRVPPAPPPEAPGRQNLSGAAAGEALIGAAGFPQHGDTGSVEGAPQPTDNSFTP
                     KCEIVGKDALSALARASTKHCQQEIANVVCLHQAGNLMPKSVPRHCQLAGKVSPGIQW
                     EEVRAQQPVSGPLVRIAYMLVVHGRAVRQLKRLLKAVYHEEHFFYIHVDKRSNYLYRE
                     VVELAQHYDNVRVTPWRMVTIWGGASLLRMYLRSMKDLLEIPGWTWDFFINLSATDYP
                     TRTNEELVAFLSKNRDKNFLKSHGRDNSRFIKKQGLDRLFHECDSHMWRLGERQIPAG
                     IVVDGGSDWFVLTRSFVEYVVYTEDPLVAQLRQFYTYTLLPAESFFHTVLENSPACES
                     LVDNNLRVTNWNRKLGCKCQYKHIVDWCGCSPNDFKPQDFLRLQQVSRPTFFARKFES
                     TVNQEVLEILDFHLYGSYPPGTPALKAYWENIYDMADGPSGLSDVLLTAYTAFARISL
                     RHAATVSPLATAVCRFEPRGLPSSVHLYFYDDHFQGYLVTQAVQPSAQGPAETLEMWL
                     MPQRLLKLLGHSDQASRLQSLEVGTEWDPKERLFRNFGGLLGPLDEPVAMQRWARGPN
                     LTATVVWIDPTYVVATSYDITVDADTEVTQYKPPLSLPLRPGAWTVRLLQFWEPLGET
                     RFLVLPLTFNRKLPLRKDDASWLHAGPPHNEYMEQSFQGLSGILNLPQPEAVEEAARR
                     HTELTGPALEAWTDGELSSFWSVAGLCAIGPSSCPSLELCRLTSWSSLSPDPKSELGP
                     VKADGRLR"
     exon            140..632
                     /gene="Xylt2"
                     /gene_synonym="xylt-II"
                     /inference="alignment:Splign:2.1.0"
     exon            633..808
                     /gene="Xylt2"
                     /gene_synonym="xylt-II"
                     /inference="alignment:Splign:2.1.0"
     exon            809..1011
                     /gene="Xylt2"
                     /gene_synonym="xylt-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1092
                     /gene="Xylt2"
                     /gene_synonym="xylt-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1309
                     /gene="Xylt2"
                     /gene_synonym="xylt-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1486
                     /gene="Xylt2"
                     /gene_synonym="xylt-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1746
                     /gene="Xylt2"
                     /gene_synonym="xylt-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1942
                     /gene="Xylt2"
                     /gene_synonym="xylt-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2276
                     /gene="Xylt2"
                     /gene_synonym="xylt-II"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..3361
                     /gene="Xylt2"
                     /gene_synonym="xylt-II"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagatggtg gcgagcgcgc gggtgcagaa gctggtgcgg cgctacaagc tggcgatcgc
       61 caccgcgctg gccatcctgc tgctgcaggg cctggtggtg tggagcttca gcggcctgga
      121 ggaggacgag ccgggcgaga aaggaaggca gagaaagcca cggccgctag accctggaga
      181 gggttccaag gacacggaca gctctgcagg gcgtaggggc agtgctggga gaaggcacgg
      241 acggtggcgg ggccgcgccg agagcccagg tgtgcctgtg gccaaggtgg tgcgggcagt
      301 aaccagtcgg cagagagcca gccgacgggt gccccctgcc ccacctccag aggcaccagg
      361 ccgccagaac ctgagtggag cagcagccgg ggaagcactg ataggtgccg ccggcttccc
      421 acaacatgga gacacaggga gtgtggaggg tgcccctcag cccacggata acagcttcac
      481 tccgaagtgt gagattgtgg gcaaggatgc actgtcagca ctggcccggg ccagcaccaa
      541 gcattgtcaa caagagattg ctaatgtagt gtgcctgcac caagctggga acctaatgcc
      601 caagtctgtg ccccggcact gccagctggc tggcaaggtg agccctggca tccagtggga
      661 agaggtccgg gcccagcagc ctgtgagtgg ccctctggta cgcatcgcct acatgctggt
      721 ggttcacggc cgtgctgtgc gccagctgaa gcgtcttctg aaggccgtct accacgagga
      781 gcacttcttt tatattcatg tggacaagcg ttccaactac ctgtaccggg aggtggtaga
      841 gctggcccag cactacgaca atgtacgggt aacaccttgg cgcatggtca ccatctgggg
      901 tggggctagc cttctgagga tgtacctgcg gagcatgaag gaccttctgg agattcctgg
      961 ctggacctgg gacttcttca tcaacctgag cgctactgac tatccaacca ggacgaatga
     1021 ggagctggta gcgttcttat ccaagaaccg ggacaagaat ttcctcaagt cacacgggcg
     1081 agacaattcc aggttcatca agaagcaagg cctggaccgg cttttccatg agtgtgattc
     1141 ccacatgtgg cgcctgggtg aacggcagat cccggcaggc atcgtggtgg atggtggctc
     1201 tgactggttc gtgctgacac gcagctttgt ggaatatgtg gtgtatacag aggatcctct
     1261 ggtggcccag cttcgccagt tctatacata cacattgctt ccagccgagt ccttcttcca
     1321 cacagtgctg gagaacagcc cagcctgtga gagcctagtg gacaacaacc tgcgggttac
     1381 caactggaac cggaagctgg gctgcaagtg ccagtacaag cacatcgtgg actggtgtgg
     1441 ctgctccccc aacgacttca agccacagga cttcctgcgg cttcagcaag tctccagacc
     1501 caccttcttt gcccggaagt ttgagtcgac tgtgaaccag gaagtcctgg aaattttgga
     1561 cttccacctg tatggcagct acccacccgg caccccagcc ctcaaggcct actgggagaa
     1621 catctacgac atggccgatg gccctagtgg actcagcgat gtcctactca ctgcttacac
     1681 agcctttgcc cgtatcagtc tgcgtcatgc tgccactgtt tccccactgg ccactgcagt
     1741 ctgcaggttt gagcccaggg ggttgccgtc cagcgtgcac ctgtatttct atgacgacca
     1801 tttccagggc tacctggtga cgcaggcagt gcagccctca gcccaggggc cagcagagac
     1861 acttgagatg tggctgatgc cccagaggtt gctgaagctg ttggggcaca gtgaccaggc
     1921 cagccggctc cagagtctgg aggttggcac tgagtgggac cccaaagaac gtctcttccg
     1981 gaactttggg ggcctgttgg gaccactgga tgaacctgtg gccatgcagc gctgggcccg
     2041 gggccccaac ctcacagcca ctgtggtctg gattgacccc acctatgttg tggccacatc
     2101 ctatgacatc acggtagatg cggacactga agtcacgcag tacaagcccc cactgagcct
     2161 gccactgcgg ccaggagcct ggactgttcg attgcttcag ttctgggagc ccctgggtga
     2221 gacccgcttc ctcgtgctgc cattgacctt caaccgcaaa ctacctctca ggaaagatga
     2281 tgccagctgg ctgcatgcgg gaccacccca caacgaatac atggaacaga gtttccaggg
     2341 actaagtggc atcctgaatc tgcctcagcc agaggccgtg gaggaggctg cccggcggca
     2401 cacagagctc acaggtcctg cacttgaggc ctggacagat ggggaactga gcagtttctg
     2461 gtctgttgca ggattgtgtg ccatagggcc ttcttcttgt ccctccctgg agctctgcag
     2521 actgaccagc tggagctctc tgtctcctga ccccaagtca gagctggggc ctgtcaaagc
     2581 tgacggacga ctcaggtagc aggaccccag ccagcacaac ccggaggagc cggggaattg
     2641 caccttacag acaatggagg gacgtctctc ccacagacca gaaccagagg cccaggcagt
     2701 atgcccattt gagccatcag gaccctatac tgagggcagg gaaggtgggt gcagtactcc
     2761 ctactgctga cggatctaca agagaccagc agtccaccgg aaccatgagg aggctcttcc
     2821 tctgctcctc gctagtttat acttttttaa taattaaaat gagtggcaga gggaggaaga
     2881 tgtgcaatag ggctcagagc cccaggatgt aggccatggc catggggagc accatggaga
     2941 atatctgcta ctgctctggg gaggcatggt ctgcctcacc ctccagagcc tccgtcccca
     3001 gcctgggcct gagctgctca cagctgaggc tcttaagagg cccaggggcc tcccaggctc
     3061 tgaggccagg aggacaggtg atctaggggg gctactgtgg agctggactt tagtgagaca
     3121 gcctctcctc tggtagccag ggagccctag aacagtggtg gggctgtctg tctgtcaggc
     3181 tttcctagga aatggacgac atcaggccct gctgagatcc atgaagtttc cccactggag
     3241 gagggagccc cactggcagc acaggaagac tgtcagagcg ctcagaagag tcgcgttgtg
     3301 cctgaagctc agtgtgaagt ctgaaatatg caacagagga aatatatctc tatctctcca
     3361 aaaaaaaaaa aaaaa
//
