LOCUS       NM_022295               6004 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus xylosyltransferase 1 (Xylt1), mRNA.
ACCESSION   NM_022295 XM_006223458
VERSION     NM_022295.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6004)
  AUTHORS   Briggs,D.C. and Hohenester,E.
  TITLE     Structural Basis for the Initiation of Glycosaminoglycan
            Biosynthesis by Human Xylosyltransferase 1
  JOURNAL   Structure 26 (6), 801-809 (2018)
   PUBMED   29681470
REFERENCE   2  (bases 1 to 6004)
  AUTHORS   Ye,W., Zhou,J., Markova,D.Z., Tian,Y., Li,J., Anderson,D.G.,
            Shapiro,I.M. and Risbud,M.V.
  TITLE     Xylosyltransferase-1 expression is refractory to inhibition by the
            inflammatory cytokines tumor necrosis factor alpha and IL-1beta in
            nucleus pulposus cells: novel regulation by AP-1, Sp1, and Sp3
  JOURNAL   Am J Pathol 185 (2), 485-495 (2015)
   PUBMED   25476526
  REMARK    GeneRIF: These results suggest that XT-1 expression is refractory
            to the disease process and to inhibition by inflammatory cytokines
            and that signaling through AP-1, Sp1, and Sp3 is important in the
            maintenance of XT-1 levels in NP cells.
REFERENCE   3  (bases 1 to 6004)
  AUTHORS   Mis,E.K., Liem,K.F. Jr., Kong,Y., Schwartz,N.B., Domowicz,M. and
            Weatherbee,S.D.
  TITLE     Forward genetics defines Xylt1 as a key, conserved regulator of
            early chondrocyte maturation and skeletal length
  JOURNAL   Dev Biol 385 (1), 67-82 (2014)
   PUBMED   24161523
REFERENCE   4  (bases 1 to 6004)
  AUTHORS   Venkatesan,N., Barre,L., Magdalou,J., Mainard,D., Netter,P.,
            Fournel-Gigleux,S. and Ouzzine,M.
  TITLE     Modulation of xylosyltransferase I expression provides a mechanism
            regulating glycosaminoglycan chain synthesis during cartilage
            destruction and repair
  JOURNAL   FASEB J 23 (3), 813-822 (2009)
   PUBMED   19001053
  REMARK    GeneRIF: Expression of xylosyltransferase I (XT-I) gene initiating
            proteoglycan-glycosaminoglycan chain synthesis was significantly
            reduced in antigen-induced arthritis rat cartilage and was
            associated with a decrease in proteoglycan synthesis.
REFERENCE   5  (bases 1 to 6004)
  AUTHORS   Hurtado,A., Podinin,H., Oudega,M. and Grimpe,B.
  TITLE     Deoxyribozyme-mediated knockdown of xylosyltransferase-1 mRNA
            promotes axon growth in the adult rat spinal cord
  JOURNAL   Brain 131 (Pt 10), 2596-2605 (2008)
   PUBMED   18765417
REFERENCE   6  (bases 1 to 6004)
  AUTHORS   Schon,S., Prante,C., Bahr,C., Tarnow,L., Kuhn,J., Kleesiek,K. and
            Gotting,C.
  TITLE     The xylosyltransferase I gene polymorphism c.343G>T (p.A125S) is a
            risk factor for diabetic nephropathy in type 1 diabetes
  JOURNAL   Diabetes Care 29 (10), 2295-2299 (2006)
   PUBMED   17003309
REFERENCE   7  (bases 1 to 6004)
  AUTHORS   Schon,S., Schulz,V., Prante,C., Hendig,D., Szliska,C., Kuhn,J.,
            Kleesiek,K. and Gotting,C.
  TITLE     Polymorphisms in the xylosyltransferase genes cause higher serum
            XT-I activity in patients with pseudoxanthoma elasticum (PXE) and
            are involved in a severe disease course
  JOURNAL   J Med Genet 43 (9), 745-749 (2006)
   PUBMED   16571645
REFERENCE   8  (bases 1 to 6004)
  AUTHORS   Bahr,C., Schon,S., Kuhn,J., Groop,P.H., Parkkonen,M., Wessman,M.,
            Kleesiek,K. and Gotting,C.
  TITLE     Novel sequence variants in the human xylosyltransferase I gene and
            their role in diabetic nephropathy
  JOURNAL   Diabet Med 23 (6), 681-684 (2006)
   PUBMED   16759312
REFERENCE   9  (bases 1 to 6004)
  AUTHORS   Kuhn,J., Gotting,C., Schnolzer,M., Kempf,T., Brinkmann,T. and
            Kleesiek,K.
  TITLE     First isolation of human UDP-D-xylose: proteoglycan core protein
            beta-D-xylosyltransferase secreted from cultured JAR
            choriocarcinoma cells
  JOURNAL   J Biol Chem 276 (7), 4940-4947 (2001)
   PUBMED   11087729
REFERENCE   10 (bases 1 to 6004)
  AUTHORS   Gotting,C., Kuhn,J., Zahn,R., Brinkmann,T. and Kleesiek,K.
  TITLE     Molecular cloning and expression of human UDP-d-Xylose:proteoglycan
            core protein beta-d-xylosyltransferase and its first isoform XT-II
  JOURNAL   J Mol Biol 304 (4), 517-528 (2000)
   PUBMED   11099377
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000043.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_022295.3.
            
            On Nov 27, 2020 this sequence version replaced NM_022295.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-356               JACYVU010000043.1  9018383-9018738
            357-395             JACYVU010000043.1  9112914-9112952
            396-909             JACYVU010000043.1  9186051-9186564
            910-1082            JACYVU010000043.1  9229341-9229513
            1083-1285           JACYVU010000043.1  9231000-9231202
            1286-1366           JACYVU010000043.1  9260203-9260283
            1367-1583           JACYVU010000043.1  9271288-9271504
            1584-1760           JACYVU010000043.1  9274184-9274360
            1761-2023           JACYVU010000043.1  9280053-9280315
            2024-2219           JACYVU010000043.1  9287090-9287285
            2220-2553           JACYVU010000043.1  9292107-9292440
            2554-6004           JACYVU010000043.1  9297791-9301241
FEATURES             Location/Qualifiers
     source          1..6004
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q35"
     gene            1..6004
                     /gene="Xylt1"
                     /gene_synonym="Xt1; XYLT-1"
                     /note="xylosyltransferase 1"
                     /db_xref="GeneID:64133"
                     /db_xref="RGD:620093"
     exon            1..356
                     /gene="Xylt1"
                     /gene_synonym="Xt1; XYLT-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..2876
                     /gene="Xylt1"
                     /gene_synonym="Xt1; XYLT-1"
                     /EC_number="2.4.2.26"
                     /note="xylosyltransferase I; peptide O-xylosyltransferase
                     1"
                     /codon_start=1
                     /product="xylosyltransferase 1"
                     /protein_id="NP_071631.1"
                     /db_xref="GeneID:64133"
                     /db_xref="RGD:620093"
                     /translation="MVAAPCARRLARRSHSALLAALMVLLLQTLVVWNFSSLDSGAGE
                     QRRAGAAAGAAEQQQQQPAAPRRERRDLAAHLPAARGGPGGRAGGGGARGGGPGGARA
                     QQPASRGALAARARDPHPSPLITLETQDGYFSHRPKEKVRTDSNNENSVPKDFENVDN
                     SNFAPRTQKQKHQPELAKKPLSRQKERLQRKLGAQDKGQGQSVLGKGPKEVLPPREKA
                     PGNSSQGKDLSRHSHSRKSGGGGSPETKSDQVPKCDISGKEAISALTRAKSKHCRQEI
                     AETYCRHKLGLLMPEKVARFCPLEGKANKNVQWDEDAVEYMPPNPVRIAFVLVVHGRA
                     SRQLQRMFKAIYHKDHFYYIHVDKRSNYLHRQVLQFSRQYDNVRVTSWRMATIWGGAS
                     LLSTYLQSMRDLLEMTDWPWDFFINLSAADYPIRTNDQLVAFLSRYRDMNFLKSHGRD
                     NARFIRKQGLDRLFLECDTHMWRLGDRRIPEGIAVDGGSDWFLLNRKFVEYVAFSTDD
                     LVTKMKQFYSYTLLPAESFFHTVLENSPHCDTMVDNNLRITNWNRKLGCKCQYKHIVD
                     WCGCSPNDFKPQDFHRFQQTARPTFFARKFEAIVNQEIIGQLDSYLYGNYPAGTPGLR
                     SYWENVYDEPDGIQSLSDVALTMYHSFIRLGLRRAESSLHTDGENSCRYYPMGHPASV
                     HLYFLADRFQGFLIKHHVTNLAVSKLETLETWMMPKKVFKVASPPSDFGRLQFSEVGT
                     DWDAKERLFRNFGGLLGPMDEPVGMQKWGKGPNVTVTVIWVDPVNVIAATYDILIEST
                     AEFTHYKPPLNLPLRPGVWTVKILHHWVPVAETKFLVAPLTFSNKQPIKPEEALKLHN
                     GPPRSAYMEQSFQSLNPVLSLHINPAQVEQARKNAAFTGTALEAWLDSLVGGTWTAMD
                     VCATGPTACPVMQTCSQTAWSSFSPDPKSELGAVKPDGRLR"
     exon            357..395
                     /gene="Xylt1"
                     /gene_synonym="Xt1; XYLT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            396..909
                     /gene="Xylt1"
                     /gene_synonym="Xt1; XYLT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1082
                     /gene="Xylt1"
                     /gene_synonym="Xt1; XYLT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1285
                     /gene="Xylt1"
                     /gene_synonym="Xt1; XYLT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1366
                     /gene="Xylt1"
                     /gene_synonym="Xt1; XYLT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1583
                     /gene="Xylt1"
                     /gene_synonym="Xt1; XYLT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1760
                     /gene="Xylt1"
                     /gene_synonym="Xt1; XYLT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..2023
                     /gene="Xylt1"
                     /gene_synonym="Xt1; XYLT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2219
                     /gene="Xylt1"
                     /gene_synonym="Xt1; XYLT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2553
                     /gene="Xylt1"
                     /gene_synonym="Xt1; XYLT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2554..6004
                     /gene="Xylt1"
                     /gene_synonym="Xt1; XYLT-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcggaagat ggtggcggcg ccgtgcgctc ggaggctggc gcggcgctcg cactcggcgc
       61 tgctggcggc gctcatggtg ctgctgctgc agacgctggt ggtgtggaat ttcagcagcc
      121 tggactccgg ggctggagag cagcggcgcg cgggggcagc ggcgggagca gcggagcagc
      181 agcagcagca gcccgcggcc ccgcgccggg agcgcaggga cctggctgcc catctgcccg
      241 cagcccgcgg aggacctgga ggccgagccg gcggaggagg agcacgggga ggcggccccg
      301 gaggagcccg cgcacagcag cctgccagcc gcggggcact agccgcccgg gcgagggatc
      361 cacacccaag tccactgatc accctagaga cccaggatgg ctacttctct caccggccca
      421 aagagaaagt tcggaccgac agcaacaatg agaactcagt ccccaaggac tttgagaatg
      481 tggacaacag caacttcgca cccaggaccc agaagcagaa gcaccagcca gagttggcaa
      541 agaagcccct cagcaggcag aaagagcgtt tgcagagaaa gctgggcgcc caggacaaag
      601 gacaggggca gtcagtccta ggaaaaggcc ccaaggaggt gctgcctcct cgggaaaaag
      661 ccccaggcaa cagtagccaa gggaaggatc tctcaagaca cagccatagc aggaagagtg
      721 gtggcggtgg gtccccggaa actaagtctg accaggtccc caagtgtgac atctctggca
      781 aggaggccat ctcagcgctg acccgcgcta agtccaagca ctgtcgccag gagattgcag
      841 aaacctactg tcgccacaag ctggggctgc tgatgccaga gaaggtggct cgattctgtc
      901 ccctggaagg caaagccaac aagaatgtcc agtgggatga ggatgctgtt gagtacatgc
      961 cccccaaccc agtcagaatc gcctttgtcc tggtggtcca tggccgtgcc tctcgacagc
     1021 tgcagcgcat gtttaaggcc atctaccaca aagaccattt ctactatatc catgtggata
     1081 agcgttccaa ttacctgcat cggcaagtgc tccagttctc caggcagtac gacaacgtcc
     1141 gagtcacttc ctggaggatg gccaccattt ggggcggagc cagcctcctg tccacttacc
     1201 tgcagagcat gcgggatcta ctggagatga ctgactggcc ctgggacttc ttcatcaacc
     1261 tcagtgctgc tgactacccc atcaggacaa atgaccagct cgtagcattt ctttccagat
     1321 accgagatat gaatttcctg aagtcacatg gtcgggacaa tgcaaggttc atccgaaagc
     1381 agggcctgga ccgtctcttc ctggagtgtg atacacacat gtggcgcctg ggggaccggc
     1441 gaatcccaga gggcattgct gtagatggcg gctctgattg gttcctgcta aaccggaagt
     1501 ttgtagagta tgtggcattc tccacagatg acctggtgac caagatgaag cagttctact
     1561 cttataccct cctccctgct gagtcctttt tccacacggt cctggagaac agcccccact
     1621 gtgacaccat ggtggataac aacctgcgca tcaccaattg gaaccgcaag ctgggctgca
     1681 agtgccagta caagcatatt gtggactggt gtggctgctc tcccaatgac ttcaagcctc
     1741 aggacttcca tcgcttccag cagacggccc ggcccacctt ctttgcccga aagttcgaag
     1801 ccatagtgaa ccaggaaatc attgggcagt tggactctta cctgtatggc aactatcctg
     1861 cgggcacccc gggcctccgc tcttactggg agaatgtcta tgacgaacca gatggcatcc
     1921 agagcctcag cgatgtggca ctcaccatgt atcattcctt catccgcctg ggtcttcgaa
     1981 gggctgagtc atcgctacac acggatgggg agaacagctg caggtactat ccaatgggcc
     2041 acccagcgtc tgtccacctc tacttcctgg ctgaccgatt ccagggcttt ctgatcaagc
     2101 accatgtgac caaccttgct gtgagcaaac tggagacact ggagacatgg atgatgccaa
     2161 agaaagtctt caaggtcgca agtcccccca gtgactttgg gaggcttcag ttttctgagg
     2221 ttggcactga ctgggatgcc aaggagagac tattccggaa ctttggtggt cttttggggc
     2281 ccatggatga gccggtggga atgcagaaat gggggaaggg acccaatgtg accgtgactg
     2341 ttatttgggt ggatcctgtc aatgtcatcg cagccaccta tgatatcctg atcgagtcca
     2401 ctgcggaatt cacacactac aaaccccctt tgaatctgcc tctgaggcct ggtgtctgga
     2461 cagtgaagat tctccatcac tgggtaccag ttgcagagac caaattcctt gtcgcacctc
     2521 tgaccttctc caacaagcag cccatcaaac cagaggaggc tttgaagctg cacaatgggc
     2581 cacctcgcag tgcctacatg gagcagagtt tccagagcct aaacccagtc ctcagcctgc
     2641 acatcaatcc tgcccaagta gagcaggccc ggaagaacgc agccttcact gggacagcac
     2701 tagaagcctg gctggactcg ctggtgggtg ggacttggac tgccatggac gtctgtgcca
     2761 caggccccac tgcctgccca gtcatgcaga cctgcagcca aacagcctgg agttccttca
     2821 gccctgatcc caagtcagag ctgggtgcag tgaagcctga tggtcggctc aggtagcact
     2881 ggccacatgg gactgataca gcctgaaccc tggcctctga tcttatatgg gggaggggtt
     2941 ccttctgttc aaggacctct gttgcctgta ggacagtgga aagagaggat ttggaggcca
     3001 gagagaagtc agcctgtatt tgtgaagctg gcctctggga taggtcgact cagccccagg
     3061 gccacaatgg tctccttcta ccggttgttg ctcagtcctg caggctcccg ttctccccct
     3121 ccgatggcct gcacccctac aagtgagttt taaactttta ttttgagcgg cagaactttg
     3181 tttactgggc acagtcagag gtggaagggc aagaccaaga tgaaatccag gctgctctgg
     3241 ttgaagccga gtttccttct cgaaactcag ccagccaggt ggtcctttgc caagggcatc
     3301 tctaaggtac ctcttctgaa cccaagggct ctgtttaagc cagtttgaca agcactgccc
     3361 tgagcaaggg tgggatcgcc atcccagcct tccattaatc tcttcatttc tgtggctggg
     3421 aaaccttgtg cccatgctaa aggtagcaag ctgcaggaag ccatgctcct ggccttccca
     3481 gggaggcgga gacatgggag aattccaagg ttcctgttgc cactcagtga gctgttttct
     3541 ctgaaaacca gaggttcagg aaagcctttt gatgtgaagc agccaaggtc cccagacatg
     3601 tgactgccaa cttgccatct gtccagatca gcctcttcca aggctgtcac aaatggtagc
     3661 aggaacaggg taaagcatac agagcctgag cttcaattct acctgcccct gggctaggag
     3721 acagctactg tggcctcttt ggtacttgaa agtgggagca gtgcagaact ggggctctga
     3781 atctcaaagg ggattatgtg gatcggagct tctgacctgg atggctgcac agtaacaccc
     3841 cttacgttct gaggtcagat gccccaaacc tttgtgaact gtgcacttgg tgctgtttgc
     3901 tgtgaccaaa ctgcatggat cagactcctc ccacgcagga acaaacattt cagattgggt
     3961 ccttaatttc atatccttcc tcaccgaggt tgccaacagg cttagtctgg ccacaccacg
     4021 taaaaggaag gttgagtttc aacagtggga aggtggttca aaaaatagtg ttattcatat
     4081 tgcttgagtt accagaaacc caagggtctt cttgccatgt gtattcgagg ggcactgagg
     4141 aagagtaccc cttcctcctg gagtccccca aatgacagag ttctctcgga aaagtttcac
     4201 ccattcttgt gtctctccca gcatggataa ggtaccgaag tcctcctgga tgatacatct
     4261 attgcacagc ccctccccca tctaacatgg cgggcataga gaagggaccc ttgatattta
     4321 ttatttatat gttttagtca atgactaatt agtaggtgct gtttttgcag cttgtcaatt
     4381 atgttatctt actaactgaa attgccttta ttcacaaaag gctccctctc ccctcccttt
     4441 ccctggtctg cttgcctttt ctctcattct ctttctgtct gtctctcagt gtccaccttc
     4501 tggttcttag aacgaagcag gggtgtagga caccaaggcc cagtttcaac cagtgcgccc
     4561 actctcagga agcaggccca ttagaatggc tggaatctcc ttttcgctta cacaggatgc
     4621 tggtgtcacc tttccctcta aattcaaaag tgttgaaatg cctgagttcc ccacttaccc
     4681 atggaccagg atgtgatggg ctcattggct tggggaggga gaagtgtgcc aagcatagaa
     4741 ctatagatcc actcagttgc ccccacatca ggcttcttgg tgagcacaag ctatcactag
     4801 cagaggaaga caggctcctt ccaagagtga ttgatcttag gagggatggg ttcagaccca
     4861 ccaggagagc tcaggaggta gctactgtct gtgctggtgg tggagccttt ggatggcttc
     4921 ctctaaaaac ccataggatt tacattggtt tcacaaacct gtgggagcca tgagcctgtt
     4981 gtcccattct ctcagtgtcc ctatattttg ctttggtcaa agcttccctg ggaccatgga
     5041 aactctttga attctccctt gacccctttt gctctaaaca cttgtgtatt ctgttgtaga
     5101 agttccttgg aagccacaga ctctgagaca aggtctgtct agacccagtg acactcgatg
     5161 acatatttca tactgaagac acttgggaat ggagagtcta cttactctgg ggacactctg
     5221 ctccctcttt tctcaccaca actaatttgg ggatatttgt ttcctctgtt tttggagcca
     5281 gaaaataatt ttacttttag taaaaacaaa caaacgaacg aacaaaaaca aaaatggaga
     5341 atttaaaaca agttcagcat aatttaagaa aagatgtttt cctacggaaa atggcataac
     5401 tccttatcta ttgctgtttt cctgcctgaa aaccatagat ttgttggagg ccatgaggga
     5461 aacagcagcc ttgggaggtg gctgcctggg agttttgaaa gcatggagcc atcatctcca
     5521 ggaaccttaa agtctgtagc ctgcacaagc aaaaagcttg ggcttagctg atgaccggaa
     5581 gggtattcct tatgggggga gtattttaga tggcatctct ccatgccatt tggtaactac
     5641 ccctcccaaa gccaacttcc aggctgtgca ggaagctgta agtctctgag aaggaaggga
     5701 acaactcccg atgccccatt tgttttaaca atgcagttct tttcctgttc cccaaaggct
     5761 tttctggtgg agatcgggga cagggcggag ctcctggttt catttctcat tattggttta
     5821 acttttaaaa ctgagattaa gttagagggt aaaaacatgg ccacacaaat atacacacac
     5881 aggcactcat gcacacacac acacacacac acacacacac acacacacac agaggcatgc
     5941 acgcacatga atgcacactc ctaaggggtt tgtttctact ttggatgtac cctgggtgtg
     6001 tata
//
