LOCUS       NM_001108596            3344 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus 5'-3' exoribonuclease 2 (Xrn2), mRNA.
ACCESSION   NM_001108596 XM_001055882 XM_006235156 XM_017602625 XM_342535
VERSION     NM_001108596.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3344)
  AUTHORS   Kinjo,E.R., Higa,G.S., Santos,B.A., de Sousa,E., Damico,M.V.,
            Walter,L.T., Morya,E., Valle,A.C., Britto,L.R. and Kihara,A.H.
  TITLE     Pilocarpine-induced seizures trigger differential regulation of
            microRNA-stability related genes in rat hippocampal neurons
  JOURNAL   Sci Rep 6, 20969 (2016)
   PUBMED   26869208
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3344)
  AUTHORS   Sloan,K.E., Bohnsack,M.T., Schneider,C. and Watkins,N.J.
  TITLE     The roles of SSU processome components and surveillance factors in
            the initial processing of human ribosomal RNA
  JOURNAL   RNA 20 (4), 540-550 (2014)
   PUBMED   24550520
REFERENCE   3  (bases 1 to 3344)
  AUTHORS   Davidson,B., Abeler,V.M., Forsund,M., Holth,A., Yang,Y.,
            Kobayashi,Y., Chen,L., Kristensen,G.B., Shih,Ie.M. and Wang,T.L.
  TITLE     Gene expression signatures of primary and metastatic uterine
            leiomyosarcoma
  JOURNAL   Hum Pathol 45 (4), 691-700 (2014)
   PUBMED   24485798
REFERENCE   4  (bases 1 to 3344)
  AUTHORS   Kinjo,E.R., Higa,G.S., de Sousa,E., Casado,O.A., Damico,M.V.,
            Britto,L.R. and Kihara,A.H.
  TITLE     A possible new mechanism for the control of miRNA expression in
            neurons
  JOURNAL   Exp Neurol 248, 546-558 (2013)
   PUBMED   23933240
REFERENCE   5  (bases 1 to 3344)
  AUTHORS   de Sousa,E., Walter,L.T., Higa,G.S., Casado,O.A. and Kihara,A.H.
  TITLE     Developmental and functional expression of miRNA-stability related
            genes in the nervous system
  JOURNAL   PLoS One 8 (5), e56908 (2013)
   PUBMED   23700402
  REMARK    GeneRIF: XRN2 and PAPD4 and are highly expressed in the retina and
            have distinct gene expression profiles during development.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3344)
  AUTHORS   Lu,Y., Liu,P., James,M., Vikis,H.G., Liu,H., Wen,W., Franklin,A.
            and You,M.
  TITLE     Genetic variants cis-regulating Xrn2 expression contribute to the
            risk of spontaneous lung tumor
  JOURNAL   Oncogene 29 (7), 1041-1049 (2010)
   PUBMED   19915612
REFERENCE   7  (bases 1 to 3344)
  AUTHORS   West,S., Gromak,N. and Proudfoot,N.J.
  TITLE     Human 5' --> 3' exonuclease Xrn2 promotes transcription termination
            at co-transcriptional cleavage sites
  JOURNAL   Nature 432 (7016), 522-525 (2004)
   PUBMED   15565158
REFERENCE   8  (bases 1 to 3344)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
REFERENCE   9  (bases 1 to 3344)
  AUTHORS   Zhang,M., Yu,L., Xin,Y., Hu,P., Fu,Q., Yu,C. and Zhao,S.
  TITLE     Cloning and mapping of the XRN2 gene to human chromosome
            20p11.1-p11.2
  JOURNAL   Genomics 59 (2), 252-254 (1999)
   PUBMED   10409438
REFERENCE   10 (bases 1 to 3344)
  AUTHORS   Shobuike,T., Sugano,S., Yamashita,T. and Ikeda,H.
  TITLE     Characterization of cDNA encoding mouse homolog of fission yeast
            dhp1+ gene: structural and functional conservation
  JOURNAL   Nucleic Acids Res 23 (3), 357-361 (1995)
   PUBMED   7885830
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1 and FQ201757.1.
            
            On or before Sep 3, 2019 this sequence version replaced
            XM_006235156.3, XM_017602625.1, NM_001108596.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. This RefSeq transcript is based on
            transcript alignments from orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.14770.1,
                                           SRR26643429.13825.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               JAXUCZ010000003.1  154890361-154890480
            121-248             JAXUCZ010000003.1  154905339-154905466
            249-360             JAXUCZ010000003.1  154905547-154905658
            361-472             JAXUCZ010000003.1  154906047-154906158
            473-531             JAXUCZ010000003.1  154907253-154907311
            532-621             JAXUCZ010000003.1  154907388-154907477
            622-694             JAXUCZ010000003.1  154908181-154908253
            695-745             JAXUCZ010000003.1  154908474-154908524
            746-903             JAXUCZ010000003.1  154908962-154909119
            904-978             JAXUCZ010000003.1  154910348-154910422
            979-1112            JAXUCZ010000003.1  154910505-154910638
            1113-1170           JAXUCZ010000003.1  154910737-154910794
            1171-1278           JAXUCZ010000003.1  154910878-154910985
            1279-1323           JAXUCZ010000003.1  154915424-154915468
            1324-1455           JAXUCZ010000003.1  154917086-154917217
            1456-1574           JAXUCZ010000003.1  154919307-154919425
            1575-1710           JAXUCZ010000003.1  154924873-154925008
            1711-1818           JAXUCZ010000003.1  154926201-154926308
            1819-1908           JAXUCZ010000003.1  154926388-154926477
            1909-1981           JAXUCZ010000003.1  154927064-154927136
            1982-2065           JAXUCZ010000003.1  154931660-154931743
            2066-2163           JAXUCZ010000003.1  154933325-154933422
            2164-2243           JAXUCZ010000003.1  154934030-154934109
            2244-2300           JAXUCZ010000003.1  154935702-154935758
            2301-2369           JAXUCZ010000003.1  154946127-154946195
            2370-2501           JAXUCZ010000003.1  154946285-154946416
            2502-2629           JAXUCZ010000003.1  154948349-154948476
            2630-2693           JAXUCZ010000003.1  154954029-154954092
            2694-2835           JAXUCZ010000003.1  154959156-154959297
            2836-3331           JAXUCZ010000003.1  154961998-154962493
            3332-3344           FQ201757.1         1-13                c
FEATURES             Location/Qualifiers
     source          1..3344
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..3344
                     /gene="Xrn2"
                     /note="5'-3' exoribonuclease 2"
                     /db_xref="GeneID:362229"
                     /db_xref="RGD:1310218"
     exon            1..120
                     /gene="Xrn2"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..2901
                     /gene="Xrn2"
                     /EC_number="3.1.13.-"
                     /codon_start=1
                     /product="5'-3' exoribonuclease 2"
                     /protein_id="NP_001102066.2"
                     /db_xref="GeneID:362229"
                     /db_xref="RGD:1310218"
                     /translation="MGVPAFFRWLSRKYPSIIVNCVEEKPKECNGVKIPVDASKPNPN
                     DVEFDNLYLDMNGIIHPCTHPEDKPAPKNEDEMMVAIFEYIDRLFNIVRPRRLLYMAI
                     DGVAPRAKMNQQRSRRFRASKEGMEAAVEKQRVREEILAKGGFLPPEEIKERFDSNCI
                     TPGTEFMDNLAKCLRYYIADRLNNDPGWKNLTVILSDASAPGEGEHKIMDYIRRQRAQ
                     PNHDPNTHHCLCGADADLIMLGLATHEPNFTIIREEFKPNKPKPCALCNQFGHEVKDC
                     EGLPREKKGKHDELADSLPCAEGEFIFLRLNVLREYLERELTMASLPFPFDVERSIDD
                     WVFMCFFVGNDFLPHLPSLEIREGAIDRLVNIYKNVVHKTGGYLTESGYVNLQRVQMI
                     MLAVGEVEDSIFKKRKDDEDSFRRRQKEKRKRMKRDQPAFTPSGILTPYALGSRNSPG
                     CQVASNPRQAAYEMRMQSNSSPSISPNTSFASDGSPSPLGGLKRKAEDSDSEPEPEDN
                     VRLWEAGWKQRYYKNKFDVDAADEKFRRKVVQSYVEGLCWVLRYYYQGCASWKWYYPF
                     HYAPFASDFEGIADMPSEFEKGTKPFKPLEQLMGVFPAASGNFLPPTWRKLMSDPDSS
                     IIDFYPEDFAIDLNGKKYAWQGVALLPFVDERRLRAALEEVYPDLTPEENRRNSLGSD
                     VLFVGKVHPLHDFILELYQTGSTEPVDVPPELCHGIQGKFSLDEEAILPDQTVCSPVP
                     MLRDLTQNTAISINFKDPQFAEDYVFKAIMLPGARKPAAVLKPGDWEKSSNGRQWKPQ
                     LGFNRDRRPVHLDQAAFRTLGHVIPRGSGTGVYSNTAPPPANYQGNVYRPLLRGQAQI
                     PKLMSNMRPQDNWRGPPPLFQQQRFDRSVGAEPLLPWNRMLQTQNAAFQPNQYQMLAG
                     PGGYPPRRDDHRGGRQGYPREGRKYPLPPPSGRYSWN"
     exon            121..248
                     /gene="Xrn2"
                     /inference="alignment:Splign:2.1.0"
     exon            249..360
                     /gene="Xrn2"
                     /inference="alignment:Splign:2.1.0"
     exon            361..472
                     /gene="Xrn2"
                     /inference="alignment:Splign:2.1.0"
     exon            473..531
                     /gene="Xrn2"
                     /inference="alignment:Splign:2.1.0"
     exon            532..621
                     /gene="Xrn2"
                     /inference="alignment:Splign:2.1.0"
     exon            622..694
                     /gene="Xrn2"
                     /inference="alignment:Splign:2.1.0"
     exon            695..745
                     /gene="Xrn2"
                     /inference="alignment:Splign:2.1.0"
     exon            746..903
                     /gene="Xrn2"
                     /inference="alignment:Splign:2.1.0"
     exon            904..978
                     /gene="Xrn2"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1112
                     /gene="Xrn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1170
                     /gene="Xrn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1278
                     /gene="Xrn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1323
                     /gene="Xrn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1455
                     /gene="Xrn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1574
                     /gene="Xrn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1710
                     /gene="Xrn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1818
                     /gene="Xrn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1908
                     /gene="Xrn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..1981
                     /gene="Xrn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1982..2065
                     /gene="Xrn2"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2163
                     /gene="Xrn2"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2243
                     /gene="Xrn2"
                     /inference="alignment:Splign:2.1.0"
     exon            2244..2300
                     /gene="Xrn2"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..2369
                     /gene="Xrn2"
                     /inference="alignment:Splign:2.1.0"
     exon            2370..2501
                     /gene="Xrn2"
                     /inference="alignment:Splign:2.1.0"
     exon            2502..2629
                     /gene="Xrn2"
                     /inference="alignment:Splign:2.1.0"
     exon            2630..2693
                     /gene="Xrn2"
                     /inference="alignment:Splign:2.1.0"
     exon            2694..2835
                     /gene="Xrn2"
                     /inference="alignment:Splign:2.1.0"
     exon            2836..3332
                     /gene="Xrn2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acactctccc gctgcccggc tgctgcttcg agctgcccgc tggtcatggg agtcccggcg
       61 ttcttccgct ggctcagccg caagtacccg tccatcattg tcaattgcgt ggaggagaag
      121 ccaaaagaat gcaatggtgt gaagattcca gttgatgcca gtaaacctaa tccaaatgat
      181 gtggagtttg ataatctgta tttggatatg aatggaatca tccatccctg tactcatcct
      241 gaagacaaac cagcaccaaa aaatgaagat gaaatgatgg ttgcaatttt tgagtacatt
      301 gacagacttt tcaatattgt aagaccaaga agacttctct atatggcaat agatggagtg
      361 gcaccacgtg ccaaaatgaa ccagcagcgt tcaaggaggt tcagagcatc taaggaagga
      421 atggaagccg cagttgagaa gcagcgagtc agagaggaaa tacttgcaaa aggtggcttt
      481 cttcctccag aagaaataaa agaaagattt gacagcaact gtattacacc aggaactgag
      541 ttcatggaca atcttgctaa atgccttcgc tattacatag ctgatcgttt aaataatgac
      601 cccgggtgga aaaatttgac agttatatta tctgacgcta gtgcgcctgg tgaaggagaa
      661 cacaaaatca tggattacat tagaagacaa agagcccagc ctaaccatga cccaaatact
      721 catcattgtt tatgtggagc tgatgctgat ctcattatgc ttggtcttgc tacacatgaa
      781 cctaacttca ccataatcag agaagaattc aaaccaaata aacctaaacc atgtgctctt
      841 tgtaatcagt ttggacacga ggtcaaggac tgtgaaggtt tgcccagaga aaagaagggg
      901 aagcatgatg aacttgcaga tagtcttcct tgtgcagaag gggagttcat cttccttcgg
      961 ctgaatgtcc ttcgagagta tctggaacga gagctcacca tggccagctt accgttccca
     1021 tttgatgtgg agaggagcat cgatgactgg gtgttcatgt gcttctttgt ggggaatgat
     1081 ttccttcctc acttgccgtc actagagatt agggaaggtg caattgatcg tttggttaac
     1141 atatacaaaa acgtggtaca caaaactggg ggttacctta cagaaagtgg ttatgtcaat
     1201 ctacaaagag tacagatgat catgttagca gttggtgaag ttgaggatag catttttaaa
     1261 aagagaaaag atgatgagga cagttttaga agacgacaga aagaaaaaag aaagaggatg
     1321 aagagagatc aaccagcttt tactcctagt ggaatattaa caccttacgc tttgggttca
     1381 agaaattctc caggttgtca agtagccagt aatccaagac aagccgccta tgaaatgagg
     1441 atgcagagta actctagtcc ttcaatatcc cctaatacaa gttttgcatc tgatggctcc
     1501 ccatctccac taggaggact taagagaaaa gcagaagata gtgatagtga gccagagcca
     1561 gaggataacg tcaggttatg ggaagctggt tggaagcagc gatactacaa gaacaaattt
     1621 gatgtagatg cagctgatga gaaattccga cgtaaggttg ttcagtctta tgttgaagga
     1681 ttgtgctggg ttcttcgata ttattaccag ggctgtgctt cctggaagtg gtattaccca
     1741 ttccattatg cgccgtttgc ctcagacttt gaaggtattg cagacatgcc ttctgaattt
     1801 gaaaagggca caaaaccgtt taaaccactg gaacagctaa tgggggtttt tccagctgca
     1861 agtggtaact ttttacctcc aacatggcgg aagctcatga gtgaccctga ttctagtata
     1921 attgacttct atcctgaaga ctttgctatt gatttgaatg ggaagaagta tgcatggcaa
     1981 ggtgttgctc tgttgccatt tgtggatgag cgaaggctgc gagcggccct agaagaggtg
     2041 tacccagacc tcactccaga agagaacagg agaaatagtc ttggaagtga tgttttgttt
     2101 gtgggaaaag ttcatccact acacgacttc attttagagc tgtatcagac aggttctaca
     2161 gagccagtag atgtgccgcc tgagttgtgt cacgggattc aagggaagtt ttctttggat
     2221 gaagaagcca tacttccaga ccaaacagta tgttcccctg tgcccatgtt acgggacttg
     2281 acacagaaca ctgcaatcag tattaatttt aaagatccac agtttgcgga agattatgtt
     2341 tttaaagcta taatgcttcc aggagcaaga aagccagcag cagttctgaa acccggagac
     2401 tgggaaaaat ccagcaatgg gcggcaatgg aaaccccagc ttggctttaa ccgggaccgg
     2461 cggcctgttc acctggacca ggcagccttt agaactttag gccatgttat accaagaggc
     2521 tcagggactg gtgtttacag caacactgca cccccacctg ccaattacca ggggaacgta
     2581 tacaggccac tgctgagagg tcaagctcag atcccaaaac taatgtcaaa tatgaggccc
     2641 caagataact ggcgaggtcc tcctcctctt ttccagcagc agagatttga cagaagtgtt
     2701 ggagctgaac ccctactgcc gtggaaccga atgctccaaa cccaaaatgc agcctttcag
     2761 ccaaatcagt accagatgct ggctgggccc ggaggatatc cacccagacg tgatgaccat
     2821 cgaggagggc gacagggata tcccagagaa ggaaggaagt accctttgcc accgccctcg
     2881 ggaagataca gttggaatta ggcttttgta aagcttccca cattcctttc accattttac
     2941 actttcatgc tatttgtgga aaggtttctt tctcaagtag tagtttttaa taaaactata
     3001 gtactttgtg tatttctttt aactgtgtgt atatttttac tgatctgatc tcactgtttt
     3061 atgttgcttt ctagagatgt gtattgcata atacagtggg tctgaattta ttattgcttg
     3121 taaacacatt tgatgaaatt aggagtcctg ggttttcatt atggttaaaa ctcaaaacag
     3181 ctctatgctg attttaatgc acattaataa ttaggtatgg acatttgaac tgcacattct
     3241 gcagactaga gcatatattg ttcaacattt ctttgaaaac atttcattaa agtacttgtc
     3301 ttacagaaat ttgtggactt tagtaaaaaa aaaaaaaaaa aaaa
//
